View source for Desoxycorticosterone acetate

{{Short description|Steroid medication}}
{{Drugbox
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 
| IUPAC_name = [2-[(8''S'',9''S'',10''R'',13''S'',14''S'',17''S'')-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[''a'']phenanthren-17-yl]-2-oxoethyl] acetate
| image = Desoxycorticosterone acetate.svg
| width = 

<!--Clinical data-->
| tradename = Percorten Acetate, Decosterone, others
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status = 
| routes_of_administration = [[Intramuscular injection]]
| class = [[Corticosteroid]]; [[Mineralocorticoid]]

<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 

<!-- Identifiers -->
| CAS_number_Ref = 
| CAS_number = 56-47-3
| CAS_supplemental = 
| ATC_prefix = 
| ATC_suffix = 
| ATC_supplemental = 
| PubChem = 5952
| IUPHAR_ligand = 
| DrugBank_Ref = 
| DrugBank = DB06780
| ChemSpiderID_Ref = 
| ChemSpiderID = 5737
| UNII = 6E0A168OB8
| KEGG = D03698
| ChEBI = 34671
| ChEMBL = 1200542
| synonyms = DOCA; 11-Deoxycorticosterone 21-acetate; 21-Acetoxypregn-4-ene-3,20-dione

<!--Chemical data-->
| C=23 | H=32 | O=4
| SMILES = CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
| StdInChI_Ref = 
| StdInChI = 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
| StdInChIKey_Ref = 
| StdInChIKey = VPGRYOFKCNULNK-ACXQXYJUSA-N
}}

'''Desoxycorticosterone acetate''' (also known as '''DOCA''' and '''11-deoxycorticosterone 21-acetate''' and sold under the brand names '''Percorten Acetate''' and '''Decosterone''', among others) is a [[mineralocorticoid]] medication and a [[mineralocorticoid ester]].<ref name="Elks2014">{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA665|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=665–}}</ref><ref name="IndexNominum2000">{{cite book|author=Swiss Pharmaceutical Society|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA306|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=306–307}}</ref> It is formulated as an [[oil solution]] and is administered once daily by [[intramuscular injection]].<ref name="pmid6113276">{{cite journal | vauthors = Chien YW | title = Long-acting parenteral drug formulations | journal = J Parenter Sci Technol | volume = 35 | issue = 3 | pages = 106–39 | date = 1981 | pmid = 6113276 | doi = | url = https://journal.pda.org/content/35/3/106.short}}</ref> The medication is the C21 [[acetate]] [[ester]] of [[11-deoxycorticosterone]].<ref name="Elks2014" /><ref name="IndexNominum2000" />

==References==
{{Reflist}}


{{Mineralocorticoids and antimineralocorticoids}}
{{Mineralocorticoid receptor modulators}}
{{Progesterone receptor modulators}}

[[Category:Acetate esters]]
[[Category:Corticosteroid esters]]
[[Category:Diketones]]
[[Category:Mineralocorticoids]]
[[Category:Pregnanes]]
[[Category:Prodrugs]]
[[Category:Progestogens]]


{{Steroid-stub}}