View source for Phosalone

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 464204750
| ImageFile= Phosalone Structure.svg 
| ImageSize=
| ImageFile1=Phosalone-spacefilling-from-AHRLS-2011.png
| ImageSize1=200px
| PIN=''S''-[(6-Chloro-2-oxo-1,3-benzoxazol-3(2''H'')-yl)methyl] ''O'',''O''-diethyl phosphorodithioate
| OtherNames=Zolone
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4629
| InChI = 1/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3
| InChIKey = IOUNQDKNJZEDEP-UHFFFAOYAA
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = IOUNQDKNJZEDEP-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=2310-17-0
| PubChem=4793
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1528531
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C11028
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 448B85HT8M
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 8121
| SMILES = Clc2ccc1c(OC(=O)N1CSP(=S)(OCC)OCC)c2
}}
|Section2={{Chembox Properties
| C=12 | H=15 | Cl=1 | N=1 | O=4 | P=1 | S=2
| Appearance = Colorless crystalline
| Odor = garlic
| Density = 1.39 g cm<sup>−3</sup>
| MeltingPtC = 47.5 to 48
| BoilingPt =
| Solubility = 3.05 mg/L
| SolubleOther = many organic solvents
  }}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
  }}
}}

'''Phosalone''' is an [[organophosphate]] chemical commonly used as an [[insecticide]] and [[acaricide]]. It is developed by [[Rhône-Poulenc]] in France but EU eliminated it from pesticide registration in December 2006.

The [[median lethal dose]] of oral exposure in rat is 85&nbsp;mg/kg and that of dermal is 390&nbsp;mg/kg.<ref name="Jaish">[http://www.jaish.gr.jp/anzen/gmsds/2310-17-0.html 製品安全データシート（安全衛生情報センター）] {{webarchive|url=https://web.archive.org/web/20141025104610/http://www.jaish.gr.jp/anzen/gmsds/2310-17-0.html |date=2014-10-25 }}</ref>。It is a weak [[acetylcholinesterase inhibitor]].<ref name="nihs">{{Cite web |url=http://www.nihs.go.jp/ICSC/icssj-c/icss0797c.html |title=国際化学物質安全性カード |access-date=2012-09-06 |archive-url=https://web.archive.org/web/20121211034027/http://www.nihs.go.jp/ICSC/icssj-c/icss0797c.html |archive-date=2012-12-11 |url-status=dead }}</ref> It is taken by not only oral and inhalation but skin and it causes toxic symptoms peculiar to [[organophosphorus compounds]] such as [[miosis]], [[hypersalivation]], [[hyperhidrosis]], chest pressure, [[pulmonary edema]] and [[fecal incontinence]].<ref name="Sanseido">{{Cite book
| author=植村振作・河村宏・辻万千子・冨田重行・前田静夫著
| year=2002
| title=農薬毒性の事典 改訂版
| publisher=三省堂
| isbn=978-4385356044
}}</ref> It is flammable and decomposes to toxic gases such as [[phosphorus oxides]], [[sulfur oxides]] and [[nitrogen oxides]].<ref name="nihs"/> It is harmful especially to water creatures.

==References==
{{Reflist}}

==External links==
* [http://www.hclrss.demon.co.uk/phosalone.html Phosalone Fact Sheet]
* [http://www.epa.gov/pesticides/op/phosalone.htm EPA Webpage on Phosolone]
* {{PPDB|520}}

{{Insecticides}}
{{Acetylcholine metabolism and transport modulators}}

[[Category:Acetylcholinesterase inhibitors]]
[[Category:Organophosphate insecticides]]
[[Category:Chloroarenes]]
[[Category:Carbamates]]
[[Category:Benzoxazoles]]
[[Category:Phosphorodithioates]]
[[Category:Ethyl esters]]

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