View source for Esophageal spasm

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{{Infobox medical condition (new)
| name            =  Esophageal spasm
| synonyms        = Oesophageal spasm
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| specialty       = [[Gastroenterology]]
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| differential    = [[Achalasia]], [[angina]], [[scleroderma]], [[esophageal cancer]], [[esophagitis]]<ref name=Stat2019/>
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'''Esophageal spasm''' is a disorder of [[motility]] of the [[esophagus]].<ref name=Pt2019>{{cite web |url= http://patient.info/doctor/oesophageal-spasm|publisher= [[EMIS Health]] |title= Oesophageal Spasm|accessdate= 2015-11-15}}</ref>

There are two types of esophageal spasm:<ref name=Pt2019/>
* [[Diffuse esophageal spasm|Diffuse or distal esophageal spasm]] (DES), where there is uncoordinated esophageal contractions
* [[Nutcracker esophagus]] (NE) also known as hypertensive peristalsis, where the contractions are coordinated but with an excessive amplitude.

Both conditions are linked to [[gastroesophageal reflux disease]] (GERD).<ref name=Pt2019/> DES and nutcracker esophagus present similarly and can may require [[esophageal manometry]] for differentiation.<ref>{{cite book |last1=Lightdale |first1=Charles J. |title=The Foregut: Function-dysfunction |date=2009 |publisher=John Libbey Eurotext |isbn=9782742007219 |page=50 |url=https://books.google.com/books?id=5EXvwKUo-ToC&pg=PA50 |language=en}}</ref>

When the coordinated [[muscle contraction]] are irregular or uncoordinated, this condition may be called diffuse esophageal spasm. These spasms can prevent food from reaching the stomach where food gets stuck in the esophagus. At other times the coordinated muscle contraction is very powerful, which is called nutcracker esophagus. These contractions move food through the esophagus but can cause severe pain.<ref name="Muscle">{{cite web |url= http://www.webmd.com/digestive-disorders/tc/esophageal-spasm-topic-overview|website= [[WebMD]] |title= Esophageal Spasm – Topic Overview|accessdate= 2015-11-15}}</ref>

==Signs and symptoms==
The symptoms may include [[dysphagia|trouble swallowing]], [[Regurgitation (digestion)|regurgitation]], [[chest pain]],<ref name="Web">{{cite web |url= http://emedicine.medscape.com/article/174975-overview|website= [[WebMD]] |title= Esophageal Spasm|accessdate= 2015-11-15}}</ref> [[heartburn]],<ref name="Heart">{{cite web |url= http://emedicine.medscape.com/article/174975-clinical|website= [[WebMD]] |title= Esophageal Spasm Clinical Presentation – History|accessdate= 2015-11-15}}</ref> [[globus pharyngeus]] (which is a feeling that something is stuck in the [[throat]]) or a dry [[cough]].<ref name="Health">{{cite web |url= https://my.clevelandclinic.org/health/diseases_conditions/hic-esophageal-spasms-strictures|publisher= [[Cleveland Clinic]] |title= Esophageal Spasms & Strictures|accessdate= 2015-11-15}}</ref>

==Causes==
It is not clear what causes esophageal spasms.<ref name=Stat2019>{{cite journal |last1=Goel |first1=S |last2=Nookala |first2=V |title=Diffuse Esophageal Spasm |date=January 2019 |pmid=31082150}}</ref><ref name="Health"/> Sometimes esophageal spasms start when someone eats hot or cold foods or drinks. However, they can also occur without eating or drinking.<ref name="Health"/> The increased release of [[acetylcholine]] may also be a factor, but the triggering event is not known.<ref name="Heart"/> Spasms may also be the result of a food intolerance.

==Diagnosis==
The diagnosis is generally confirmed by [[esophageal manometry]].<ref name=Pt2019/> DES is present when more than a fifth of swallows results in distal esophageal contractions.<ref name=Pt2019/> NE is present if the average strength of the contractions of the distal esophagus is greater than 180 mmHg but the contraction of the esophagus is otherwise normal.<ref name=Pt2019/>

===Differential diagnosis===
Often, symptoms that may suggest esophageal spasm are the result of another condition such as food intolerance, [[gastroesophageal reflux disease]] (GERD) or [[achalasia]].<ref name="Muscle"/> The symptoms can commonly be mistaken as heart palpitations.

==Treatment==
Since esophageal spasms are often associated with other disorders, management in these cases involve attempts to correct the underlying problem. Medications may include use of [[calcium channel blockers]] (CCBs) and nitrates. [[Tricyclic antidepressants]] (TCA) and [[sildenafil]] can be used as alternative treatment options. If caused by food allergy, an elimination diet may be necessary.

There have been reports of treatment of distal esophageal spasm in 8 patients using low amounts of [[peppermint oil]] (five drops of peppermint oil in 10ml of water),<ref>{{Cite journal |last1=Pimentel |first1=M. |last2=Bonorris |first2=G. G. |last3=Chow |first3=E. J. |last4=Lin |first4=H. C. |date=July 2001 |title=Peppermint oil improves the manometric findings in diffuse esophageal spasm |url=https://pubmed.ncbi.nlm.nih.gov/11418786/ |journal=Journal of Clinical Gastroenterology |volume=33 |issue=1 |pages=27–31 |doi=10.1097/00004836-200107000-00007 |issn=0192-0790 |pmid=11418786|s2cid=46427292 }}</ref> and a report of treatment of an elderly patient with the same diagnosis.<ref>{{Cite journal |last1=Parvataneni |first1=Swetha |last2=Vemuri-Reddy |first2=Sireesha |date=2020-03-06 |title=Role of Peppermint Oil in Diffuse Esophageal Spasm in the Geriatric Population |journal=Cureus |volume=12 |issue=3 |pages=e7192 |doi=10.7759/cureus.7192 |doi-access=free |issn=2168-8184 |pmc=7137643 |pmid=32269872}}</ref>

===Procedures===
If medical therapy fails either [[botulinum toxin]] injection or surgical [[myotomy]] may be tried in distal esophageal spasms.<ref name=Rom2015>{{cite journal |last1=Roman |first1=S |last2=Kahrilas |first2=PJ |title=Distal esophageal spasm. |journal=Current Opinion in Gastroenterology |date=July 2015 |volume=31 |issue=4 |pages=328–33 |doi=10.1097/MOG.0000000000000187 |pmid=26039725|s2cid=25972582 }}</ref>

==Epidemiology==
Distal esophageal spasm is rare.<ref name=Rom2015/>

== References ==
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{{Digestive tract}}
{{Human systems and organs}}
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[[Category:Abdomen]]
[[Category:Digestive system]]
[[Category:Diseases of oesophagus, stomach and duodenum]]