View source for Loperamide/simethicone

{{Short description|Combination drug}}
{{Infobox drug
| type              = combo
| image             = 
| width             = 
| alt               = 
| caption           = 

<!-- Combo data -->
| component1        = Loperamide
| class1            = [[Antidiarrheal]]
| component2        = Simethicone
| class2            = Gas reducer

<!-- Clinical data -->
| tradename         = Imodium Multi-Symptom Relief, Imodium Plus, Imodium Plus Comfort
| Drugs.com         = 
| MedlinePlus       = 
| DailyMedID        = Loperamide and simethicone
| pregnancy_AU      = B3
| pregnancy_AU_comment = 
| pregnancy_category= 
| routes_of_administration = [[Oral administration|By mouth]]
| ATCvet            = 
| ATC_prefix        = A07
| ATC_suffix        = DA53
| ATC_supplemental  = 

<!-- Legal status -->
| legal_AU          = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment  = 
| legal_BR          = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment  = 
| legal_CA          = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment  = 
| legal_DE          = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment  = 
| legal_NZ          = <!-- Class A, B, C -->
| legal_NZ_comment  = 
| legal_UK = P
| legal_UK_comment  = /&nbsp;GSL
| legal_US = OTC
| legal_US_comment  = 
| legal_EU          = 
| legal_EU_comment  = 
| legal_UN          = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment  = 
| legal_status      = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number        = 
| CAS_supplemental  = 
| PubChem           = 
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| IUPHAR_ligand     = 
| DrugBank          = 
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| UNII              = 
| KEGG              = 
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| synonyms          = 
}}

'''[[Loperamide]]/[[simethicone]]''' is combination [[medication]] sold under the brand name '''Imodium Multi-Symptom Relief''' (formerly Imodium A-D Advanced) used to treat [[diarrhea]] and [[bloating|gas]] simultaneously. It is manufactured by the [[McNeil Laboratories#McNeil Consumer & Specialty medicals products|McNeil Consumer Healthcare Division]] of [[McNeil Laboratories|McNeil PPC, Inc]]. It contains [[loperamide]] and [[simethicone]].

Loperamide is a [[Mu Opioid receptor|μ-opioid receptor]] [[agonist]] that works in the [[intestines]].<ref>[https://www.drugs.com/cons/imodium-a-d.html Imodium], drugs.com</ref> Although it is an [[opioid]], it has no effects on the [[central nervous system]]. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the [[intestinal lumen]].

Simethicone reduces gas by allowing smaller gas bubbles to [[:wikt:coalesce|coalesce]] into larger bubbles in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects.<ref>[https://www.drugs.com/mtm/simethicone.html Simethicone], drugs.com</ref><ref>{{cite web|title=Bloody Diarrhea |url=http://ehomeremedies.com/parvo/|accessdate=2013-02-11}}</ref>

==References==
{{Reflist}}

{{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}}
{{Opioid receptor modulators}}
{{Portal bar | Medicine}}

{{DEFAULTSORT:Loperamide Simethicone}}
[[Category:Antidiarrhoeals]]
[[Category:Synthetic opioids]]
[[Category:Combination drugs]]
[[Category:Mu-opioid receptor agonists]]


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