View source for Cingulate cortex

{{Short description|Part of the limbic lobe of the brain cortex}}
{{Infobox brain
| Name            = Cingulate cortex
| Latin           = cortex cingularis, gyrus cinguli
| Image           = Gray727 cingulate sulcus.svg
| Caption         = Medial surface of left cerebral hemisphere, with cingulate gyrus, and cingulate sulcus shown in red.
| IsPartOf        = [[Cerebral cortex]]
| Components      =
| Artery          = [[Anterior cerebral artery|Anterior cerebral]]
| Vein            = [[Superior sagittal sinus]]
| Acronym         = Cg
}}
[[File:MRI cingulate cortex.png|thumb|alt=Sagittal MRI slice with highlighting indicating location of the cingulate cortex.|Sagittal MRI slice with highlighting indicating location of the cingulate cortex.]]
[[File:Gray743 cingulate gyrus.png|thumb|250px|[[Coronal section]] of brain. Cingulate cortex is shown in yellow.]]
The '''cingulate cortex''' is a part of the [[brain]] situated in the medial aspect of the [[cerebral cortex]]. The cingulate cortex includes the entire '''cingulate gyrus'''<!--term redirects here-->, which lies immediately above the [[corpus callosum]], and the continuation of this in the cingulate sulcus. The cingulate cortex is usually considered part of the [[limbic lobe]].

It receives inputs from the [[thalamus]] and the [[neocortex]], and projects to the [[entorhinal cortex]] via the [[cingulum (anatomy)|cingulum]]. It is an integral part of the [[limbic system]], which is involved with emotion formation and processing,<ref>{{cite journal|last=Hadland|first=K. A.|author2=Rushworth M.F.|title=The effect of cingulate lesions on social behaviour and emotion|journal=Neuropsychologia|year=2003|volume=41|issue=8|pages=919–931|doi=10.1016/s0028-3932(02)00325-1|pmid=12667528|s2cid=16475051|display-authors=etal}}</ref> learning,<ref>{{cite journal|title=Cingulate binds learning|journal=Trends Cogn Sci|year=1997|volume=1|issue=1|page=2|doi=10.1016/s1364-6613(97)85002-4|pmid=21223838|s2cid=33697898}}</ref> and memory.<ref>{{cite journal|last=Kozlovskiy|first=S. |author2=Vartanov A. |author3=Pyasik M. |author4=Nikonova E. |author5=Velichkovsky B. |title=Anatomical Characteristics of Cingulate Cortex and Neuropsychological Memory Tests Performance|journal=Procedia - Social and Behavioral Sciences|date=10 October 2013|volume=86|pages=128–133|doi=10.1016/j.sbspro.2013.08.537|doi-access=free}}<!--|access-date=24 December 2013--></ref><ref>{{cite journal|last=Kozlovskiy|first=S.A.|author2=Vartanov A.V.|author3=Nikonova E.Y.|author4=Pyasik M.M.|author5=Velichkovsky B.M.|title=The Cingulate Cortex and Human Memory Processes|journal=Psychology in Russia: State of the Art|year=2012|volume=5|pages=231–243|doi=10.11621/pir.2012.0014|doi-access=free}}<!--|access-date=24 December 2013--></ref> The combination of these three functions makes the cingulate gyrus highly influential in linking motivational outcomes to behavior (e.g. a certain action induced a positive emotional response, which results in learning).<ref>{{Cite journal | last1 = Hayden | first1 = B. Y. | last2 = Platt | first2 = M. L. | doi = 10.1523/JNEUROSCI.4874-09.2010 | title = Neurons in Anterior Cingulate Cortex Multiplex Information about Reward and Action | journal = Journal of Neuroscience | volume = 30 | issue = 9 | pages = 3339–3346 | year = 2010 | pmid =  20203193| pmc =2847481 }}</ref> This role makes the cingulate cortex highly important in disorders such as [[Major depressive disorder|depression]]<ref name="Drevets 2008">{{Cite journal | last1 = Drevets | first1 = W. C. | last2 = Savitz | first2 = J. | last3 = Trimble | first3 = M. | title = The subgenual anterior cingulate cortex in mood disorders | journal = CNS Spectrums | volume = 13 | issue = 8 | pages = 663–681 | year = 2008 | pmid = 18704022 | pmc = 2729429 | doi=10.1017/s1092852900013754}}</ref><ref name=":0" /> and [[schizophrenia]].<ref name="Adams 2007">{{Cite journal | doi = 10.2147/nedt.2007.3.1.87 | last1 = Adams | first1 = R. | last2 = David | first2 = A. S. | title = Patterns of anterior cingulate activation in schizophrenia: A selective review | journal = Neuropsychiatric Disease and Treatment | volume = 3 | issue = 1 | pages = 87–101 | year = 2007 | pmid = 19300540 | pmc = 2654525 | doi-access = free }}</ref> It also plays a role in [[executive function]] and respiratory control.

[[File:Gray727-Brodman.png|thumb|right|Brodmann areas of a medial section of the right hemisphere.]]

==Structure==
Based on [[Cytoarchitectonics of the cerebral cortex|cerebral cytoarchitectonics]] it has been divided into the [[Brodmann area]]s [[Brodmann area 23|23]], [[Brodmann area 24|24]], [[Brodmann area 26|26]], [[Brodmann area 29|29]], [[Brodmann area 30|30]], [[Brodmann area 31|31]], [[Brodmann area 32|32]] and [[Brodmann area 33|33]]. The areas [[Brodmann area 26|26]], [[Brodmann area 29|29]] and [[Brodmann area 30|30]] are usually referred to as the retrosplenial areas.

[[File:Spindle neurons - very high mag.jpg|thumb|right|[[Micrograph]] showing [[spindle neuron]]s of the cingulate cortex. [[H&E stain|HE]]-[[LFB stain]].]]

===Anterior cingulate cortex===
{{main|Anterior cingulate cortex}}
This corresponds to areas 24, 32 and 33 of Brodmann and LA of [[Constantin von Economo]] and Bailey and von Bonin. 
It is continued anteriorly by the '''subgenual area''' ([[Brodmann area 25]]), located below the [[genu of the corpus callosum]]).
It is cytoarchitectonically [[agranular cortex|agranular]]. It has a [[gyrus|gyral]] and a [[Sulcus (neuroanatomy)|sulcal]] part. 
[[Anterior cingulate cortex]] can further be divided in the perigenual anterior cingulate cortex (near the genu) and midcingulate cortex. The anterior cingulate cortex receives primarily its afferent axons from the [[Intralaminar nuclei of thalamus|intralaminar]] and [[Midline nuclear group|midline]] thalamic nuclei (see [[thalamus]]). 
The nucleus anterior receives mamillo-thalamic afferences. The mamillary neurons receive axons from the [[subiculum]]. 
The whole forms a [[neural circuit]] in the limbic system known as the [[Papez circuit]].<ref>{{cite book|last=Dorland's|title=Illustrated medical dictionary|date=2 May 2011 |publisher=Elsevier Saunders|isbn=978-14160-6257-8|pages=363}}</ref>
The anterior cingulate cortex sends axons to the anterior nucleus and through the [[cingulum (anatomy)|cingulum]] to other Broca's limbic areas. The ACC is involved in error and conflict detection processes.

===Posterior cingulate cortex===
{{main|Posterior cingulate cortex}}
This corresponds to areas 23 and 31 of Brodmann LP of von Economo and Bailey and von Bonin. Its cellular structure is granular. It is followed posteriorly by the retrosplenial cortex (area 29).{{citation needed|date=January 2011}}
Dorsally is the granular area 31. The posterior cingulate cortex receives a great part of its afferent axons from the superficial nucleus (or nucleus superior- falsely LD-{{Citation needed|date=October 2011}}) of the thalamus (see [[thalamus]]), which itself receives axons from the subiculum. To some extent it thus duplicates Papez' circuit. It receives also direct afferents from the subiculum of the hippocampus. Posterior cingulate cortex hypometabolism (with 18F-FDG PET) has been defined in Alzheimer's disease.

===Inputs of the anterior cingulate gyrus===
A retrograde tracing experiment on macaque monkeys revealed that the [[ventral anterior nucleus]] (VA) and the [[ventral lateral nucleus]] (VL) of the thalamus are connected with motor areas of the cingulate sulcus.<ref name="McFarland 2000">{{cite journal | last1 = McFarland | first1 = N. R. | last2 = Haber | first2 = S. N. | year = 2000 | title = Convergent Inputs from Thalamic Motor Nuclei and Frontal Cortical Areas to the Dorsal Striatum in the Primate | journal = The Journal of Neuroscience | volume = 20 | issue = 10| pages = 3798–3813 | doi = 10.1523/JNEUROSCI.20-10-03798.2000 | pmid = 10804220 | pmc = 6772665 | doi-access = free }}</ref> The retrosplenial region (Brodmann's area 26, 29 and 30) of cingulate gyrus can be divided into three parts: ''i.e.'', retrosplenial granular cortex A, retrosplenial granular cortex B and retrosplenial dysgranular cortex.  The hippocampal formation sends dense projections to retrosplenial granular cortex A and B and fewer projections to the retrosplenial dysgranular cortex. The postsubiculum sends projections to retrosplenial granular cortex A and B and to the retrosplenial dysgranular cortex. The dorsal subiculum sends projections to retrosplenial granular cortex B, while ventral subiculum sends projections to retrosplenial granular cortex A. Entorhinal cortex – caudal parts – sends projections to the retrosplenial dysgranular cortex.<ref name="Wyss 1999">{{Cite journal | last1 = Wyass | first1 = J. M. | last2 = Van Groen | first2 = T. | doi = 10.1002/hipo.450020102 | title = Connections between the retrosplenial cortex and the hippocampal formation in the rat: A review | journal = Hippocampus | volume = 2 | issue = 1 | pages = 1–11 | year = 1992 | pmid =  1308170| s2cid = 14385024 }}</ref>

===Outputs of the anterior cingulate gyrus===
The rostral cingulate gyrus (Brodmanns's area 32) projects to the rostral superior temporal gyrus, midorbitofrontal cortex and lateral prefrontal cortex.<ref name="Pandya 1981">{{Cite journal | last1 = Pandya | first1 = D. N. | last2 = Hoesen | first2 = G. W. | last3 = Mesulam | first3 = M. -M. | title = Efferent connections of the cingulate gyrus in the rhesus monkey | doi = 10.1007/BF00237497 | journal = Experimental Brain Research | volume = 42–42 | issue = 3–4 | year = 1981 | pmid =  6165607| pages=319–330| s2cid = 12274921 }}</ref>
The ventral anterior cingulate (Brodmann's area 24) sends projections to the anterior insular cortex, premotor cortex (Brodmann's area 6), Brodmann's area 8, the perirhinal area, the orbitofrontal cortex (Brodmann's area 12), the laterobasal nucleus of amygdala, and the rostral part of the inferior parietal lobule.<ref name="Pandya 1981"/> Injecting [[wheat germ agglutinin]] and [[horseradish peroxidase]] conjugate into the anterior cingulate gyrus of cats, revealed that the anterior cingulate gyrus has reciprocal connections with the rostral part of the thalamic posterior lateral nucleus and rostral end of the [[pulvinar nuclei|pulvinar]].<ref name="Fujii 1983">{{Cite journal | last1 = Fujii | first1 = M. | title = Fiber connections between the thalamic posterior lateral nucleus and the cingulate gyrus in the cat | doi = 10.1016/0304-3940(83)90066-6 | journal = Neuroscience Letters | volume = 39 | issue = 2 | pages = 137–142 | year = 1983 | pmid =  6688863| s2cid = 34795697 }}</ref>
The postsubiculum receives projections from the retrosplenial dysgranular cortex and the retrosplenial granular cortex A and B. The parasubiculum receives projections from the retrosplenial dysgranular cortex and retrosplenial granular cortex A. Caudal and lateral parts of the entorhinal cortex get projections from the retrosplenial dysgranular cortex, while the caudal medial entorhinal cortex receives projections from the retrosplenial granular cortex A. The retrosplenial dysgranular cortex sends projections to the perirhinal cortex. The retrosplenial granular cortex A sends projection to the rostral presubiculum.<ref name="Wyss 1999"/>

===Outputs of the posterior cingulate gyrus===
The posterior cingulate cortex (Brodmann's area 23) sends projections to dorsolateral prefrontal cortex (Brodmann's area 9), anterior prefrontal cortex (Brodmann's area 10), orbitofrontal cortex (Brodmanns’ area 11), the parahippocampal gyrus, posterior part of the inferior parietal lobule, the presubiculum, the superior temporal sulcus and the retrosplenial region.<ref name="Pandya 1981"/>
The retrosplenial cortex and caudal part of the cingulate cortex are connected with rostral prefrontal cortex via cingulate fascicule in macaque monkeys<ref name="Petrides 2007">{{cite journal|last=Petrides|first=M|author2=Pandya, DN|title=Efferent association pathways from the rostral prefrontal cortex in the macaque monkey.|journal=The Journal of Neuroscience|date=Oct 24, 2007|volume=27|issue=43|pages=11573–86|pmid=17959800|pmc=6673207|doi=10.1523/JNEUROSCI.2419-07.2007}}<!--|access-date=18 April 2013--></ref> Ventral posterior cingulate cortex was found to be reciprocally connected with the caudal part of the posterior parietal lobe in rhesus monkeys.<ref name="Cavada 1989">{{Cite journal | last1 = Cavada | first1 = C. | last2 = Goldman-Rakic | first2 = P. S. | doi = 10.1002/cne.902870402 | title = Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections | journal = The Journal of Comparative Neurology | volume = 287 | issue = 4 | pages = 393–421 | year = 1989 | pmid =  2477405| s2cid = 5873407 }}</ref> Also the medial posterior parietal cortex is connected with posterior ventral bank of the cingulate sulcus.<ref name="Cavada 1989"/>

===Other connections===
The anterior cingulate is connected to the posterior cingulate at least in rabbits. Posterior cingulate gyrus is connected with retrosplenial cortex and this connection is part of the dorsal splenium of the corpus callosum. The anterior and posterior cingulate gyrus and retrosplenial cortex send projections to subiculum and presubiculum.<ref name="Adey 1951">{{Cite journal | last1 = Adey | first1 = W. R. | title = An Experimental Study of the Hippocampal Connexions of the Cingulate Cortex in the Rabbit | doi = 10.1093/brain/74.2.233 | journal = Brain | volume = 74 | issue = 2 | pages = 233–247 | year = 1951 | pmid =  14858747| doi-access = free }}</ref>

==Clinical significance ==

=== Schizophrenia ===
{{Summarize section|date=November 2024}}
Using a three-dimensional magnetic resonance imaging procedure to measure the volume of the rostral anterior cingulate gyrus (perigenual cingulate gyrus), Takahashi et al. (2003) found that the rostral anterior cingulate gyrus is larger in control (healthy) females than males, but this sex difference was not found in people with schizophrenia. People with schizophrenia also had a smaller volume of perigenual cingulate gyrus than control subjects.<ref name="Takahashi 2003">{{Cite journal | last1 = Takahashi | first1 = T. | last2 = Suzuki | first2 = M. | last3 = Kawasaki | first3 = Y. | last4 = Hagino | first4 = H. | last5 = Yamashita | first5 = I. | last6 = Nohara | first6 = S. | last7 = Nakamura | first7 = K. | last8 = Seto | first8 = H. | last9 = Kurachi | first9 = M. | doi = 10.1016/S0006-3223(02)01483-X | title = Perigenual cingulate gyrus volume in patients with schizophrenia: A magnetic resonance imaging study | journal = Biological Psychiatry | volume = 53 | issue = 7 | pages = 593–600 | year = 2003 | pmid =  12679237| s2cid = 11482948 }}</ref>

Haznedar et al. (2004) studied metabolic rate of glucose in anterior and posterior cingulate gyrus in people with schizophrenia, [[schizotypal personality disorder]] (SPD) and compared them with a control group. The metabolic rate of glucose was found to be lower in the left anterior cingulate gyrus and the right posterior cingulate gyrus in people with schizophrenia relative to controls. Although people with SPD were expected to show a glucose metabolic rate somewhere between the individual with schizophrenia and controls, they actually had higher metabolic glucose rate in the left posterior cingulate gyrus. The volume of the left anterior cingulate gyrus was reduced in people with schizophrenia as compared with controls, but there was not any difference between people with SPD and people with schizophrenia. From these results it appears that the schizophrenia and SPD are two different disorders.<ref name="Haznedar 2004">{{Cite journal | last1 = Haznedar | first1 = M. M. | last2 = Buchsbaum | first2 = M. S. | last3 = Hazlett | first3 = E. A. | last4 = Shihabuddin | first4 = L. | last5 = New | first5 = A. | last6 = Siever | first6 = L. J. | doi = 10.1016/j.schres.2004.02.025 | title = Cingulate gyrus volume and metabolism in the schizophrenia spectrum | journal = Schizophrenia Research | volume = 71 | issue = 2–3 | pages = 249–262 | year = 2004 | pmid =  15474896| s2cid = 28889346 }}</ref>

A study of the volume of the gray and white matter in the anterior cingulate gyrus in people with schizophrenia and their healthy first and second degree relatives revealed no significant difference in the volume of the white matter in the people with schizophrenia and their healthy relatives. Nonetheless a significant difference in the volume of gray matter was detected, people with schizophrenia had smaller volume of gray matter than their second degree relatives, but not relative to their first degree relatives. Both the person with schizophrenia and their first degree healthy relatives have smaller gray matter volume than the second degree healthy relatives. It appears that genes are responsible for the decreased volume of gray matter in people with schizophrenia.<ref name="Costain 2010">{{Cite journal | last1 = Costain | first1 = G. | last2 = Ho | first2 = A. | last3 = Crawley | first3 = A. P. | last4 = Mikulis | first4 = D. J. | last5 = Brzustowicz | first5 = L. M. | last6 = Chow | first6 = E. W. C. | last7 = Bassett | first7 = A. S. | doi = 10.1016/j.schres.2010.06.014 | title = Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: A preliminary report | journal = Schizophrenia Research | volume = 122 | issue = 1–3 | pages = 81–84 | year = 2010 | pmid =  20638248| pmc =3129334 }}</ref>
 
Fujiwara et al. (2007) did an experiment in which they correlated the size of anterior cingulate gyrus in people with schizophrenia with their functioning on social cognition, psychopathology and emotions with control group. The smaller the size of anterior cingulate gyrus, the lower was the level of social functioning and the higher was the psychopathology in the people with schizophrenia. The anterior cingulate gyrus was found to be bilaterally smaller in people with schizophrenia as compared with control group. No difference in IQ tests and basic visuoperceptual ability with facial stimuli was found between people with schizophrenia and the control.<ref name="Fujiwara 2007">{{Cite journal | last1 = Fujiwara | first1 = H. | last2 = Hirao | first2 = K. | last3 = Namiki | first3 = C. | last4 = Yamada | first4 = M. | last5 = Shimizu | first5 = M. | last6 = Fukuyama | first6 = H. | last7 = Hayashi | first7 = T. | last8 = Murai | first8 = T. | doi = 10.1016/j.neuroimage.2007.03.068 | title = Anterior cingulate pathology and social cognition in schizophrenia: A study of gray matter, white matter and sulcal morphometry | journal = NeuroImage | volume = 36 | issue = 4 | pages = 1236–1245 | year = 2007 | pmid =  17524666| url = https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/124279/3/yigak03320.pdf | hdl = 2433/124279 | s2cid = 25750603 | hdl-access = free }}</ref>

==== Summary ====
People with schizophrenia have differences in the anterior cingulate gyrus when compared with controls. The anterior cingulate gyrus was found to be smaller in people with schizophrenia.<ref name="Fujiwara 2007"/> The volume of the gray matter in the anterior cingulate gyrus was found to be lower in people with schizophrenia.<ref name="Haznedar 2004"/><ref name="Costain 2010"/> Healthy females have larger rostral anterior cingulate gyrus than males, this sex difference in size is absent in people with schizophrenia.<ref name="Takahashi 2003"/> The metabolic rate of glucose was lower in the left anterior cingulate gyrus and in the right posterior cingulate gyrus.<ref name="Haznedar 2004"/>

In addition to changes in the cingulate cortex more brain structures show changes in people with schizophrenia as compared to controls. The hippocampus in people with schizophrenia was found to be smaller in size when compared with controls of the same age group,<ref name="Koolschijn 2010">{{Cite journal | last1 = Koolschijn | first1 = P. C. D. M. P. | last2 = Van Haren | first2 = N. E. M. | last3 = Cahn | first3 = W. | last4 = Schnack | first4 = H. G. | last5 = Janssen | first5 = J. | last6 = Klumpers | first6 = F. | last7 = Hulshoff Pol | first7 = H. E. | last8 = Kahn | first8 = R. S. | doi = 10.4088/JCP.08m04574yel | title = Hippocampal Volume Change in Schizophrenia | journal = The Journal of Clinical Psychiatry | volume = 71 | issue = 6 | pages = 737–744 | year = 2010 | pmid =  20492835}}</ref> and, similarly, the caudate and putamen were found to be smaller in volume in a longitudinal study of people with schizophrenia.<ref name="Mitelman 2009">{{Cite journal | last1 = Mitelman | first1 = S. A. | last2 = Canfield | first2 = E. L. | last3 = Chu | first3 = K. W. | last4 = Brickman | first4 = A. M. | last5 = Shihabuddin | first5 = L. | last6 = Hazlett | first6 = E. A. | last7 = Buchsbaum | first7 = M. S. | doi = 10.1016/j.schres.2009.06.022 | title = Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen | journal = Schizophrenia Research | volume = 113 | issue = 2–3 | pages = 241–245 | year = 2009 | pmid =  19616411| pmc =2763420 }}</ref> While the volume of gray matter is smaller, the size of the lateral and third ventricles is larger in people with schizophrenia.<ref name="Kempton 2010">{{Cite journal | last1 = Kempton | first1 = M. J. | last2 = Stahl | first2 = D. | last3 = Williams | first3 = S. C. R. | last4 = Delisi | first4 = L. E. | title = Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies | doi = 10.1016/j.schres.2010.03.036 | journal = Schizophrenia Research | volume = 120 | issue = 1–3 | pages = 54–62 | year = 2010 | pmid =  20537866| s2cid = 25389387 | url = https://kclpure.kcl.ac.uk/ws/files/9033332/Meta_analysis_longitudinal_MKempton_112_schizophrenia_research_with_figures_preprint.pdf }}</ref>

=== Depression ===
The cingulate gyrus is heavily implicated in [[Major depressive disorder|depressive disorders]]. The subgenual region, which lies below the genu of the [[corpus callosum]], is especially important.<ref name=":0" /> This site is the target of [[Deep brain stimulation|deep-brain stimulation therapy]] for depression, an invasive therapy used when all other treatment methods have failed.<ref name=":0">{{Cite book |last=Martin |first=John H. |title=Neuroanatomy: text and atlas |date=2021 |publisher=McGraw Hill |isbn=978-1-259-64249-4 |edition=5th |location=New York |chapter=Chapter 16: The Limbic System and Cerebral Circuits for Reward, Emotions, and Memory}}</ref>

Isolated [[stroke]] of the cingulate gyrus has also been found to induce depression, potentially implicating this region in [[post-stroke depression]] which may occur following stroke of a larger part of the brain.<ref>{{Cite journal |last1=Ribeiro |first1=Nuno Filipe |last2=Madruga |first2=Luís |date=May 2021 |title=A sudden and severe depressive episode after a left cingulate gyrus stroke: a case report of post-stroke depression and review of literature |url=https://pubmed.ncbi.nlm.nih.gov/33825944 |journal=Journal of Neural Transmission (Vienna, Austria: 1996) |volume=128 |issue=5 |pages=711–716 |doi=10.1007/s00702-021-02334-y |issn=1435-1463 |pmid=33825944}}</ref>

=== Age-related cognitive impairment ===
The cingulate cortex plays a key role in cognitive aging, particularly in the cingulo-opercular.<ref name="10.1038/s41598-024-83696-7">{{cite journal | vauthors = Saberi M, Rieck JR, Golafshan S, Grady CL, Misic B, Dunkley BT, Khatibi A | title = The brain selectively allocates energy to functional brain networks under cognitive control | journal = Scientific Reports | date = 2024 | volume = 14 | issue = 1 | pages = 32032 | doi = 10.1038/s41598-024-83696-7 | pmid = 39738735 | url = https://doi.org/10.1038/s41598-024-83696-7 | pmc = 11686059 | bibcode = 2024NatSR..1432032S }}</ref> Greater connectivity in the cingulo-opercular network is linked to better episodic memory, attention, and executive function, but declines with age, impacting cognitive performance.<ref name="10.3389/fnagi.2020.00177">{{Cite journal |last1=Hausman |first1=H. K. |title=The role of resting-state network functional connectivity in cognitive aging |journal=Frontiers in Aging Neuroscience |volume=12 |pages=177 |year=2020 |doi=10.3389/fnagi.2020.00177 |doi-access=free |pmid=32754160|pmc=7365865 }}</ref><ref name="10.1093/cercor/bhu012">{{Cite journal |last1=Geerligs |first1=L. |last2=Renken |first2=R. J. |last3=Saliasi |first3=E. |last4=Maurits |first4=N. M. |last5=Lorist |first5=M. M. |title=A brain-wide study of age-related changes in functional connectivity |journal=Cerebral Cortex |volume=25 |issue=7 |pages=1987–1999 |year=2014 |doi=10.1093/cercor/bhu012 |pmid=24408955}}</ref> Reduced connectivity in the anterior cingulate cortex within the [[salience network]] correlates with cognitive decline.<ref name="10.1162/jocn_a_00269">{{Cite journal |last1=Onoda |first1=K. |last2=Ishihara |first2=M. |last3=Yamaguchi |first3=S. |title=Decreased functional connectivity by aging is associated with cognitive decline |journal=Journal of Cognitive Neuroscience |volume=24 |issue=11 |pages=2186–2198 |year=2012 |doi=10.1162/jocn_a_00269 |pmid=22784203}}</ref> Age-related decreases in cingulo-opercular connectivity, especially in the left insula, mediate declines in visual processing speed.<ref name="doi.org/10.1016/j.neurobiolaging.2018.09.014">{{Cite journal |last1=Ruiz-Rizzo |first1=A. L. |title=Decreased cingulo-opercular network functional connectivity mediates the impact of aging on visual processing speed |journal=Neurobiology of Aging |volume=73 |pages=50–60 |year=2019 |doi=10.1016/j.neurobiolaging.2018.09.014 |pmid=30366314|url=https://eprints.bbk.ac.uk/id/eprint/27066/1/Decreased%20cingulo-opercular%20network%20functional%20connectivity-Accepted_manuscript.pdf }}</ref> Its predictive value in aging models highlights its potential as a biomarker for cognitive decline.<ref name="10.1038/s41598-024-83696-7">{{cite journal | vauthors = Saberi M, Rieck JR, Golafshan S, Grady CL, Misic B, Dunkley BT, Khatibi A | title = The brain selectively allocates energy to functional brain networks under cognitive control | journal = Scientific Reports | date = 2024 | volume = 14 | issue = 1 | pages = 32032 | doi = 10.1038/s41598-024-83696-7 | pmid = 39738735 | url = https://doi.org/10.1038/s41598-024-83696-7 | pmc = 11686059 | bibcode = 2024NatSR..1432032S }}</ref>

==History==
''[[Cingulum (anatomy)|Cingulum]]'' means "belt" in Latin.<ref>{{cite OED|cingulate}}</ref> The name was likely chosen because this cortex, in great part, surrounds the [[corpus callosum]]. 
The cingulate cortex is a part of the ''"grand lobe limbique"'' of [[Paul Broca|Broca (1878)]] that consisted of a superior cingulate part (supracallosal) and an inferior hippocampic part (infracallosal).<ref>Broca, P (1878). "Anatomie comparee des circonvolutions cerebrales: Le grand lobe limbique et la scissure limbique dans la serie des mammifères". ''Revue d'Anthropologie''. '''1''': 385–498</ref> The [[limbic lobe]] was separated from the remainder of the cortex by Broca for two reasons: first because it is not convoluted, and second because the gyri are directed parasagittally (contrary to the transverse [[gyrification]]). Since the parasagittal gyrification is observed in non-primate species, the limbic lobe was thus declared to be "bestial". As with other parts of the cortex, there have been and continue to be discrepancies concerning boundaries and naming. [[Korbinian Brodmann|Brodmann (1909)]] further distinguished Areas 24 (anterior cingulate) and 23 (posterior) based on granularity. More recently, it was included as a part of the [[limbic lobe]] in the Terminologia Anatomica (1998)<ref>{{Terminologia Anatomica|A14.1.09.230}}</ref> following von Economo's (1925) system.<ref>''Economo, C., Koskinas, G.N. (1925).'' Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Wien: Springer Verlag.</ref>

==Additional images==
<gallery>

File:Slide2ZEN.JPG|Medial surface of cerebral hemisphere. Medial view. Deep dissection.
File:Slide3ZEN.JPG|Medial surface of cerebral hemisphere. Medial view. Deep dissection.
File:Slide4ZE.JPG|Medial surface of cerebral hemisphere. Medial view. Deep dissection.
File:Cingulate cortex.gif|3D view of the cingulate gyrus (green) and paracingulate gyrus (yellow) in an average human brain
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== References ==
{{Reflist|30em}}

==External links==
{{Commons category|Cingulate_cortex}}
*[https://web.archive.org/web/20170923110052/http://www.thehumanbrain.org/Vogt.htm Four Regions of Cingulate Cortex and Disease Vulnerability], Brent A. Vogt.
* {{BrainMaps|Cingulate}}
*[http://www.eurekalert.org/pub_releases/2006-05/bcom-ma051506.php Mapping 'self' and 'other' in the brain]
*[http://www.glittra.com/yvonne/neuropics/cingulateparts.jpg A nice picture of the cingulate cortex and its parts] {{Webarchive|url=https://web.archive.org/web/20110711100427/http://www.glittra.com/yvonne/neuropics/cingulateparts.jpg |date=2011-07-11 }}
{{Prosencephalon}}
{{Obsessive–compulsive disorder}}
{{Authority control}}

[[Category:Cerebral cortex]]
[[Category:Gyri]]