View source for HLA-DQ8

{{Technical|date=May 2017}}
{{Infobox heteroisoform
| isoformgroup = HLA-DQ8
| polymer_type = [[MHC Class II]], [[HLA-DQ|DQ]] cell surface antigen
| image        = HLA-DQ8_insulin.png
| image_source = Rendering of HLA-DQ8 with immundominant insulin peptide in the binding pocket.
| isoformCount = 2
| subunit1     = [[HLA-DQA1|DQA1]]
| subunit2     = [[HLA-DQB1|DQB1]]
| isoform1     = DQ α<sup>3</sup>β<sup>8</sup>
| nick1        = [[#DQ8.1|DQ8.1]]
| allele1a     = {{HQAA|0301}}
| allele1b     = [[#DQB1*0302|*0302]]
| isoform2     = DQ α<sup>3</sup>β<sup>8</sup>
| nick2        = DQ8.1v
| allele2a     = {{HQAA|0302}}
| allele2b     = *0302
| rareIsoforms = 2
| risoform1    = DQ α<sup>4</sup>β<sup>8</sup>
| rnick1       = DQ8.4
| rallele1a    = {{HQAA|0401}}
| rallele1b    = *0302
| risoform2    = DQ α<sup>5</sup>β<sup>8</sup>
| rnick2       = DQ8.5
| rallele2a    = {{HQAA|0503}}
| rallele2b    = *0302
}}

'''HLA-DQ8''' ('''DQ8''') is a [[human leukocyte antigen]] [[serotype]] within the [[HLA-DQ]] (DQ) serotype group. DQ8 is a [[wikt:split antigen|split antigen]] of the [[HLA-DQ3|DQ3]] [[wikt:broad antigen|broad antigen]]. DQ8 is determined by the [[#Serology|antibody recognition of β<sup>8</sup>]] and this generally detects the gene product of DQB1[[#DQB1*0302|*0302]].

DQ8 is commonly linked to [[autoimmune disease]] in the human population. DQ8 is the second most predominant [[wikt:isoform|isoform]] linked to [[coeliac disease]] and the DQ most linked to [[Diabetes mellitus type 1|Type 1 Diabetes]]. DQ8 increases the risk for [[rheumatoid arthritis]] and is linked to the primary risk locus for RA, [[HLA-DR4]]. DR4 also plays an important role in Type 1 Diabetes. While the DQ8.1 haplotype is associated with disease, there is no known association with the DQB1*0305, DQ8.4 or DQ8.5 haplotypes (see infobox) with autoimmune disease; however, this may be the result of lack of study in populations that carry these and the very low frequency.

DQ8.1 also differs from other HLA in population frequencies. Typically for [[MHC Class II]] antigens in humans, haplotype frequencies do not exceed 40%. For example, in the US the highest haplotype frequency, the haplotype that encoded DQ6.2, is around 15%, this translates into phenotype frequencies of less than 30%. Atypically haplotype frequencies exceed 40%.

For DQ8 the highest haplotype frequencies approach 80% in parts of Central and South America and the phenotype frequencies approach 90%. This is the highest phenotype frequency observed for any DR or DQ phenotype in the human population by a wide margin.

==Serology==
{| border="0" align="left" cellspacing="0" cellpadding="0" style="text-align:center; background:#ffffff; margin-right: 2em; border:2px #e0e0ff solid;"
|+ Serotype recognition of some DQB1*03 alleles<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html Allele Query Form] [[HLA Informatics Group|IMGT/HLA]] - [[European Bioinformatics Institute]]</ref>
|- style="text-align:center;background:#f0f0ff"
| style="width:60px" | DQB1* || style="width:60px" | '''DQ8'''
| style="width:60px" | {{color|brown|DQ3}} || style="width:60px" | {{color|red|DQ7}} || style="width:60px" | Sample
|- style="text-align:center;background:#f0f0ff"
| allele || % || % || % || size (N)
|- style="text-align:center"
| style="background:#e8e8f8" | {{HQBA|0302}} || 66|| {{color|brown|23}} || {{color|red|4}} || 6687
|- style="text-align:center"
| style="background:#e8e8f8" | {{HQBA|0304}} || 8 || {{color|brown|35}} || {{color|red|40}} || 111
|- style="text-align:center"
| style="background:#e8e8f8" | {{HQBA|0305}} || 34 || {{color|brown|30}} || || 70
|-
| colspan = 5 style="font-size:smaller" | {{color|red|Red indicates the level of 'false' reaction in non-DQ8 serotypes}}
|-
| colspan = 5 style="font-size:smaller" | Alleles link-out to [[HLA Informatics Group|IMGT/HLA]] Databease at [[European Bioinformatics Institute|EBI]]
|}
{| align="right" border="0" cellspacing="0" cellpadding="1" style="text-align:center; margin-left: 3em;  border:1px #ffeebb solid; background:#f8f6f8; "
|+ Select list of<br> '''HLA DQB1*0302 frequencies'''
|- style="background:#efe5ef"
|  ||   || freq
|- style="background:#eee5ef"
| ref. || align="left" |Population || style="width:50px" | (%)
|-
| <ref name="pmid12753660">{{cite journal | vauthors = Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database: <nowiki>http://www.allelefrequencies.net</nowiki> | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x | doi-access = free }}</ref>  || align="left"|Guatemala Mayans||48.1
|-
|  || align="left"|Mexico N.Leon Mestizos||22.5
|-
|  || align="left"|USA South Texas Hispanics||20.6
|-
|  || align="left"|Sweden||18.7
|-
|  || align="left"|Russia Siberia Negidal||18.6
|-
|  || align="left"|Russia Murmansk Saomi||18.5
|-
|  || align="left"|Jordan Amman||17.8
|-
|  || align="left"|Samoa||17.2
|-
|  || align="left"|England Caucasoid||16.4
|-
|  || align="left"|Finland||15.7
|-
|  || align="left"|France||14.5
|-
|  || align="left"|Japan Central||10.8
|-
|  || align="left"|Greece Crete||9.2
|-
|  || align="left"|Spain Basque Arratia Valley||6.7
|-
|  || align="left"| Algeria Oran||6.6
|-
|  || align="left"|China Beijing and Xian||6.1
|-
|  || align="left"|Ethiopia Amhara||5.6
|-
|  || align="left"|USA SE African American||4.9
|-
|  || align="left"|USA Alaska Yupik Natives||3.8
|-
|  || align="left"|India North Hindus||3.0
|-
|  || align="left"|Zimbabwe Harare Shona||2.2
|-
|  || align="left"|Russia Siberia Eskimos||0.9
|-
|  || align="left"|Rwanda Kigali Hutu and Tutsi||0.5
|-
|  || align="left"|PNG Eastern Highlands Goroka||0.0
|-
|  || align="left"|Tunisia Jerba Berber||0.0
|}
Although false reaction with DQB1*0302 is low, the efficiency of the positive reaction is not good and there is a risk of false detection of DQB1*0305 which could create incompatibility. For disease diagnosis and confirmation, there is no known association of DQB1*0305 with either coeliac or autoimmune diabetes. Therefore, it is prudent to use high resolution DQB1 typing for DQ8.

==Alleles==
{| align="left" border="0" cellspacing="0" cellpadding="0" style="text-align:center; background:#ffffff; margin-right: 2em; border:2px #e0e0ff solid;"
|+ DQ8 haplotypes in Caucasian Americans
|- style="background:#f0f0ff"
! style="background:#e8e8f8" |{{color|purple|DQ}}
! {{color|purple|DQ}}
! colspan="3" style="background:#f7e7ff" |{{color|purple|DQ}}
! colspan="2" | Freq
| width="15" | || width="5" |
|- style="background:#f0f0ff"
! style="background:#e8e8f8; font-size:80%" | Serotype
| width="80" | cis-isoform
| width="30" style="background:#f7e7ff" | {{color|green|Subtype}}
! width="45" style="background:#f7e7ff" | {{color|#bb00bb|A1}}
! width="45" style="background:#f7e7ff" | {{color|blue|B1}}
| colspan="2" | '''%'''<ref name="pmid12974796">{{cite journal |vauthors=Klitz W, Maiers M, Spellman S, etal |title=New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans |journal=Tissue Antigens |volume=62 |issue=4 |pages=296–307 |date=October 2003 |pmid=12974796 |doi=10.1034/j.1399-0039.2003.00103.x }}</ref>
| colspan="2"  | <sup>rank</sup>
|- style="background:#ffe7e7"
| style="background:#f7dfdf" rowspan="2" | DQ8
| rowspan="2" | <span style="color:#bb00bb;">α<sup>3</sup></span>-<span style="color:blue;">β<sup>8</sup></span>
| rowspan = 2 | {{color|green|8.1}}
| {{color|#bb00bb|0301}} || {{color|blue|0302}}
! style="background:#fbfbfb" align = right | 9.
! style="background:#fbfbfb" align = left | 62
| style="background:#fbfbfb" align = right |<sup>6th</sup>
|- style="background:#ffe8e8"
| {{color|#bb00bb|0302}}<sup>♠</sup> || {{color|blue|0302}}
! style="background:#fbfbfb" align = right | 0.
! style="background:#fbfbfb" align = left | 93
| style="background:#fbfbfb" align = right |
|-
| colspan = 5 style="font-size:smaller" | <sup>♠</sup>DQA1*0302 & *0303 not resolved
|}

DQ8 is determined by the antibody recognition of β<sup>8</sup> and is complicated by the fact that DQ8 recognizes some HLA-DQB1{{color|DarkGreen|*03}} encoded isoforms well, partially or not well at all (See [[#Serology|serology]]) DQ β<sup>3.2</sup> and β<sup>3.5</sup> are best recognized as DQ8. These split antigens are the allele products of the DQB1{{color|DarkGreen|*0302}} and DQB1{{color|DarkGreen|*0305}}, respectively.

===DQB1*0302===
{| align="left" border="0" cellspacing="0" cellpadding="1" style="text-align:center; margin-right: 1em;  border:1px #ffeebb solid; background:#f8f6f8; "
|+ '''HLA DQB1*0305 frequencies'''
|- style="background:#efe5ef"
|  ||   || freq
|- style="background:#eee5ef"
| ref. || align="left" |Population || style="width:50px" | (%)
|-
| <ref name="pmid12753660"/>  || align="left"|Lebanon Kafar Zubian||5.9
|-
|  || align="left"|Lebanon Niha el Shouff||2.5
|-
|  || align="left"|Lakota Sioux||2.1
|-
|  || align="left"|Tunisia||2.0
|-
|  || align="left"|Lebanon Yuhmur||1.8
|-
|  || align="left"|Guatemala Mayans||1.5
|-
|  || align="left"|Morocco||1.0
|-
|  || align="left"|Pakistan||1.0
|-
|  || align="left"|Saudi Arabia Guraiat and Hail||0.8
|-
|  || align="left"|China Lijiang Naxi||0.7
|-
|  || align="left"|Russia Chuvash||0.6
|-
|  || align="left"|Tunisia Matmata Berber||0.6
|-
|  || align="left"|Czech Republic||0.5
|-
|  || align="left"|India Delhi||0.5
|}
DQB1{{color|green|*0302}} and is found most often in the haplotype DQA1{{color|purple|*0301}}:DQB1{{color|green|*0302}}, about 10% of the time it is found in the haplotype DQA1{{color|purple|*0302}}:DQB1{{color|green|*0302}}. DQB1*0302 are almost always linked to DR4, DRB1{{color|brown|*0401}}, {{color|brown|*0402}}, and {{color|brown|*0404}} in caucasians. The first and third DRB1 are most strongly associated with rheumatoid arthritis.

===DQB1*0305===
DQB1{{color|green|*0305}} gene product reacts slightly more intensely with DQ8 than DQ7 its generally rare in Europe and
North America, except in a few indigenous populations. Levels of DQB1{{color|green|*0305}} are probably higher given earlier tests did not discriminate well between different *03.
{{clear}}

==Haplotypes==
DQ8 β-chains combine with α-chains, encoded by genetically linked [[HLA-DQA1]] alleles, to form the [[wikt:cis|cis]]-[[wikt:haplotype|haplotype]] isoforms. There is only one common cis-isoform of DQ8 because the linked DQA1{{color|DarkOrchid|*03}} alleles(2) occur over the majority of the population, DQ8.1 is the overwhelming majority cis-isoform of DQ8. A rare haplotype DQA1{{color|DarkOrchid|*0503}}:DQB1{{color|DarkGreen|*0302}} is detected below 1% of all DQ8 haplotypes in Asia and Mesoamerica. Another rarer haplotype, DQA1{{color|DarkOrchid|*0401}}:DQB1{{color|DarkGreen|*0302}}

===DQ8.1===
{| align="right" border="0" cellspacing="0" cellpadding="1" style="text-align:center; margin-left: 2em;  border:1px #bbffbb solid; background:#f8fff8; "
|+ style="font-size:90%"|  '''DQA1*03:DQB1*0302 haplotype frequencies in the Americas'''<br />(given as frequency in %)
|- style="background:#dfffdf"
! width="20" |
! width="170" style="text-align:left" |Reference
! width="55" style="font-size:85%" |DQA1
! width="55" Style="font-size:85%" |DQB1
! width="65" Style="font-size:80%" |Estimated
|- style="background:#dfffdf"
!
! style="text-align:left" | Population
| style="font-size:90%" | *03 ||  | *0302
! DQ8.1
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref name="Mayan-Mexico">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mexico%20Mayan%20Lacandon |title=Review Population Study<br />(Proceedings of IHW Workshop, Seattle 2002) - Mexico Mayan Lacandon |work=Allele frequencies in worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004938/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mexico%20Mayan%20Lacandon |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
| style="text-align:left; background:#f0fff0"  | Lacandon Mayan<br />(Mexico)
|  79.0   ||77.9
! style="background:#fdfffd" | 77.9
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref name="YucpaI-II">{{cite journal | vauthors = Layrisse Z, Guedez Y, Domínguez E, Paz N, Montagnani S, Matos M, Herrera F, Ogando V, Balbas O, Rodríguez-Larralde A | title = Extended HLA haplotypes in a Carib Amerindian population: the Yucpa of the Perija Range. | journal = Hum Immunol | volume = 62 | issue = 9 | pages = 992–1000 | year = 2001 | pmid = 11543901 | doi = 10.1016/S0198-8859(01)00297-X}}</ref>
| style="text-align:left; background:#f0fff0"  | Perija-Yucpa<br />(Venezuela)
|  74.0   ||  75.0
! style="background:#fdfffd" | 74.9
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" |<ref>{{cite journal | vauthors = Gómez-Casado E, Martínez-Laso J, Moscoso J, Zamora J, Martin-Villa M, Perez-Blas M, Lopez-Santalla M, Lucas Gramajo P, Silvera C, Lowy E, Arnaiz-Villena A | title = Origin of Mayans according to HLA genes and the uniqueness of Amerindians. | journal = Tissue Antigens | volume = 61 | issue = 6 | pages = 425–36 | year = 2003 | pmid = 12823766 | doi = 10.1034/j.1399-0039.2003.00040.x}}</ref>
| style="text-align:left; background:#f0fff0" | Mayan<br />(Guatemala)
|     || 48.1
! style="background:#fdfffd" | 47.6
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" |<ref>{{cite journal | vauthors = Arnaiz-Villena A, Vargas-Alarcón G, Granados J, Gómez-Casado E, Longas J, Gonzales-Hevilla M, Zuñiga J, Salgado N, Hernández-Pacheco G, Guillen J, Martinez-Laso J | title = HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians. | journal = Tissue Antigens | volume = 56 | issue = 5 | pages = 405–16 | year = 2000 | pmid = 11144288 | doi = 10.1034/j.1399-0039.2000.560503.x}}</ref>
| style="text-align:left; background:#f0fff0" | Mazatecans<br />(Mexico)
| 48.5 || 48.5
! style="background:#fdfffd" | 47.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Moscoso J, Seclen S, Serrano-Vela J, Villena A, Martinez-Laso J, Zamora J, Moreno A, Ira-Cachafeiro J, Arnaiz-Villena A | title = HLA genes in Lamas Peruvian-Amazonian Amerindians. | journal = Mol Immunol | volume = 43 | issue = 11 | pages = 1881–9 | year = 2006 | pmid = 16337001 | doi = 10.1016/j.molimm.2005.10.013}}</ref>
| style="text-align:left; background:#f0fff0" | Lamas<br />(Peru)
|     || 45.2
! style="background:#fdfffd" | 44.7
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" |<ref name="Dakota-Sioux">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20South%20Dakota%20Sioux |title=Review Population Study<br />(Proceedings of IHW Workshop, Seattle 2002) - USA South Dakota Sioux |work=Allele frequencies in worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004919/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20South%20Dakota%20Sioux |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
| style="text-align:left; background:#f0fff0" | Dakota Sioux<br />(S. Dakota)
| 52.1 || 45.0
! style="background:#fdfffd" | 44.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Hollenbach J, Thomson G, Cao K, Fernandez-Vina M, Erlich H, Bugawan T, Winkler C, Winter M, Klitz W | title = HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives. | journal = Hum Immunol | volume = 62 | issue = 4 | pages = 378–90 | year = 2001 | pmid = 11295471 | doi = 10.1016/S0198-8859(01)00212-9}}</ref>
|style="text-align:left; background:#f0fff0" | Mixtec<br />(Oaxaca, Mexico)
| 40.0 || 35.9
! style="background:#fdfffd" | 35.4
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Leffell M, Fallin M, Hildebrand W, Cavett J, Iglehart B, Zachary A | title = HLA alleles and haplotypes among the Lakota Sioux: report of the ASHI minority workshops, part III. | journal = Hum Immunol | volume = 65 | issue = 1 | pages = 78–89 | year = 2004 | pmid = 14700599 | doi = 10.1016/j.humimm.2003.10.001}}</ref>
|style="text-align:left; background:#f0fff0"  | Lakota Sioux<br />(S. Dakota)
|    || 25.7
! style="background:#fdfffd" | 25.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Lázaro A, Moraes M, Marcos C, Moraes J, Fernández-Viña M, Stastny P | title = Evolution of HLA-class I compared to HLA-class II polymorphism in Terena, a South-American Indian tribe. | journal = Hum Immunol | volume = 60 | issue = 11 | pages = 1138–49 | year = 1999 | pmid = 10600013 | doi = 10.1016/S0198-8859(99)00092-0}}</ref>
|style="text-align:left; background:#f0fff0"  | Terena<br />(Brazil)
|   || 17.5
! style="background:#fdfffd" |  17.0
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" |<ref name="San-Antonio_Cauc">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20San%20Antonio%20Caucasians |title=Review Population Study - USA San Antonio Caucasians |work=Allele frequencies in worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004912/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20San%20Antonio%20Caucasians |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
|style="text-align:left; background:#f0fff0"  | Cauc., San Antonio<br />(USA)
|   || 11.7
! style="background:#fdfffd" | 11.7
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Matsuzaka Y, Makino S, Nakajima K, Tomizawa M, Oka A, Bahram S, Kulski J, Tamiya G, Inoko H | title = New polymorphic microsatellite markers in the human MHC class III region. | journal = Tissue Antigens | volume = 57 | issue = 5 | pages = 397–404 | year = 2001 | pmid = 11556964 | doi = 10.1034/j.1399-0039.2001.057005397.x}}</ref>
|style="text-align:left; background:#f0fff0"  | Caucasian<br />(USA)
| 18.5 || 10.5
! style="background:#fdfffd" | 10.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Kuffner T, Whitworth W, Jairam M, McNicholl J | title = HLA class II and TNF genes in African Americans from the Southeastern United States: regional differences in allele frequencies. | journal = Hum Immunol | volume = 64 | issue = 6 | pages = 639–47 | year = 2003 | pmid = 12770797 | doi = 10.1016/S0198-8859(03)00056-9 }}</ref>
|style="text-align:left; background:#f0fff0"  | African American<br />(SE. USA)
|   || 4.9
! style="background:#fdfffd" |  4.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref name="TlingletI-II">{{cite journal | vauthors = Nelson J, Boyer G, Templin D, Lanier A, Barrington R, Nisperos B, Smith A, Mickelson E, Hansen J | title = HLA antigens in Tlingit Indians with rheumatoid arthritis. | journal = Tissue Antigens | volume = 40 | issue = 2 | pages = 57–63 | year = 1992 | pmid = 1412417 | doi = 10.1111/j.1399-0039.1992.tb01960.x}}</ref>
|style="text-align:left; background:#f0fff0"  | Tlinglet<br />(Alaska, USA)
| 14.0  || 8.5
! style="background:#fdfffd" | 8.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref>{{cite journal | vauthors = Leffell M, Fallin M, Erlich H, Fernandez-Vĩna M, Hildebrand W, Mack S, Zachary A | title = HLA antigens, alleles and haplotypes among the Yup'ik Alaska natives: report of the ASHI Minority Workshops, Part II. | journal = Hum Immunol | volume = 63 | issue = 7 | pages = 614–25 | year = 2002 | pmid = 12072196 | doi = 10.1016/S0198-8859(02)00415-9}}</ref>
|style="text-align:left; background:#f0fff0"  | Eskimo<br />(Alaska, USA)
|   || 3.8
! style="background:#fdfffd" | 3.8
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" |<ref name="Navajo">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20New%20Mexico%20Canoncito%20Navajo |title=Review Population Study<br />(Proceedings of IHW Workshop, Seattle 2002) - USA New Mexico Canoncito Navajo |work=Allele frequencies in worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004820/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=USA%20New%20Mexico%20Canoncito%20Navajo |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
|style="text-align:left; background:#f0fff0"  |Canoncito Navajo<br />(NM, USA)
| 6.3  || 3.5
! style="background:#fdfffd" | 3.5
|-
|style="text-align:right; background:#f0fff0; padding-right:1em" | <ref name="Eskimo-GL">{{cite journal | vauthors = Welinder L, Graugaard B, Madsen M | title = HLA antigen and gene frequencies in Eskimos of East Greenland. | journal = European Journal of Immunogenetics | volume = 27 | issue = 2 | pages = 93–7 | year = 2000 | pmid = 10792425 | doi = 10.1046/j.1365-2370.2000.00209.x}}</ref>
|style="text-align:left; background:#f0fff0"  | Eskimo<br />(E. Greenland)
|  0.0 || 0.0
! style="background:#fdfffd" |0.0
|-
|}

DQA1{{color|DarkOrchid|*0301}}:DQB1{{color|DarkGreen|*0302}} (DQ8.1) is the most common DQ8 subtype representing over 98% of the DQ8 bearing population. Infrequently,  DQA1{{color|DarkOrchid|*0302}}:DQB1{{color|DarkGreen|*0302}}, but this substitution of the alpha chain, DQA1*{{color|DarkOrchid|*0301}} versus {{color|DarkOrchid|*0302}}, is outside the binding cleft and appears not to alter DQ8 function. DQ8.1 is found almost ubiquitously in every human regional population, but because of its unique distribution it becomes an object of molecular anthropology. There are 3 places where haplotype frequency is elevated, Central and South America, NE Pacific Rim, and Northern Europe.

====High frequencies in the Americas====
The global node for DQ8 is in Central America and northern South America where it reaches the highest frequency for any single DQ serotype, close to 90% phenotype frequency (77% haplotype frequency), and is at relatively high frequency in the indigenous North American population, and the coastal regions of the Gulf of Mexico and up the Mississippi Valley. The high frequency of DQ8 in South America's northeastern regions<ref name="YucpaI-II"/> and low frequency in Indigenous Americans of more recent Asian ancestry<ref name="TlingletI-II"/><ref name="Eskimo-GL"/> or Siberian origin<ref name="Nivkhi">{{cite journal | vauthors = Lou H, Li H, Kuwayama M, Yashiki S, Fujiyoshi T, Suehara M, Osame M, Yamashita M, Hayami M, Gurtsevich V, Ballas M, Imanishi T, Sonoda S | title = HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-I in Sakhalin, Far Eastern Russia. | journal = Tissue Antigens | volume = 52 | issue = 5 | pages = 444–51 | year = 1998 | pmid = 9864034 | doi = 10.1111/j.1399-0039.1998.tb03071.x}}</ref> suggest that DQ8 was at high frequency in the earliest Amerinds. The pattern of distribution is consistent with recent mtDNA results suggesting the first migrants to the New World settled in the lowland coastal regions, river valleys and moved slowly inland, subsequent settlers moved into the highland regions.  DQ8 and DQ2.5 have many analogous functional similarities, and this first settler bias may be a reason for the similarity. Studies on Epstein Barr Virus<ref name=EBV_DQ2_DQ8>{{cite journal | vauthors = Sidney J, del Guercio MF, Southwood S, and Sette A | title = The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity. | journal = Journal of Immunology | volume = 169 | issue = 9 | pages = 5098–5108 | year = 2002 | pmid = 12391226 | doi=10.4049/jimmunol.169.9.5098| doi-access = free }}</ref> and other proteins suggest both proteins are acidic (meaning peptides with increased negative charge) peptide presenters (see DQ8 for an illustration of the presentation process) and may have been adaptive for certain hunting and gathering lifestyles, possibly coastal foragers.

{| align="left" border="0" cellspacing="0" cellpadding="1" style="text-align:center; margin-right: 1em;  border:1px #bbbbff solid; background:#f8f8ff; "
|+ '''DQA1*03:DQB1*0302 levels in the Asia'''<br />(given as frequency in %)
|- style="background:#dfdfff"
! width="20" |
! width="170" style="text-align:left" |Reference
! width="55" style="font-size:85%" |DQA1
! width="55" Style="font-size:85%" |DQB1
! width="65" Style="font-size:80%" |Estimated
|- style="background:#dfdfff"
!
! style="text-align:left" | Population
| style="font-size:90%" | *03 ||  | *0302
! DQ8.1
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Nivkhi"/>
| style="text-align:left; background:#f0f0ff" | Nivkhi<br />(NNE. Sakalin I.)
|    ||  0.0
! style="background:#fdfdff" | 0
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Yadz">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Iran%20Yazd%20Zoroastrians |title=Review Population Study - Iran Yazd Zoroastrians |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005111/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Iran%20Yazd%20Zoroastrians |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Farjadian S, Moqadam F, Ghaderi A | title = HLA class II gene polymorphism in Parsees and Zoroastrians of Iran. | journal = International Journal of Immunogenetics | volume = 33 | issue = 3 | pages = 185–91 | year = 2006 | pmid = 16712649 | doi = 10.1111/j.1744-313X.2006.00594.x| s2cid = 12667253 }}</ref>
| style="text-align:left; background:#f0f0ff" | Zorastra, Yadz<br />(Iran)
| 20.8   || 0.8
! style="background:#fdfdff" | 0.8
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Khoton">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khoton%20Tarialan |title=Review Population Study - Mongolia Khoton Tarialan |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004720/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khoton%20Tarialan |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Machulla H, Batnasan D, Steinborn F, Uyar F, Saruhan-Direskeneli G, Oguz F, Carin M, Dorak M | title = Genetic affinities among Mongol ethnic groups and their relationship to Turks. | journal = Tissue Antigens | volume = 61 | issue = 4 | pages = 292–9 | year = 2003 | pmid = 12753667 | doi = 10.1034/j.1399-0039.2003.00043.x}}</ref>
| style="text-align:left; background:#f0f0ff" | Khoton<br />(Mongolia)
| 24.4   ||  1.2
! style="background:#fdfdff" | 1.2
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="PNG_Madang">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Papua%20New%20Guinea%20Madang |title=Review Population Study - Papua New Guinea Madang |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005118/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Papua%20New%20Guinea%20Madang |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
| style="text-align:left; background:#f0f0ff" | Madang<br />(Papua New Guinea)
| 1.5   ||  1.5
! style="background:#fdfdff" | 1.5
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Yunnan%20Province%20Yao |title=Review Population Study - China Yunnan Province Yao |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004859/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Yunnan%20Province%20Yao |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Liu Y, Liu Z, Fu Y, Jia Z, Chen S, Xu A | title = Polymorphism of HLA class II genes in Miao and Yao nationalities of Southwest China. | journal = Tissue Antigens | volume = 67 | issue = 2 | pages = 157–9 | year = 2006 | pmid = 16441488 | doi = 10.1111/j.1399-0039.2006.00510.x}}</ref>
| style="text-align:left; background:#f0f0ff"  | Yao<br />(China)
|    || 2.6
! style="background:#fdfdff" | 2.6
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Lijiang%20Naxi |title=Review Population Study - China Lijiang Naxi |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005017/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Lijiang%20Naxi |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | doi = 10.1034/j.1399-0039.2003.00012.x | vauthors = Fu Y, Liu Z, Lin J, Jia Z, Chen W, Pan D, Liu Y, Zhu Y, Chen R, Xu A | title = HLA-DRB1, DQB1 and DPB1 polymorphism in the Naxi ethnic group of South-western China. | journal = Tissue Antigens | volume = 61 | issue = 2 | pages = 179–83 | year = 2003 | pmid = 12694588}}</ref>
| style="text-align:left; background:#f0f0ff" | Naxi<br />(Lijiang, China)
|    ||  2.7
! style="background:#fdfdff" | 2.7
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Ainu2">{{cite journal | vauthors = Bannai M, Tokunaga K, Imanishi T, Harihara S, Fujisawa K, Juji T, Omoto K | title = HLA class II alleles in Ainu living in Hidaka District, Hokkaidō, northern Japan. | journal = Am J Phys Anthropol | volume = 101 | issue = 1 | pages = 1–9 | year = 1996 | pmid = 8876810 | doi = 10.1002/(SICI)1096-8644(199609)101:1<1::AID-AJPA1>3.0.CO;2-Z}}</ref>
| style="text-align:left; background:#f0f0ff"  | Ainu<br />(Japan)
|    || 3.0
! style="background:#fdfdff" |  3.0
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="Shandong">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Shandong%20Han |title=Review Population Study - China Shandong Han |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004741/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Shandong%20Han |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Zhou L, Lin B, Xie Y, Liu Z, Yan W, Xu A | title = Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. | journal = Tissue Antigens | volume = 66 | issue = 1 | pages = 37–43 | year = 2005 | pmid = 15982255 | doi = 10.1111/j.1399-0039.2005.00418.x}}</ref>
| style="text-align:left; background:#f0f0ff"  | Shandong Han<br />(China)
|    || 3.1
! style="background:#fdfdff" | 3.1
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Khalkha">Four references:1.{{cite journal | vauthors = Machulla H, Batnasan D, Steinborn F, Uyar F, Saruhan-Direskeneli G, Oguz F, Carin M, Dorak M | title = Genetic affinities among Mongol ethnic groups and their relationship to Turks. | journal = Tissue Antigens | volume = 61 | issue = 4 | pages = 292–9 | year = 2003 | pmid = 12753667 | doi = 10.1034/j.1399-0039.2003.00043.x}}, 2.{{cite journal | vauthors = Chimge N, Tanaka H, Kashiwase K, Ayush D, Tokunaga K, Saji H, Akaza T, Batsuuri J, Juji T | title = The HLA system in the population of Mongolia. | journal = Tissue Antigens | volume = 49 | issue = 5 | pages = 477–83 | year = 1997 | pmid = 9174140 | doi = 10.1111/j.1399-0039.1997.tb02782.x}}, 3.{{cite web |url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khalkha |title= Review Population Study - Mongolia Khalkha |work= Allele frequencies in the worldwide population |archive-url=https://web.archive.org/web/20070927004832/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khalkha |archive-date=2007-09-27 |access-date= 2008-08-17}}, and 4.{{cite web |url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khalkh%20Ulaanbaatar |title= Review Population Study - Mongolia Khalkh Ulaanbaatar |work= Allele frequencies in the worldwide population |archive-url=https://web.archive.org/web/20070927004852/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Mongolia%20Khalkh%20Ulaanbaatar |archive-date=2007-09-27 |access-date= 2008-08-17}}</ref>
| style="text-align:left; background:#f0f0ff" | Khalkha<br />(Mongolia)
| 22.3   || 6.1
! style="background:#fdfdff" | 6.1
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Thailand |title=Review Population Study - Thailand |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005045/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Thailand |archive-date=2007-09-27 |access-date=2008-08-17}}</ref>
| style="text-align:left; background:#f0f0ff" | Thais
| 21.5 ||  7.4
! style="background:#fdfdff" | 7.4
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="Ket">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Ket%20Lower%20Yenisey |title=Review Population Study - Russia Siberia Ket Lower Yenisey |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004800/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Ket%20Lower%20Yenisey |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Uinuk-Ool T, Takezaki N, Derbeneva O, Volodko N, Sukernik R | title = Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations. | journal = European Journal of Immunogenetics | volume = 31 | issue = 1 | pages = 43–51 | year = 2004 | pmid = 15009181 | doi = 10.1111/j.1365-2370.2004.00443.x}}</ref>
| style="text-align:left; background:#f0f0ff"  | Ket, Yenisey<br />(Siberia)
| 14.7 || 8.4
! style="background:#fdfdff" |  8.4
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Korea485">{{cite journal | vauthors = Lee K, Oh D, Lee C, Yang S | title = Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. | journal = Tissue Antigens | volume = 65 | issue = 5 | pages = 437–47 | year = 2005 | pmid = 15853898 | doi = 10.1111/j.1399-0039.2005.00386.x}}</ref>
| style="text-align:left; background:#f0f0ff" | South Korea
|    || 10.3
! style="background:#fdfdff" | 10.3
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="JapaneseI-II">{{cite journal | vauthors = Saito S, Ota S, Yamada E, Inoko H, Ota M | title = Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. | journal = Tissue Antigens | volume = 56 | issue = 6 | pages = 522–9 | year = 2000 | pmid = 11169242 | doi = 10.1034/j.1399-0039.2000.560606.x| doi-access = free }}</ref>
| style="text-align:left; background:#f0f0ff" | Japanese
|    ||  10.8
! style="background:#fdfdff" |  10.8
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="Ngansan">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Nganasan%20Dudinka |title=Review Population Study - Russia Siberia Nganasan Dudinka |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005004/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Nganasan%20Dudinka |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Uinuk-Ool T, Takezaki N, Derbeneva O, Volodko N, Sukernik R | title = Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations. | journal = European Journal of Immunogenetics | volume = 31 | issue = 1 | pages = 43–51 | year = 2004 | pmid = 15009181 | doi = 10.1111/j.1365-2370.2004.00443.x}}</ref>
| style="text-align:left; background:#f0f0ff"  | Nganasan<br />(Siberia)
| 39.6 || 11.4
! style="background:#fdfdff" |  11.4
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="Uygar">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Urumqi%20Uygur |title=Review Population Study - China Urumqi Uygur |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004734/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=China%20Urumqi%20Uygur |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | doi = 10.1111/j.1399-0039.1998.tb03104.x | vauthors = Mizuki N, Ohno S, Ando H, Sato T, Imanishi T, Gojobori T, Ishihara M, Goto K, Ota M, Geng Z, Geng L, Li G, Inoko H | title = Major histocompatibility complex class II alleles in an Uygur population in the Silk Route of Northwest China. | journal = Tissue Antigens | volume = 51 | issue = 3 | pages = 287–92 | year = 1998 | pmid = 9550330}}</ref>
| style="text-align:left; background:#f0f0ff"  | Uygars, Ürümqi <br />(China)
| 21.9 || 11.4
! style="background:#fdfdff" | 11.4
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Kazak">{{cite journal | vauthors = Mizuki M, Ohno S, Ando H, Sato T, Imanishi T, Gojobori T, Ishihara M, Ota M, Geng Z, Geng L, Li G, Kimura M, Inoko H | title = Major histocompatibility complex class II alleles in Kazak and Han populations in the Silk Route of northwestern China. | journal = Tissue Antigens | volume = 50 | issue = 5 | pages = 527–34 | year = 1997 | pmid = 9389328 | doi = 10.1111/j.1399-0039.1997.tb02909.x}}</ref>
| style="text-align:left; background:#f0f0ff"  | Kazakh
|    || 11.4
! style="background:#fdfdff" | 11.4
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" |<ref name="Negidal">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Negidal |title=Review Population Study - Russia Siberia Negidal |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004813/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Siberia%20Negidal |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Uinuk-Ool T, Takezaki N, Sukernik R, Nagl S, Klein J | s2cid = 20940785 | title = Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies. | journal = Hum Genet | volume = 110 | issue = 3 | pages = 209–26 | year = 2002 | pmid = 11935333 | doi = 10.1007/s00439-001-0668-0}}</ref>
| style="text-align:left; background:#f0f0ff"  | Negidal<br />(Siberia)
|  50.0  || 18.6
! style="background:#fdfdff" |  18.6
|-
|style="text-align:right; background:#f0f0ff; padding-right:1em" | <ref name="Coo_I.">{{cite journal | vauthors = Velickovic Z, Delahunt B, Carter J | title = HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. | journal = Tissue Antigens | volume = 59 | issue = 5 | pages = 397–406 | year = 2002 | pmid = 12144623 | doi = 10.1034/j.1399-0039.2002.590506.x}}</ref>
| style="text-align:left; background:#f0f0ff" | Cook Isl.<br />(Pacific)
|    ||  25.0
! style="background:#fdfdff" | 25.0
|-
|}{{clear right}}

====Abundance in Asia====
'''Hiatus of DQ8 in the NE Siberian Arctic, Elevated Levels in Amur Region and Eastern Turks'''

The levels of DQ8 in SW to West Pacific Rim are at variable haplotype frequencies, from 2 to 30%, and level off around 10% for Ryūkyūan, Japanese, Koreans, Amur Regions and in the NW Pacific Rim drop to less than 1% in the Nivkhi. There is a modern hiatus of DQ8 in the Alaska-Eastern Siberian region and it is unclear whether this is due to replacement, selection, or the mode in which first Americans arrived (i.e. strictly maritime route). The DR types associated with DQ8 are DRB1*0403, *0404, *0406, *0407, *0408, and *0401 is split between many DQA1:B1 haplotypes. DQB1*0405 is commonly associated with DQA1*0303:DQB1*04 and so it is not included in DRB1*0401 in high resolution assessments. The Cook Island DQ8 had only one associated DR haplotype suggesting diversity limiting introduction into the region, either via the TW-(Japan/Korea/China) route or through the west, for example the Bunun have high DRB1*0403. The majority of DRB1*04 appear to have redistributed from eastern Asia from an unknown source, possibly in Central Asia or India.  The distribution can be compared with Native Groups such as South Americans. Three groups with high levels, the Kogui, Sikuni, and Yucpa, have about 75% DQ8, the dominant DRB1* allele in 2 of 3 is the *0411 (N. China = 0), but *0407 (Ryūkyū, Japanese, Mansi-Eastern Ural, Naxi Chinese) and *0403 (Nganasan, Buryat, Negidal, Tunisians, Ryūkyū, Korea, Ainu) are also found. In North America DRB1*0404 and *0407 are more common than *0403 and, in the Lakota Sioux, B1*0411 is rare. The DRB1*0404-DQ8 haplotype is more common in North Western Asia, and Northern Europe.

{| align="right" border="0" cellspacing="0" cellpadding="1" style="text-align:center; margin-left: 2em;  border:1px #ffbbf8 solid; background:#fff8fd; "
|+ '''DQA1*03/DQB1*0302 levels in Europe, Middle East and Africa'''<br />(given as frequency in %)
|- style="background:#ffe7fb"
! width="20" |
! width="170" style="text-align:left" |Reference
! width="55" style="font-size:85%" |DQA1
! width="55" Style="font-size:85%" |DQB1
! width="65" Style="font-size:80%" |Estimated
|- style="background:#ffe7fb"
!
! style="text-align:left" | Population
| style="font-size:90%" | *03 ||  | *0302
! DQ8.1
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" |<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Nenets |title=Review Population Study - Russia Nenets |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004807/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Nenets |archive-date=2007-09-27 |access-date=2008-08-17}} and 2. {{cite journal | vauthors = Evseeva I, Spurkland A, Thorsby E, Smerdel A, Tranebjaerg L, Boldyreva M, Groudakova E, Gouskova I, Alexeev L | title = HLA profile of three ethnic groups living in the North-Western region of Russia. | journal = Tissue Antigens | volume = 59 | issue = 1 | pages = 38–43 | year = 2002 | pmid = 11972877 | doi = 10.1034/j.1399-0039.2002.590107.x}}</ref>
| style="text-align:left; background:#fff0fb" | Nenets <br />(N. Russia)
| 40.9   ||  20.9
! style="background:#fffbfe" | 20.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Murmansk%20Saomi |title=Review Population Study - Russia Murmansk Saomi |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004747/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Murmansk%20Saomi |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Evseeva I, Spurkland A, Thorsby E, Smerdel A, Tranebjaerg L, Boldyreva M, Groudakova E, Gouskova I, Alexeev L | title = HLA profile of three ethnic groups living in the North-Western region of Russia. | journal = Tissue Antigens | volume = 59 | issue = 1 | pages = 38–43 | year = 2002 | pmid = 11972877 | doi = 10.1034/j.1399-0039.2002.590107.x}}</ref>
| style="text-align:left; background:#fff0fb" | Murmansk Saomi<br />(Russia)
| 38.3   ||  18.5
! style="background:#fffbfe" | 17.2
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref name="Pomors">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Arkhangelsk%20Pomors |title=Review Population Study - Russia Arkhangelsk Pomors |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005051/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Arkhangelsk%20Pomors |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Evseeva I, Spurkland A, Thorsby E, Smerdel A, Tranebjaerg L, Boldyreva M, Groudakova E, Gouskova I, Alexeev L | title = HLA profile of three ethnic groups living in the North-Western region of Russia. | journal = Tissue Antigens | volume = 59 | issue = 1 | pages = 38–43 | year = 2002 | pmid = 11972877 | doi = 10.1034/j.1399-0039.2002.590107.x}}</ref>
| style="text-align:left; background:#fff0fb" | Arkhange Pomors<br />(Russia)
| 22.6   ||  17.1
! style="background:#fffbfe" | 16.4
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" |<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Sweden |title=Review Population Study - Sweden |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004846/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Sweden |archive-date=2007-09-27 |access-date=2008-08-17}} and 2. {{cite book  | last =  Kimiyoshi | first = Tsuji |author2=Aizawa M |author3=Sasazuki T   | title = Proceedings of the Eleventh International Histocompatibility Workshop and Conference Held in Yokohoma, Japan, 6–13 November 1991  | publisher =  Oxford University Press  | year = 1992  |location = Oxford  | isbn = 0-19-262390-7}}</ref>
| style="text-align:left; background:#fff0fb" |Swedish
| 24.2   || 18.7
! style="background:#fffbfe" | 16.1
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=England%20Caucasoid |title=Review Population Study - England Caucasoid |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927005105/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=England%20Caucasoid |archive-date=2007-09-27  |access-date=2008-08-17}} and 2. {{cite journal | vauthors = Doherty D, Vaughan R, Donaldson P, Mowat A | title = HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids. | journal = Hum Immunol | volume = 34 | issue = 1 | pages = 53–63 | year = 1992 | pmid = 1399722 | doi = 10.1016/0198-8859(92)90085-2 }}</ref>
| style="text-align:left; background:#fff0fb" | Caucasian<br />(England)
|  23.7  || 16.4
! style="background:#fffbfe" | 15.9
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Finland |title=Review Population Study - Finland |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004951/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Finland |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | title = 12th International Histocompatibility Conference. Genetic diversity of HLA: functional and medical implications. Paris, France, June 9–12, 1996. Abstracts. | journal = Hum Immunol | volume = 47 | issue = 1–2 | pages = 1–184 | year = 1996| pmid = 8909580}}</ref>
| style="text-align:left; background:#fff0fb" | Finland
|    || 15.7
! style="background:#fffbfe" | 15.2
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" |<ref>{{cite journal | vauthors = Bugawan T, Klitz W, Blair A, Erlich H | title = High-resolution HLA class I typing in the CEPH families: analysis of linkage disequilibrium among HLA loci | journal = Tissue Antigens | volume = 56 | issue = 5 | pages = 392–404 | year = 2000 | pmid = 11144287 | doi = 10.1034/j.1399-0039.2000.560502.x}}</ref>
| style="text-align:left; background:#fff0fb" | France's CEPH
| 21.3   ||  14.5
! style="background:#fffbfe" | 13.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref>{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Denmark |title=Review Population Study - Denmark |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004704/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Denmark |archive-date=2007-09-27 |access-date=2008-08-17}} and 2. {{cite book  | last =  Kimiyoshi | first = Tsuji |author2=Aizawa M |author3=Sasazuki T   | title = Proceedings of the Eleventh International Histocompatibility Workshop and Conference Held in Yokohoma, Japan, 6–13 November 1991  | publisher =  Oxford University Press  | year = 1992  |location = Oxford  | isbn = 0-19-262390-7}}</ref>
| style="text-align:left; background:#fff0fb" |Dane
| 20.9   ||  13.2
! style="background:#fffbfe" | 13.2
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" |<ref>{{cite journal | vauthors = Schipper R, Schreuder G, D'Amaro J, Oudshoorn M | title = HLA gene and haplotype frequencies in Dutch blood donors | journal = Tissue Antigens | volume = 48 | issue = 5 | pages = 562–74 | year = 1996 | pmid = 8988539 | doi = 10.1111/j.1399-0039.1996.tb02670.x}}</ref>
| style="text-align:left; background:#fff0fb" | Dutch
|    || 11.2
! style="background:#fffbfe" | 11.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" |
| style="text-align:left; background:#fff0fb" | Irish
|    ||
! style="background:#fffbfe" | 10.6
|-
|style="text-align:right; background:#fff0fb; padding-right:1em"|<ref name="NW russians">{{cite web|url=http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Northwest%20Slavic |title=Review Population Study - Russia Northwest Slavic |work=Allele frequencies in the worldwide population |url-status=dead |archive-url=https://web.archive.org/web/20070927004727/http://www.allelefrequencies.net/test/searchAllelePart3-1.asp?Population=Russia%20Northwest%20Slavic |archive-date=2007-09-27 |access-date=2008-08-17}} and 2.{{cite journal | vauthors = Kapustin S, Lyshchov A, Alexandrova J, Imyanitov E, Blinov M | title = HLA class II molecular polymorphisms in healthy Slavic individuals from North-Western Russia | journal = Tissue Antigens | volume = 54 | issue = 5 | pages = 517–20 | year = 1999 | pmid = 10599891 | doi = 10.1034/j.1399-0039.1999.540509.x}}</ref>
| style="text-align:left; background:#fff0fb" | NW Slavic <br />(Russia)
| 16.0   ||  11.0
! style="background:#fffbfe" | 10.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11">{{cite book  | last =  Kimiyoshi | first = Tsuji |author2=Aizawa M |author3=Sasazuki T   | title = Proceedings of the Eleventh International Histocompatibility Workshop and Conference Held in Yokohoma, Japan, 6–13 November 1991  | publisher =  Oxford University Press  | year = 1992  |location = Oxford  | isbn = 0-19-262390-7}}</ref>
|style="text-align:left; background:#fff0fb" | German
|    || 10.5
! style="background:#fffbfe" | 9.9
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Evseeva I, Spurkland A, Thorsby E, Smerdel A, Tranebjaerg L, Boldyreva M, Groudakova E, Gouskova I, Alexeev L | title = HLA profile of three ethnic groups living in the North-Western region of Russia | journal = Tissue Antigens | volume = 59 | issue = 1 | pages = 38–43 | year = 2002 | pmid = 11972877 | doi = 10.1034/j.1399-0039.2002.590107.x}}</ref>
|style="text-align:left; background:#fff0fb" | Russian
|    || 8.9
! style="background:#fffbfe" | 7.2
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Sanchez-Velasco P, Gomez-Casado E, Martinez-Laso J, Moscoso J, Zamora J, Lowy E, Silvera C, Cemborain A, Leyva-Cobián F, Arnaiz-Villena A | title = HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 384–92 | year = 2003 | pmid = 12753657 | doi = 10.1034/j.1399-0039.2003.00041.x}}</ref>
|style="text-align:left; background:#fff0fb" | Cantabarian<br />(Spain)
| 19.3   || 8.4
! style="background:#fffbfe" | 7.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
|style="text-align:left; background:#fff0fb" | Spanish
|    || 8.9
! style="background:#fffbfe" | 6.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
| style="text-align:left; background:#fff0fb" | Sardinian
|    || 4.9
! style="background:#fffbfe" | 4.9
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
| style="text-align:left; background:#fff0fb" | Italian
|    || 4.6
! style="background:#fffbfe" | 4.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Valluri V, Valluei V, Mustafa M, Santhosh A, Middleton D, Alvares M, Alvales M, El Haj E, Gumama O, Abdel-Wareth L, Abdel-Waieth L | title = Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population | journal = Tissue Antigens | volume = 66 | issue = 2 | pages = 107–13 | year = 2005 | pmid = 16029430 | doi = 10.1111/j.1399-0039.2005.00441.x}}</ref>
| style="text-align:left; background:#fff0fb" | United Arab Emirates
|    || 0.83
! style="background:#fffbfe" | 0.8
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Sánchez-Velasco P, Karadsheh N, García-Martín A, Ruíz de Alegría C, Leyva-Cobián F | title = Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations | journal = Hum Immunol | volume = 62 | issue = 9 | pages = 901–9 | year = 2001 | pmid = 11543892 | doi = 10.1016/S0198-8859(01)00289-0}}</ref>
| style="text-align:left; background:#fff0fb" |Jordan
| 24.1   ||  17.9
! style="background:#fffbfe" | 17.9
|-style="background:#fff0fb"
! Colspan="5" | Africa
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
| style="text-align:left; background:#fff0fb" | [[ǃKung people|!Kung]]
|    || 36.7
! style="background:#fffbfe" | 36.7
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
| style="text-align:left; background:#fff0fb" | Khoi
|    || 14.9
! style="background:#fffbfe" | 13.9
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="Oromo_Amhara">{{cite journal | doi = 10.1111/j.1399-0039.1998.tb02971.x | vauthors = Fort M, de Stefano G, Cambon-Thomsen A, Giraldo-Alvarez P, Dugoujon J, Ohayon E, Scano G, Abbal M | title = HLA class II allele and haplotype frequencies in Ethiopian Amhara and Oromo populations | journal = Tissue Antigens | volume = 51 | issue = 4 Pt 1 | pages = 327–36 | year = 1998 | pmid = 9583804}}</ref>
| style="text-align:left; background:#fff0fb" | Oromo
| 17.5   || 9.0
! style="background:#fffbfe" | 9.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Gómez-Casado E, del Moral P, Martínez-Laso J, García-Gómez A, Allende L, Silvera-Redondo C, Longas J, González-Hevilla M, Kandil M, Zamora J, Arnaiz-Villena A | title = HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians | journal = Tissue Antigens | volume = 55 | issue = 3 | pages = 239–49 | year = 2000 | pmid = 10777099 | doi = 10.1034/j.1399-0039.2000.550307.x}}</ref>
| style="text-align:left; background:#fff0fb" | Morocco
| 17.2   ||   8.9
! style="background:#fffbfe" | 8.6
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Ayed K, Ayed-Jendoubi S, Sfar I, Labonne M, Gebuhrer L | title = HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data | journal = Tissue Antigens | volume = 64 | issue = 4 | pages = 520–32 | year = 2004 | pmid = 15361135 | doi = 10.1111/j.1399-0039.2004.00313.x}}</ref>
| style="text-align:left; background:#fff0fb" | Tunisia
| 10.31   ||  10.0
! style="background:#fffbfe" | 8.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="Oromo_Amhara"/>
| style="text-align:left; background:#fff0fb" | Amhara
| 11.2   || 5.6
! style="background:#fffbfe" | 5.6
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="Aka_Bantu">{{cite journal | vauthors = Renquin J, Sanchez-Mazas A, Halle L, Rivalland S, Jaeger G, Mbayo K, Bianchi F, Kaplan C | title = HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity | journal = Tissue Antigens | volume = 58 | issue = 4 | pages = 211–22 | year = 2001 | pmid = 11782272 | doi = 10.1034/j.1399-0039.2001.580401.x}}</ref>
| style="text-align:left; background:#fff0fb" | Aka pygmies
|    || 3.2
! style="background:#fffbfe" | 3.0
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="IHWC11"/>
| style="text-align:left; background:#fff0fb" | Negroid<br />(N. Africa)
|    || 3.1
! style="background:#fffbfe" |2.7
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Pimtanothai N, Hurley C, Leke R, Klitz W, Johnson A | title = HLA-DR and -DQ polymorphism in Cameroon | journal = Tissue Antigens | volume = 58 | issue = 1 | pages = 1–8 | year = 2001 | pmid = 11580849 | doi = 10.1034/j.1399-0039.2001.580101.x}}</ref>
| style="text-align:left; background:#fff0fb" | Cameron
| 11.5   ||   1.5
! style="background:#fffbfe" | 1.2
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref name="Aka_Bantu"/>
| style="text-align:left; background:#fff0fb" | Bantu Congo
|    || 0.6
! style="background:#fffbfe" | 0.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = Schnittger L, May J, Loeliger C, Gallin M, Erttmann K, Bienzle U, Kremsner P, Meyer C | title = HLA DRB1-DQA1-DQB1 haplotype diversity in two African populations | journal = Tissue Antigens | volume = 50 | issue = 5 | pages = 546–51 | year = 1997 | pmid = 9389330 | doi = 10.1111/j.1399-0039.1997.tb02911.x}}</ref>
| style="text-align:left; background:#fff0fb" | Gabonese
| 7.5   ||
! style="background:#fffbfe" | 0.5
|-
|style="text-align:right; background:#fff0fb; padding-right:1em" | <ref>{{cite journal | vauthors = de Pablo R, García-Pacheco J, Vilches C, Moreno M, Sanz L, Rementería M, Puente S, Kreisler M | title = HLA class I and class II allele distribution in the Bubi population from the island of Bioko<br />(Equatorial Guinea) | journal = Tissue Antigens | volume = 50 | issue = 6 | pages = 593–601 | year = 1997 | pmid = 9458112 | doi = 10.1111/j.1399-0039.1997.tb02917.x}}</ref>
| style="text-align:left; background:#fff0fb" | Bubi
| 17.5   || 0.0
! style="background:#fffbfe" | 0.0
|-
|}{{clear left}}

====High levels of DQ8 in Northern Europe====
DQ8 is also abundant also in '''Northern Europe''' and is found at high frequencies in the German-Scandinavian-Uralic population north of Switzerland. HLA A-B haplotypes suggest that a migration from people east of the Urals is responsible for DQ8, possibly from as far east as the West Pacific Rim. The high level of DQ8 and DQ2.5 is something of great interest for DQ mediated diseases of Scandinavia and Northern Europe. DQ8 is also found in Iberia and places where east to west gene flow by other genetic markers cannot be substantiated, and the levels within the African or Middle Eastern population are possible sources, Iberia has considerable A1/B1 equilibration suggesting independent sources from Africa.

==Global spread of DQ8==
DQ8 along with a few other haplotypes appears to be split NW/SE in Eurasia and with the evidence for DQ2.5 and other haplotypes suggest an ancient Central Asian population was displaced by a more recent African migration. There are many common markers found in France, Germans, Danes, Swedes, Tibetans, Amur River, Japanese and Koreans that are potential indicators of this bilateral spread. The DQ8 haplotypes is found at high frequencies in the [[ǃKung people|!Kung]], albeit one expects more DQ8 in Austronesia it is ubiquitously spread if at some times low frequencies, other times higher frequencies (Thai). The path of DQ8 spread to the New World is enigmatic, certainly Japan and Amur River are potent sources, but other displaced populations cannot be ruled out. If the mode of travel was through the Beringia corridor as proposed by archaeologist, the very low frequency of DQ8 at present is a very unusual find with regard to evidence for complete displacement elsewhere in the World. Markers that are shared between Japanese, TW-aboriginals tend to decline in frequency as one approaches Siberia, mtDNA markers decline in the Kuril chain. During the Jōmon period of Japan it appears there would have been displacement by Ninhvet/Ainu ancestors and depression of DQ8 throughout northern Japan, but the decline throughout the region is somewhat inexplicable outside of a catastrophic climate event between the settling of the New World and the current time.

An alternative model is that there were multiple sources of DQ8 in the peopling of NE Asia, some sources were from central Asia and some from the indochinese region, some of the DQ8 found in NW Eurasia could be from an admixture of West pacific Rim and Central Asian sources, and were displaced from the more central regions but not from the more Eastern regions.

==DQ8 and selection==
Like DQ2.5, DQ8 might have been under selection for maritime, coastal foraging peoples and in particular for peoples adapted to the climate/habitat situation on the northern end of the habitable west pacific rim at the Last Glacial Maximum. [[Triticeae]] cultivation may apply negative selection on DQ8.  While there were numerous members of ''Triticeae'' species similar to Mid-Eastern wild ''Triticeae'' in the Americas, and a great number of domesticated plants in the new world, no single species of ''Triticeae'' appears to have been domesticated in the New World, and no clear examples in closely related tribes of grasses. Among new world grass species in post Columbian times, one species of ''Elymus'' has been domesticated for human consumption and another as a pastoral cultivar. This could be interpreted in 2 ways. First, that levels of DQ8, negatively, inhibited the domestication of ''Triticeae'' strains. Second, that the absence of such cultivars more suitable than already developed cultivars allowed DQ8 to rise or remain high, while DQ2.5 levels in NW under much longer term selection have fallen, or a little of both. Most of American cultivars were domesticated south of the [[Rio Grande]] (exceptions are Caddo rice and Texas varigated squash, etc.). Wheat, particularly barley and rye, are preferential cultivars in cooler climate, whereas ''Zea'' is more adaptive in tropical climates and some cultivars are relatively drought-tolerant, ''Zea'' however lacks certain amino acids that must be supplemented by other foods to prevent malnutrition. The proximity of neolithization to the Equator in the New World may have much to do with the unapparent negative selection of DQ8 relative to the neolithization of Western Eurasia.
[[File:DQ8-Insulin peptide.PNG|frame|left|Rendering of HLA-DQ8 with insulin peptide in the binding pocket looking down over the binding groove]]

==DQ8 and disease==
In '''Europe''', DQ8 is associated with [[Type 1 diabetes]] and [[coeliac disease]] (also known as celiac disease). The highest risk factor for type 1 diabetes is the HLA DQ8/DQ2.5 phenotype. In parts of eastern Scandinavia both DQ2.5 and DQ8 are high increases frequencies of late onset Type I and ambiguous Type I/II diabetes. DQ8 is also found in many indigenous peoples of '''Asia''', it was detected early on in the Bedoin population of Arabia where DQ2.5 is frequently absent, and in these instances DQ8 is solely associated HLA in coeliac disease.

In the '''United States''', however there appears to be shift in autoimmune disease risk for immigrants from Mexico. Increased immunoreactivity of Hispanics in Houston appear to be associated with DR4-DQ8. The haplotype may incur the highest risk for rheumatoid arthritis.

In '''Japan''' DQ3 (DQ7, DQ8, DQ9) is associated with ''myasthenia gravis'' in the early onset female population, though it does not appear DQ8 has the greater role, there are similarities between ''myasthenia gravis'' in Japan and that detected in the Houston Hispanic population, with DQ8 associated with younger females relative to the associations of all other HLA DQ types. Coeliac disease is on the rise in Japan, and it is clear that dietary shifts are the reason, but, also there is no DQ2.5 in Japan while DQ8 levels are moderate.

===The DR4 linkage===
Many disease associated with DQ8 have dual linkage with DR4, and certain DR4 (*0405) have independent and dependent risk association with DQ8, for example with Type 1 Diabetes.<ref>{{cite journal | vauthors = Park Y, Tait B, Kawasaki E, Rowley M, Mackay I | title = Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients | journal = Annals of the New York Academy of Sciences | volume = 1037 | issue = 1| pages = 104–9 | year = 2004| pmid = 15699500 | doi = 10.1196/annals.1337.015| bibcode = 2004NYASA1037..104P | s2cid = 38178367 }}</ref><ref>{{cite journal | vauthors = Hermann R, Turpeinen H, Laine A, Veijola R, Knip M, Simell O, Sipilä I, Akerblom H, Ilonen J | title = HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families | journal = Tissue Antigens | volume = 62 | issue = 2 | pages = 162–9 | year = 2003 | pmid = 12889996 | doi = 10.1034/j.1399-0039.2003.00071.x}}</ref>

==References==
{{reflist|2}}

==External links==
'''Coeliac Disease'''
* [http://www.coeliac.co.uk/ Coeliac UK] {{Webarchive|url=https://web.archive.org/web/20060527003650/http://www.coeliac.co.uk/ |date=2006-05-27 }} (charity)
* [http://www.celiac.org/ The Celiac Disease Foundation] {{Webarchive|url=https://web.archive.org/web/20061023223612/http://www.celiac.org/ |date=2006-10-23 }} (U.S.)
* [http://www.csaceliacs.org/ The Celiac Sprue Association] (U.S.)
* [https://web.archive.org/web/20090720193635/http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/ National Digestive Diseases Clearinghouse] - page on coeliac disease
* [http://www.celiacawareness.org National Foundation for Celiac Awareness] (U.S.)
* [http://www.celiaccenter.org/ University of Maryland Center for Celiac Research]

'''Type 1 Diabetes'''
*[http://www.childrenwithdiabetes.com/ Children with Diabetes]
*[https://web.archive.org/web/20091030082136/https://www.diabetes.org/type-1-diabetes.jsp Type 1 Diabetes] at the [[American Diabetes Association]]

{{DQ serotypes}}
{{gluten sensitivity}}

{{DEFAULTSORT:Hla-Dq8}}
[[Category:HLA-DQ haplotypes|8]]
[[Category:Human MHC mediated diseases|8]]