View source for EGF module-containing mucin-like hormone receptor

{{Short description|G protein-coupled receptor}}
{{notability|date=February 2021}}
{{infobox protein
| Name = [[EMR1|egf-like module containing, mucin-like, hormone receptor-like 1]]
| caption = 
| image = 
| width = 
| HGNCid = 3336
| Symbol = EMR1
| AltSymbols = TM7LN3
| IUPHAR_id = yes
| EntrezGene = 2015
| OMIM = 600493
| RefSeq = NM_001974
| UniProt = Q14246
| PDB = 
| ECnumber = 
| Chromosome = 19
| Arm = p
| Band = 13.3
| LocusSupplementaryData = 
}}
{{infobox protein
| Name = [[EMR2|egf-like module containing, mucin-like, hormone receptor-like 2]]
| caption = 
| image = 
| width = 
| HGNCid = 3337
| Symbol = EMR2
| AltSymbols = 
| IUPHAR_id = yes
| EntrezGene = 30817
| OMIM = 606100
| RefSeq = NM_152916
| UniProt = Q9UHX3
| PDB = 
| ECnumber = 
| Chromosome = 19
| Arm = p
| Band = 13.1
| LocusSupplementaryData = 
}}
{{infobox protein
| Name = [[EMR3|egf-like module containing, mucin-like, hormone receptor-like 3]]
| caption = 
| image = 
| width = 
| HGNCid = 23647
| Symbol = EMR3
| AltSymbols = 
| IUPHAR_id = yes
| EntrezGene = 84658
| OMIM = 606101
| RefSeq = NM_032571
| UniProt = Q9BY15
| PDB = 
| ECnumber = 
| Chromosome = 19
| Arm = p
| Band = 13.1
| LocusSupplementaryData = 
}}
{{infobox protein
| Name = egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
| caption = 
| image = 
| width = 
| HGNCid = 19240
| Symbol = EMR4P
| AltSymbols = GPR127
| EntrezGene = 326342
| OMIM = 
| RefSeq = XM_940358
| UniProt = Q86SQ3
| PDB = 
| ECnumber = 
| Chromosome = 19
| Arm = p
| Band = 13.3
| LocusSupplementaryData = 
}}
The '''EGF module-containing Mucin-like hormone Receptor'''s ('''EMR'''s) are closely related subgroup of [[G protein-coupled receptor]]s (GPCRs). These receptors have a unique hybrid structure in which an extracellular [[epidermal growth factor]] (EGF)-like domain is fused to a GPCR domain through a [[mucin]]-like stalk.<ref name="pmid7601460">{{cite journal | vauthors = Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M | title = EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments | journal = Genomics | volume = 26 | issue = 2 | pages = 334–44 | year = 1995 | pmid = 7601460 | doi = 10.1016/0888-7543(95)80218-B }}</ref><ref name="pmid10903844">{{cite journal | vauthors = Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ | title = Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97 | journal = Genomics | volume = 67 | issue = 2 | pages = 188–200 | year = 2000 | pmid = 10903844 | doi = 10.1006/geno.2000.6238 }}</ref><ref name="pmid11279179">{{cite journal | vauthors = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 18863–70 | year = 2001 | pmid = 11279179 | doi = 10.1074/jbc.M101147200 | doi-access =free  }}</ref><ref name="pmid16753812">{{cite journal | vauthors = Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD | title = Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE | journal = DNA Seq. | volume = 17 | issue = 1 | pages = 8–14 | year = 2006 | pmid = 16753812 | doi = 10.1080/10425170500355737 | s2cid = 11216477 }}</ref>  There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as [[CD55]].<ref name="pmid14647991">{{cite journal | vauthors = Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J | title = The EGF-TM7 family: a postgenomic view | journal = Immunogenetics | volume = 55 | issue = 10 | pages = 655–66 | year = 2004 | pmid = 14647991 | doi = 10.1007/s00251-003-0625-2 | s2cid = 28689160 }}</ref>

==References==
{{Reflist}}

==External links==
* {{MeshName|EMR1+protein,+human}}
* {{MeshName|EMR2+protein,+human}}
* {{MeshName|EMR3+protein,+human}}
* {{MeshName|EMR4+protein,+human}}

{{G protein-coupled receptors}}

[[Category:G protein-coupled receptors]]


{{transmembranereceptor-stub}}