View source for Desmoglein

{{Short description|Family of proteins}}
{{Infobox protein family
| Symbol = DSG
| Name = Desmoglein
| image = 
| width = 
| caption = 
| Pfam = 
| Pfam_clan =  
| InterPro = IPR009123
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
| Membranome family = 243
}}

The '''desmogleins''' are a family of desmosomal [[cadherin]]s consisting of proteins [[DSG1]], [[DSG2]], [[DSG3]], and [[DSG4]]. They play a role in the formation of [[desmosome]]s that join cells to one another.<ref>{{Citation|last1=Kline|first1=Crystal F.|title=Chapter Four - Evolving Form to Fit Function: Cardiomyocyte Intercalated Disc and Transverse-Tubule Membranes|date=2013-01-01|url=http://www.sciencedirect.com/science/article/pii/B9780124170278000040|journal=Current Topics in Membranes|volume=72|pages=121–158|editor-last=Bennett|editor-first=Vann|series=Functional Organization of Vertebrate Plasma Membrane|publisher=Academic Press|language=en|doi=10.1016/b978-0-12-417027-8.00004-0|access-date=2020-10-23|last2=Mohler|first2=Peter J.|pmid=24210429|url-access=subscription}}</ref>

==Pathology==
Desmogleins are targeted in the [[autoimmune disease]] [[pemphigus]].<ref name="pmid16211092">{{cite journal |vauthors=Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D |title=Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction |journal=J. Clin. Invest. |volume=115 |issue=11 |pages=3157–65 |date=November 2005 |pmid=16211092 |pmc=1242188 |doi=10.1172/JCI23475}}</ref><ref name="pmid12705872">{{cite journal  |vauthors=Kljuic A, Bazzi H, Sundberg JP, etal |title=Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris |journal=Cell |volume=113 |issue=2 |pages=249–60 |date=April 2003 |pmid=12705872 |doi= 10.1016/S0092-8674(03)00273-3|doi-access=free }}</ref><ref name="pmid19456767">{{cite journal |vauthors=Müller R, Heber B, Hashimoto T, etal |title=Autoantibodies against desmocollins in European patients with pemphigus |journal=Clin. Exp. Dermatol. |volume=34 |issue=8 |pages=898–903 |date=May 2009 |pmid=19456767 |doi=10.1111/j.1365-2230.2009.03241.x |s2cid=774308 |url=https://zenodo.org/record/3436428 }}{{Dead link|date=January 2024 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>

Desmoglein proteins are a type of cadherin, which is a [[transmembrane protein]] that binds with other cadherins to form junctions known as desmosomes between cells. These desmoglein proteins thus hold cells together, but, when the body starts producing [[Antibody|antibodies]] against desmoglein, these junctions break down, and this results in subsequent [[blister]] or [[Vesicle (biology and chemistry)|vesicle formation]].<ref>A Clinician's Guide to Pemphigus Vulgarishttp://www.springer.com/gp/book/9783319677583</ref><ref>Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier
Saunders; 2012</ref>

==References==
{{Reflist}}

==External links==
* {{BUHistology|20502loa}}
* {{MeshName|Desmogleins}}

{{Cell adhesion molecules}}
{{Epithelial tissue}}
{{Authority control}}

[[Category:Cadherins]]
[[Category:Single-pass transmembrane proteins]]
[[Category:Protein families]]


{{Membrane-protein-stub}}