View source for Alternative-complement-pathway C3/C5 convertase

{{Infobox enzyme
| Name       = Alternative-complement-pathway C3/C5 convertase
| EC_number  = 3.4.21.47
| CAS_number = 80295-67-6
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
'''Alternative-[[Complement system|complement]]-pathway C3/C5 convertase''' ({{EC number|3.4.21.47}}, ''complement component C3/C5 convertase (alternative)'', ''proenzyme factor B'', ''properdin factor B'', ''C3 proactivator'', ''glycine-rich beta-glycoprotein'', ''heat-labile factor'', ''C3 convertase'', ''C3b,Bb,CVF,Bb,C5 convertase'', ''(C3b)n,Bb'', ''complement C 3(C 5) convertase (amplification)'', ''alternative complement pathway C3(C5) convertase'', ''[[C5 convertase]]'', ''CVF,Bb'', ''(CVF)-dependent glycine-rich-beta-glucoprotein'', ''cobra venom factor-dependent C3 convertase'') is an [[enzyme]].<ref>{{cite book | vauthors = Kerr MA | title = Human factor B | chapter = &#91;8&#93; Human factor B | series = Methods in Enzymology | volume = 80 Pt C | pages = 102–12 | year = 1981 | pmid = 7043188 | doi = 10.1016/s0076-6879(81)80010-9 | isbn = 9780121819804 }}</ref><ref>{{cite journal | vauthors = Morley BJ, Campbell RD | title = Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen | journal = The EMBO Journal | volume = 3 | issue = 1 | pages = 153–7 | date = January 1984 | pmid = 6323161 | pmc = 557312 | doi=10.1002/j.1460-2075.1984.tb01776.x}}</ref><ref>{{cite journal | vauthors = Müller-Eberhard HJ | title = Molecular organization and function of the complement system | journal = Annual Review of Biochemistry | volume = 57 | pages = 321–47 | year = 1988 | pmid = 3052276 | doi = 10.1146/annurev.bi.57.070188.001541 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: Cleavage of Arg-Ser bond in [[complement component]] C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield C5a and C5b

This enzyme is a bimolecular complex of complement fragment Bb with either C3b or cobra venom factor.

== See also ==
* [[Alternative complement pathway]]

== References ==
{{reflist}}

== External links ==
* {{MeshName|Alternative-complement-pathway+C3/C5+convertase}}

{{Serine endopeptidases}}
{{Enzymes}}
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{{DEFAULTSORT:Alternative-complement-pathway C3 C5 convertase}}
[[Category:EC 3.4.21]]