View source for Metanephrine

{{About|the chemical compound|the group of related compounds|Metanephrines}}
{{Chembox
| Watchedfields = changed
| verifiedrevid = 415700033
| ImageFile = 3-Methoxyadrenalin Structural Formulae V.1.svg
| ImageSize = 
| IUPACName = 4-(1-hydroxy-2-methylamino-ethyl)-2-methoxy-phenol
| OtherNames = 
|Section1={{Chembox Identifiers
| IUPHAR_ligand = 6644
| Abbreviations = 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 19844
| InChI = 1/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
| InChIKey = JWJCTZKFYGDABJ-UHFFFAOYAB
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 775
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JWJCTZKFYGDABJ-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 5001-33-2
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 1ZE0530JEJ
| EINECS = 
| PubChem = 21100
| SMILES = Oc1ccc(cc1OC)C(O)CNC
| RTECS =
| MeSHName = Metanephrine
| ChEBI =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = 
}}
|Section2={{Chembox Properties
| Formula = C<sub>10</sub>H<sub>15</sub>NO<sub>3</sub>
| MolarMass = 197.231 g/mol
| Appearance =
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| IsoelectricPt = 
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|Section7={{Chembox Hazards
| ExternalSDS = 
| MainHazards = 
| NFPA-H = 
| NFPA-F = 
| NFPA-R = 
| NFPA-S =
| FlashPt = 
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| ExploLimits = 
| PEL = 
 }}
}}

'''Metanephrine''', also known as '''metadrenaline''', is a [[metabolite]] of [[epinephrine]] (also known as adrenaline) created by action of [[catechol-O-methyl transferase]] on epinephrine. An article in the ''[[Journal of the American Medical Association]]'', 2002, indicated that the measurement of plasma free levels of the [[metanephrines]] group of molecules (including metanephrine and [[normetanephrine]]) is the best tool in the diagnosis of [[pheochromocytoma]], an adrenal medullary [[neoplasm]].<ref>{{cite journal |vauthors=Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G |title=Biochemical diagnosis of pheochromocytoma: which test is best? |journal=JAMA |volume=287 |issue=11 |pages=1427–34 |year=2002 |pmid=11903030 |doi=10.1001/jama.287.11.1427|doi-access=free }} [http://jama.ama-assn.org/cgi/content/full/287/11/1427 Free full text with registration]</ref>

<gallery>
 Image:Adrenalin - Adrenaline.svg|[[epinephrine]]
</gallery>

==References==
{{Reflist}}

{{Neurotransmitter metabolism intermediates}}
{{Phenethylamines}}

[[Category:Methoxyphenethylamines]]
[[Category:Phenylethanolamines]]


{{Amine-stub}}