View source for Drug-induced hyperthermia

{{Short description|Symptom}}
{{one source|date=October 2018}}
{{This article is about|hyperthermia as an undesired byproduct of a particular drug treatment|deliberately inducing fever as a means of treating infection|Pyrotherapy|the practice in oncology|Hyperthermia therapy|using heat to treat pain|Heat therapy}}
'''Drug-induced fever''' is a [[symptom]] of an [[adverse drug reaction]] wherein the administration of [[Medication|drugs]] intended to help a patient causes a hypermetabolic state resulting in [[fever]]. The drug may interfere with heat dissipation peripherally, increase the rate of [[metabolism]], evoke a cellular or humoral [[immune response]], mimic endogenous [[Pyrogen (fever)|pyrogen]], or damage tissues.

==Triggers==
* Directly caused by the drug,'' e.g.'' [[lamotrigine]], [[progesterone]], or [[chemotherapeutics]] causing [[tumor]] [[necrosis]]
* Possible side effect of stimulants and entactogens (''e.g.'' [[cocaine]], [[MDMA]], [[methamphetamine]], [[Para-methoxyamphetamine|PMA]], [[4-MTA]])
* As an adverse reaction to drugs, ''e.g.'' [[antibiotic]]s or [[Sulfonamide (medicine)|sulfa drug]]s.
* After [[drug withdrawal|drug discontinuation]], ''e.g.'' [[heroin]] or [[fentanyl]] withdrawal
* [[Neuroleptic malignant syndrome]]; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics) ''e.g.'' Haloperidol, [[Chlorpromazine]]
* [[Serotonin syndrome]]; excessive serotonergic activity due usually to combined use of serotonergic drugs (''e.g.'' [[antidepressants]], [[stimulants]], [[triptans]])
* [[5HT2A]] [[agonists]], ''e.g.'' [[psilocybin]] or [[LSD]]
* [[Malignant hyperthermia]]

==Clinical treatment==
The primary treatment strategy is to eliminate or discontinue the offensive agent. Supportive therapy, such as ice packs, may be provided to get the body temperature within physiologic range. In severe cases, when the fever is high enough (generally at or above ~104°F or 40°C), aggressive cooling such as an ice bath and pharmacologic therapy such as benzodiazepines may be deemed appropriate.<ref>Diagnosis and treatment of drug-induced hyperthermia. Musselman, ME. Saely, S. doi: 10.2146/ajhp110543
American Journal of Health-System Pharmacy January 1, 2013 vol. 70 no. 1 34-42</ref>

==References==
{{reflist}}

==External links==
* {{cite journal |author=Tabor PA |title=Drug-induced fever |journal=Drug Intell Clin Pharm |volume=20 |issue=6 |pages=413–20 |date=June 1986 |doi=10.1177/106002808602000601 |pmid=3522163 |s2cid=22448592 }}

{{General symptoms and signs}}

[[Category:Fever]]
[[Category:Drug-induced diseases]]