View source for ACVR2B

{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Activin receptor type-2B''' is a [[protein]] that in humans is encoded by the ''ACVR2B'' [[gene]].<ref name="pmid8161782">{{cite journal | vauthors = Hildén K, Tuuri T, Erämaa M, Ritvos O | title = Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor | journal = Blood | volume = 83 | issue = 8 | pages = 2163–70  | date = May 1994 | pmid = 8161782 | doi =  10.1182/blood.V83.8.2163.2163| doi-access = free }}</ref><ref name="pmid9621519">{{cite journal | vauthors = Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y | title = Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene | journal = J. Hum. Genet. | volume = 43 | issue = 2 | pages = 132–4  | date = July 1998 | pmid = 9621519 | doi = 10.1007/s100380050054 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACVR2B activin A receptor, type IIB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93}}</ref>  ACVR2B is an [[activin type 2 receptor]].

== Function ==

[[Activin]]s are dimeric growth and differentiation factors which belong to the [[transforming growth factor-beta]] (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of [[receptor protein serine/threonine kinase|receptor serine kinases]] which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with [[cysteine]]-rich region, a [[transmembrane domain]], and a [[cytoplasmic]] domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in [[phosphorylation]] of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.<ref name="entrez"/>

== Interactions ==

ACVR2B has been shown to [[Protein-protein interaction|interact]] with [[ACVR1B]]<ref name = pmid8622651>{{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066–73  | date = March 1996 | pmid = 8622651 | pmc = 231089 | doi =  10.1128/mcb.16.3.1066}}</ref><ref name = pmid8612709>{{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34  | date = May 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}</ref> and [[SYNJ2BP]].<ref name = pmid11882656>{{cite journal | vauthors = Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H | title = Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19008–18  | date = May 2002 | pmid = 11882656 | doi = 10.1074/jbc.M112472200 | doi-access = free }}</ref>

== References ==
{{reflist}}

==External links==
* {{UCSC gene info|ACVR2B}}
* {{PDBe-KB2|Q13705|Human Activin receptor type-2B}}
* {{PDBe-KB2|P27040|Mouse Activin receptor type-2B}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Burdine RD, Schier AF | title = Conserved and divergent mechanisms in left-right axis formation | journal = Genes Dev. | volume = 14 | issue = 7 | pages = 763–76 | year = 2000 | doi = 10.1101/gad.14.7.763 | pmid = 10766733 | s2cid = 34764551 | doi-access = free }}
* {{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34 | year = 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}
* {{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066–73 | year = 1996 | pmid = 8622651 | pmc = 231089 | doi =  10.1128/MCB.16.3.1066}}
* {{cite journal | vauthors = Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K | title = Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 | journal = J. Biol. Chem. | volume = 271 | issue = 35 | pages = 21345–52 | year = 1996 | pmid = 8702914 | doi = 10.1074/jbc.271.35.21345 | doi-access = free }}
* {{cite journal | vauthors = Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH | title = Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells | journal = Endocrinology | volume = 138 | issue = 7 | pages = 2928–36 | year = 1997 | pmid = 9202237 | doi = 10.1210/endo.138.7.5250 | doi-access = free }}
* {{cite journal | vauthors = Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL | title = Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25628–36 | year = 1998 | pmid = 9748228 | doi = 10.1074/jbc.273.40.25628 | doi-access = free }}
* {{cite journal | vauthors = Kosaki R, Gebbia M, Kosaki K, Lewin M, Bowers P, Towbin JA, Casey B | title = Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB | journal = Am. J. Med. Genet. | volume = 82 | issue = 1 | pages = 70–6 | year = 1999 | pmid = 9916847 | doi = 10.1002/(SICI)1096-8628(19990101)82:1<70::AID-AJMG14>3.0.CO;2-Y }}
* {{cite journal | vauthors = Lee S, Alexander J, Blowes R, Ingram D, Milner AD | title = Determination of resonance frequency of the respiratory system in respiratory distress syndrome | journal = Arch. Dis. Child. Fetal Neonatal Ed. | volume = 80 | issue = 3 | pages = F198-202 | year = 1999 | pmid = 10212081 | pmc = 1720943 | doi = 10.1136/fn.80.3.F198 }}
* {{cite journal | vauthors = McPherron AC, Lawler AM, Lee SJ | title = Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11 | journal = Nat. Genet. | volume = 22 | issue = 3 | pages = 260–4 | year = 1999 | pmid = 10391213 | doi = 10.1038/10320 | s2cid = 1172738 }}
* {{cite journal | vauthors = Bondestam J, Horelli-Kuitunen N, Hildén K, Ritvos O, Aaltonen J | title = Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH | journal = Cytogenet. Cell Genet. | volume = 87 | issue = 3–4 | pages = 219–20 | year = 1999 | pmid = 10702675 | doi = 10.1159/000015429 | s2cid = 36135054 }}
* {{cite journal | vauthors = Chapman SC, Woodruff TK | title = Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP) | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 668–79 | year = 2001 | pmid = 11266516 | doi = 10.1210/mend.15.4.0616 | doi-access = free }}
* {{cite journal | vauthors = Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB | title = Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19495–502 | year = 2001 | pmid = 11278302 | doi = 10.1074/jbc.M006473200 | doi-access = free }}
* {{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19332–9 | year = 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 | doi-access = free }}
* {{cite journal | vauthors = Choi KC, Kang SK, Nathwani PS, Cheng KW, Auersperg N, Leung PC | title = Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE) | journal = Mol. Cell. Endocrinol. | volume = 174 | issue = 1–2 | pages = 99–110 | year = 2001 | pmid = 11306176 | doi = 10.1016/S0303-7207(00)00447-0 | s2cid = 10648768 }}
* {{cite journal | vauthors = Lee SJ, McPherron AC | title = Regulation of myostatin activity and muscle growth | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 16 | pages = 9306–11 | year = 2001 | pmid = 11459935 | pmc = 55416 | doi = 10.1073/pnas.151270098 | bibcode = 2001PNAS...98.9306L | doi-access = free }}
* {{cite journal | vauthors = Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H | title = Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19008–18 | year = 2002 | pmid = 11882656 | doi = 10.1074/jbc.M112472200 | doi-access = free }}
* {{cite journal | vauthors = Schneider-Kolsky ME, Manuelpillai U, Waldron K, Dole A, Wallace EM | title = The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour | journal = Placenta | volume = 23 | issue = 4 | pages = 294–302 | year = 2002 | pmid = 11969340 | doi = 10.1053/plac.2002.0787 }}
{{refend}}

{{PDB Gallery|geneid=93}}
{{TGF beta signaling}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{TGFβ receptor superfamily modulators}}
{{Portal bar|Biology|border=no}}

{{DEFAULTSORT:Acvr2b}}
<!--Categories-->
[[Category:GS domain]]
[[Category:TS domain]]
[[Category:S/T domain]]
[[Category:Human proteins]]
[[Category:EC 2.7.11]]


{{gene-3-stub}}