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{{Short description|1=Overview of and topical guide to immunology}}
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{{TopicTOC-Immunology}}
The following [[Outline (list)|outline]] is provided as an overview of and topical guide to immunology:

'''[[Immunology]]''' &ndash; study of all aspects of the [[immune system]] in all [[organism]]s.<ref>[https://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=imm.TOC&depth=2 Janeway's Immunobiology textbook] Searchable free online version at the [[National Center for Biotechnology Information]]</ref> It deals with the [[physiology|physiological]] functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders ([[autoimmune diseases]], [[hypersensitivity|hypersensitivities]], [[immune deficiency]], [[transplant rejection]]); the physical, chemical and physiological characteristics of the components of the immune system [[in vitro]], [[in situ]], and [[in vivo]].

{{TOC limit|limit=2}}

== Essence of immunology ==


[[Immunology]]
* Branch of [[Biomedical science]]
* [[Immune system]]
* [[Immunity (medical)|Immunity]]

# Branches of immunology:
1. General Immunology
2. Basic Immunology
3. Advanced Immunology
4. Medical Immunology
5. Pharmaceutical Immunology
9. Clinical Immunology
6. Environmental Immunology
8. Cellular and Molecular Immunology
9. Food and Agricultural Immunology
--------------------------------------------------------------------------------
* [[Classical immunology]]
* [[Clinical immunology]]
* [[Computational immunology]]
* [[Diagnostic immunology]]
* [[Evolutionary immunology]]
* [[Systems immunology]]
* [[Immunomics]]
* [[Immunoproteomics]]
* [[Immunophysics]]
* [[Immunochemistry]]
* [[Ecoimmunology]]
* [[Immunopathology]]
* [[Nutritional immunology]]
* [[Psychoneuroimmunology]]
* [[Reproductive immunology]]
* [[Circadian immunology]]
* [[Immunotoxicology]]
* [[Palaeoimmunology]]
* [[Tissue-based immunology]]
:* [[Testicular immunology]] - [[Testes]]
:* [[Immunodermatology]] - [[Skin]]
:* [[Intravascular immunology]] - [[Blood]]
:* [[Osteoimmunology]] - [[Bone]]
:* [[Mucosal immunology]] - [[Mucosal surfaces]]
::* [[Respiratory tract antimicrobial defense system]] - [[Respiratory tract]]
:* [[Neuroimmunology]] - [[Neuroimmune system]] in the [[Central nervous system]]
:* [[Ocularimmunology]] - [[Ocular immune system]] in the [[Eye]]
:* [[Cancer immunology]]/[[Immunooncology]] - [[Tumor]]s

== History of immunology ==

[[History of immunology]]
* [[Timeline of immunology]]

== General immunological concepts ==
* [[Immunity (medical)|Immunity]]:
:* Immunity against:
::* [[Pathogen]]s
::** [[Pathogenic bacteria]]
::** [[Virus]]es
::** [[Fungi]]
::** [[Protozoa]]
::* [[Parasite]]s
::* [[Tumor]]s
::* [[Allergen]]s
::* [[Self-protein]]s
:* [[Autoimmunity]]
:* [[Alloimmunity]]
:* [[Cross-reactivity]]
* [[Immune tolerance|Tolerance]]
:* [[Central tolerance]]
:* [[Peripheral tolerance]]
:* [[Clonal anergy]]
:* [[Clonal deletion]]
:* [[Tolerance in pregnancy]]
:* [[Immunodeficiency]]
* [[Antigen]]
:* [[Antigenicity]]
:* [[Immunogen]]
:* [[Superantigen]]
:* [[Allergen]]
:* [[Hapten]]
:* [[Epitope]]
::* [[Linear]]
::* [[Protein conformation|Conformation]]al
::* [[Mimotope]]
:* [[Tumor antigen]]
:* [[Antigen-antibody interaction]]
* [[Immunogenetics]]
:* [[Affinity maturation]]
::* [[Somatic hypermutation]]
::* [[Clonal selection]]
:* [[V(D)J recombination]]
::* [[Artemis complex]]
::* [[Recombination-activating gene]]
:::* [[RAG1]]
:::* [[RAG2]]
::* [[Recombination signal sequences]]
:* [[Junctional diversity]]
:* [[Immunoglobulin class switching]]
:* [[Allelic exclusion]]
:* [[Polyclonal response]]
* [[Phagocytosis]]
:* [[Opsonin]]
* [[Intrinsic immunity]]
* [[Leukocyte extravasation]]
* [[Cross-presentation]]
* [[Immune repertoire]]
* [[Original antigenic sin]]
* [[Antigen presentation]]
* [[Immunological synapse]]
* [[Co-stimulation]]

== Components of the immune system ==

[[Immune system]]

===&nbsp;&nbsp;Adaptive immune system===

[[Adaptive immune system]]
:* [[Humoral immunity]]
::* [[Antibody|Antibodies]]
:::* Kinds of antibodies
::::* [[Monoclonal antibodies]]
::::* [[Polyclonal antibodies]]
::::* [[Autoantibody]]
::::* [[Microantibody]]
::::* [[Neutralizing antibody]]
:::* Classification
::::* [[Allotype (immunology)|Allotype]]
::::* [[Isotype (immunology)|Isotype]]
::::* [[Idiotype]]
:::* Functions
::::* [[Antibody opsonization]]
::::* [[Neutralisation (immunology)|Neutralisation]]
:::* Regions
::::* [[Paratope]]
::::* [[Complementarity-determining region]] (CDRs)
::::* [[Hypervariable region]]
::::* [[Framework region]]
::::* [[Fragment antigen-binding|Fab Region]]
::::* [[Fragment crystallizable region|Fc Region]]
::* [[Polyclonal B cell response]]
:* [[Cell-mediated immunity]]

===&nbsp;&nbsp;Innate immune system===

[[Innate immune system]]
:* [[Complement system]]
::* [[Classical complement pathway]]
::* [[Mannan-binding lectin pathway]]
::* [[Alternate complement pathway]]
::* [[Complement membrane attack complex]]
:*[[Immune system#Surface barriers|Surface barriers]] &ndash; Physical or chemical barriers that prevent infection (i.e. [[skin]], [[tears]], [[mucus]], [[saliva]], [[Gastric acid]], etc.)
::*[[Antimicrobial peptides]]
::*[[Defensins]]
::*[[Lysozyme]]
:* [[Inflammation]]
::* [[Inflammatory reflex]]
::* [[Inflammasome]]
::* [[Granuloma]]
::* [[Acute-phase protein]]s
:::* [[Amyloid]]
{{flatlist|indent=5}}
* [[Serum amyloid P component|SAP]]
* [[Serum amyloid A|SAA]]
{{endflatlist}}
:::* Positive
{{flatlist|indent=5}}
* [[Alpha 1-antichymotrypsin]]
* [[Alpha 1-antitrypsin]] 
* [[Alpha 2-macroglobulin]] 
* [[C-reactive protein]] 
* [[Ceruloplasmin]]
* [[C3 (complement)|C3]] 
* [[Ferritin]] 
* [[Fibrin]] 
* [[Haptoglobin]] 
* [[Hemopexin]] 
* [[Orosomucoid]]
{{endflatlist}}
:::* Negative
{{flatlist|indent=5}}
* [[Serum albumin]] 
* [[Transferrin]]
{{endflatlist}}

{{Inflammation |state=collapsed}}

== Organs of the immune system ==

[[Lymphatic system]]

=== &nbsp;&nbsp;Primary lymphoid organs ===

[[Primary lymphoid organs]]
:* [[Thymus]] - Site of [[T cell]] maturation
:* [[Bone marrow]] - Site of [[haematopoiesis]] and [[B cell]] maturation

=== &nbsp;&nbsp;Secondary lymphoid organs ===

[[Secondary lymphoid organs]]
:* [[Spleen]]
:** [[White pulp]]
:** [[Red pulp]]
:** [[Marginal zone]]
:* [[Lymph node]]s
:* [[Mucosa-associated lymphoid tissue]]
::* [[Gut-associated lymphoid tissue]]
::* [[Bronchus-associated lymphoid tissue]]
{{Lymphoid system |state=collapsed}}

== Cells of the immune system ==

[[White blood cells]]

=== &nbsp;&nbsp;Myeloid cells ===
:{{main|Myeloid cells|Phagocytes}}
:{{See also|Sentinel cell}}
:* [[Granulocyte]]s
:** [[Neutrophil]]s
:** [[Eosinophil]]s
:** [[Basophil]]s
:**[[Mast cells]]
:* [[Monocyte]]s
:* [[Macrophage]]s
::* [[Histiocyte]]s (Tissue resident macrophages)
:::* [[Adipose tissue macrophages]]
:::* [[Kupffer cell]] - [[Liver]]
:::* [[Alveolar macrophage]] (Dust cell) - [[Lung]]
:::* [[Langerhans cell]] - [[Skin]]
:::* [[Dermal macrophage]] - [[Dermis]]
:::* [[Microglia]] - [[Central nervous system|CNS]]
:::* [[Perivascular macrophage]]
:::* [[Meningeal macrophage]] - [[Meninges]]
:::* [[Hofbauer cell]] - [[Placenta]]
:::* [[Osteoclasts]] - [[Bone]]
:::* [[Bone marrow macrophage]] - [[Bone marrow]]
:::* [[Marginal zone macrophage]] - [[Spleen]]
:::* [[Metallophilic macrophage]] - Spleen
:::* [[Red pulp macrophage]] - [[Red pulp|Splenic red pulp]]
:::* [[Tingible body macrophage]] (White pulp macrophage) - [[White pulp|Splenic white pulp]]
::* [[Giant cell]]s
:::* [[Foreign-body giant cell]]
:::* [[Langhans giant cell]]
:::* [[Touton giant cells]]
::* [[Epithelioid cell]]s
::* [[Bone marrow-derived macrophage]]s - Generated [[in vitro]]
:*[[Dendritic Cell]]s
::*[[Conventional Dendritic Cell]]s
::*[[Plasmacytoid dendritic cell]]s

=== &nbsp;&nbsp;Lymphoid cells ===

[[Lymphoid cells]]
:* [[B cell]]s
:** [[Plasma B cell]]s
:** [[Memory B cell]]s
:** [[B-1 cell]]s
:** [[B-2 cell]]s (the conventional B cells most texts refer to)
:** [[Marginal-zone B cell]]s
:** [[Follicular B cell]]s
:* [[T cell]]s
:** [[Naive T cell]]s
:** [[Helper T cell]]s - Commonly termed CD4+ T cells
:*** [[Th1 cell]]s
:*** [[Th2 cell]]s
:*** [[Th3 cell]]s
:*** [[Th17 cell]]s
:*** [[Follicular B helper T cells|T<sub>FH</sub> cells]] - Follicular helper T cells
:** [[Cytotoxic T cell]]s - Commonly termed CD8+ T cells
:** [[Memory T cells]]
:** [[Regulatory T cell]]s
:** [[Natural Killer T cell]]s (NKT cells)
:** [[gamma/delta T cells|γδ T cell]]s
:** [[Mucosal associated invariant T cell]]s
:* [[Innate lymphoid cell]]s (ILC)
:** [[Group 1 ILC]]
:*** [[Natural killer cell]]s (NK cells)
:** [[Group 2 ILC]]
:*** [[Nuocyte]]
:** [[Group 3 ILC]]
:*** [[Lymphoid Tissue inducer cell]]s (LTi cells)

=== &nbsp;&nbsp;Others ===
:(Non-hematopoietic cells with immune functions)
:* [[Stromal cell]]s
::* [[Lymph node stromal cell]]s
::* [[Follicular dendritic cell]]s
:* [[Epithelial cell]]s
:* [[Pericyte]]s
:* [[Microfold cell]]s (M cells)

=== &nbsp;&nbsp;Hematopoiesis ===
:{{main|Hematopoiesis|Hematopoietic stem cell}}
:{{See also|Leukopoiesis|Extramedullary hematopoiesis|Cellular differentiation}}
:* [[Lymphopoiesis]]
::* [[Lymphoblast]]
::* [[Prolymphocyte]]
:::* [[T cell development]]
::::* [[Thymocyte]]
:::* [[B cell development]]
::::* [[Pre-pro-B cell]]
::::* [[Early pro-B cell]]
::::* [[Late pro-B cell]]
::::* [[Pre-B cell|Large pre-B cell]]
::::* [[Small pre-B cell]]
::::* [[Immature B cell]]
:* [[Myelopoiesis]]
::* [[Common myeloid progenitor]] (CFU-GEMM)
:::* [[Granulocyte-macrophage progenitor]] (CFU-GM)
::::* [[Granulopoiesis]]
:::::* [[Myeloblast]] (CFU-G)
:::::* [[Promyelocyte]]
:::::* [[Myelocyte]]
:::::* [[Metamyelocyte]]
:::::* [[Band cell]]
::::* [[Monocytopoiesis]]
:::::* [[Monoblast]] (CFU-M)
::::::* [[CFU-DL]] - [[Dendritic cell]] / [[Langerhans cell]] precursor
:::::* [[Promonocyte]]
:::* [[CFU-Baso]] (Basophil precursor)
:::* [[CFU-Eos]] (Eosinophil precursor)
:::* [[Megakaryocyte-erythroid progenitor cell]] (MEP)
::::* [[Megakaryocytopoiesis]]
:::::* [[CFU-Meg]]
:::::* [[Megakaryoblast]]
:::::* [[Promegakaryocyte]]
:::::* [[Megakaryocyte]]
:::::* [[Thrombopoiesis]]
::::::* [[Thrombocyte]] ([[Platelet]]s)
::::* [[Erythropoiesis]]
:::::* [[Proerythroblast]]
:::::* [[Normoblast]]
:::::* [[Reticulocyte]]
:::* [[CFU-Mast]]
::::* [[Mast cell precursor]]s

==Molecules of the immune system==

=== Immune receptors ===
{{main|Immune receptor|co-receptors}}
{{See also|List of immune receptors}}

==== &nbsp;&nbsp;&nbsp;Antigen receptors ====
:* [[B cell]]s
::* Antigen receptor - [[B cell receptor]] (BCR)
::* Subunits- [[Immunoglobulin heavy chain]] / [[Immunoglobulin light chain]]
::* Co-receptors
:::* Stimulatory
::::* [[CD21]]
::::* [[CD19]]
::::* [[CD81]]
:::* Inhibitory
::::* [[CD22]]
::* Accessory molecule ([[CD79]])
:::* [[Ig-α]] (CD79A)
:::* [[Ig-β]] (CD79B) 
:* [[T cell]]s
::* Antigen receptor - [[T cell receptor]] (TCR)
:::* Subunits - [[TRA@]] / [[TRB@]] / [[TRD@]] / [[TRG@]]
::* Co-receptors
:::* [[CD8]] ([[CD8α]] / [[CD8β]])
:::* [[CD4]]
::* Accessory molecules
:::* [[CD3 (immunology)|CD3]]
::::* Subunits - one [[CD3γ]] / one [[CD3δ]] / two [[CD3ε]]
:::* [[ζ-chain]] (CD247, CD3ζ, TCRζ)

==== &nbsp;&nbsp;&nbsp;Pattern recognition receptors (PRRs) ====

[[Pattern recognition receptor]]
{{See also|List of pattern recognition receptors}}
{{See also|Pathogen-associated molecular pattern|Damage-associated molecular pattern}}
:* [[Membrane-bound PRR]]s
::* [[Toll-like receptor]]s (TLRs)
{{flatlist|indent = 4}}
* [[TLR1]]
* [[TLR2]]
* [[TLR3]]
* [[TLR4]]
* [[TLR5]]
* [[TLR6]]
* [[TLR7]]
* [[TLR8]]
* [[TLR9]]
* [[TLR10]]
* [[TLR11]]
* [[TLR12]]
* [[TLR13]]
{{endflatlist}}
::* [[C-type lectin receptor]]s (CLRs) <ref>{{cite web|url=https://www.genenames.org/data/genegroup/#!/group/1298|access-date=2019-08-30 | title = HGNC Gene Group: C-type lectin domain containing}}</ref><ref>{{cite journal |vauthors=Geijtenbeek TB, Gringhuis SI |title=Signalling through C-type lectin receptors: shaping immune responses |journal=Nat. Rev. Immunol. |volume=9 |issue=7 |pages=465–79 |date=July 2009  |pmid=19521399 |doi=10.1038/nri2569 |pmc=7097056 }}</ref> 
:::{{See also|C-type lectin}}
:::* Group 1 CLRs - [[Mannose receptor]]s
{{flatlist|indent=5}}
* [[MRC1]]
* [[MRC2]]
* [[DEC205]] (CD205)
{{endflatlist}}
:::* Group 2 CLRs - [[Asialoglycoprotein]] receptor family
{{flatlist|indent=5}}
* [[DC-SIGN]] (CD209)
* [[Langerin]] (CD207)
* [[CLEC10A]] (CD301, MGL)
* [[CLEC5A]] (MDL1)
{{endflatlist}}
::::* Dectin 1 subfamily
{{flatlist|indent=6}}
* [[Dectin 1]] (CLEC7A)
* [[CLEC12A|MICL]] (CLEC12A)
* [[CLEC2]]
* [[DNGR1]] (CLEC9A)
{{endflatlist}}
::::* DCIR subfamily
{{flatlist|indent=6}}
* [[Dectin 2]] (CLEC6A)
* [[BDCA2]] (CD303)
* [[Mincle]] (CLEC4E)
* [[DCIR]] (CLEC4A)
{{endflatlist}}
::* [[scavenger receptor (immunology)|Scavenger receptor]]s
:::* Class A - Trimers
{{flatlist|indent=5}}
* [[MSR1]] (SCARA1)
* [[MARCO]] (SCARA2)
* [[SCARA3]]
* [[SCARA4]] (COLEC12)
* [[SCARA5]]
{{endflatlist}}
:::* Class B - Two transmembrane domains
{{flatlist|indent=5}}
* [[SCARB1]]
* [[SCARB2]]
* [[CD36]] (SCARB3)
{{endflatlist}}
:::* Others
{{flatlist|indent=5}}
* [[CD68]]
* [[LOX-1]]
{{endflatlist}}
::* [[Formyl peptide receptor]]s (FPRs)
{{flatlist|indent=4}}
* [[FPR1]]
* [[FPR2]]
* [[FPR3]]
{{endflatlist}}
:* [[Cytoplasmic PRR]]s
::* [[NOD-like receptor]]s (NLRs)
:::* NLRA (A for acidic transactivating domain)
::::* [[CIITA]]
:::* NLRB (B for BIR, or [[Inhibitor of apoptosis domain]])
::::* [[NAIP (gene)|NAIP]]
:::* NLRC (C for [[CARD domain]])
{{flatlist|indent=5}}
* [[NOD1]]
* [[NOD2]]
* [[NLRC3]]
* [[NLRC4]] (IPAF)
* [[NLRC5]]
{{endflatlist}}
:::* NLRP (P for [[Pyrin domain]])
{{flatlist|indent=5}}
* [[NLRP1]]
* [[NLRP2]]
* [[NLRP3]]
* [[NLRP4]]
* [[NLRP5]] 
* [[NLRP6]] 
* [[NLRP7]] 
* [[NLRP8]] 
* [[NLRP9]] 
* [[NLRP10]] 
* [[NLRP11]] 
* [[NLRP12]]
* [[NLRP13]]
* [[NLRP14]]
{{endflatlist}}
:::* NLRX
::::* [[NLRX1]]
::* [[RIG-I-like receptor]]s (RLRs) - Intracellular sensors of viral replication by direct interaction with [[dsRNA]]
{{flatlist|indent=4}}
* [[RIG-I]]
* [[MDA5]]
* [[LGP2]]
{{endflatlist}}
:* [[Secreted PRR]]s
::* [[Complement system]] (see complement proteins section)
::* [[Collectin]]s
{{flatlist|indent=4}}
* [[Mannan-binding lectin]] (MBL)
* [[Surfactant protein A]] (SP-A)
* [[Surfactant protein D]] (SP-D)
* [[CL-L1]]
* [[CL-P1]]
* [[CL-K1]]
{{endflatlist}}
::* [[Peptidoglycan recognition protein]]s (PGRPs)<ref>{{cite journal |vauthors=Royet J, Gupta D, Dziarski R |title=Peptidoglycan recognition proteins: modulators of the microbiome and inflammation |journal=Nat. Rev. Immunol. |volume=11 |issue=12 |pages=837–51 |date=December 2011  |pmid=22076558 |doi=10.1038/nri3089 |s2cid=5266193 }}</ref>
{{flatlist|indent=4}}
* [[PGLYRP1]]
* [[PGLYRP2]]
* [[PGLYRP3]]
* [[PGLYRP4]]
{{endflatlist}}
::* [[Ficolin]]s
{{flatlist|indent=4}}
* [[FCN1]]
* [[FCN2]]
* [[FCN3]]
{{endflatlist}}

==== &nbsp;&nbsp;&nbsp;Complement receptors ====

[[Complement receptor]]
:* [[Complement receptor 1|CR1]] (CD35)
:* [[Complement receptor 2|CR2]] (CD21)
:* [[Macrophage-1 antigen|CR3]] - Heterodimer: [[CD11b]] / [[CD18]]
:* [[Integrin alphaXbeta2|CR4]] - Heterodimer: [[CD11c]] / [[CD18]]
:* [[CRIg]] (Complement receptor of the immunoglobulin family)
:* [[Anaphylatoxin receptors]]
::* [[C3a receptor]]
::* [[C5a receptor]] (CD88)
::* [[C5AR2]]

==== &nbsp;&nbsp;&nbsp;Fc receptors ====

[[Fc receptor]]
{{see also|List of Fc receptors}}
:* [[Fc-gamma receptor]]s (FcγR)
::* [[FcγRI]] (CD64)
::* [[FcγRIIA]] (CD32A)
::* [[FcγRIIB]] (CD32B)
::* [[FcγRIIIA]] (CD16a)
::* [[FcγRIIIB]] (CD16b)
::* [[FcγRT]] (Neonatal Fc receptor)
:* [[Fc-alpha receptor]]s (FcαR)
::* [[FcαRI]] (CD89, FCAR)
::* [[Fcα/μR]]
:* [[Fc-epsilon receptor]]s (FcεR)
::* [[FcεRI]] - Tetramer: [[FCER1A]] / [[FCER1B]] / two [[FCER1G]]
::* [[FcεRII]] (CD23)
:* Secreted Fc receptors
::* [[Polymeric immunoglobulin receptor]] (poly-Ig)
:* [[Fc receptor-like molecule]]s
{{flatlist|indent=3|
* [[FCRL1]]
* [[FCRL2]]
* [[FCRL3]]
* [[FCRL4]]
* [[FCRL5]]
* [[FCRL6]]
* [[FCRLA]]
* [[FCRLB]]
}}

==== &nbsp;&nbsp;&nbsp;Cytokine receptors ====

[[Cytokine receptor]]
{{See also|List of cytokine receptors}}
:* [[Type I cytokine receptor]]s ([[Hemopoietin]] receptors) - Share extracellular WSXWS motif, Grouped by common receptor subunits
::*[[Common gamma chain]] (γ-chain, CD132)
:::* [[IL2R]] - Heterotrimer: [[IL2RA]] (CD25) / [[IL2RB]] (CD122) / γ<sub>c</sub>
:::* [[IL4R]] / [[IL13R]] - Heterodimer: [[IL4RA]] / ([[IL13RA1]]/[[IL13RA2]])
:::* [[IL7R]] - Heterodimer: [[IL7RA]] (CD127) / γ-chain
:::* [[IL9R]] - Heterodimer: IL9R / γ-chain
:::* [[IL15R]] - Heterotrimer: [[IL15RA]] / [[IL2RB]] / γ-chain
:::* [[IL21R]] - Heterodimer: IL21R / γ-chain
::*[[Common beta chain]] (β-chain, CD131)
:::* [[IL3R]] - Heterodimer: [[IL3RA]] / β-chain
:::* [[IL5R]] - Heterodimer: [[IL5RA]] / β-chain
:::* [[GM-CSFR]] (CD116) - Heterdimer: [[GM-CSFRA]] / β-chain
::* [[Common gp130 subunit]] (gp130, CD130)
:::* [[IL6R]] - Heterodimer: [[IL6RA]] / gp130
:::* [[IL11R]] - Heterodimer: [[IL11RA]] / gp130
:::* [[IL27R]] - Heterodimer: [[IL27RA]] / gp130
:::* [[OSMR]] - Heterodimer: [[OSMR]] / gp130
:::* [[LIFR]] (CD118) - Heterodimer: [[LIFR]] / gp130
::* [[IL12 receptor beta 1 subunit]] (IL12RB1)
:::* [[IL12R]] - Heterodimer: [[IL12RB1]] / [[IL12RB2]]
:::* [[IL23R]] - Heterodimer: [[IL23RA]] / [[IL12RB1]]
::* Others
:::* [[Erythropoietin receptor|EPOR]] (Erythropoietin receptor) - Homodimer
:::* [[G-CSFR]] (CD114) - Homodimer upon ligand binding
:::* [[Thrombopoietin receptor|MPL]] (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
:::* [[Growth hormone receptor|GHR]] (Growth hormone receptor) - Homodimer upon ligand binding
:::* [[Prolactin receptor|PRLR]] (Prolactin receptor)
:* [[Type II cytokine receptor]] - Lack WSXWS motif
::* [[Interferon receptors]]
:::* [[Interferon-α/β receptor]] (IFNAR) - Heterodimer: [[IFNAR1]] / [[IFNAR2]]
:::* [[Interferon-γ receptor]] (IFNGR) - Heterodimer: [[IFNGR1]] / [[IFNGR2]]
::* Interleukin receptors
:::* [[IL10R]] - Heterodimer: [[IL10RA]] / [[IL10RB]]
:::* [[IL20R]] - Heterodimer: [[IL20RA]] / [[IL20RB]]
:::* [[IL22R]] - Heterodimer: [[IL22RA1]] / [[IL10RB]]
:::* [[IL28R]] - Heterodimer: [[IL28RA]] / [[IL10RB]]
:* [[Immunoglobulin superfamily]] (Some members)
::* [[CSF1]]
::* [[CD117]] (c-KIT)
::* [[IL1 receptor family]] ([[IL1R]])
:::* [[IL1R type 1]] (CD121a)
:::* [[IL1R type 2]] (CD121b)
:::* [[IL1R accessory protein]] (IL1RAP)
:::* [[IL1RL1]] (IL33R, ST2)
::* [[IL18R]] - Heterodimer: [[IL18R1]] / [[IL18RAP]]
:* [[IL17 family]]
::* [[IL17RA]]
::* [[IL17RB]]
::* [[IL17RC]]
::* [[IL17RD]]
::* [[IL17RE]]
:* [[Tumor necrosis factor receptor family|Tumor necrosis factor (TNF) receptor family]] - Trimeric cytokine receptors
{{col-start}}
{{col-5}}
:::* [[TNFRSF1A]] (CD120a)
:::* [[TNFRSF1B]] (CD120b)
:::* [[TNFRSF3]] (Lymphotoxin βR)
:::* [[TNFRSF4]] (CD134, OX40)
:::* [[TNFRSF5]] (CD40)
:::* [[TNFRSF6]] (FAS)
{{col-5}}
:::* [[TNFRSF6B]]
:::* [[TNFRSF7]] (CD27)
:::* [[TNFRSF8]] (CD30)
:::* [[TNFRSF9]] (CD137)
:::* [[TNFRSF10A]] (CD261)
:::* [[TNFRSF10B]] (CD262)
{{col-5}}
:::* [[TNFRSF10C]] (CD263)
:::* [[TNFRSF10D]] (CD264)
:::* [[TNFRSF11A]] (CD265, RANK)
:::* [[TNFRSF11B]] (Osteoprotegerin)
:::* [[TNFRSF12A]] (CD266)
:::* [[TNFRSF13B]] (CD267)
{{col-5}}
:::* [[TNFRSF13C]]
:::* [[TNFRSF14]] (CD268)
:::* [[TNFRSF16]] (LNGRF)
:::* [[TNFRSF17]] (CD269)
:::* [[TNFRSF18]]
:::* [[TNFRSF19]]
{{col-5}}
:::* [[TNFRSF21]]
:::* [[TNFRSF25]]
:::* [[TNFRSF27]]
{{col-end}}
:* [[Chemokine receptors]] - 7-transmembrane [[G protein-coupled receptors]]
::* [[CC chemokine receptors]] (CCRs)
{{col-start}}
{{col-5}}
:::* [[CCR1]]
:::* [[CCR2]]
{{col-5}}
:::* [[CCR3 (gene)|CCR3]]
:::* [[CCR4]]
{{col-5}}
:::* [[CCR5]]
:::* [[CCR6]]
{{col-5}}
:::* [[CCR7]]
:::* [[CCR8]]
{{col-5}}
:::* [[CCR9]]
:::* [[CCR10]]
{{col-end}}
::* [[CXC chemokine receptors]] (CXCRs)
{{col-start}}
{{col-5}}
:::* [[CXCR1]]
:::* [[CXCR2]]
{{col-5}}
:::* [[CXCR3]]
:::* [[CXCR4]]
{{col-5}}
:::* [[CXCR5]]
{{col-5}}
:::* [[CXCR6]]
{{col-5}}
:::* [[CXCR7]]
{{col-end}}
::* [[C chemokine receptors]] (XCRs)
:::* [[XCR1]]
::* [[CX3C chemokine receptors|CX<sub>3</sub>C chemokine receptors]] (CX<sub>3</sub>CRs)
:::* [[CX3CR1|CX<sub>3</sub>CR1]] (Fractalkine receptor)
:* [[TGF beta receptors]] - Single transmembrane pass serine/threonine kinase receptors
::* [[TGFBR1]]
::* [[TGFBR2]]
::* [[TGFBR3]]

==== &nbsp;&nbsp;&nbsp;Natural killer cell receptors ====

[[Natural killer cell receptors]]
:* [[Killer activation receptors]] (KARs)
::* [[Natural cytotoxicity receptor]]s (NCRs)
{{flatlist|indent=4}}
* [[NCR1]]
* [[NCR2]]
* [[NCR3]]
{{endflatlist}}
::* [[Natural killer group 2]] receptors (NKG2s)
{{flatlist|indent=4}}
* [[NKG2A]]
* [[NKG2B]]
* [[NKG2C]]
* [[NKG2D]]
* [[NKG2E]]
* [[NKG2H]]
{{endflatlist}}
::* Activating KIRs
:::* [[KIR2DS1]]
:* [[Killer inhibitory receptors]] (KIRs)
::* Two domains, long cytoplasmic tail
{{flatlist|indent=4}}
* [[KIR2DL1]]
* [[KIR2DL2]]
* [[KIR2DL3]]
* [[KIR2DL4]]
* [[KIR2DL5A]]
* [[KIR2DL5B]]
{{endflatlist}}
::* Two domains, short cytoplasmic tail
{{flatlist|indent=4}}
* [[KIR2DS1]]
* [[KIR2DS2]]
* [[KIR2DS3]]
* [[KIR2DS4]]
* [[KIR2DS5]]
{{endflatlist}}
::* Three domains, long cytoplasmic tail
{{flatlist|indent=4}}
* [[KIR3DL1]]
* [[KIR3DL2]]
* [[KIR3DL3]]
{{endflatlist}}
::* Three domains, short cytoplasmic tail
:::* [[KIR3DS1]]

==== &nbsp;&nbsp;&nbsp;Others ====
:* [[Leukocyte immunoglobulin-like receptor]]s (LILRs)
::* [[LILR subfamily A]]
{{flatlist|indent=4}}
* [[LILRA1]]
* [[LILRA2]]
* [[LILRA3]]
* [[LILRA4]]
* [[LILRA5]]
* [[LILRA6]]
{{endflatlist}}
::* [[LILR subfamily B]]
{{flatlist|indent=4}}
* [[LILRB1]]
* [[LILRB2]]
* [[LILRB3]]
* [[LILRB4]]
* [[LILRB5]]
{{endflatlist}}

:* [[Eicosanoid receptor]]s

=== Antibodies ===

[[Antibodies]]
* [[Immunoglobulin A]] (IgA) 
** [[IgA1]]
** [[IgA2]]
* [[Immunoglobulin D]] (IgD)
* [[Immunoglobulin E]] (IgE)
* [[Immunoglobulin G]] (IgG)
** [[IgG1]]
** [[IgG2]]
** [[IgG3]]
** [[IgG4]]
* [[Immunoglobulin M]] (IgM)
{{Antibodies |state=collapsed}}

=== Cytokines ===

[[Cytokine]]
{{See also|Proinflammatory cytokine|Monokine|Lymphokine}}
* [[Chemokine]]s
:{{See also|Chemotaxis}}
:* [[CC chemokines]]
{{col-begin}}
{{col-5}}
::* [[CCL1]]
::* [[CCL2]]
::* [[CCL3]]
::* [[CCL4]]
::* [[CCL5]]
::* [[CCL6]]
{{col-5}}
::* [[CCL7]]
::* [[CCL8]]
::* [[CCL9]]/CCL10
::* [[CCL11]]
::* [[CCL12]]
::* [[CCL13]]
{{col-5}}
::* [[CCL14]]
::* [[CCL15]]
::* [[CCL16]]
::* [[CCL17]]
::* [[CCL18]]
{{col-5}}
::* [[CCL19]]
::* [[CCL20]]
::* [[CCL21]]
::* [[CCL22]]
::* [[CCL23]]
{{col-5}}
::* [[CCL24]]
::* [[CCL25]]
::* [[CCL26]]
::* [[CCL27]]
::* [[CCL28]]
{{col-end}}
:* [[CXC chemokines]]
{{col-begin}}
{{col-5}}
::* [[CXCL1]]
::* [[CXCL2]]
::* [[CXCL3]]
::* [[CXCL4]]
{{col-5}}
::* [[CXCL5]]
::* [[CXCL6]]
::* [[CXCL7]]
::* [[CXCL8]]
{{col-5}}
::* [[CXCL9]]
::* [[CXCL10]]
::* [[CXCL11]]
{{col-5}}
::* [[CXCL12]]
::* [[CXCL13]]
::* [[CXCL14]]
{{col-5}}
::* [[CXCL15]]
::* [[CXCL16]]
::* [[CXCL17]]
{{col-end}}
:* [[C chemokines]]
::* [[XCL1]]
::* [[XCL2]]
:* [[CX3C chemokines|CX<sub>3</sub>C chemokines]]
::* [[CX3CL1|CX<sub>3</sub>CL1]] (Fractalkine, Neurotactin)
* [[Interferons]]
** [[Interferon type I]]
*** [[IFN-α]] 
*** [[IFN-β]] 
*** [[IFN-ω]] 
** [[Interferon type II]]
*** [[IFN-γ]]
* [[Interleukins]]
{{col-begin}}
{{col-5}}
:* [[IL1A]]
:* [[IL1B]]
:* [[IL1RA]]
:* [[Interleukin 2|IL2]]
:* [[Interleukin 3|IL3]]
:* [[Interleukin 4|IL4]]
:* [[Interleukin 5|IL5]]
:* [[Interleukin 6|IL6]]
:* [[Interleukin 7|IL7]]
:* [[Interleukin 8|IL8]]
{{col-5}}
:* [[Interleukin 9|IL9]]
:* [[Interleukin 10|IL10]]
:* [[Interleukin 11|IL11]]
:* [[Interleukin 12|IL12]]
:* [[Interleukin 13|IL13]]
:* [[Interleukin 14|IL14]]
:* [[Interleukin 15|IL15]]
:* [[Interleukin 16|IL16]]
:* [[Interleukin 17A|IL17A]]
:* [[Interleukin 17F|IL17F]]
{{col-5}}
:* [[Interleukin 18|IL18]]
:* [[Interleukin 19|IL19]]
:* [[Interleukin 20|IL20]]
:* [[Interleukin 21|IL21]]
:* [[Interleukin 22|IL22]]
:* [[Interleukin 23|IL23]]
:* [[Interleukin 24|IL24]]
:* [[Interleukin 25|IL25]]
:* [[Interleukin 26|IL26]]
{{col-5}}
:* [[IL27]]
:* [[IL28A]]
:* [[IL28B]]
:* [[IL29]]
:* [[Interleukin 30|IL30]]
:* [[IL31]]
:* [[Interleukin 32|IL32]]
:* [[IL33]]
:* [[IL34]]
{{col-5}}
:* [[IL35]]
:* [[IL36A]]
:* [[IL36B]]
:* [[IL36G]]
:* [[IL36RA]]
:* [[IL37]]
:* [[TSLP]]
:* [[Leukemia inhibitory factor|LIF]] (Leukemia inhibitory factor)
:* [[Oncostatin M|OSM]] (Oncostatin M)
{{col-end}}
* [[Tumor necrosis factors]]
{{col-begin}}
{{col-5}}
:* [[TNFA]]
:* [[TNFB]] ([[Lymphotoxin]]-α)
:* [[Lymphotoxin beta|TNFC]] ([[Lymphotoxin]]-β)
:* [[TNFSF4]] (OX40L)
{{col-5}}
:* [[TNFSF5]] (CD40L)
:* [[TNFSF6]] (FasL)
:* [[TNFSF7]] (CD70, CD27L)
:* [[TNFSF8]] (CD153, CD30L)
{{col-5}}
:* [[TNFSF9]] (4-1BBL)
:* [[TNFSF10]] (TRAIL)
:* [[TNFSF11]] (RANK-L, OPG-L)
:* [[TNFSF12]] (TWEAK)
{{col-5}}
:* [[TNFSF13]] (APRIL, CD256)
:* [[TNFSF13B]] (BAFF, CD257)
:* [[TNFSF14]] (LIGHT, CD258)
{{col-5}}
:* [[TNFSF15]] (VEGI)
:* [[TNFSF18]]
:* [[EDA (gene)|EDA]]
{{col-end}}
* [[Colony stimulating factors]]
:* [[CSF1]] (M-CSF)
:* [[CSF2]] (GM-CSF)
:* [[CSF3]] (G-CSF)
{{Cytokines |state=collapsed}}

=== MHCs ===

[[Major histocompatibility complex]]
{{see also|Human leukocyte antigen}}
* [[MHC class I]]
{{flatlist|indent=2}}
* [[HLA-A]]
* [[HLA-B]]
* [[HLA-C]]
* [[HLA-E]]
* [[HLA-F]]
* [[HLA-G]]
{{endflatlist}}

*[[MHC class II]]
{{flatlist|indent=2}}
* [[HLA-DM]]
** [[HLA-DMA|α]]
** [[HLA-DMB|β]]
* [[HLA-DO]]
** [[HLA-DOA|α]]
** [[HLA-DOB|β]]
* [[HLA-DP]]
** [[HLA-DPA1|α1]]
** [[HLA-DPB1|β1]]
* [[HLA-DQ]]
** [[HLA-DQA1|α1]]
** [[HLA-DQA2|α2]]
** [[HLA-DQB1|β1]]
** [[HLA-DQB2|β2]]
** [[HLA-DQB3|β3]]
* [[HLA-DR]]
** [[HLA-DRA|α]]
** [[HLA-DRB1|β1]]
** [[HLA-DRB3 (gene)|β3]]
** [[HLA-DRB4|β4]]
** [[HLA-DRB5|β5]]
{{endflatlist}}

=== Complement proteins ===
* Early stage (divided by pathway)
:* [[Classical complement pathway]]
::* [[C1Q complex]] - [[Complement component 1R|C1R]] / [[Complement component 1S|C1S]]
::* [[Complement component 4|C4]] - [[C4a]]
::* [[Complement component 2|C2]]
:* [[Mannan-binding lectin pathway]]
::* [[MASP1 (protein)|MASP1]] / [[MASP2 (protein)|MASP2]]
::* [[Mannan-binding lectin]]
:* [[Alternative complement pathway]]
::* [[Complement factor B|Factor B]]
::* [[Factor D]]
::* [[Factor P]] (Properdin)
* Middle stage
:* [[Complement component 3|C3]] - [[C3a (complement)|C3a]] / [[C3b]] / [[iC3b]]
:* [[Complement component 5|C5]] - [[Complement component 5a|C5a]]
:* [[C3-convertase]]
:* [[C5-convertase]]
* Late stage
:* [[Membrane attack complex]] (MAC)
::* [[Complement component 6|C6]]
::* [[Complement component 7|C7]]
::* [[C8 complex|C8]]
::* [[Complement component 9|C9]]
* Complement pathway inhibitors
:* [[C1-inhibitor]] - Classical, Lectin, Alternate
:* [[Decay-accelerating factor]] (CD59) - Classical, Lectin, Alternate
:* [[Complement factor I|Factor I]] - Classical, Lectin, Alternate
:* [[C4BP]] - Classical, Lectin
:* [[Factor H]] - Alternate

=== Antimicrobial peptides ===

[[Antimicrobial peptides]]
{{Granule contents |state=collapsed}}
{{Pore-forming toxins |state=collapsed}}

=== Transcription factors ===
* [[NF-κB]]
* [[AP-1 transcription factor|AP-1]]
* [[Interferon regulatory factors]] (IRF)
* [[NFAT]]
{{flatlist|indent=2|
* [[NFATc1]]
* [[NFATc2]]
* [[NFATc3]]
* [[NFATc4]]
* [[NFAT5]]
}}
* [[T-bet]] - T<sub>H</sub>1 differentiation
* [[GATA3]] - T<sub>H</sub>2 differentiation
* [[RORγT]] - T<sub>H</sub>17 differentiation
* [[BCL6]] - T<sub>FH</sub> differentiation
* [[FoxP3]] - T<sub>reg</sub> differentiation

=== Signaling pathways ===
* [[JAK-STAT signaling pathway]]
{{JAK-STAT signaling pathway |state=collapsed}}
* [[TGF beta signaling pathway]]
* [[TLR signalling pathway]]
{{TLR signaling pathway |state=collapsed}}

=== Cell adhesion molecules (CAMs) ===

[[Cell adhesion molecules]]
{{See also|List of cell adhesion molecules}}
* [[Integrin]]s - [[Obligate]] [[heterodimer]]s of one alpha and one beta subunits
:* Alpha subunits
{{flatlist|indent=3|
* [[CD49a|A1]]
* [[CD49b|A2]]
* [[CD49c|A3]]
* [[CD49d|A4]]
* [[CD49e|A5]]
* [[ITGA6|A6]]
* [[ITGA7|A7]]
* [[ITGA8|A8]]
* [[ITGA9|A9]]
* [[ITGA10|A10]]
* [[ITGA11|A11]]
* [[ITGAD|AD]]
* [[ITGAE|AE]]
* [[CD11a|AL]] (CD11a)
* [[CD11b|AM]] (CD11b)
* [[ITGAV|AV]]
* [[CD11c|AX]] (CD11c)
}}
:* Beta subunits
{{flatlist|indent=3|
* [[CD29|B1]]
* [[CD18|B2]]
* [[CD61|B3]]
* [[ITGB4|B4]]
* [[Integrin beta 5|B5]]
* [[Integrin beta 6|B6]]
* [[ITGB7|B7]]
* [[ITGB8|B8]]
}}
:* Dimers
::* Cytoadhesin receptor
:::* [[Integrin alpha6beta4]] 
:::* [[Glycoprotein IIb/IIIa]] - Heterodimer: [[ITGA2B]] / [[ITGB3]]
::* [[Fibrinogen]] receptor	
:::* [[Macrophage-1 antigen]] (CR3) - Heterodimer:  [[CD11b]] / [[CD18]]
::* [[Fibronectin]] receptor:	
:::* [[Integrin alpha2beta1]]
:::* [[Integrin alpha4beta1]] 
:::* [[Integrin alpha5beta1]]
::* Leukocyte-adhesion receptor:	
:::* [[LFA-1]] - Heterodimer: [[CD11a]] / [[CD18]] 
:::* [[Macrophage-1 antigen]] (CR3) - Heterodimer: [[CD11b]] / [[CD18]] 
:::* [[Integrin alphaXbeta2]] (CR4) - Heterodimer:  [[CD11c]] / [[CD18]]
::* Very late antigen receptor:	
:::* [[Integrin alpha1beta1]] 
:::* [[Integrin alpha2beta1]] 
:::* [[Integrin alpha3beta1]] 
:::* [[VLA-4]] - Heterodimer: [[CD49d]] / [[CD29]] 
:::* [[Alpha-5 beta-1]] 
:::* [[Integrin alpha6beta1]]
::* [[Vitronectin]] receptor:	
:::* [[Alpha-v beta-3]] 
:::* [[Alpha-v beta-5]]
* [[Immunoglobulin superfamily CAMs]]
::* [[SynCAM]]s - Synaptic cell adhesion molecules
::* [[NCAM]]s - Neural cell adhesion molecules
::* [[Intercellular adhesion molecule]]s (ICAMs)
{{flatlist|indent=4|
* [[ICAM-1]]
* [[ICAM2]]
* [[ICAM3]]
* [[ICAM4]]
* [[ICAM5]]
}}
::* [[VCAM-1]] (CD106)
::* [[PECAM-1]] (CD31)
::* [[L1 family]]
{{flatlist|indent=4|
* [[L1 (protein)|L1-CAM]]
* [[CHL1]]
* [[Neurofascin]]
* [[NrCAM]]
}}
::* [[SIGLEC]] family - [[Sialic acid]] binding [[lectin]]s
{{flatlist|indent=4|
* [[SIGLEC1]] (Sialoadhesin)
* [[SIGLEC2]] (CD22)
* [[SIGLEC3]] (CD33)
* [[SIGLEC4]] (MAG)
* [[SIGLEC5]]
* [[SIGLEC6]]
* [[SIGLEC7]]
* [[SIGLEC8]]
* [[SIGLEC9]]
* [[SIGLEC10]]
* [[SIGLEC11]]
* [[SIGLEC12]]
* [[SIGLEC14]]
* [[SIGLEC15]]
}}
::* [[CTX family]]
{{flatlist|indent=4|
* [[CTX family|CTX]]
* [[Junctional adhesion molecule]]
* [[BT-IGSF]]
* [[Coxsackie virus and adenovirus receptor|CAR]]
* [[VSIG]]
* [[ESAM (gene)|ESAM]]
}}
::* [[Nectin]]s
{{flatlist|indent=4|
* [[PVRL1]]
* [[PVRL2]]
* [[PVRL3]]
* [[Nectin-4]]
* [[CADM1]]
* [[CADM3]]
* [[NECL3]]
* [[NECL4]]
* [[NECL5]]
}}
::* [[CD2 family]]
:::* [[CD2]]
:::* [[CD58]]
:::* [[Signaling lymphocytic activation molecule]]s (SLAMs)
{{flatlist|indent=5|
* [[SLAMF1]] (CD150)
* [[SLAMF2]] (CD48)
* [[SLAMF3]] (CD229, LY9)
* [[SLAMF4]] (CD244)
* [[SLAMF5]] (CD84)
* [[SLAMF6]] (CD352)
* [[SLAMF7]] (CD319)
* [[SLAMF8]] (CD353)
* [[SLAMF9]]
}}
* [[Cadherins]]
* [[Selectin]]s
:* [[E-selectin]]
:* [[L-selectin]]
:* [[P-selectin]]
* Others
:* [[Lymphocyte homing receptor]]s
::* [[CD34]]
::* [[GLYCAM-1]]
::* [[Addressin]] (MAdCAM-1)
:* [[CD44]]
:* [[Carcinoembryonic antigen]]s
{{flatlist|indent=3|
* [[CEACAM1]]
* [[CEACAM3]]
* [[CEACAM4]]
* [[CEACAM5]]
* [[CEACAM6]]
* [[CEACAM7]]
* [[CEACAM8]]
* [[CEACAM16]]
* [[CEACAM18]]
* [[CEACAM19]]
* [[CEACAM20]]
* [[CEACAM21]]
}}
:* [[CD24]]
:* [[CD44]]
:* [[CD146]]
:* [[CD164]]

=== Others ===
* [[CD69]]
* [[Sphingosine-1-phosphate receptor]]s
{{flatlist|indent=2|
* [[S1PR1]]
* [[S1PR2]]
* [[S1PR3]]
* [[S1PR4]]
* [[S1PR5]]
}}
* [[Co-stimulatory molecules]]
:* [[CD80]] - Expressed by APCs
:* [[CD86]] - Expressed by APCs
:* [[CD28 family receptors]]
::* [[CD28]] - Expressed by T Cells
::* [[CD278]] (ICOS) - Homodimer, expressed by T Cells
::* [[CTLA-4]] (CD152)
::* [[PD-1]] (CD279)

== Immune system disorders ==

[[Immune disorder]]

=== Hypersensitivity and Allergy ===
{{main|Hypersensitivity|Autoimmunity|Autoimmune disease}}
:* [[Type 1 hypersensitivity]] / [[Allergy]] / [[Atopy]]
::* Foreign ([[Allergen]])
:::* [[Atopic eczema]]
:::* [[Allergic urticaria]]
:::* [[Allergic rhinitis]] (Hay fever)
:::* [[Allergic asthma]]
:::* [[Anaphylaxis]]
:::* [[Food allergy]]
::::* [[Milk allergy]]
::::* [[Egg allergy]]
::::* [[Peanut allergy]]
::::* [[Tree nut allergy]]
::::* [[Seafood allergy]]
::::* [[Soy allergy]]
::::* [[Wheat allergy]]
::::* [[Garlic allergy]]
:::* [[Penicillin allergy]]
{{Allergic conditions |state=collapsed}}
:* [[Type 2 hypersensitivity]] / [[Antibody-dependent cell-mediated cytotoxicity]] (ADCC)
::* Foreign
:::* [[Pernicious anemia]]
:::* [[Hemolytic disease of the newborn]]
::* Autoimmune
:::* [[Cytotoxicity|Cytotoxic]]
::::* [[Autoimmune hemolytic anemia]]
::::* [[Idiopathic thrombocytopenic purpura]]
::::* [[Bullous pemphigoid]]
::::* [[Pemphigus vulgaris]]
::::* [[Rheumatic fever]]
::::* [[Goodpasture's syndrome]]
:::* [[Hypersensitivity#Type V|Type 5]] / Receptor mediated
::::* [[Graves' disease]]
::::* [[Myasthenia gravis]]
:* [[Type 3 hypersensitivity]] / [[Immune complex]]
::* Foreign
:::* [[Henoch–Schönlein purpura]]
:::* [[Hypersensitivity vasculitis]] 
:::* [[Reactive arthritis]] 
:::* [[Farmer's lung]] 
:::* [[Post-streptococcal glomerulonephritis]] 
:::* [[Serum sickness]] 
:::* [[Arthus reaction]]
::* Autoimmune
:::* [[Systemic lupus erythematosus]]
:::* [[Subacute bacterial endocarditis]] 
:::* [[Rheumatoid arthritis]]
:* [[Type 4 hypersensitivity]] (Delayed-Type Hypersensitivity)
::* Foreign
:::* [[Allergic contact dermatitis]]
:::* [[Mantoux test]]
::* Autoimmune
:::* [[Diabetes mellitus type 1]] 
:::* [[Hashimoto's thyroiditis]] 
:::* [[Guillain–Barré syndrome]] 
:::* [[Multiple sclerosis]] 
:::* [[Coeliac disease]] 
:::* [[Giant-cell arteritis]]
::* [[GVHD]] (Graft-versus-host disease)
:::* [[Transfusion-associated graft versus host disease]]
:* Unknown/Multiple types
::* Foreign
:::* [[Hypersensitivity pneumonitis]] 
:::* [[Allergic bronchopulmonary aspergillosis]] 
:::* [[Transplant rejection]] 
:::* [[Latex allergy]] (I+IV)
::* Autoimmune
:::* [[Sjögren's syndrome]]
:::* [[Autoimmune hepatitis]] 
:::* [[Autoimmune polyendocrine syndrome]] ([[APS1]] / [[APS2]])
:::* [[Autoimmune adrenalitis]] 
:::* [[Systemic autoimmune disease]]

=== Immunodeficiency ===

[[Immunodeficiency]]
{{see also|Immunocompetence}}
:* [[Primary immunodeficiency]]
:* [[Acquired immunodeficiency]]
:* [[Complement deficiency]]
{{Lymphoid and complement immunodeficiency |state=collapsed}}

=== Cancers of the immune system ===
{{Lymphoid malignancy |state=collapsed}}
{{Myeloid malignancy |state=collapsed}}

=== Myeloid diseases ===
{{Monocyte and granulocyte disease |state=collapsed}}
{{Histiocytosis |state=collapsed}}

=== Inflammatory diseases ===
:* [[Sepsis]]
:* [[Inflammatory bowel disease]] (IBD)
:* [[Cytokine storm]]

=== Immunoproliferative immunoglobulin disorders ===

[[Immunoproliferative immunoglobulin disorders]]
{{Immunoproliferative immunoglobulin disorders |state=collapsed}}

=== Lymphatic organ disease ===
{{Lymphatic organ disease |state=collapsed}}

== Immunologic techniques and tests ==
* [[Flow cytometry]]
* [[Mass cytometry]]
* [[Histology]]
* [[Adoptive cell transfer]]
* Experiments in immunology
* [[Genetically modified mouse]]
* [[Immunofluorescence]]
* [[Immunofixation]]
* [[Immunoadsorption]]
* [[MHC multimer]]
* [[Hybridoma technology]]
:* [[Rabbit hybridoma]]
:* [[Developmental studies hybridoma bank]]
{{Immunologic techniques and tests |state=collapsed}}
{{Myeloid blood tests |state=collapsed}}

== Immunology and health ==
* [[Prevention (medical)|Prevention]]
* [[Immunostimulant]]s
* [[Immunotherapy]]
:* [[Activation immunotherapy]]
::* [[Cancer immunotherapy]]
::* [[Autologous immune enhancement therapy]]
:* [[Immunosuppression]]
::* [[Sublingual immunotherapy]]
::* [[Allergen immunotherapy]]
::* [[Immunosuppressive drug]]
{{Immunosuppressants |state=collapsed}}
* [[Artificial induction of immunity]]
* [[Immunization]]
:* [[Active immunotherapy]]
:* [[Passive immunity]]
::* [[Temporarily induced immunity]]
::* [[Adoptive immunity]]
* [[Vaccination]]
:* [[Vaccine-naive]]
:* [[Vaccine]]
:* [[Herd immunity]]
:* [[Adjuvant]]
{{Vaccines |state=collapsed}}
* [[Organ transplantation]]
:* [[Allotransplant]]
:* [[Transplant rejection]]

== Immunologists ==

[[List of immunologists]]

== Immunology lists ==
* [[List of autoimmune diseases]]
* [[List of immunologists]]
* [[List of viruses]]
* [[List of human clusters of differentiation]]
* [[List of vaccine ingredients]]
* [[List of allergens]]
* [[List of cytokines]]
* [[List of cytokine receptors]]
* [[List of pattern recognition receptors]]
* [[List of tissue-resident macrophages]]
* [[List of branches of immunology]]
* [[List of acute-phase proteins]]
* [[List of immune cells]]

==References==
{{Reflist}}

== External links ==
{{sisterlinks|Immunology}}
* [http://www.biomedcentral.com/bmcimmunol/ BMC: Immunology]- [[BioMed Central]]:Immunology is an [[open access journal]] publishing original peer-reviewed research articles.
* [[Nature Reviews Immunology]] ([http://www.nature.com/nri/index.html  journal home])
* [https://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=imm.TOC&depth=2 Janeway's Immunobiology textbook] Searchable free online version at the [[National Center for Biotechnology Information]]
* [https://web.archive.org/web/20080418052406/http://www.lib.mcg.edu/edu/esimmuno/progmenu.htm Overview] at [[Medical College of Georgia]]
* [http://www.mugen-noe.org/ MUGEN NoE] murine models for immunological disease
* [http://medweb2.unige.ch/immunologie/ Transplantation Immunology]{{dead link|date=March 2018 |bot=InternetArchiveBot |fix-attempted=yes }} Interesting web site made by the faculty of medicine of the University of Geneva dealing with the immunological issues linked with the transplantation of materials genetically different between donor and recipient (hematopoietical stem cells, organs or the transfusion of blood).
* [https://web.archive.org/web/20080509061914/http://media.med.sc.edu/microbiology2007/ Online lectures in immunology] University of South Carolina
* [http://www.brt-labs.com/ BRT-Burleson Research Technologies] Tests the effects of pharmaceuticals in the developmental stage on the immune system.

{{Outline footer}}

[[Category:Outlines of natural sciences|Immunology]]
[[Category:Immunology|*]]
[[Category:Immune system| ]]
[[Category:Immunology lists| ]]
[[Category:Outlines of health and fitness|Immunology]]
[[Category:Outlines|Immunology]]