View source for CA 15-3

'''CA 15-3''', for Carcinoma Antigen 15-3, is a [[tumor marker]] for many types of cancer, most notably [[breast cancer]].<ref>http://www.oncolink.org/experts/article.cfm?c=3&s=13&ss=22&id=1911 "CA15-3"</ref><ref name="pmid14726467">{{cite journal |vauthors=Duffy MJ, Duggan C, Keane R |title=High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer |journal=Clin. Chem. |volume=50 |issue=3 |pages=559–63 |date=March 2004 |pmid=14726467 |doi=10.1373/clinchem.2003.025288 |display-authors=etal|doi-access=free }}</ref><ref>{{MeshName|CA-15-3+Antigen}}</ref>

It is derived from [[MUC1]].<ref name="pmid18161663">{{cite journal |vauthors=Bearz A, Talamini R, Vaccher E |title=MUC-1 (CA 15-3 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients |journal=Int. J. Biol. Markers |volume=22 |issue=4 |pages=307–11 |year=2007 |pmid=18161663 |doi= 10.1177/172460080702200411|display-authors=etal}}</ref> CA 15-3 and associated [[Ca 27-29|CA 27-29]] are different epitopes on the same protein antigen product of the breast cancer-associated [[MUC1]] gene.

Elevated CA15-3, in conjunction with [[alkaline phosphatase]] (ALP), was found to be associated with an increased chance of early recurrence in [[breast cancer]].<ref>[https://web.archive.org/web/20070910114324/http://annonc.oxfordjournals.org/cgi/content/abstract/18/4/701 CA15-3 and alkaline phosphatase as predictors for breast cancer recurrence: a combined analysis of seven International Breast Cancer Study Group trials - Keshaviah et al. 18 (4): 701 - Annals of Oncology. 2007]</ref>

Both CA 15-3 and CA 27-29 may be elevated in patients with benign ovarian cysts, benign breast disease, and benign liver disease.  Elevations may also be seen in cirrhosis, sarcoidosis and lupus.  

==References==
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{{Tumor markers}}

[[Category:Tumor markers]]


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