View source for Bone morphogenetic protein receptor

{{short description|Group of three receptors to bone morphogenetic proteins}}
{{Pfam_box
| Symbol = TKL
| Name = TKL Ser/Thr protein kinase family
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| Membranome family= 1216
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'''Bone morphogenetic protein receptors''' are [[serine-threonine kinase]] receptors. [[Transforming growth factor beta family]] proteins bind to these receptors.<ref>{{cite journal | vauthors = Miyazono K, Kamiya Y, Morikawa M | title = Bone morphogenetic protein receptors and signal transduction | journal = Journal of Biochemistry | volume = 147 | issue = 1 | pages = 35–51 | date = January 2010 | pmid = 19762341 | doi = 10.1093/jb/mvp148 | doi-access = free }}</ref> There are four bone morphogenetic protein receptors:<ref>{{cite journal| vauthors = Pasche B |date= December 2008 |title=The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008. |journal=The Quarterly Review of Biology |volume=83 |issue=4 |pages=405–405 |doi=10.1086/596254 }}</ref>

* [[Bone morphogenetic protein receptor, type 1]]:
** [[ACVR1]]
**[[BMPR1A]]
** [[BMPR1B]]
* [[Bone morphogenetic protein receptor, type 2]]

== Structure ==
Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.<ref name="Mace_2006">{{cite journal | vauthors = Mace PD, Cutfield JF, Cutfield SM | title = High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding | journal = Biochemical and Biophysical Research Communications | volume = 351 | issue = 4 | pages = 831–8 | date = December 2006 | pmid = 17094948 | doi = 10.1016/j.bbrc.2006.10.109 }}</ref> Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the [[SMAD (protein)|SMAD]] signaling cascade.<ref name="Mace_2006" /> The wrist epitope motif on [[Bone morphogenetic protein 2|BMP-2]] has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.<ref>{{cite book | vauthors = Miyazono K, Shimanuki T | chapter = Chapter 55: Bone morphogenetic protein receptors and actions. | veditors = Bilezikian JP, Raisz LG, Martin TJ | title = Principles of bone biology | edition = Third | date = January 2008 | pages = 1177–1196 |place=San Diego | publisher = Academic Press |isbn=978-0-12-373884-4 | doi = 10.1016/B978-0-12-373884-4.00069-0 }}</ref>

== See also ==
* [[Bone morphogenetic protein]]

== References ==
{{Reflist}}

== External links ==
* {{MeshName|Bone+Morphogenetic+Protein+Receptors}}

{{Growth factor receptors}}
{{TGF beta signaling}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{TGFβ receptor superfamily modulators}}
{{Portal bar|Biology|border=no}}

[[Category:Bone morphogenetic protein]]
[[Category:EC 2.7.11]]

{{transmembranereceptor-stub}}