View source for Michael Stuart Brown

{{Short description|American geneticist and Nobel laureate (born 1941)}}
{{Other people|Michael Brown}}
{{BLP sources|date=July 2023}}
{{Infobox scientist
| name = Michael Brown
| honorific_suffix = ForMemRS
| birth_name              = Michael Stuart Brown
| image             = Mike_Brown_2003.jpg
| image_size       = 180px
| birth_date        = {{birth date and age|mf=yes|1941|4|13}}
| birth_place       = [[Brooklyn, New York]], U.S.
| field             = Biology
| work_institution  =
| education         = {{Plainlist|
* [[University of Pennsylvania]]
* [[University of Pennsylvania School of Medicine]]}}
| doctoral_advisor  =
| doctoral_students =
| known_for         = Regulation of [[cholesterol]] metabolism
| prizes            = {{Plainlist|
* [[Heinrich Wieland Prize]]  {{small|(1974)}}
* [[Richard Lounsbery Award]]  {{small|(1979)}}
* [[William Allan Award]] {{small|(1985)}}
* [[Nobel Prize in Physiology or Medicine]] <small>(1985)</small>
* [[National Medal of Science]] <small>(1988)</small>
<!--* [[Fellow of the Royal Society|ForMemRS]] <small>(1991)</small><ref name=formemrs/>-->}}
|spouse={{marriage|Alice Lapin|1964}}{{citation needed|date=November 2015}}
| children = two{{citation needed|date=November 2015}}
| website = {{URL|http://profiles.utsouthwestern.edu/profile/10894/michael-brown.html}}
}}

'''Michael Stuart Brown''' [[Foreign Member of the Royal Society|ForMemRS]] [[National Academy of Sciences|NAS]] [[American Academy of Arts and Sciences|AAA&S]] [[American Philosophical Society|APS]] (born April 13, 1941) is an American [[geneticist]] and [[Nobel laureate]]. He was awarded the [[Nobel Prize in Physiology or Medicine]] with [[Joseph L. Goldstein]] in 1985 for describing the regulation of [[cholesterol]] [[metabolism]].<ref>{{cite web   | title=Biography: Michael S. Brown | url=http://www.nndb.com/people/174/000123802 | work=The Notable Names Database | publisher=Soylent Communications| year=2008 | access-date=2008-06-15}}</ref><ref>{{cite web|url=http://www.nobelprizeii.org/nobel-laureate/michael-brown/ |title=Michael Brown - Nobel Prize Inspiration Initiative |publisher=Nobelprizeii.org |access-date=2015-11-06}}</ref><ref name="nobelprize1985">{{cite web|url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/1985/brown-bio.html |title=Michael S. Brown - Biographical |publisher=Nobelprize.org |date=1941-04-13 |access-date=2015-11-06}}</ref><ref>{{cite web|url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/1985/brown-lecture.html |title=Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis |publisher=Nobelprize.org |date=1985-12-08 |access-date=2015-11-06}}</ref>

== Education and early life ==
Brown was born in [[Brooklyn, New York]], the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman.<ref name="nobelprize1985"/><ref>{{cite web|url=http://persona.rin.ru/eng/view/f/0/17629/brown-brown,-michael |title=BROWN (Brown), Michael, photo, biography |publisher=Persona.rin.ru |date=1941-04-13 |access-date=2015-11-06}}</ref> His family is [[Jews|Jewish]].<ref>{{Cite web |title=Jewish Nobel Prize Winners in Medicine |url=https://www.jinfo.org/Nobels_Medicine.html |access-date=2023-03-30 |website=www.jinfo.org}}</ref> He graduated from [[Cheltenham High School]] (Wyncote, Pennsylvania).  Brown graduated from the [[University of Pennsylvania]] in 1962 and received his M.D. from the [[University of Pennsylvania School of Medicine]] in 1966.{{cn|date=July 2023}}

==Career and research==
Moving to the University of Texas Health Science Center in Dallas, now the [[UT Southwestern Medical Center]], Brown and colleague [[Joseph L. Goldstein]] researched cholesterol metabolism and discovered that human cells have [[low-density lipoprotein]] (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in [[familial hypercholesterolemia]], which predisposes heavily for cholesterol-related diseases.  In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - [[receptor-mediated endocytosis]]. Their findings led to the development of [[statin]] drugs, the [[cholesterol]]-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States.{{citation needed|date=November 2018}} Their discoveries are improving more lives every year, both in the US and around the world.{{citation needed|date=November 2018}} New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people.  Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein [[prenylation]]) in [[cancer]]. In 1984 he was awarded the [[Louisa Gross Horwitz Prize]] from [[Columbia University]] together with [[Joseph L. Goldstein]] (co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received the [[National Medal of Science]] for his contributions to medicine.

In 1993, their trainees [[Xiaodong Wang (biochemist)|Xiaodong Wang]] and Michael Briggs purified the [[sterol regulatory element binding protein]]s (SREBPs).  Since 1993, Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.

Brown holds the W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine.{{citation needed|date=November 2018}}

Brown is also on the Prix Galien USA Committee that "recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines".{{cn|date=July 2023}}

== Awards and honors ==
Brown has won numerous awards and honors, including:
{{colbegin||colwidth=30em}}
*2016 - Keynote Speaker at the Congress of Future Medical Leaders
* 2011 - Stadtman Distinguished Scientist Award, American Society for Biochemistry and Molecular Biology<ref>{{cite web|url=http://www.asbmb.org/Page.aspx?id=6128 |title=Earl and Thressa Stadtman Distinguished Scientist Award |publisher=Asbmb.org |access-date=2015-11-06}}</ref>
* 2007 - Builders of Science Award, Research!America<ref>{{cite web|url=http://www.researchamerica.org/release_07mar21_builders |title=University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award |publisher=Research!America |date=2007-03-21 |access-date=2015-11-06}}</ref>
* 2005 - [[Woodrow Wilson Award for Public Service]]<ref>[http://www.wilsoncenter.org/sites/default/files/psawardeesfeb2012.pdf]  {{webarchive |url=https://web.archive.org/web/20131008080415/http://www.wilsoncenter.org/sites/default/files/psawardeesfeb2012.pdf |date=October 8, 2013 }}</ref>
* 2005 - Herbert Tabor Award, American Society for Biochemistry and Molecular Biology<ref>{{cite web|url=http://www.asbmb.org/Page.aspx?id=536 |title=Herbert Tabor Research Award |publisher=Asbmb.org |access-date=2015-11-06}}</ref>
* 2003 - [[Albany Medical Center Prize]]<ref>{{cite web|url=http://www.amc.edu/Academic/AlbanyPrize/Recipients/recipients_previous/2003.cfm |title=Albany Medical College: 2003 |publisher=Amc.edu |date=2015-08-14 |access-date=2015-11-06}}</ref>
* 2002 - Kober Medal, Association of American Physicians<ref>{{cite web|url=http://www.jci.org/articles/view/120039/files/pdf |format=PDF |title=Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown |author1=Daniel W. Foster |author2=Jean D. Wilson |publisher=Jci.org |access-date=2015-11-06}}</ref>
* 1999 - [[Warren Alpert Foundation Prize]], Harvard Medical School<ref>[http://www.warrenalpert.org/award/#Winners ] {{webarchive |url=https://web.archive.org/web/20120410003013/http://www.warrenalpert.org/award/#Winners |date=April 10, 2012 }}</ref>
* [[List of Fellows of the Royal Society elected in 1991|1991 - Elected a Foreign Member of the Royal Society (ForMemRS)]]<ref name=formemrs>{{cite web|archive-url=https://web.archive.org/web/20151106214111/https://royalsociety.org/people/michael-brown-11147/|archive-date=2015-11-06|url=https://royalsociety.org/people/michael-brown-11147/|title=Professor Michael Brown ForMemRS|publisher=[[Royal Society]]|location=London}}</ref>
* 1987 - Elected member of the [[American Philosophical Society]]<ref>{{cite web|url=https://search.amphilsoc.org/memhist/search?creator=Michael+S.+Brown&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced| title=APS Member History }}</ref>
* 1986 - Golden Plate Award of the [[Academy of Achievement|American Academy of Achievement]]<ref>{{cite web|title= Golden Plate Awardees of the American Academy of Achievement |website=www.achievement.org|publisher=[[American Academy of Achievement]]|url=https://achievement.org/our-history/golden-plate-awards/#science-exploration}}</ref>
* 1985 - [[Nobel Prize]] for physiology and medicine<ref>{{cite web |title=The Nobel Prize in Physiology or Medicine 1985 |url=https://www.nobelprize.org/prizes/medicine/1985/summary/ |website=nobelprize.org |publisher=The Nobel Foundation |access-date=18 October 2022}}</ref>
* 1985 - [[Albert Lasker Award for Basic Medical Research]]<ref>{{cite web|url=http://www.laskerfoundation.org/awards/1985basic.htm |title=1985 Basic Medical Research Award |publisher=The Lasker Foundation |date=2007-09-16 |access-date=2015-11-06 |url-status=dead |archive-url=https://web.archive.org/web/20150913005532/http://www.laskerfoundation.org/awards/1985basic.htm |archive-date=2015-09-13 }}</ref>
* 1985 - [[William Allan Award]], American Society of Human Genetics<ref>{{cite web |url=http://www.ashg.org/pages/awards_pastrecipients.shtml#allan |title=Past ASHG Award Recipients |publisher=ASHG |access-date=2015-11-06 |archive-url=https://web.archive.org/web/20141003163707/http://www.ashg.org/pages/awards_pastrecipients.shtml#allan |archive-date=2014-10-03 |url-status=dead }}</ref>
* 1984 - [[Louisa Gross Horwitz Prize]]<ref>{{cite web |title=Horwitz Prize Awardees |url=https://www.cuimc.columbia.edu/research/louisa-gross-horwitz-prize/horwitz-prize-awardees |website=cuimc.columbia.edu |date=20 June 2018 |publisher=Columbia University |access-date=18 October 2022}}</ref>
* 1981 - [[Gairdner Foundation International Award]]<ref>{{cite web|url=http://www.gairdner.org/content/joseph-l-goldstein |title=Joseph L. Goldstein |publisher=Gairdner |access-date=2015-11-06}}</ref>
* 1981 - Elected member of the [[American Academy of Arts and Sciences]]<ref>{{cite web|url=https://www.amacad.org/person/michael-stuart-brown|title=Michael Stuart Brown |date=3 October 2024 }}</ref>
* 1980 - elected member of the [[National Academy of Sciences]]<ref>{{cite web|url=http://www.nasonline.org/member-directory/members/57317.html|title=Michael Brown|website=www.nasonline.org|access-date=23 March 2018}}</ref>
* 1979 - [[Lounsbery Award]], U.S. [[National Academy of Sciences]]<ref>{{cite web|url=http://www.nasonline.org/programs/awards/richard-lounsbery-award.html |title=Richard Lounsbery Award |publisher=Nasonline.org |access-date=2015-11-06}}</ref>
* 1978 - [[Passano Foundation|Passano Award]], Johns Hopkins University<ref>[http://passanofoundation.org/#/past-recipients/4513087930]  {{webarchive |url=https://web.archive.org/web/20121007072908/http://passanofoundation.org/#/past-recipients/4513087930 |date=October 7, 2012 }}</ref>
* 1976 - [[Pfizer Award in Enzyme Chemistry]], American Chemical Society<ref>{{cite web|url=http://www.divbiolchem.org/content/pfizerawardees1 |title=Pfizer Award in Enzyme Chemistry |publisher=Divbiolchem.org |access-date=2015-11-06}}</ref>
* 1974 - [[Heinrich Wieland Prize]]<ref>{{cite web |title=Heinrich Wieland Prize Laureates 1970 - 1979 |url=https://www.heinrich-wieland-prize.de/heinrich-wieland-laureates/id-1979-1970.html |website=Boehringer Ingelheim Stiftung |access-date=18 October 2022}}</ref>
{{colend}}

== Bibliography ==
{{colbegin||colwidth=30em}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man |journal=Science |volume=185 |issue=4145 |pages=61–3 |date=Jul 1974 |pmid=4366052 |doi=10.1126/science.185.4145.61 |bibcode=1974Sci...185...61B |s2cid=31493564}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Regulation of the activity of the low density lipoprotein receptor in human fibroblasts |journal=Cell |volume=6 |issue=3 |pages=307–16 |date=Nov 1975 |pmid=212203 |doi=10.1016/0092-8674(75)90182-8 |s2cid=28312936}}
* {{Cite journal |vauthors=Goldstein JL, Basu SK, Brunschede GY, Brown MS |title=Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans |journal=Cell |volume=7 |issue=1 |pages=85–95 |date=Jan 1976 |pmid=181140 |doi=10.1016/0092-8674(76)90258-0 |s2cid=23110979}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Receptor-mediated control of cholesterol metabolism |journal=Science |volume=191 |issue=4223 |pages=150–4 |date=Jan 1976 |pmid=174194 |doi=10.1126/science.174194 |bibcode=1976Sci...191..150B}}
* {{Cite journal |vauthors=Goldstein JL, Sobhani MK, Faust JR, Brown MS |title=Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus |journal=Cell |volume=9 |issue=2 |pages=195–203 |date=Oct 1976 |pmid=184960 |doi=10.1016/0092-8674(76)90110-0 |s2cid=26944871}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein |journal=Cell |volume=9 |issue=4 PT 2 |pages=663–74 |date=Dec 1976 |pmid=189940 |doi=10.1016/0092-8674(76)90130-6 |s2cid=6706608}}
* {{Cite journal |vauthors=Anderson RG, Brown MS, Goldstein JL |title=Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts |journal=Cell |volume=10 |issue=3 |pages=351–64 |date=Mar 1977 |pmid=191195 |doi=10.1016/0092-8674(77)90022-8 |s2cid=25657719}}
* {{Cite journal |vauthors=Goldstein JL, Brown MS, Stone NJ |title=Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic |journal=Cell |volume=12 |issue=3 |pages=629–41 |date=Nov 1977 |pmid=200368 |doi=10.1016/0092-8674(77)90263-X |s2cid=13211975}}
* {{Cite journal |vauthors=Anderson RG, Goldstein JL, Brown MS |title=A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts |journal=Nature |volume=270 |issue=5639 |pages=695–9 |year=1977 |pmid=201867 |doi=10.1038/270695a0 |bibcode=1977Natur.270..695A |s2cid=4152556}}
* {{Cite journal |vauthors=Anderson RG, Vasile E, Mello RJ, Brown MS, Goldstein JL |title=Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution |journal=Cell |volume=15 |issue=3 |pages=919–33 |date=Nov 1978 |pmid=215316 |doi=10.1016/0092-8674(78)90276-3 |s2cid=35345591}}
* {{Cite journal |vauthors=Goldstein JL, Anderson RG, Brown MS |title=Coated pits, coated vesicles, and receptor-mediated endocytosis |journal=Nature |volume=279 |issue=5715 |pages=679–85 |date=Jun 1979 |pmid=221835 |doi=10.1038/279679a0 |bibcode=1979Natur.279..679G |s2cid=4353842}}
* {{Cite journal |vauthors=Mello RJ, Brown MS, Goldstein JL, Anderson RG |title=LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment |journal=Cell |volume=20 |issue=3 |pages=829–37 |date=Jul 1980 |pmid=6251975 |doi=10.1016/0092-8674(80)90329-3 |s2cid=23996668}}
* {{Cite journal |vauthors=Brown MS, Kovanen PT, Goldstein JL |title=Regulation of plasma cholesterol by lipoprotein receptors |journal=Science |volume=212 |issue=4495 |pages=628–35 |date=May 1981 |pmid=6261329 |doi=10.1126/science.6261329 |bibcode=1981Sci...212..628B}}
* {{Cite journal |vauthors=Basu SK, Goldstein JL, Anderson RG, Brown MS |title=Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts |journal=Cell |volume=24 |issue=2 |pages=493–502 |date=May 1981 |pmid=6263497 |doi=10.1016/0092-8674(81)90340-8 |s2cid=29553611}}
* {{Cite journal |vauthors=Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS |title=Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia |journal=Cell |volume=30 |issue=3 |pages=715–24 |date=Oct 1982 |pmid=6291781 |doi=10.1016/0092-8674(82)90276-8 |s2cid=30013697}}
* {{Cite journal |vauthors=Basu SK, Goldstein JL, Brown MS |title=Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages |journal=Science |volume=219 |issue=4586 |pages=871–3 |date=Feb 1983 |pmid=6823554 |doi=10.1126/science.6823554 |bibcode=1983Sci...219..871B}}
* {{Cite journal |vauthors=Brown MS, Anderson RG, Goldstein JL |title=Recycling receptors: the round-trip itinerary of migrant membrane proteins |journal=Cell |volume=32 |issue=3 |pages=663–7 |date=Mar 1983 |pmid=6299572 |doi=10.1016/0092-8674(83)90052-1 |s2cid=34919831}}
* {{Cite journal |vauthors=Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL |title=The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor |journal=Cell |volume=32 |issue=3 |pages=941–51 |date=Mar 1983 |pmid=6299582 |doi=10.1016/0092-8674(83)90079-X |s2cid=39955408}}
* {{Cite journal |vauthors=Larkin JM, Brown MS, Goldstein JL, Anderson RG |title=Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts |journal=Cell |volume=33 |issue=1 |pages=273–85 |date=May 1983 |pmid=6147196 |doi=10.1016/0092-8674(83)90356-2 |s2cid=22848187}}
* {{Cite journal |vauthors=Orci L, Brown MS, Goldstein JL, Garcia-Segura LM, Anderson RG |title=Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells |journal=Cell |volume=36 |issue=4 |pages=835–45 |date=Apr 1984 |pmid=6705048 |doi=10.1016/0092-8674(84)90033-3 |s2cid=24586649}}
* {{Cite journal |author=Chin DJ |title=Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum |journal=Nature |volume=308 |issue=5960 |pages=613–7 |year=1984 |pmid=6546784 |doi=10.1038/308613a0 |name-list-style=vanc |author2=Gil G |author3=Russell DW |display-authors=3 |last4=Liscum |first4=Laura |last5=Luskey |first5=Kenneth L. |last6=Basu |first6=Sandip K. |last7=Okayama |first7=Hiroto |last8=Berg |first8=Paul |last9=Goldstein |first9=Joseph L. |bibcode=1984Natur.308..613C |s2cid=4308995}}
* {{Cite journal |vauthors=Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL |title=Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor |journal=Cell |volume=37 |issue=2 |pages=577–85 |date=Jun 1984 |pmid=6327078 |doi=10.1016/0092-8674(84)90388-X |s2cid=29839468}}
* {{Cite journal |author=Reynolds GA |title=HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions |journal=Cell |volume=38 |issue=1 |pages=275–85 |date=Aug 1984 |pmid=6088070 |doi=10.1016/0092-8674(84)90549-X |name-list-style=vanc |author2=Basu SK |author3=Osborne TF |display-authors=3 |last4=Chin |first4=Daniel J. |last5=Gil |first5=Gregorio |last6=Brown |first6=Michael S. |last7=Goldstein |first7=Joseph L. |last8=Luskey |first8=Kenneth L. |s2cid=11644830}}
* {{Cite journal |author=Yamamoto T |title=The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA |journal=Cell |volume=39 |issue=1 |pages=27–38 |date=Nov 1984 |pmid=6091915 |doi=10.1016/0092-8674(84)90188-0 |name-list-style=vanc |author2=Davis CG |author3=Brown MS |display-authors=3 |last4=Schneider |first4=Wolfgang J. |last5=Casey |first5=M.Linette |last6=Goldstein |first6=Joseph L. |last7=Russell |first7=David W. |s2cid=25822170}}
* {{Cite journal |vauthors=Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW |title=Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains |journal=Science |volume=227 |issue=4683 |pages=140–6 |date=Jan 1985 |pmid=3155573 |doi=10.1126/science.3155573 |pmc=4449727 |bibcode=1985Sci...227..140L}}
* {{Cite journal |vauthors=Südhof TC, Goldstein JL, Brown MS, Russell DW |title=The LDL receptor gene: a mosaic of exons shared with different proteins |journal=Science |volume=228 |issue=4701 |pages=815–22 |date=May 1985 |pmid=2988123 |doi=10.1126/science.2988123 |pmc=4450672 |bibcode=1985Sci...228..815S}}
* {{Cite journal |vauthors=Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI |title=Cassette of eight exons shared by genes for LDL receptor and EGF precursor |journal=Science |volume=228 |issue=4701 |pages=893–5 |date=May 1985 |pmid=3873704 |doi=10.1126/science.3873704 |bibcode=1985Sci...228..893S}}
* {{Cite journal |vauthors=Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS |title=Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme |journal=Cell |volume=41 |issue=1 |pages=249–58 |date=May 1985 |pmid=3995584 |doi=10.1016/0092-8674(85)90078-9 |s2cid=22530611}}
* {{Cite journal |vauthors=Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ |title=Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain |journal=Cell |volume=41 |issue=3 |pages=735–43 |date=Jul 1985 |pmid=3924410 |doi=10.1016/S0092-8674(85)80054-4 |s2cid=27773467}}
* {{Cite journal |vauthors=Osborne TF, Goldstein JL, Brown MS |title=5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription |journal=Cell |volume=42 |issue=1 |pages=203–12 |date=Aug 1985 |pmid=3860301 |doi=10.1016/S0092-8674(85)80116-1 |s2cid=37319421}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Scavenger cell receptor shared |journal=Nature |volume=316 |issue=6030 |pages=680–1 |year=1985 |pmid=4033768 |doi=10.1038/316680a0 |s2cid=4349775}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=A receptor-mediated pathway for cholesterol homeostasis |journal=Science |volume=232 |issue=4746 |pages=34–47 |date=Apr 1986 |pmid=3513311 |doi=10.1126/science.3513311 |bibcode=1986Sci...232...34B}}
* {{Cite journal |vauthors=Davis CG, Lehrman MA, Russell DW, Anderson RG, Brown MS, Goldstein JL |title=The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors |journal=Cell |volume=45 |issue=1 |pages=15–24 |date=Apr 1986 |pmid=3955657 |doi=10.1016/0092-8674(86)90533-7 |s2cid=8147673}}
* {{Cite journal |vauthors=Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW |title=Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit |journal=Science |volume=232 |issue=4755 |pages=1230–7 |date=Jun 1986 |pmid=3010466 |doi=10.1126/science.3010466 |pmc=4451858 |bibcode=1986Sci...232.1230Y}}
* {{Cite journal |vauthors=Lehrman MA, Goldstein JL, Russell DW, Brown MS |title=Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia |journal=Cell |volume=48 |issue=5 |pages=827–35 |date=Mar 1987 |pmid=3815525 |doi=10.1016/0092-8674(87)90079-1 |s2cid=35887205}}
* {{Cite journal |vauthors=Südhof TC, Russell DW, Brown MS, Goldstein JL |title=42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter |journal=Cell |volume=48 |issue=6 |pages=1061–9 |date=Mar 1987 |pmid=3030558 |doi=10.1016/0092-8674(87)90713-6 |s2cid=42788737}}
* {{Cite journal |vauthors=Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS |title=Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region |journal=Nature |volume=326 |issue=6115 |pages=760–5 |year=1987 |pmid=3494949 |doi=10.1038/326760a0 |bibcode=1987Natur.326..760D |s2cid=4347695}}
* {{Cite journal |vauthors=Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE |title=Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice |journal=Science |volume=239 |issue=4845 |pages=1277–81 |date=Mar 1988 |pmid=3344433 |doi=10.1126/science.3344433 |bibcode=1988Sci...239.1277H}}
* {{Cite journal |vauthors=Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS |title=Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides |journal=Cell |volume=62 |issue=1 |pages=81–8 |date=Jul 1990 |pmid=2194674 |doi=10.1016/0092-8674(90)90242-7 |s2cid=30887422}}
* {{Cite journal |vauthors=Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL |title=Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors |journal=Science |volume=250 |issue=4985 |pages=1273–5 |date=Nov 1990 |pmid=2244210 |doi=10.1126/science.2244210 |bibcode=1990Sci...250.1273Y}}
* {{Cite journal |vauthors=Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL |title=Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit |journal=Cell |volume=65 |issue=3 |pages=429–34 |date=May 1991 |pmid=2018975 |doi=10.1016/0092-8674(91)90460-G |s2cid=54388220}}
* {{Cite journal |vauthors=Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS |title=cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1 |journal=Cell |volume=66 |issue=2 |pages=327–34 |date=Jul 1991 |pmid=1855253 |doi=10.1016/0092-8674(91)90622-6 |s2cid=36722957}}
* {{Cite journal |vauthors=Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL |title=Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product |journal=Cell |volume=70 |issue=6 |pages=1049–57 |date=Sep 1992 |pmid=1525821 |doi=10.1016/0092-8674(92)90253-9 |s2cid=26223659}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=Koch's postulates for cholesterol |journal=Cell |volume=71 |issue=2 |pages=187–8 |date=Oct 1992 |pmid=1423585 |doi=10.1016/0092-8674(92)90346-E |s2cid=33048207}}
* {{Cite journal |author=Andres DA |title=cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein |journal=Cell |volume=73 |issue=6 |pages=1091–9 |date=Jun 1993 |pmid=8513495 |doi=10.1016/0092-8674(93)90639-8 |name-list-style=vanc |author2=Seabra MC |author3=Brown MS |display-authors=3 |last4=Armstrong |first4=Scott A. |last5=Smeland |first5=Tor E. |last6=Cremers |first6=Frans P.M. |last7=Goldstein |first7=Joseph L. |s2cid=26120573}}
* {{Cite journal |author=Yokoyama C |title=SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene |journal=Cell |volume=75 |issue=1 |pages=187–97 |date=Oct 1993 |pmid=8402897 |doi=10.1016/S0092-8674(05)80095-9 |name-list-style=vanc |author2=Wang X |author3=Briggs MR |display-authors=3 |last4=Admon |first4=A |last5=Wu |first5=J |last6=Hua |first6=X |last7=Goldstein |first7=JL |last8=Brown |first8=MS |s2cid=2784016}}
* {{Cite journal |vauthors=Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS |title=Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle |journal=Cell |volume=76 |issue=5 |pages=865–73 |date=Mar 1994 |pmid=8124722 |doi=10.1016/0092-8674(94)90361-1 |s2cid=22137883}}
* {{Cite journal |vauthors=Wang X, Sato R, Brown MS, Hua X, Goldstein JL |title=SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis |journal=Cell |volume=77 |issue=1 |pages=53–62 |date=Apr 1994 |pmid=8156598 |doi=10.1016/0092-8674(94)90234-8 |s2cid=44899129}}
* {{Cite journal |vauthors=Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL |title=Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment |journal=Cell |volume=85 |issue=7 |pages=1037–46 |date=Jun 1996 |pmid=8674110 |doi=10.1016/S0092-8674(00)81304-5 |s2cid=6130686 |doi-access=free}}
* {{Cite journal |vauthors=Hua X, Nohturfft A, Goldstein JL, Brown MS |title=Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein |journal=Cell |volume=87 |issue=3 |pages=415–26 |date=Nov 1996 |pmid=8898195 |doi=10.1016/S0092-8674(00)81362-8 |s2cid=1963192 |doi-access=free}}
* {{Cite journal |vauthors=Brown MS, Goldstein JL |title=The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor |journal=Cell |volume=89 |issue=3 |pages=331–40 |date=May 1997 |pmid=9150132 |doi=10.1016/S0092-8674(00)80213-5 |s2cid=17882616 |doi-access=free}}
* {{Cite journal |vauthors=DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ |title=Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi |journal=Cell |volume=99 |issue=7 |pages=703–12 |date=Dec 1999 |pmid=10619424 |doi=10.1016/S0092-8674(00)81668-2 |doi-access=free}}
* {{Cite journal |vauthors=Brown MS, Ye J, Rawson RB, Goldstein JL |title=Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans |journal=Cell |volume=100 |issue=4 |pages=391–8 |date=Feb 2000 |pmid=10693756 |doi=10.1016/S0092-8674(00)80675-3 |s2cid=12194770 |doi-access=free}}
* {{Cite journal |vauthors=Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ |title=Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes |journal=Cell |volume=102 |issue=3 |pages=315–23 |date=Aug 2000 |pmid=10975522 |doi=10.1016/S0092-8674(00)00037-4 |s2cid=18054832 |doi-access=free}}
* {{Cite journal |author=Yang T |title=Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER |journal=Cell |volume=110 |issue=4 |pages=489–500 |date=Aug 2002 |pmid=12202038 |doi=10.1016/S0092-8674(02)00872-3 |name-list-style=vanc |author2=Espenshade PJ |author3=Wright ME |display-authors=3 |last4=Yabe |first4=Daisuke |last5=Gong |first5=Yi |last6=Aebersold |first6=Ruedi |last7=Goldstein |first7=Joseph L. |last8=Brown |first8=Michael S. |s2cid=15052132 |doi-access=free}}
{{colend}}

== See also ==

* [[List of Jewish Nobel laureates]]

==References==
{{Reflist|colwidth=30em}}

==External links ==
* {{Nobelprize|name=Michael S. Brown}}
{{Commons category|Michael S. Brown}}

{{Nobel Prize in Physiology or Medicine Laureates 1976-2000}}
{{1985 Nobel Prize winners}}
{{Winners of the National Medal of Science|biological}}
{{FRS 1991}}
{{Pfizer Award in Enzyme Chemistry}}

{{Authority control}}

{{DEFAULTSORT:Brown, Michael Stuart}}
[[Category:1941 births]]
[[Category:Living people]]
[[Category:Nobel laureates in Physiology or Medicine]]
[[Category:American Nobel laureates]]
[[Category:Richard-Lounsbery Award laureates]]
[[Category:American geneticists]]
[[Category:Jewish biologists]]
[[Category:Foreign members of the Royal Society]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:The Daily Pennsylvanian people]]
[[Category:Jewish American scientists]]
[[Category:National Medal of Science laureates]]
[[Category:Perelman School of Medicine at the University of Pennsylvania alumni]]
[[Category:Scripps Research]]
[[Category:Recipients of the Albert Lasker Award for Basic Medical Research]]
[[Category:People from Cheltenham, Pennsylvania]]
[[Category:Members of the American Philosophical Society]]
[[Category:Members of the National Academy of Medicine]]
[[Category:University of Texas Southwestern Medical Center faculty]]