View source for LPAR2

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}

'''Lysophosphatidic acid receptor 2''' also known as '''LPA<sub>2</sub>''' is a [[protein]] that in humans is encoded by the ''LPAR2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9170}}</ref><ref name="pmid9525886">{{cite journal |vauthors=An S, Bleu T, Hallmark OG, Goetzl EJ | title = Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 7906–10 | date=April 1998| pmid = 9525886 | doi = 10.1074/jbc.273.14.7906| doi-access = free }}</ref><ref name="pmid9804623">{{cite journal |vauthors=An S, Bleu T, Zheng Y, Goetzl EJ | title = Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization | journal = Mol. Pharmacol. | volume = 54 | issue = 5 | pages = 881–8 | date=November 1998| pmid = 9804623 | doi = 10.1124/mol.54.5.881| s2cid = 37327084 }}</ref> LPA<sub>2</sub> is a [[G protein-coupled receptor]] that binds the lipid signaling molecule [[lysophosphatidic acid]] (LPA).<ref name = "Choi_2010">{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J | date=January 2010| title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | pmid=20055701}}</ref>

== Function ==
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca<sup>2+</sup> mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.<ref name="entrez"/>

==Interactions==
LPAR2 has been shown to [[Protein–protein interaction|interact]] with [[TRIP6]].<ref name=pmid14688263>{{cite journal |last=Xu |first=Jun |author2=Lai Yun-Ju |author3=Lin Weei-Chin |author4=Lin Fang-Tsyr  |date=March 2004|title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor |journal=J. Biol. Chem. |volume=279 |issue=11 |pages=10459–68 |location = United States| issn = 0021-9258| pmid = 14688263 |doi = 10.1074/jbc.M311891200 |pmc=3904432|doi-access=free }}</ref>

== Evolution ==

=== [[Sequence homology|Paralogues]] ===
Source:<ref>{{Cite web |title=GeneCards®: The Human Gene Database |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR2&keywords=LPAR2#paralogs}}</ref><ref>{{Cite web |title=Ensembl Genome Browser |url=https://useast.ensembl.org/Homo_sapiens/Gene/Compara_Paralog?db=core;g=ENSG00000064547;r=19:19623655-19628930}}</ref>

* [[LPAR1]]
* [[LPAR3]]
* [[S1PR1]]
* [[S1PR5]]
* [[S1PR4]]
* [[S1PR2]]
* [[S1PR3]]
* [[GPR6]]
* [[GPR3]]
* [[GPR12]]
* [[Melanocortin 4 receptor|MC4R]]
* [[Melanocortin 5 receptor|MC5R]]
* [[Cannabinoid receptor 1|CNR1]]
* [[Melanocortin 3 receptor|MC3R]]
* [[Cannabinoid receptor 2|CNR2]]
* [[Melanocortin 1 receptor|MC1R]]
* [[GPR119]]
* [[ACTH receptor|MC2R]]

==See also==
* [[Lysophospholipid receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue=  1|pages= 54–60 |year= 2000 |pmid= 10818441 |doi=10.1111/j.1749-6632.2000.tb06537.x  |bibcode=2000NYASA.905...54S |s2cid=9257870 }}
*{{cite journal  |vauthors=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi=  10.1124/mol.58.6.1188|s2cid=6936621 }}
*{{cite journal   |vauthors=Goetzl EJ, Dolezalova H, Kong Y, etal |title=Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5370–5 |year= 1999 |pmid= 10537322 }}
*{{cite journal  |vauthors=Contos JJ, Chun J |title=Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. |journal=Genomics |volume=64 |issue= 2 |pages= 155–69 |year= 2000 |pmid= 10729222 |doi= 10.1006/geno.2000.6122 }}
*{{cite journal   |vauthors=Bandoh K, Aoki J, Taira A, etal |title=Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. |journal=FEBS Lett. |volume=478 |issue= 1–2 |pages= 159–65 |year= 2000 |pmid= 10922489 |doi=10.1016/S0014-5793(00)01827-5  |s2cid=21584151 |doi-access=free }}
*{{cite journal   |vauthors=Young KW, Bootman MD, Channing DR, etal |title=Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38532–9 |year= 2001 |pmid= 10954727 |doi= 10.1074/jbc.M006631200 |doi-access=  free}}
*{{cite journal  |vauthors=Zheng Y, Voice JK, Kong Y, Goetzl EJ |title=Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. |journal=FASEB J. |volume=14 |issue= 15 |pages= 2387–9 |year= 2001 |pmid= 11024010 |doi= 10.1096/fj.00-0492fje |doi-access=free |s2cid=24778289 }}
*{{cite journal   |vauthors=Hama K, Bandoh K, Kakehi Y, etal |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1–3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=10.1016/S0014-5793(02)02976-9  |s2cid=44924895 |doi-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932  | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Fujita T, Miyamoto S, Onoyama I, etal |title=Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. |journal=Cancer Lett. |volume=192 |issue= 2 |pages= 161–9 |year= 2003 |pmid= 12668280 |doi=10.1016/S0304-3835(02)00713-9  }}
*{{cite journal  |vauthors=Hu YL, Albanese C, Pestell RG, Jaffe RB |title=Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. |journal=J. Natl. Cancer Inst. |volume=95 |issue= 10 |pages= 733–40 |year= 2003 |pmid= 12759391 |doi=10.1093/jnci/95.10.733  |doi-access=free }}
*{{cite journal  |vauthors=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200 |pmc=3904432 |doi-access=free }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access=free }}
*{{cite journal   |vauthors=Oh YS, Jo NW, Choi JW, etal |title=NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 5069–79 |year= 2004 |pmid= 15143197  | pmc=416407 |doi= 10.1128/MCB.24.11.5069-5079.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334  | pmc=528928 |doi= 10.1101/gr.2596504 }}
{{refend}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991 | title = Lysophospholipid Receptors: LPA<sub>2</sub> | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-05 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303171034/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991 | url-status = dead }}
* {{MeshName|Lysophospholipid+receptors}}

{{G protein-coupled receptors}}

{{NLM content}}


{{DEFAULTSORT:Lpar2}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}