View source for Osler's node

{{short description|Painful raised skin lesions of the hands and feet}}
{{distinguish|Janeway lesion}}
{{for|other Osler's signs|Osler's sign (disambiguation)}}
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 |caption       = Osler's lesions found on the hand and fingers of a 43-year-old male with subacute bacterial endocarditis
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 |differential  = infective endocarditis
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'''Osler's nodes''' are painful, [[Erythema|red]], raised [[lesion]]s found typically on the hands and feet.<ref name=Parashar2022>{{cite journal |last1=Parashar |first1=Krishan |last2=Daveluy |first2=Steven |title=Osler Node and Janeway Lesions |journal=StatPearls |date=2022 |pmid=32491553 |url=https://pubmed.ncbi.nlm.nih.gov/32491553/ |publisher=StatPearls Publishing  }}</ref> They are associated with a number of conditions, including [[infective endocarditis]], and are caused by [[immune complex]] deposition. Their presence is one definition of Osler's sign.<ref>{{DorlandsDict|seven/000097190|Osler sign}}</ref>
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==Causes==
Osler's nodes result from the deposition of [[immune complex]]es.<ref name="pmid947688">{{cite journal|last1=Farrior|first1=JB|last2=Silverman|first2=ME|title=A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis|journal=Chest|volume=70|issue=2|pages=239–43|date=August 1976|url=http://journal.publications.chestnet.org/data/Journals/CHEST/20983/239.pdf|pmid=947688|doi=10.1378/chest.70.2.239}}</ref> The resulting [[inflammation|inflammatory response]] leads to swelling, redness, and pain that characterize these lesions.

The nodes are commonly indicative of [[subacute bacterial endocarditis]].<ref>{{DorlandsDict|six/000072701|Osler nodes}}</ref> 10–25% of endocarditis patients will have Osler's nodes.<ref>{{cite web |url=https://www.lecturio.com/concepts/endocarditis/| title=Endocarditis
|website=The Lecturio Medical Concept Library |access-date= 19 July 2021}}</ref> Other signs of endocarditis include [[Roth's spot]]s and [[Janeway lesion]]s. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are non-tender.<ref name="pmid947688" />

Osler's nodes can also be seen in
* [[Lupus erythematosus|Systemic lupus erythematosus]]
* [[Marantic endocarditis]]
* Disseminated [[gonococcus|gonococcal]] infection
* Distal to infected arterial [[catheter]]

==Etymology==
Osler's nodes are named after Sir [[William Osler]] who described them in the early twentieth century.<ref>{{WhoNamedIt|synd|1702}}</ref><ref name="Osler">{{cite journal|last=Osler|first=W|title=Chronic infectious endocarditis|journal=Quarterly Journal of Medicine|year=1908–1909|volume=2|pages=219–230|publisher=Oxford}}</ref> He described them as "ephemeral spots of a painful nodular erythema, chiefly in the skin of the hands and feet."<ref name=Parashar2022/>

==References==
{{reflist}}

{{Cardiovascular system symptoms and signs}}

[[Category:Symptoms and signs: Cardiac]]
[[Category:William Osler]]