View source for Calamine

{{Short description|Cream or lotion for treating skin conditions}}
{{distinguish|Chamomile}}
{{about|the medication}}
{{Infobox drug
| drug_name         =
| type              = combo
| image = Calamine lotion.png
| width             =
| alt  = A puddle of a thin pink lotion, next to a pink plastic bottle
| caption = A puddle of calamine lotion next to a pink plastic bottle

<!-- Combo data -->
| component1        = zinc oxide
| class1            = [[astringent]]
| component2        = ferric oxide
| class2            = [[antipruritic]]

<!-- Clinical data -->
| pronounce         = {{respell|KAL|ə|mine}}<ref name=MTM2016/>
| tradename         =
| Drugs.com         =
| MedlinePlus       =
| licence_EU =
| DailyMedID        = Calamine
| licence_US =
| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU_comment =
| pregnancy_category=
| routes_of_administration = [[Topical administration|Topical]]
| ATCvet            =
| ATC_prefix        = D02
| ATC_suffix        = AB
| ATC_supplemental  =

<!-- Legal status -->
| legal_AU          = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment  =
| legal_BR          = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment  =
| legal_CA          = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment  =
| legal_DE          = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment  =
| legal_NZ          = <!-- Class A, B, C -->
| legal_NZ_comment  =
| legal_UK          = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment  =
| legal_US = OTC
| legal_US_comment  =
| legal_EU          =
| legal_EU_comment  =
| legal_UN          = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment  =
| legal_status      = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number        = 8011-96-9
| CAS_supplemental  =
| PubChem           = 23083748
| IUPHAR_ligand     =
| DrugBank          =
| ChemSpiderID = 16112062
| UNII              =
| KEGG              = D03284
| ChEBI             =
| ChEMBL = 3989426
| synonyms          = Calamine lotion

<!-- Chemical and physical data -->
| StdInChI=1S/2Fe.4O.Zn/q2*+3;4*-2;+2
| StdInChIKey = CPYIZQLXMGRKSW-UHFFFAOYSA-N
| SMILES = [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2]
}}

{{wikt | calamine}}
<!-- Definition and medical uses -->
'''Calamine''', also known as '''calamine lotion''', is a medication made from powdered [[calamine (mineral)|calamine mineral]] that is used to treat mild [[itchiness]].<ref name=BNF69/><ref name=WHO2008>{{cite book | title = WHO Model Formulary 2008 | year = 2009 | isbn = 9789241547659 | vauthors = ((World Health Organization)) | veditors = Stuart MC, Kouimtzi M, Hill SR | hdl = 10665/44053 | author-link = World Health Organization | publisher = World Health Organization | page = 303 }}</ref> Conditions treated include [[sunburn]], insect bites, [[Toxicodendron radicans|poison ivy]], [[poison oak]], and other mild skin conditions.<ref name=UK2016a>{{cite web|title= Aqueous Calamine Cream BP - Summary of Product Characteristics (SPC) - (eMC)|url= https://www.medicines.org.uk/emc/medicine/25283|website= www.medicines.org.uk|access-date= 29 December 2016|date= 18 November 2016|url-status= live|archive-url= https://web.archive.org/web/20161230000012/https://www.medicines.org.uk/emc/medicine/25283|archive-date=30 December 2016}}</ref><ref name=Ric2015/> It may also help dry out secretions resulting from skin irritation.<ref name=MTM2016>{{cite web|title= Calamine (topical) medical facts from Drugs.com|url= https://www.drugs.com/mtm/calamine-topical.html|website= www.drugs.com|url-status= live|archive-url= https://web.archive.org/web/20171107030453/https://www.drugs.com/mtm/calamine-topical.html|archive-date= 2017-11-07}}</ref> It is applied on the skin as a [[cream (pharmaceutical)|cream]] or [[lotion]].<ref name=BNF69>{{cite book|title= British National Formulary: BNF 69 |date= 2015|publisher= British Medical Association|isbn= 9780857111562|page= 801|edition= 69}}</ref>

<!-- Side effects and mechanism -->
Side effects may include skin irritation.<ref name=UK2016a/> It is considered to be safe in [[pregnancy]].<ref name=UK2016a/> Calamine is a combination of [[zinc oxide]] and 0.5%  [[iron(III) oxide|ferric oxide]] (Fe<sub>2</sub>O<sub>3</sub>).<ref name=Br2012/> The lotion is produced with additional ingredients such as [[phenol]] and [[calcium hydroxide]].<ref name=Br2012>{{cite book| vauthors = Braun-Falco O, Plewig G, Wolff HH, Burgdorf W | chapter = Topical Therapy |title= Dermatology|date= 2012|publisher= Springer Science & Business Media|isbn= 9783642979316|page= 1724|edition=2nd | chapter-url= https://books.google.com/books?id=kK_rCAAAQBAJ&pg=PA1724|language= en|url-status= live|archive-url= https://web.archive.org/web/20161229170841/https://books.google.ca/books?id=kK_rCAAAQBAJ&pg=PA1724|archive-date= 2016-12-29}}</ref><ref>{{cite book| vauthors = Ma JK, Hadzija B | chapter = Rheology in Pharmacy |title= Basic Physical Pharmacy|date= 2012|publisher= Jones & Bartlett Publishers|isbn= 9780763757342|page= 327| chapter-url = https://books.google.com/books?id=NLabiVZSE7QC&pg=PA327|language= en|url-status= live|archive-url= https://web.archive.org/web/20161230000202/https://books.google.ca/books?id=NLabiVZSE7QC&pg=PA327|archive-date= 2016-12-30}}</ref>

<!-- History and culture -->
The use of calamine lotion dates back as far as 1500 BC.<ref>{{cite book| vauthors = Darnton-Hill I, Ahmed F, Samman S | chapter = The impact of micronutrients on inflammation and health in low-and middle-income countries. | veditors = Bendich A, Deckelbaum RJ |title= Preventive Nutrition: The Comprehensive Guide for Health Professionals|date= 2016|publisher= Springer|isbn= 9783319224312|pages = 597-644 (608) |edition= 5th |chapter-url= https://books.google.com/books?id=l7xPCwAAQBAJ&pg=PA608|language= en|url-status= live|archive-url= https://web.archive.org/web/20161230000055/https://books.google.ca/books?id=l7xPCwAAQBAJ&pg=PA608|archive-date= 2016-12-30}}</ref> It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 21st list 2019 | year = 2019 | hdl = 10665/325771 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access=free }}</ref> Calamine is available [[over-the-counter]] as a [[generic medication]].<ref name=Ric2015>{{cite book | vauthors = Hamilton R | title = Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition | date = 2015 | publisher = Jones & Bartlett Learning | isbn = 9781284057560 | page = 191 }}</ref>

== Medical uses ==
Calamine is used to treat [[itchiness]].<ref name=BNF69/> This includes [[sunburn]], insect bite, or other mild skin conditions.<ref name=UK2016a/><ref name=Ric2015/>

===Effectiveness===
The [[Food and Drug Administration|FDA]] recommends applying some topical over-the-counter skin products, such as calamine, to absorb the weeping of the skin caused by poisonous plants such as [[poison ivy]], [[poison oak]], and [[Toxicodendron vernix|poison sumac]]. For relieving the pain or itching caused by these plants, the FDA document recommends a cold water compress and topical [[corticosteroid]]s.<ref>{{Cite web |title=Outsmarting Poison Ivy and Other Poisonous Plants |author= |work=U.S. Food and Drug Administration: Consumer Updates |date=9 June 2021 |orig-date=Originally posted c. June 2009, since updated but advice unchanged |url= https://www.fda.gov/consumers/consumer-updates/outsmarting-poison-ivy-and-other-poisonous-plants |url-status=dead |archive-url=https://web.archive.org/web/20090605155630/http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm049342.htm |archive-date=5 June 2009 }}</ref>

== References ==
{{Reflist}}

== External links ==
* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/calamine | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Calamine }}

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[[Category:Antiseptics]]
[[Category:Alchemical substances]]
[[Category:Skin care]]
[[Category:Antipruritics]]
[[Category:World Health Organization essential medicines]]
[[Category:Wikipedia medicine articles ready to translate]]
[[Category:Combination drugs]]