View source for L-seryl-tRNASec selenium transferase

{{Short description|Selenocysteine biosynthesis enzyme}}
{{enzyme
| EC_number = 2.9.1.1
| CAS_number = 
| GO_code = 0004125
| image = L-seryl-tRNA(Sec) selenium transferase (3W1K).png
| caption = SelA in complex with its tRNA substrate, ''Aquifex aeolicus'' {{PDB|3W1K}}
| name=L-seryl-tRNASec selenium transferase
| image_size=240}}
In [[enzymology]], a '''L-seryl-tRNASec selenium transferase''' ({{EC number|2.9.1.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:L-seryl-tRNASec + selenophosphate <math>\rightleftharpoons</math> L-selenocysteinyl-tRNASec + phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[L-seryl-tRNASec]] and [[selenophosphate]], whereas its two [[product (chemistry)|products]] are [[L-selenocysteinyl-tRNASec]] and [[phosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring selenium-containing groups selenotransferases.  The [[List of enzymes|systematic name]] of this enzyme class is '''selenophosphate:L-seryl-tRNASec selenium transferase'''. Other names in common use include '''L-selenocysteinyl-tRNASel synthase''', '''L-selenocysteinyl-tRNASec synthase selenocysteine synthase''', '''cysteinyl-tRNASec-selenium transferase''', and '''cysteinyl-tRNASec-selenium transferase'''.  This enzyme participates in [[selenoamino acid metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[pyridoxal phosphate]].

==References==
{{Reflist}}
* {{cite journal |vauthors=Forchhammer K, Bock A | date = 1991 | title = Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence | journal = J. Biol. Chem.  | volume = 266 | pages = 6324&ndash;8  | pmid = 2007585 | issue = 10 | doi = 10.1016/S0021-9258(18)38121-3 | doi-access = free }}

{{Selenium-containing group transferases}}
{{enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 2.9.1]]
[[Category:Pyridoxal phosphate enzymes]]
[[Category:Enzymes of unknown structure]]


{{transferase-stub}}