View source for List of epidemics and pandemics

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[[File:Pandemics-Timeline-Death-Tolls-OWID 9818.png|thumb|upright=2|Pandemics timeline death tolls]]

This is a list of the largest known [[epidemic]]s and [[pandemic]]s caused by an [[infectious disease]] in humans. Widespread [[non-communicable diseases]] such as [[cardiovascular disease]] and [[cancer]] are not included. An epidemic is the rapid spread of [[disease]] to a large number of people in a given population within a short period of time; in [[meningococcal infection]]s, an [[attack rate]] in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.<ref name="Green">{{cite journal |author1=Green MS |author2=Swartz T |author3=Mayshar E |author4=Lev B |author5=Leventhal A |author6=Slater PE |author7=Shemer Js |title=When is an epidemic an epidemic? |journal=Isr. Med. Assoc. J. |volume=4 |issue=1 |pages=3–6 |date=January 2002 |pmid=11802306}}</ref> Due to the long time spans, the [[first plague pandemic]] (6th century – 8th century) and the [[second plague pandemic]] (14th century – early 19th century) are shown by individual outbreaks, such as the [[Plague of Justinian]] (first pandemic) and the [[Black Death]] (second pandemic).

Infectious diseases with high prevalence are listed separately (sometimes in addition to their epidemics), such as [[malaria]], which may have killed 50–60 billion people.<ref name=Whitfield>{{cite journal|author=Whitfield, J.|title=Portrait of a serial killer|journal=Nature|year=2002|doi=10.1038/news021001-6|url=https://www.nature.com/articles/news021001-6|access-date=2023-03-30|archive-date=2023-10-17|archive-url=https://web.archive.org/web/20231017135035/https://www.nature.com/articles/news021001-6|url-status=live|url-access=subscription}}</ref>

==Major epidemics and pandemics==
===By death toll===
Ongoing epidemics and pandemics are in {{strong|boldface}}. For a given epidemic or pandemic, the average of its estimated death toll range is used for ranking. If the death toll averages of two or more epidemics or pandemics are equal, then the smaller the range, the higher the rank. For the historical records of major changes in the world population, see [[world population]].<ref name=":9">{{Cite web|title=World Population History|url=https://worldpopulationhistory.org/|access-date=2021-03-01|website=World Population|language=en-US|archive-date=2021-02-26|archive-url=https://web.archive.org/web/20210226183322/https://worldpopulationhistory.org/|url-status=live}}</ref>
{{Clear}}
{| class="sortable wikitable"
|+Epidemics and pandemics with at least 1 million deaths
!scope="col"|Rank
!scope="col"|Epidemics/pandemics
!scope="col"|Disease
!scope="col"|Death toll
!scope="col"|Percentage of population lost
!scope="col"|Years
!scope="col"|Location
|-
|1
|[[Spanish flu|1918 "Spanish" influenza pandemic]]
|[[Influenza|Influenza A/H1N1]]
| <!-- Death toll --> data-sort-value="58,500,000" |17–100 million
|1–5.4% of global population<ref>{{Cite web|title=The Spanish flu (1918–20): The global impact of the largest influenza pandemic in history|url=https://ourworldindata.org/spanish-flu-largest-influenza-pandemic-in-history|access-date=2021-02-06|website=Our World in Data|date=4 March 2020 |archive-date=2021-09-07|archive-url=https://web.archive.org/web/20210907022931/https://ourworldindata.org/spanish-flu-largest-influenza-pandemic-in-history|url-status=live |last1=Roser |first1=Max }}</ref>
|1918–1920
|Worldwide
|-
|2
|[[Plague of Justinian]]
|Bubonic plague
| data-sort-value="57,500,000" |15–100 million
|25–60% of European population<ref name=":4" />
|541–549
|North Africa, Europe, and Western Asia
|- style="font-weight: bold;"
|3
|[[Epidemiology of HIV/AIDS|HIV/AIDS pandemic]]
|[[HIV/AIDS]]
| data-sort-value="43,000,000" |44 million ({{as of|2025|lc=y}})
|–
|1981–present<ref>{{cite journal |vauthors=Beyrer C |title=A pandemic anniversary: 40 years of HIV/AIDS |journal=Lancet |volume=397 |issue=10290 |pages=2142–2143 |date=June 2021 |pmid=34087110 |doi=10.1016/S0140-6736(21)01167-3 |s2cid=235273243 |type=Review}}</ref>
|Worldwide
|-
|4
|[[Black Death]]
|[[Bubonic plague]]
| data-sort-value="37,500,000" |25–50 million
|30–60% of European population<ref>{{Cite web|last=Wade|first=Lizzie|date=2020-05-14|title=From Black Death to fatal flu, past pandemics show why people on the margins suffer most|url=https://www.science.org/content/article/black-death-fatal-flu-past-pandemics-show-why-people-margins-suffer-most|access-date=2021-02-06|website=Science|language=en|archive-date=2021-10-01|archive-url=https://web.archive.org/web/20211001204644/https://www.science.org/content/article/black-death-fatal-flu-past-pandemics-show-why-people-margins-suffer-most|url-status=live}}</ref>
|1346–1353
|Europe, Asia, and North Africa
|- style="font-weight: bold;"
|5
|[[COVID-19 pandemic]]
|[[COVID-19]]
| data-sort-value="21,000,000" |7.1–36.5 million<ref>{{cite web |title=WHO COVID-19 dashboard |url=https://data.who.int/dashboards/covid19/deaths?n=c |access-date=14 January 2024 |date=14 January 2024 |work=WHO |archive-date=6 February 2024 |archive-url=https://web.archive.org/web/20240206183245/https://data.who.int/dashboards/covid19/deaths?n=c |url-status=live }}</ref><ref>{{cite news|title=The pandemic's true death toll |access-date=2024-02-08|url=https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates |archive-url=https://web.archive.org/web/20240208015904/https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates |url-status=dead |archive-date=2024-02-08 |newspaper=[[The Economist]]}}</ref> ({{as of|2025|lc=y}})
|–
|2019{{efn|name=COVID2}}–present<ref>{{cite web |publisher=Word Health Organization |url=https://www.who.int/news/item/27-04-2020-who-timeline---covid-19 |title=Archived: WHO Timeline - COVID-19 |date=27 April 2020 |access-date=7 March 2024 |archive-date=29 April 2020 |archive-url=https://web.archive.org/web/20200429012212/https://www.who.int/news-room/detail/27-04-2020-who-timeline---covid-19 |url-status=live }}</ref><ref>{{Cite news |date=2024-01-03 |title=COVID is still a pandemic, WHO leader says |language=en |work=TheMessenger |url=https://themessenger.com/health/covid-pandemic-who-cdc-russia-world-health-organization/ |access-date=2024-01-03 |archive-date=Jan 2, 2024 |archive-url=https://web.archive.org/web/20240102205706/https://themessenger.com/health/covid-pandemic-who-cdc-russia-world-health-organization |url-status=dead }}</ref><!--PANDEMIC IS ONGOING: This article matches the article [[COVID-19 pandemic]]. If you have high-quality sources indicating the pandemic has ended, please present them on that talk page. DO NOT DELETE THIS COMMENT-->{{efn|The disease was a [[public health emergency of international concern]] from January 30, 2020 to May 5, 2023.}}
|Worldwide
|-
|6
|[[Third plague pandemic]]
|Bubonic plague
| data-sort-value="13,500,000" |12–15 million
|–
|1855–1960
|Worldwide
|-
|7
|[[Cocoliztli epidemics|Cocoliztli epidemic of 1545–1548]]
| Cocoliztli, caused by an unidentified pathogen
| data-sort-value="10,000,000" |5–15 million
|27–80% of Mexican population<ref name="Megadrought and Megadeath in 16th Century Mexico" />
|1545–1548
|Mexico
|-
|8
|[[Antonine Plague]]
|[[Smallpox]] or [[measles]]
| data-sort-value="7,500,000" |5–10 million
|25–33% of Roman population<ref>{{Cite web|title=Antonine Plague|url=https://www.worldhistory.org/Antonine_Plague/|access-date=2021-02-06|website=[[World History Encyclopedia]]|archive-date=2023-08-28|archive-url=https://web.archive.org/web/20230828132159/https://www.worldhistory.org/Antonine_Plague/|url-status=live}}</ref>
| data-sort-value="0165" |165–180 (possibly up to 190)
|[[Roman Empire]]
|-
|9
|[[History of smallpox in Mexico|1520 Mexico smallpox epidemic]]
|Smallpox
| data-sort-value="6,500,000" |5–8 million
|23–37% of Mexican population<ref name="Megadrought and Megadeath in 16th Century Mexico" />
|1519–1520
|[[New Spain|Mexico]]
|-
|10
|[[1957–1958 influenza pandemic]]
|[[Influenza A virus subtype H2N2|Influenza A/H2N2]]
| data-sort-value="2,500,000" |1–4 million
|–
|1957–1958
|Worldwide
|-
|11
|[[Hong Kong flu]]
|[[Influenza A virus subtype H3N2|Influenza A/H3N2]]
| data-sort-value="2,500,000" |1–4 million
|–
|1968–1969
|Worldwide
|-
|12
|[[Epidemic typhus#20th century|1918–1922 Russia typhus epidemic]]
|[[Typhus]]
| data-sort-value="2,500,000" |2–3 million
|1–1.6% of Russian population<ref>{{Cite web|title=Population of Russia|url=https://www.tacitus.nu/historical-atlas/population/russia.htm|access-date=2021-03-01|website=www.tacitus.nu|archive-date=2021-10-18|archive-url=https://web.archive.org/web/20211018005539/https://tacitus.nu/historical-atlas/population/russia.htm|url-status=dead}}</ref>
|1918–1922
|[[Russian Soviet Federative Socialist Republic|Russia]]
|-
|13
|[[Cocoliztli epidemic of 1576]]
|Cocoliztli
| data-sort-value="2,250,000"|2–2.5 million
|50% of Mexican population<ref name="Megadrought and Megadeath in 16th Century Mexico" />
|1576–1580
|Mexico
|-
|14
|[[1772–1773 Persian Plague]]
|Bubonic plague
| data-sort-value="2,000,000"|2 million
|–
|1772–1773
|[[Persia]]
|-
|15
|[[735–737 Japanese smallpox epidemic]]
|Smallpox
| data-sort-value="2,000,000"|2 million
|33% of Japanese population<ref name="Suzuki" />
|735–737
|Japan
|-
|16
|[[Naples Plague (1656)|Naples Plague]]
|Bubonic plague
| data-sort-value="1,250,000"|1.25 million
|–
|1656–1658
|Southern Italy
|-
|17
|[[1889–1890 pandemic]]
|Influenza or [[human coronavirus OC43]]<ref name="Knowable">{{Cite journal |author=Knowable Magazine Staff |title=Pandemics in recent history |url=https://knowablemagazine.org/article/health-disease/2020/pandemics-recent-history |journal=Knowable Magazine |date=July 16, 2020 |doi=10.1146/knowable-071520-2 |doi-access=free |access-date=June 29, 2021 |archive-date=November 29, 2022 |archive-url=https://web.archive.org/web/20221129190516/https://knowablemagazine.org/article/health-disease/2020/pandemics-recent-history |url-status=live }}</ref><ref name="auto">{{cite journal |last1=King |first1=Anthony |title=An uncommon cold |journal=New Scientist |date=May 2020 |volume=246 |issue=3280 |pages=32–35 |doi=10.1016/S0262-4079(20)30862-9 |pmid=32501321 |pmc=7252012 |bibcode=2020NewSc.246...32K }}</ref>
| data-sort-value="1,000,000" |1 million
| –
| 1889–1890
| Worldwide
|-
|18
|[[1629–1631 Italian plague]]
|Bubonic plague
| data-sort-value="1,000,000" |1 million
|–
|1629–1631
|Italy
|-
|19
|[[1846–1860 cholera pandemic]]
|[[Cholera]]
| data-sort-value="1,000,000"|1 million
|–
|1846–1860
|Worldwide
|}

===Depopulation of the Americas===
{{main|Population history of Indigenous peoples of the Americas#Depopulation by Old World diseases}}
Not included in the above table are many waves of deadly diseases brought by Europeans to the Americas and Caribbean. Western Hemisphere populations were ravaged mostly by [[smallpox]], but also [[typhus]], [[measles]], [[influenza]], [[bubonic plague]], [[cholera]], [[malaria]], [[tuberculosis]], [[mumps]], [[yellow fever]], and [[pertussis]]. The lack of written records in many places and the destruction of many native societies by disease, war, and colonization make estimates uncertain. Deaths probably numbered in the tens or perhaps over a hundred million, with perhaps 90% of the population dead in the worst-hit areas. Lack of scientific knowledge about microorganisms and lack of surviving medical records for many areas makes attribution of specific numbers to specific diseases uncertain.

===Infectious diseases with high prevalence===
{{further|List of causes of death by rate}}

There have been various major infectious diseases with high prevalence worldwide, but they are currently not listed in the above table as epidemics/pandemics due to the lack of definite data, such as time span and death toll.

[[File:Malaria Patient, Nyangaton, Ethiopia (15151075077).jpg|thumb|An [[Ethiopia]]n child with malaria, a disease with an annual death rate of 619,000 as of 2021.<ref>{{cite web |url=https://www.who.int/news-room/fact-sheets/detail/malaria |title=Malaria |publisher=World Health Organization |date=2023-03-29 |access-date=2023-05-25 |archive-date=2020-05-02 |archive-url=https://web.archive.org/web/20200502021814/https://www.who.int/news-room/fact-sheets/detail/malaria |url-status=live }}</ref>]]
* '''[[Malaria]]''' has had multiple documented temporary epidemics in otherwise non-affected or low-prevalence areas. Malaria is commonly spread by mosquitoes. The vast majority of its deaths are due to its constant prevalence in affected areas.<ref name=Whitfield/>
* '''[[Tuberculosis]]''' (TB) became [[History of tuberculosis#Epidemic tuberculosis|epidemic]] in Europe in the 18th and 19th century, showing a seasonal pattern, and is still taking place globally. TB causes symptoms including consumption (coughing up blood due to TB). TB is serious and if caught, needs strong antibiotics immediately. <ref name=":03">{{Cite web|last=Frith|first=John|title=History of Tuberculosis. Part 1 – Phthisis, consumption and the White Plague|url=https://jmvh.org/article/history-of-tuberculosis-part-1-phthisis-consumption-and-the-white-plague/|access-date=2021-02-26|website=Journal of Military and Veterans' Health|archive-date=2021-04-08|archive-url=https://web.archive.org/web/20210408050305/https://jmvh.org/article/history-of-tuberculosis-part-1-phthisis-consumption-and-the-white-plague/|url-status=live}}</ref><ref name=":52">{{Cite journal|last1=Zürcher|first1=Kathrin|last2=Zwahlen|first2=Marcel|last3=Ballif|first3=Marie|last4=Rieder|first4=Hans L.|last5=Egger|first5=Matthias|last6=Fenner|first6=Lukas|date=2016-10-05|title=Influenza Pandemics and Tuberculosis Mortality in 1889 and 1918: Analysis of Historical Data from Switzerland|journal=PLOS ONE|volume=11|issue=10|pages=e0162575|bibcode=2016PLoSO..1162575Z|doi=10.1371/journal.pone.0162575|issn=1932-6203|pmc=5051959|pmid=27706149|doi-access=free}}</ref><ref name=":8">{{Cite web|title=Tuberculosis|url=https://www.who.int/health-topics/tuberculosis#tab=tab_1|access-date=2021-02-26|website=World Health Organization|language=en|archive-date=2021-04-11|archive-url=https://web.archive.org/web/20210411012351/https://www.who.int/health-topics/tuberculosis#tab=tab_1|url-status=live}}</ref> The [[Morbidity rate|morbidity]] and [[Mortality rate|mortality]] of TB and [[HIV/AIDS]] have been closely linked, known as "TB/HIV syndemic".<ref name=":8" /><ref>{{Cite journal|last=Centers for Disease Control and Prevention (CDC)|date=2012-07-06|title=CDC Grand Rounds: the TB/HIV syndemic|url=https://pubmed.ncbi.nlm.nih.gov/22763886/|journal=MMWR. Morbidity and Mortality Weekly Report|volume=61|issue=26|pages=484–489|issn=1545-861X|pmid=22763886|access-date=2021-02-26|archive-date=2021-07-12|archive-url=https://web.archive.org/web/20210712225702/https://pubmed.ncbi.nlm.nih.gov/22763886/|url-status=live}}</ref> According to the [[World Health Organization]], approximately 10 million new TB infections occur every year, and 1.5 million people die from it each year – making it the world's top infectious killer (before [[COVID-19 pandemic]]).<ref name=":8" /> However, there is a lack of sources which describe major TB epidemics with definite time spans and death tolls.
* '''[[Hepatitis B]]''': According to the World Health Organization, {{as of|2019|lc=y}} there are about 296 million people living with chronic hepatitis B, with 1.5 million new infections each year. In 2019, hepatitis B caused about 820,000 deaths, mostly from [[cirrhosis]] and [[hepatocellular carcinoma]] (primary [[liver cancer]]).<ref name=":13">{{Cite web|date=27 July 2021|title=Hepatitis B|url=https://www.who.int/news-room/fact-sheets/detail/hepatitis-b|website=World Health Organization|language=en|access-date=4 August 2021|archive-date=13 May 2020|archive-url=https://web.archive.org/web/20200513092830/https://www.who.int/news-room/fact-sheets/detail/hepatitis-b|url-status=live}}</ref> In many places of Asia and Africa, hepatitis B has become [[Endemic (epidemiology)|endemic]].<ref>{{Cite journal|last1=Franco|first1=Elisabetta|last2=Bagnato|first2=Barbara|last3=Marino|first3=Maria Giulia|last4=Meleleo|first4=Cristina|last5=Serino|first5=Laura|last6=Zaratti|first6=Laura|date=2012-03-27|title=Hepatitis B: Epidemiology and prevention in developing countries|journal=World Journal of Hepatology|volume=4|issue=3|pages=74–80|doi=10.4254/wjh.v4.i3.74|issn=1948-5182|pmc=3321493|pmid=22489259 |doi-access=free }}</ref> In addition, a person is sometimes infected with both hepatitis B virus (HBV) and HIV, and this population (about 2.7 million) accounts for about 1% of the total HBV infections.<ref name=":13" />
* '''[[Hepatitis C]]''': According to the World Health Organization, there are approximately 58 million people with chronic hepatitis C, with about 1.5 million new infections occurring per year. In 2019, approximately 290,000 people died from the disease, mostly from [[cirrhosis]] and [[hepatocellular carcinoma]] (primary [[liver cancer]]).<ref>{{Cite web|date=27 July 2021|title=Hepatitis C|url=https://www.who.int/news-room/fact-sheets/detail/hepatitis-c|access-date=|website=World Health Organization|language=en|archive-date=26 May 2020|archive-url=https://web.archive.org/web/20200526052334/https://www.who.int/en/news-room/fact-sheets/detail/hepatitis-c|url-status=live}}</ref> There have been many hepatitis C virus (HCV) epidemics in history.<ref>{{Cite journal|last=Shiffman|first=Mitchell L.|date=February 2018|title=The next wave of hepatitis C virus: The epidemic of intravenous drug use|journal=Liver International |volume=38|issue=Suppl 1 |pages=34–39|doi=10.1111/liv.13647|issn=1478-3231|pmid=29427493|s2cid=46805810|doi-access=free}}</ref><ref>{{Cite journal|last1=Rodrigo|first1=Chaturaka|last2=Eltahla|first2=Auda A.|last3=Bull|first3=Rowena A.|last4=Grebely|first4=Jason|last5=Dore|first5=Gregory J.|last6=Applegate|first6=Tanya|last7=Page|first7=Kimberly|last8=Bruneau|first8=Julie|last9=Morris|first9=Meghan D.|last10=Cox|first10=Andrea L.|last11=Osburn|first11=William|date=2016-11-01|title=Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia|journal=The Journal of Infectious Diseases|volume=214|issue=9|pages=1383–1389|doi=10.1093/infdis/jiw389|issn=0022-1899|pmc=5079374|pmid=27571901}}</ref><ref>{{Cite journal|last1=Palladino|first1=Claudia|last2=Ezeonwumelu|first2=Ifeanyi Jude|last3=Marcelino|first3=Rute|last4=Briz|first4=Verónica|last5=Moranguinho|first5=Inês|last6=Serejo|first6=Fátima|last7=Velosa|first7=José Fernando|last8=Marinho|first8=Rui Tato|last9=Borrego|first9=Pedro|last10=Taveira|first10=Nuno|date=2018-08-16|title=Epidemic history of hepatitis C virus genotypes and subtypes in Portugal|journal=Scientific Reports|language=en|volume=8|issue=1|pages=12266|doi=10.1038/s41598-018-30528-0|pmid=30116054|pmc=6095915|bibcode=2018NatSR...812266P|issn=2045-2322}}</ref>

==Chronology==
Events in {{strong|boldface}} are ongoing.
{| class="wikitable sortable"
|+Chronological table of epidemic and pandemic events in human history
|-
!scope="col"| Event
!scope="col" data-sort-type="isoDate"| Years
!scope="col"| Location
! scope="col"|Disease
! scope="col" data-sort-type="number"| Death toll (estimate)
! Ref.
|-
| 1350 BC plague of Megiddo
| data-sort-value="-1350"|c. 1350 BC
| [[Tel Megiddo|Megiddo]], land of [[Canaan]]
| [[Amarna letters]] EA 244, [[Biridiya]], mayor of Megiddo complains to [[Amenhotep III]] of his area being "consumed by death, plague and dust"
| data-sort-value="0"|Unknown
| <ref name="Amarna">''[https://www.kchanson.com/ANCDOCS/meso/amarna244.html Amarna Tablet 244] {{Webarchive|url=https://web.archive.org/web/20230404041541/https://www.kchanson.com/ANCDOCS/meso/amarna244.html |date=2023-04-04 }}''.</ref>
|-
|[[Hittite plague|Hittite Plague]]/"Hand of Nergal"
|c. 1330 BC
|[[Near East]], [[Hittite Empire]], [[Alashiya]], possibly [[New Kingdom of Egypt|Egypt]]
|Unknown, possibly [[Tularemia]]. Mentioned in [[Amarna letter EA 35]] as the "Hand of Nergal", cause of death of [[Šuppiluliuma I]].
|Unknown
|
|-
| [[Plague of Athens]]
| data-sort-value="-430"|430–426 BC
| Greece, [[Libya]], Egypt, [[Ethiopia]]
| Unknown, possibly [[typhus]], [[typhoid fever]] or [[viral hemorrhagic fever]]
| data-sort-value="87500"|75,000–100,000
| <ref>{{Cite web |url=https://www.history.com/topics/middle-ages/pandemics-timeline |title=Pandemics That Changed History |website=History.com |date=27 February 2019 |archive-url=https://web.archive.org/web/20200303184702/https://www.history.com/topics/middle-ages/pandemics-timeline |archive-date=2020-03-03 |access-date=2020-04-14}}</ref><ref>{{Cite web |url=http://umm.edu/news-and-events/news-releases/1999/plague-of-athens-another-medical-mystery-solved-at-university-of-maryland |title=Plague of Athens: Another Medical Mystery Solved at University of Maryland |website=University of Maryland Medical Center |url-status=dead |archive-url=https://web.archive.org/web/20151204030552/http://umm.edu/news-and-events/news-releases/1999/plague-of-athens-another-medical-mystery-solved-at-university-of-maryland |archive-date=2015-12-04 |access-date=2016-02-10}}</ref><ref>{{Cite journal |last1=Papagrigorakis |first1=Manolis J. |last2=Yapijakis |first2=Christos |last3=Synodinos |first3=Philippos N. |last4=Baziotopoulou-Valavani |first4=Effie |year=2007
 |title=DNA examination of ancient dental pulp incriminates typhoid fever as a probable cause of the Plague of Athens |journal=International Journal of Infectious Diseases |volume=10 |issue=3 |pages=206–214 |doi=10.1016/j.ijid.2005.09.001 |pmid=16412683|doi-access=free }}</ref><ref>{{Cite journal |last1=Olson |first1=PE |last2=Hames |first2=CS |last3=Benenson |first3=AS |last4=Genovese |first4=EN |year=1996 |title=The Thucydides syndrome: Ebola déjà vu? (or Ebola reemergent?) |journal= Emerging Infectious Diseases|volume=2 |issue=2 |pages=155–156 |doi=10.3201/eid0202.960220 |pmc=2639821 |pmid=8964060}}</ref>
|-
| [[412 BC epidemic]]
| data-sort-value="-412"|412 BC
| Greece ([[Northern Greece]], [[Roman Republic]])
| Unknown, possibly [[influenza]]
| data-sort-value="0"|473,000 (10% of the Roman Population)
| <ref>{{cite book |last=Potter |first=C. W. |title=Influenza |chapter=Foreword |date=2002 |page=vii |publisher=[[Elsevier Science]]}}</ref>
|-
| [[Antonine Plague]]
| data-sort-value="0165"|165–180 (possibly up to 190)
| [[Roman Empire]]
| Unknown, possibly [[smallpox]]
| data-sort-value="07500000"|5–10 million
| <ref>{{Cite web|title=Reactions to Plague in the Ancient & Medieval World|url=https://www.worldhistory.org/article/1534/reactions-to-plague-in-the-ancient--medieval-world/|access-date=2021-02-06|website=[[World History Encyclopedia]]|archive-date=2021-04-23|archive-url=https://web.archive.org/web/20210423143822/https://www.worldhistory.org/article/1534/reactions-to-plague-in-the-ancient--medieval-world/|url-status=live}}</ref><ref>[http://news.bbc.co.uk/2/hi/health/4381924.stm "Past pandemics that ravaged Europe"] {{Webarchive|url=https://web.archive.org/web/20171007210210/http://news.bbc.co.uk/2/hi/health/4381924.stm|date=2017-10-07}}, BBC News, 7 November 2005</ref>
|-
| Jian'an Plague
| 217
| [[Han dynasty#Eastern Han|Han dynasty]]
| Unknown, possibly [[typhoid fever]] or [[viral hemorrhagic fever]]
| data-sort-value="0"|2 Million
| <ref>{{Cite journal|last=Mazanec|first=Thomas J.|date=2020-09-01|title=Review: The Halberd at Red Cliff: Jian'an and the Three Kingdoms, by Xiaofei Tian|url=https://online.ucpress.edu/SLA/article/4/3/353/110917/Review-The-Halberd-at-Red-Cliff-Jian-an-and-the|journal=Studies in Late Antiquity|language=en|volume=4|issue=3|pages=353–359|doi=10.1525/sla.2020.4.3.353|s2cid=225333779|issn=2470-6469|access-date=2021-01-19|archive-date=2020-09-03|archive-url=https://web.archive.org/web/20200903211043/https://online.ucpress.edu/SLA/article/4/3/353/110917/Review-The-Halberd-at-Red-Cliff-Jian-an-and-the|url-status=live|url-access=subscription}}</ref><ref>{{Cite book|last=Tian|first=Xiaofei|url=https://brill.com/view/book/9781684170920/BP000003.xml|title=Plague and Poetry: Rethinking Jian'an|date=2018-10-14|publisher=Brill|isbn=978-1-68417-092-0|language=en|access-date=2021-01-19|archive-date=2021-07-12|archive-url=https://web.archive.org/web/20210712225747/https://brill.com/view/book/9781684170920/BP000003.xml|url-status=live}}</ref>
|-
| [[Plague of Cyprian]]
| data-sort-value="0249"|249–262
| Europe
| Unknown, possibly [[smallpox]]
| data-sort-value="0"|310,000
| <ref>D. Ch. Stathakopoulos ''Famine and Pestilence in the late Roman and early Byzantine Empire'' (2007) 95</ref><ref>{{cite web |last1=Harper |first1=Kyle |title=Solving the Mystery of an Ancient Roman Plague |url=https://www.theatlantic.com/science/archive/2017/11/solving-the-mystery-of-an-ancient-roman-plague/543528/ |website=The Atlantic |access-date=20 March 2020 |date=1 November 2017 |archive-date=21 January 2018 |archive-url=https://web.archive.org/web/20180121010741/https://www.theatlantic.com/science/archive/2017/11/solving-the-mystery-of-an-ancient-roman-plague/543528/ |url-status=live }}</ref>
|-
| [[Plague of Justinian]] (beginning of [[first plague pandemic]])
| data-sort-value="0541"|541–549
| Europe and [[West Asia]]
| [[Bubonic plague]]
| data-sort-value="057500000"|15–100 million
| <ref name=":4">{{Cite journal|last1=Mordechai|first1=Lee|last2=Eisenberg|first2=Merle|last3=Newfield|first3=Timothy P.|last4=Izdebski|first4=Adam|last5=Kay|first5=Janet E.|last6=Poinar|first6=Hendrik|date=2019-12-17|title=The Justinianic Plague: An inconsequential pandemic?|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=51|pages=25546–25554|doi=10.1073/pnas.1903797116|issn=0027-8424|pmid=31792176|pmc=6926030|bibcode=2019PNAS..11625546M |doi-access=free}}</ref><ref>{{Cite news|last=Tharoor|first=Ishaan|date=2010-10-26|title=Top 10 Terrible Epidemics - TIME|language=en-US|magazine=Time|url=https://content.time.com/time/specials/packages/article/0,28804,2027479_2027486_2027546,00.html|access-date=2020-12-29|issn=0040-781X|archive-date=2021-01-16|archive-url=https://web.archive.org/web/20210116214316/http://content.time.com/time/specials/packages/article/0,28804,2027479_2027486_2027546,00.html|url-status=live}}</ref><ref>{{cite web|last1=Maugh|first1=Thomas|title=An Empire's Epidemic|url=https://www.ph.ucla.edu/epi/bioter/anempiresepidemic.html|access-date=20 March 2020|website=University of California, Los Angeles|archive-date=4 August 2002|archive-url=https://web.archive.org/web/20020804054553/https://www.ph.ucla.edu/epi/bioter/anempiresepidemic.html|url-status=live}}</ref>
|-
| [[580 Dysentery Epidemic in Gaul]]
| data-sort-value="0580"|580
| [[Gaul]]
| Dysentery or possibly smallpox
| data-sort-value="000000000"|450,000 (10% of the [[Gaul]] population)
| <ref>Gregory of Tours. A History of the Franks. Pantianos Classics, 1916</ref>
|-
| [[Roman Plague of 590]] (part of [[first plague pandemic]])
| data-sort-value="0590"|590
| [[Rome]], [[Byzantine Empire]]
| [[Bubonic plague]]
| data-sort-value="000000000"|Unknown
| <ref>{{cite web|url=http://www.ph.ucla.edu/epi/bioter/anempiresepidemic.html|title=An Empire's Epidemic|first=Ralph R.|last=Frerichs|website=Ph.ucla.edu|access-date=7 July 2018|archive-date=13 December 2008|archive-url=https://web.archive.org/web/20081213013158/http://www.ph.ucla.edu/EPI/bioter/anempiresepidemic.html|url-status=live}}</ref>
|-
| [[Plague of Sheroe]] (part of [[first plague pandemic]])
| data-sort-value="0627"|627–628
| [[Bilad al-Sham]]
| [[Bubonic plague]]
| data-sort-value="25001"|25,000+
|
|-
| [[Plague of Amwas]] (part of [[first plague pandemic]])
| data-sort-value="0638"|638–639
| [[Byzantine Empire]], [[West Asia]], Africa
| [[Bubonic plague]]
| data-sort-value="25001"|25,000+
| <ref name=Turner1990>{{Cite journal|last=Turner|first=David|date=November 1990|title=The Politics of Despair: The Plague of 746–747 and Iconoclasm in the Byzantine Empire1|journal=Annual of the British School at Athens|language=en|volume=85|pages=419–434|doi=10.1017/S006824540001577X|s2cid=153709117 |issn=2045-2403}}</ref>
|-
| [[Plague of 664]] (part of [[first plague pandemic]])
| data-sort-value="0664"|664–689
| [[British Isles]]
| [[Bubonic plague]]
| data-sort-value="000000000"|Unknown
| <ref name=Maddicott1997>{{Cite journal|last=Maddicott|first=J. R.|date=1 August 1997|title=Plague in seventh century England|url=https://academic.oup.com/past/article/156/1/7/1438455|journal=Past & Present|language=en|issue=156|pages=7–54|doi=10.1093/past/156.1.7|issn=0031-2746|access-date=12 February 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308075049/https://academic.oup.com/past/article/156/1/7/1438455|url-status=live|url-access=subscription}}</ref>
|-
| Plague of 698–701 (part of [[first plague pandemic]])
| data-sort-value="0746"|698–701
| [[Byzantine Empire]], [[West Asia]], [[Syria]], [[Mesopotamia]]
| [[Bubonic plague]]
| data-sort-value="000000000"|Unknown
| <ref name="Little">{{Cite book |title=Plague and the end of Antiquity|editor-last=Little|editor-first=Lester K. |publisher=Cambridge University Press|year=2007 |isbn=978-0-521-84639-4|location=Cambridge|page=104}}</ref>
|-
| [[735–737 Japanese smallpox epidemic]]
| data-sort-value="0735"|735–737
| Japan
| [[Smallpox]]
| data-sort-value="02000000"|2 million (approx. {{frac|1|3}} of Japanese population)
| <ref name="Suzuki">{{Cite journal |last=Suzuki |first=A. |year=2011 |title=Smallpox and the epidemiological heritage of modern Japan: Towards a total history |journal=Medical History |volume=55 |issue=3 |pages=313–318 |doi=10.1017/S0025727300005329 |pmc=3143877 |pmid=21792253}}</ref><ref name="Kohn">{{Cite book |title=Encyclopedia of Plague and Pestilence: From Ancient Times to the Present |last=Kohn |first=George C. |publisher=Checkmark Books |year=2002 |isbn=978-0816048939 |location=Princeton, New Jersey |page=213}}</ref>
|-
| Plague of 746–747 (part of [[first plague pandemic]])
| data-sort-value="0746"|746–747
| [[Byzantine Empire]], [[West Asia]], Africa
| [[Bubonic plague]]
| data-sort-value="000000000"|Unknown
| <ref name=Turner1990/>
|-
| [[Black Death]] (start of the [[second plague pandemic]])
| 1346–1353
| [[Eurasia]] and [[North Africa]]
| [[Bubonic plague]]
| data-sort-value="075000000|75–200 million (30–60% of European population and 33% percent of the Middle Eastern population)
| <ref>{{Cite book |url=https://books.google.com/books?id=YiHHnV08ebkC&pg=PA21 |title=A pest in the land: new world epidemics in a global perspective |last=Austin Alchon |first=Suzanne |publisher=University of New Mexico Press |year=2003 |isbn=978-0-8263-2871-7 |page=21 |access-date=2016-04-22 |archive-url=https://web.archive.org/web/20190401101639/https://books.google.com/books?id=YiHHnV08ebkC&pg=PA21 |archive-date=2019-04-01 |url-status=live}}</ref>
|-
| [[Sweating sickness]] (multiple outbreaks)
| 1485–1551
| [[UK|Britain]] (England) and later continental Europe
| Unknown, possibly an unknown species of [[hantavirus pulmonary syndrome|hantavirus]]
| data-sort-value="10001"|10,000+
| <ref>{{cite journal |last1=Heyman |first1=Paul |last2=Simons |first2=Leopold |last3=Cochez |first3=Christel |title=Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses? |journal=Viruses |volume=6 |issue=1 |pages=151–171 |doi=10.3390/v6010151 |pmid=24402305 |pmc=3917436 |date=7 January 2014|doi-access=free }}</ref>
|-
| 1489 Spain typhus epidemic
| 1489
| [[Spanish Empire|Spain]]
| [[Typhus]]
| data-sort-value="17000"|17,000
| <ref name="Typhus, War, and Vaccines">{{cite web|title=Typhus, War, and Vaccines|url=http://www.historyofvaccines.org/content/blog/typhus-war-and-vaccines|website=historyofvaccines.org|date=16 March 2016|access-date=12 May 2020|archive-date=11 November 2020|archive-url=https://web.archive.org/web/20201111210627/https://www.historyofvaccines.org/content/blog/typhus-war-and-vaccines|url-status=dead}}</ref>
|-
| [[1510 influenza pandemic]]
| 1510
| Asia, [[North Africa]], Europe
| [[Influenza]]
| data-sort-value="0"|Unknown, around 1% of those infected
| <ref>{{Cite journal|last1=Morens|first1=David|last2=North|first2=Michael|last3=Taubenberger|first3=Jeffrey|date=4 December 2011|title=Eyewitness accounts of the 1510 influenza pandemic in Europe|url= |journal=Lancet|volume=367|issue=9756|pages=1894–1895|pmid=21155080|doi=10.1016/s0140-6736(10)62204-0|pmc=3180818}}</ref>
|-
| [[History of smallpox in Mexico|1520 Mexico smallpox epidemic]]
| 1519–1520
| [[Viceroyalty of New Spain|Mexico]]
| [[Smallpox]]
| data-sort-value="6500000" | 5–8 million (40% of population)
| <ref name="Megadrought and Megadeath in 16th Century Mexico">{{Cite journal |title=Megadrought and Megadeath in 16th Century Mexico |date=April 8, 2002 |pmc = 2730237|last1 = Acuna-Soto|first1 = R.|last2 = Stahle|first2 = D. W.|last3 = Cleaveland|first3 = M. K.|last4 = Therrell|first4 = M. D.|journal = Emerging Infectious Diseases|volume = 8|issue = 4|pages = 360–362|doi = 10.3201/eid0804.010175|pmid = 11971767}}</ref>
|-
| [[Cocoliztli epidemics|Cocoliztli epidemic of 1545–1548]]
| 1545–1548
| [[Viceroyalty of New Spain|Mexico]]
| [[Salmonella enterica|Possibly ''Salmonella enterica'']]
| data-sort-value="010000000" | 5–15 million (80% of population)
| <ref name="American plague">{{Cite web |url=https://www.newscientist.com/article/dn268-american-plague/ |title=American plague |date=December 19, 2000 |website=New Scientist |access-date=October 17, 2018 |archive-url=https://web.archive.org/web/20181017163205/https://www.newscientist.com/article/dn268-american-plague/ |archive-date=October 17, 2018 |url-status=live}}</ref><ref name="Acuna-SotoRomero2000">{{Cite journal |last1=Acuna-Soto |first1=R. |last2=Romero |first2=L. C. |last3=Maguire |first3=J. H. |year=2000 |title=Large epidemics of hemorrhagic fevers in Mexico 1545–1815 |journal=The American Journal of Tropical Medicine and Hygiene |volume=62 |issue=6 |pages=733–739 |doi=10.4269/ajtmh.2000.62.733 |pmid=11304065|doi-access=free }}</ref><ref name="Acuna-SotoStahle2002">{{Cite journal |last1=Acuna-Soto |first1=Rodolfo |last2=Stahle |first2=D. W. |last3=Cleaveland |first3=M. K. |last4=Therrell |first4=M. D. |year=2002 |title=Megadrought and Megadeath in 16th Century Mexico |journal=Emerging Infectious Diseases |volume=8 |issue=4 |pages=360–362 |doi=10.3201/eid0804.010175 |pmc=2730237 |pmid=11971767}}</ref><ref name="sal">{{Cite journal |last1=Vågene |first1=Åshild J. |last2=Herbig |first2=Alexander |last3=Campana |first3=Michael G. |last4=Robles García |first4=Nelly M. |last5=Warinner |first5=Christina |last6=Sabin |first6=Susanna |last7=Spyrou |first7=Maria A. |last8=Andrades Valtueña |first8=Aida |last9=Huson |first9=Daniel |last10=Tuross |first10=Noreen |last11=Bos |first11=Kirsten I. |year=2018 |title=Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico |journal=Nature Ecology & Evolution |volume=2 |issue=3 |pages=520–528 |doi=10.1038/s41559-017-0446-6 |pmid=29335577 |last12=Krause |first12=Johannes|bibcode=2018NatEE...2..520V |s2cid=3358440 }}</ref>
|-
| [[1557 influenza pandemic]]
| 1557–1559
| Asia, Africa, Europe, and [[Americas]]
| [[Influenza]]
| 2.5–5 Million (10% of the infected)
|
|-
| 1561 Chile smallpox epidemic
| 1561–1562
| [[Captaincy General of Chile|Chile]]
| [[Smallpox]]
| data-sort-value="0"|120,000–150,000 (20–25% of native population)
| <ref>Alonso de Góngora Marmolejo [http://www.cervantesvirtual.com/servlet/SirveObras/bameric/02582741011358306311291/p0000003.htm#I_34_ Historia de Chile desde su descubrimiento hasta el año 1575] {{Webarchive|url=https://web.archive.org/web/20150924114330/http://www.cervantesvirtual.com/servlet/SirveObras/bameric/02582741011358306311291/p0000003.htm#I_34_ |date=2015-09-24 }}. Cervantesvirtual.com. Retrieved on 2011-12-06.</ref>
|-
| [[1563 London plague]] (part of the [[second plague pandemic]])
| 1563–1564
| [[London]], England
| [[Bubonic plague]]
| data-sort-value="20101" | 20,100+
| <ref>{{cite book|url=https://play.google.com/books/reader?id=kRMLAAAAIAAJ&printsec=frontcover&pg=GBS.PA309|title=A History of Epidemics in Britain|last=Creighton|first=Charles|publisher=Cambridge University Press|year=1891|location=Cambridge, UK|page=305|access-date=2020-05-08|archive-date=2021-12-25|archive-url=https://web.archive.org/web/20211225042823/https://play.google.com/books/reader?id=kRMLAAAAIAAJ&printsec=frontcover&pg=GBS.PA309|url-status=live}}</ref>
|-
| [[Cocoliztli epidemic of 1576]]
| 1576–1580
| [[Viceroyalty of New Spain|Mexico]]
| [[Salmonella enterica|Possibly ''Salmonella enterica'']]
| data-sort-value="2250000" | 2–2.5 million (50% of population)
| <ref name="American plague" /><ref name="Acuna-SotoRomero2000" /><ref name="Acuna-SotoStahle2002" /><ref name=sal/>
|-
| [[1582 Tenerife plague epidemic]] (part of the [[second plague pandemic]])
| 1582–1583
| [[Tenerife]], [[Spanish Empire|Spain]]
| [[Bubonic plague]]
| data-sort-value="7000" | 5,000–9,000
|<ref>{{Cite web|url=https://www.museosdetenerife.org/assets/downloads/publication-f11acf7d04.pdf|title=Plague. The fourth horseman – Historic epidemics and their impact in Tenerife|language=es|page=28|access-date=15 May 2020|archive-date=25 February 2020|archive-url=https://web.archive.org/web/20200225131436/https://www.museosdetenerife.org/assets/downloads/publication-f11acf7d04.pdf|url-status=live}}</ref>
|-
| 1592–1596 Seneca nation measles epidemic
| 1592–1596
| [[Seneca nation]], North America
| [[Measles]]
| data-sort-value="0"|Unknown
| <ref>{{Cite web|url=http://www.kporterfield.com/aicttw/articles/disease.html|archive-url=https://web.archive.org/web/20150214060648/http://www.kporterfield.com/aicttw/articles/disease.html|url-status=dead|title=American Indian Epidemics|archive-date=February 14, 2015}}</ref>
|-
| [[1592–1593 Malta plague epidemic]] (part of the [[second plague pandemic]])
| 1592–1593
| [[Malta]]
| [[Bubonic plague]]
| data-sort-value="000003000" | 3,000
| <ref>{{cite news |title=Our Heritage Saved: St Roque Chapel |url=https://www.independent.com.mt/articles/2007-05-30/local-news/Our-Heritage-Saved:-St-Roque-Chapel-174165 |work=[[The Malta Independent]] |date=30 May 2007 |archive-url=https://web.archive.org/web/20200313042952/https://www.independent.com.mt/articles/2007-05-30/local-news/Our-Heritage-Saved:-St-Roque-Chapel-174165 |archive-date=13 March 2020}}</ref>
|-
| [[1592–1593 London plague]] (part of the [[second plague pandemic]])
| 1592–1593
| [[London]], England
| [[Bubonic plague]]
| data-sort-value="000019901" | 19,900+
| <ref>{{cite book |last=Creighton |first=Charles |author-link=Charles Creighton (physician) |date=November 1891 |title=A History of Epidemics in Britain: From A.D 664 to the Extinction of Plague |url=https://archive.org/stream/historyofepidemi01crei#page/350/mode/2up |location=Cambridge, UK |publisher=Cambridge University Press |pages=353–354}}</ref>
|-
| 1596–1602 Spain plague epidemic (part of the [[second plague pandemic]])
| 1596–1602
| [[Spanish Empire|Spain]]
| [[Bubonic plague]]
| data-sort-value="650000"| 600,000–700,000
| <ref>{{Cite web |url=http://libro.uca.edu/payne1/payne15.htm |title=A History of Spain |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20170327015606/http://libro.uca.edu/payne1/payne15.htm |archive-date=27 March 2017 |url-status=live}}</ref>
|-
| 1600–1650 South America malaria epidemic
| 1600–1650
| South America
| [[Malaria]]
| data-sort-value="0"|Unknown
|{{Citation needed|date=January 2021}}
|-
| [[1603 London plague]] (part of the [[second plague pandemic]])
| 1603
| [[London]], England
| [[Bubonic plague]]
| 40,000
|<ref>{{Cite web|url=https://us.macmillan.com/books/9781466864504|title=The Death of Queen Elizabeth I, the Return of the Black Plague, the Rise of Shakespeare, Piracy, Witchcraft, and the Birth of the Stuart Era|access-date=11 May 2020|archive-date=12 July 2021|archive-url=https://web.archive.org/web/20210712225740/https://us.macmillan.com/books/9781466864504|url-status=live}}</ref><ref>{{Cite web|url=http://www.shakespeare-online.com/biography/londondisease.html|title=Worst Diseases in Shakespeare's London|access-date=11 May 2020|archive-date=8 May 2020|archive-url=https://web.archive.org/web/20200508114250/http://www.shakespeare-online.com/biography/londondisease.html|url-status=live}}</ref><ref>Bell, Walter George (1951). Belinda Hollyer (ed.). The great Plague in London (folio society ed.). Folio society by arrangement with Random House. pp. 3–5</ref>
|-
| 1616 New England infections epidemic
| 1616–1620
| [[Southern New England]], [[British North America]], especially the [[Wampanoag people]]
| Unknown, possibly [[leptospirosis]] with [[Weil syndrome]]. Classic explanations include [[yellow fever]], [[bubonic plague]], [[influenza]], [[smallpox]], [[chickenpox]], [[typhus]], and [[syndemic]] infection of [[hepatitis B]] and [[hepatitis D]]
| data-sort-value="0"|1,143,000–3,429,000 (estimated 30–90% of population)
|<ref>{{Cite journal |last1=Marr |first1=John S. |last2=Cathey |first2=John T. |year=2010 |title=New Hypothesis for Cause of Epidemic among Native Americans, New England, 1616–1619 |journal=Emerging Infectious Diseases |volume=16 |issue=2 |pages=281–286 |doi=10.3201/eid1602.090276 |pmc=2957993 |pmid=20113559}}</ref><ref>{{Cite web |url=https://www.smithsonianmag.com/history/native-intelligence-109314481/ |title=Native intelligence |last=Mann |first=Charles C. |date=December 2005 |access-date=2018-10-17 |archive-url=https://web.archive.org/web/20181123170227/https://www.smithsonianmag.com/history/native-intelligence-109314481/ |archive-date=2018-11-23 |url-status=live}}</ref>
|-
| [[1629–1631 Italian plague]] (part of the [[second plague pandemic]])
| 1629–1631
| Italy
| [[Bubonic plague]]
| data-sort-value="1000000" | 1 million
| <ref name="Hays">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics their impacts on human history |last=Hays |first=J. N. |date=2005 |publisher=ABC-CLIO |isbn=978-1851096589 |location=Santa Barbara, CA|page=[https://archive.org/details/epidemicspandemi0000hays/page/103 103] |url-access=registration}}</ref>
|-
| 1632–1635 Augsburg plague epidemic (part of the [[second plague pandemic]])
| 1632–1635
| [[Augsburg]], [[Holy Roman Empire|Germany]]
| [[Bubonic plague]]
| 13,712
| <ref>{{Cite book|last1=Eckert|first1=Edward-A.|url=https://www.persee.fr/doc/adh_0066-2062_1978_num_1978_1_1378|title=Annales de Démographie Historique|page=55|date=1978|volume=1978|issue=1|doi=10.3406/adh.1978.1378|access-date=14 May 2020|archive-date=27 November 2020|archive-url=https://web.archive.org/web/20201127202244/https://www.persee.fr/doc/adh_0066-2062_1978_num_1978_1_1378|url-status=live}}</ref>
|-
| [[Massachusetts smallpox epidemic]]
| 1633–1634
| [[Massachusetts Bay Colony]], [[Thirteen Colonies]]
| [[Smallpox]]
| 1,000
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1633-34-smallpox-epidemic-new-england-natives-plymouth-colonists-ma-1000|title=1633–34 — Smallpox Epidemic, New England Natives, Plymouth Colonists, MA –>1000|website=usdeadlyevents.com|date=January 1632|access-date=13 May 2020|archive-date=8 September 2018|archive-url=https://web.archive.org/web/20180908083220/https://www.usdeadlyevents.com/1633-34-smallpox-epidemic-new-england-natives-plymouth-colonists-ma-1000|url-status=live}}</ref>
|-
| 1634–1640 Wyandot people epidemic
| 1634–1640
| [[Wyandot people]], North America
| [[Smallpox]] and [[Influenza]]
| data-sort-value="20000"|15,000–25,000
|<ref>{{cite book |last1=Johansen |first1=Bruce E. |title=American Indian Culture: From Counting Coup to Wampum [2 volumes]: From Counting Coup to Wampum |date=2015 |publisher=ABC-CLIO |isbn=978-1-4408-2874-4 |page=88 |url=https://books.google.com/books?id=mw-FCgAAQBAJ&q=wyandot+people++smallpox+1630&pg=PA88 |access-date=12 February 2020 |language=en |archive-date=6 January 2024 |archive-url=https://web.archive.org/web/20240106083412/https://books.google.com/books?id=mw-FCgAAQBAJ&q=wyandot+people++smallpox+1630&pg=PA88 |url-status=live }}</ref>
|-
| 1637 London plague epidemic (part of the [[second plague pandemic]])
| 1636–1637
| [[London]] and [[Westminster]], England
| [[Bubonic plague]]
| 10,400
|<ref>{{cite journal |last1=Newman |first1=Kira L. S.|title=Shutt up: bubonic plague and quarantine in early modern England|journal=Journal of Social History|date=2012|volume=45|issue=3|pages=809–834|doi=10.1093/jsh/shr114|jstor=41678910|pmid=22611587|s2cid=24952354|issn=0022-4529}}</ref>
|-
| [[Great Plague in the late Ming dynasty]] (part of the [[second plague pandemic]])
| 1633–1644
| [[Ming dynasty|China]]
| [[Bubonic plague]]
| data-sort-value="200000"|200,000+
| <ref name=":12">{{Cite journal|last=Ch'iu|first=Chung-lin|date=|title=The Epidemics in Ming Beijing and the Responses from the Empire's Public Health System|url=http://www.ihp.sinica.edu.tw/~bihp/75/75.2/chiu.htm|journal=中央研究院歷史語言研究所集刊|language=zh|volume=|pages=331–388|via=|access-date=2021-01-18|archive-date=2021-01-02|archive-url=https://web.archive.org/web/20210102130336/http://www.ihp.sinica.edu.tw/~bihp/75/75.2/chiu.htm|url-status=live}}</ref><ref name="Brook1999">{{Cite book |url=https://books.google.com/books?id=YuMcHWWbXqMC&pg=PA163 |title=The Confusions of Pleasure: Commerce and Culture in Ming China |last=Timothy Brook |publisher=University of California Press |year=1999 |isbn=978-0-520-22154-3 |page=163 |access-date=31 March 2011}}</ref>
|-
| [[Great Plague of Seville]] (part of the [[second plague pandemic]])
| 1647–1652
| [[Spanish Empire|Spain]]
| [[Bubonic plague]]
| 500,000
| <ref>[http://libro.uca.edu/payne1/payne15.htm Stanley G. Payne: A History of Spain and Portugal Volume 1, Ch 15 The Seventeenth-Century Decline] {{Webarchive|url=https://web.archive.org/web/20170327015606/http://libro.uca.edu/payne1/payne15.htm |date=2017-03-27 }} ''THE LIBRARY OF IBERIAN RESOURCES ONLINE'', accessed 26 May 2020</ref>
|-
| 1648 Central America yellow fever epidemic
| 1648
| [[Central America]]
| [[Yellow fever]]
| data-sort-value="0"|Unknown
| <ref>{{cite journal |last1=Rogers |first1=D.J. |last2=Wilson |first2=A.J. |last3=Hay |first3=S.I. |last4=Graham |first4=A.J. |title=The Global Distribution of Yellow Fever and Dengue |journal=Advances in Parasitology |date=2006 |volume=62 |pages=181–220 |doi=10.1016/S0065-308X(05)62006-4 |pmid=16647971 |pmc=3164798 |issn=0065-308X|isbn=9780120317622}}</ref>
|-
| [[Naples Plague (1656)|Naples Plague]] (part of the [[second plague pandemic]])
| 1656–1658
| Italy
| [[Bubonic plague]]
| data-sort-value="1250000"|1,250,000
| <ref>{{cite journal |last1=Scasciamacchia |first1=Silvia |last2=Serrecchia |first2=Luigina |last3=Giangrossi |first3=Luigi |last4=Garofolo |first4=Giuliano |last5=Balestrucci |first5=Antonio |last6=Sammartino |first6=Gilberto |last7=Fasanella |first7=Antonio |title=Plague Epidemic in the Kingdom of Naples, 1656–1658 |journal=Emerging Infectious Diseases |volume=18 |issue=1 |pages=186–188 |doi=10.3201/eid1801.110597 |pmid=22260781 |pmc=3310102 |language=en-us|year=2012}}</ref>
|-
| 1663–1664 Amsterdam plague epidemic (part of the [[second plague pandemic]])
| 1663–1664
| [[Amsterdam]], Netherlands
| [[Bubonic plague]]
| 24,148
|<ref>{{Cite web|url=https://www.amsterdam.nl/stadsarchief/stukken/rampen/pest|title=De pest|language=nl|date=23 April 2019|access-date=13 May 2020|archive-date=11 April 2020|archive-url=https://web.archive.org/web/20200411093301/https://www.amsterdam.nl/stadsarchief/stukken/rampen/pest/|url-status=live}}</ref>
|-
| [[Great Plague of London]] (part of the [[second plague pandemic]])
| 1665–1666
| England
| [[Bubonic plague]]
| data-sort-value="000100000" | 100,000
| <ref>{{Cite web |url=http://www.britainexpress.com/History/plague.htm |title=UK travel and heritage – Britain Express UK travel guide |last=Ross |first=David |website=The London Plague of 1665 |access-date=14 July 2011 |archive-url=https://web.archive.org/web/20190526192602/https://www.britainexpress.com/History/plague.htm |archive-date=26 May 2019 |url-status=live}}</ref><ref>{{Cite web |url=http://www.nationalarchives.gov.uk/education/resources/great-plague/ |title=Great Plague of 1665–1666 – The National Archives |last=Archives |first=The National |access-date=4 July 2016 |archive-url=https://web.archive.org/web/20160428020939/http://www.nationalarchives.gov.uk/education/resources/great-plague/ |archive-date=28 April 2016 |url-status=live}}</ref>
|-
| 1668 France plague (part of the [[second plague pandemic]])
| 1668
| [[Kingdom of France|France]]
| [[Bubonic plague]]
| 40,000
|<ref>{{cite journal |last1=Jones |first1=Colin |title=Plague and Its Metaphors in Early Modern France |journal=Representations |date=1996 |volume=53 |issue=53 |pages=97–127 |doi=10.2307/2928672 |issn=0734-6018|jstor=2928672}}</ref>
|-
| [[1675–1676 Malta plague epidemic]] (part of the [[second plague pandemic]])
| 1675–1676
| [[Malta]]
| [[Bubonic plague]]
| data-sort-value="000011300" | 11,300
| <ref>{{cite news |last1=Grima |first1=Noel |title=The 1676 plague in Malta |url=http://www.independent.com.mt/articles/2017-06-19/newspaper-lifestyleculture/The-1676-plague-in-Malta-6736175628 |work=[[The Malta Independent]] |date=19 June 2017 |archive-url=https://web.archive.org/web/20171112063500/http://www.independent.com.mt/articles/2017-06-19/newspaper-lifestyleculture/The-1676-plague-in-Malta-6736175628 |archive-date=12 November 2017}}</ref>
|-
| 1676–1685 Spain plague (part of the [[second plague pandemic]])
| 1676–1685
| Spain
| [[Bubonic plague]]
| data-sort-value="0"|Unknown
| <ref>{{cite book |last1=Casey |first1=James |title=Early Modern Spain: A Social History |date=1999 |publisher=Psychology Press |isbn=978-0-415-13813-0 |page=37 |url=https://books.google.com/books?id=mZJ8RnDhkgwC&q=plague+spain+1676&pg=PA37 |access-date=12 February 2020 |language=en |archive-date=6 January 2024 |archive-url=https://web.archive.org/web/20240106083413/https://books.google.com/books?id=mZJ8RnDhkgwC&q=plague+spain+1676&pg=PA37#v=snippet&q=plague%20spain%201676&f=false |url-status=live }}</ref>
|-
| 1677–1678 Boston smallpox epidemic
| 1677–1678
| [[Massachusetts Bay Colony]], [[British North America]]
| [[Smallpox]]
| data-sort-value="875" | 750–1,000
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1677-1678-smallpox-epidemic-massachusetts-bay-colony-esp-boston-vic-750-1000|title=1677–1678 — Smallpox Epidemic, Massachusetts Bay Colony, esp. Boston & vic. –750-1,000|website=usdeadlyevents|date=January 1676|access-date=17 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308180625/https://www.usdeadlyevents.com/1677-1678-smallpox-epidemic-massachusetts-bay-colony-esp-boston-vic-750-1000/|url-status=live}}</ref>
|-
| [[Great Plague of Vienna]] (part of the [[second plague pandemic]])
| 1679
| [[Vienna]], Austria
| [[Bubonic plague]]
| 76,000
| <ref name=EB1911>{{cite EB1911 |wstitle=Plague |volume=21 |page=696 |first=Joseph Frank |last=Payne}}</ref>
|-
| 1681 Prague plague epidemic (part of the [[second plague pandemic]])
| 1681
| [[Prague]], [[Czech Kingdom]]
| [[Bubonic plague]]
| 83,000
| <ref>{{Cite web|url=https://www.britannica.com/science/plague/History|title=Plague|website=britannica|access-date=14 May 2020|archive-date=16 January 2020|archive-url=https://web.archive.org/web/20200116154728/https://www.britannica.com/science/plague/History|url-status=live}}</ref>
|-
| 1687 South Africa influenza outbreak
| 1687
| [[Dutch Cape Colony|South Africa]]
| Unknown, possibly [[influenza]]
| data-sort-value="0"|Unknown
| <ref>History of South Africa 1486–1691, George McCall Theal, London, pub. Swan Sonnenschein, 1888. p. 332 ''"Towards the beginning of the winter of 1687 the colony was visited by a destructive disease, a kind of fever which carried off many of the inhabitants. The natives suffered very..."''</ref>
|-
| 1693 Boston yellow fever epidemic
| 1693
| [[Boston]], [[Massachusetts Bay Colony]], [[British North America]]
| [[Yellow fever]]
| data-sort-value="3100"|3,100+
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1693-june-17-start-yellow-fever-boston-british-fleet-arrival-from-martinique|title=1693 — June 17 start, Yellow Fever, Boston, British fleet arrival from Martinique[1]—<10?|date=17 June 1693|access-date=12 May 2020|archive-date=12 July 2021|archive-url=https://web.archive.org/web/20210712225707/https://www.usdeadlyevents.com/1693-june-17-start-yellow-fever-boston-british-fleet-arrival-from-martinique1/|url-status=live}}</ref>
|-
| 1699 Charleston and Philadelphia yellow fever epidemic
| 1699
| [[Charleston, West Virginia|Charleston]] and [[Philadelphia]], [[British North America]]
| [[Yellow fever]]
| data-sort-value="520"|520 (300 in Charleston, 220 in Philadelphia)
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1699-yellow-fever-epidemics-charleston-sc170-311-philadelphia-220-390-531|title=1699 — Yellow Fever Epidemics Charleston, SC(170–311); Philadelphia (220) –390 – 531|date=January 1699|access-date=12 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308200722/https://www.usdeadlyevents.com/1699-yellow-fever-epidemics-charleston-sc170-311-philadelphia-220-390-531/|url-status=live}}</ref>
|-
| 1702 New York City yellow fever epidemic
| 1702
| [[New York City]], [[British North America]]
| [[Yellow fever]]
| 500
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1702-summer-to-late-fall-yellow-fever-epidemic-new-york-city-ny-500-570|title=1702 — Summer to late Fall, Yellow Fever Epidemic, New York City, NY −500-570|date=June 1702|access-date=12 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308162546/https://www.usdeadlyevents.com/1702-summer-to-late-fall-yellow-fever-epidemic-new-york-city-ny-500-570/|url-status=live}}</ref>
|-
| 1702–1703 St. Lawrence Valley smallpox epidemic
| 1702–1703
| [[New France]], Canada
| [[Smallpox]]
| 1,300
| <ref>{{Cite journal |last=Desjardins |first=Bertrand |year=1996 |title=Demographic Aspects of the 1702–1703 Smallpox Epidemic in the St. Lawrence Valley |journal=Canadian Studies in Population |volume=23 |issue=1 |pages=49–67 |doi=10.25336/P6459C|doi-access=free }}</ref>
|-
| [[1707–08 Iceland smallpox epidemic|1707–1708 Iceland smallpox epidemic]]
| 1707–1709
| [[Iceland]]
| [[Smallpox]]
| data-sort-value="18001" | 18,000+ (36% of population)
| <ref name="Hays2005p131">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=131}}</ref>
|-
| [[Great Northern War plague outbreak]] (part of the [[second plague pandemic]])
| 1710–1712
| Denmark, Sweden, [[Lithuania]]
| [[Bubonic plague]]
| data-sort-value="164000" | 164,000
| <ref>{{cite book|last=Sticker|first=Georg|title=Die Pest|series=Abhandlungen aus der Seuchengeschichte und Seuchenlehre|volume=1|publisher=A. Töpelmann (vormals J. Ricker)|location=Gießen|year=1908|url=https://archive.org/details/abhandlungenausd01stic |page=213}}</ref><ref>{{cite web|last1=Kroll|first1=Stefan|last2=Grabinsky|first2=Anne|title=Städtesystem und Urbanisierung im Ostseeraum in der Neuzeit – Historisches Informationssystem und Analyse von Demografie, Wirtschaft und Baukultur im 17. und 18. Jahrhundert. B: Komplexe Historische Informationssysteme. B2: Der letzte Ausbruch der Pest im Ostseeraum zu Beginn des 18. Jahrhunderts. Chronologie des Seuchenzugs und Bestandsaufnahme überlieferter Sterbeziffern. Karte|url=https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Karte.html|publisher=[[University of Rostock]]|access-date=2012-08-14|archive-date=2007-07-03|archive-url=https://web.archive.org/web/20070703093729/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Karte.html|url-status=dead}}<br />Specific sections: [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Danzig.html Danzig] {{Webarchive|url=https://web.archive.org/web/20070703094255/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Danzig.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/K%C3%B6nigsberg.html Königsberg] {{Webarchive|url=https://web.archive.org/web/20070703094245/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/K%C3%B6nigsberg.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stettin.html Stettin] {{Webarchive|url=https://web.archive.org/web/20070703094226/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stettin.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Memel.html Memel] {{Webarchive|url=https://web.archive.org/web/20070703094352/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Memel.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Tilsit.html Tilsit] {{Webarchive|url=https://web.archive.org/web/20070703093928/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Tilsit.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Narva.html Narva] {{Webarchive|url=https://web.archive.org/web/20070703093952/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Narva.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stargard.html Stargard] {{Webarchive|url=https://web.archive.org/web/20070703094305/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stargard.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Riga.html Riga] {{Webarchive|url=https://web.archive.org/web/20070703094330/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Riga.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Pernau.html Pernau] {{Webarchive|url=https://web.archive.org/web/20070703094035/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Pernau.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Reval.html Reval] {{Webarchive|url=https://web.archive.org/web/20070703093830/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Reval.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stralsund.html Stralsund] {{Webarchive|url=https://web.archive.org/web/20070703093903/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stralsund.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stockholm.html Stockholm] {{Webarchive|url=https://web.archive.org/web/20070703094053/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Stockholm.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Visby.html Visby] {{Webarchive|url=https://web.archive.org/web/20070703093753/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Visby.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Linkoeping.html Linköping] {{Webarchive|url=https://web.archive.org/web/20070703094213/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Linkoeping.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Joenkoeping.html Jönköping] {{Webarchive|url=https://web.archive.org/web/20070703094314/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Joenkoeping.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Ystad.html Ystad] {{Webarchive|url=https://web.archive.org/web/20070703094013/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Ystad.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Malmoe.html Malmö] {{Webarchive|url=https://web.archive.org/web/20070703094157/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Malmoe.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Helsingoer.html Helsingør] {{Webarchive|url=https://web.archive.org/web/20070703093941/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Helsingoer.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Kopenhagen.html Kopenhagen] {{Webarchive|url=https://web.archive.org/web/20070703094108/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Kopenhagen.html |date=2007-07-03 }}; [https://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Hamburg.html Hamburg] {{Webarchive|url=https://web.archive.org/web/20070703094144/http://www.phf.uni-rostock.de/imd/Forschung/HomeMare2/Seuchenzug/Staedte/Hamburg.html |date=2007-07-03 }}</ref>
|-
| 1713–1715 North America measles epidemic
| 1713–1715
| [[Thirteen Colonies]] and [[New France]], Canada
| [[Measles]]
| data-sort-value="0"|Unknown
|<ref>{{cite journal |last1=Morens |first1=David M. |title=The Past Is Never Dead – Measles Epidemic, Boston, Massachusetts, 1713  |journal=Emerging Infectious Diseases |volume=21 |issue=7 |pages=1257–1260 |doi=10.3201/eid2107.150397 |pmid=26277799 |pmc=4480406 |language=en-us|year=2015}}</ref><ref>{{Cite journal |last1=Mazan |first1=Ryan |last2=Gagnon |first2=Alain |last3=Desjardins |first3=Bertrand |year=2009 |title=The Measles Epidemic of 1714–1715 in New France |journal=Canadian Studies in Population |volume=36 |issue=3–4 |pages=295–323 |doi=10.25336/P63P5Q|doi-access=free }}</ref>
|-
| [[Great Plague of Marseille]] (part of the [[second plague pandemic]])
| 1720–1722
| France
| [[Bubonic plague]]
| data-sort-value="100001" | 100,000+
| <ref>{{Cite journal |last=Devaux |first=Christian A. |year=2013 |title=Small oversights that led to the Great Plague of Marseille (1720–1723): Lessons from the past |journal=Infection, Genetics and Evolution |volume=14 |pages=169–185 |doi=10.1016/j.meegid.2012.11.016 |pmid=23246639|bibcode=2013InfGE..14..169D }}</ref>
|-
| [[1721 Boston smallpox outbreak]]
| 1721–1722
| [[Massachusetts Bay Colony]]
| [[Smallpox]]
| 844
| <ref>{{Cite web |url=http://www.todayinsci.com/B/Boylston_Zabdiel/Boylston_Zabdiel.htm |title=Zabdiel Boylston and inoculation |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20150905143618/http://www.todayinsci.com/B/Boylston_Zabdiel/Boylston_Zabdiel.htm |archive-date=5 September 2015 |url-status=live}}</ref>
|-
| 1730 Cádiz yellow fever epidemic
| 1730
| [[Cádiz]], Spain
| [[Yellow fever]]
| 2,200
| <ref>{{Cite news|url=https://www.npr.org/sections/goatsandsoda/2016/08/28/491471697/yellow-fever-timeline-the-history-of-a-long-misunderstood-disease|title=Yellow Fever Timeline: The History Of A Long Misunderstood Disease|newspaper=NPR|date=28 August 2016|access-date=12 May 2020|last1=Brink|first1=Susan|archive-date=28 May 2020|archive-url=https://web.archive.org/web/20200528200648/https://www.npr.org/sections/goatsandsoda/2016/08/28/491471697/yellow-fever-timeline-the-history-of-a-long-misunderstood-disease|url-status=live}}</ref>
|-
| 1732–1733 Thirteen Colonies influenza epidemic
| 1732–1733
| [[Thirteen Colonies]]
| [[Influenza]]
| data-sort-value="0"|Unknown
| <ref name="TurningPoints">{{Cite web |url=http://www.ambrosevideo.com/items.cfm?id=1071 |title=Ambrosevideo.com |access-date=2011-03-27 |archive-url=https://web.archive.org/web/20160417075306/http://www.ambrosevideo.com/items.cfm?id=1071 |archive-date=2016-04-17 |url-status=live}}</ref>
|-
| 1733 New France smallpox epidemic
| 1733
| [[New France]], Canada
| [[Smallpox]]
| data-sort-value="0"|Unknown
| <ref>{{Cite journal |last1=Gagnon |first1=Alain |last2=Mazan |first2=Ryan |year=2009 |title=Does exposure to infectious diseases in infancy affect old-age mortality? Evidence from a pre-industrial population |journal=Social Science & Medicine |volume=68 |issue=9 |pages=1609–1616 |doi=10.1016/j.socscimed.2009.02.008 |pmid=19269727}}</ref>
|-
| 1735–1741 diphtheria epidemic
| 1735–1741
| [[New England]], [[Province of New York]], [[Province of New Jersey]], [[British North America]]
| [[Diphtheria]]
| 20,000
| <ref>{{Cite book|last=Purvis|first=Thomas L.|url=https://books.google.com/books?id=BZRJSx3uMYEC&q=1687+thirteen+colonies+++measles&pg=PA173|title=Colonial America To 1763|page=173|date=2014|publisher=Infobase|isbn=9781438107998|access-date=17 May 2020|archive-date=6 January 2024|archive-url=https://web.archive.org/web/20240106083406/https://books.google.com/books?id=BZRJSx3uMYEC&q=1687+thirteen+colonies+++measles&pg=PA173#v=snippet&q=1687%20thirteen%20colonies%20%20%20measles&f=false|url-status=live}}</ref>
|-
| [[Great Plague of 1738]] (part of the [[second plague pandemic]])
| 1738
| [[Balkans]]
| [[Bubonic plague]]
| data-sort-value="50000" | 50,000
| <ref>{{cite web|url=http://www.genealogy.ro/cont/20c.htm|title=Banat's historical chronology for the last millennium- XVIII Century|website=www.genealogy.ro|publisher=Genealogy RO Group|access-date=26 May 2020|archive-date=4 June 2002|archive-url=https://web.archive.org/web/20020604232916/http://www.genealogy.ro/cont/20c.htm|url-status=live}}</ref>
|-
| [[1738–1739 North Carolina smallpox epidemic]]
| 1738–1739
| [[Province of Carolina]], [[Thirteen Colonies]]
| [[Smallpox]]
| data-sort-value="10,000" | 7,700–11,700
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1738-39-smallpox-catawba-ncsc-and-cherokee-natives-nc-7700-11700|title=1738–39 — Smallpox, Catawba (NC/SC) and Cherokee Natives (NC) –7,700–11,700|website=usdeadlyevents.com|date=January 1738|access-date=13 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308221130/https://www.usdeadlyevents.com/1738-39-smallpox-catawba-ncsc-and-cherokee-natives-nc-7700-11700/|url-status=live}}</ref>
|-
| 1741 Cartagena yellow fever epidemic
| 1741
| [[Cartagena, Colombia|Cartagena]], [[Colombia]]
| [[Yellow fever]]
| data-sort-value="20,000" | 20,000
| <ref name="Thomas Jefferson University">{{Cite web|url=https://jdc.jefferson.edu/cgi/viewcontent.cgi?referer=https://www.ecosia.org/&httpsredir=1&article=1004&context=yellow_fever_symposium|title=The Early History of Yellow Fever|publisher=Thomas Jefferson University|page=3|website=jdc.jefferson.edu|date=September 2009|access-date=16 May 2020|archive-date=6 January 2024|archive-url=https://web.archive.org/web/20240106083407/https://jdc.jefferson.edu/cgi/viewcontent.cgi?referer=https://www.ecosia.org/&httpsredir=1&article=1004&context=yellow_fever_symposium|url-status=live}}</ref>
|-
| 1743 Sicily plague epidemic (part of the [[second plague pandemic]])
| 1743
| [[Messina]], [[Sicily]], Italy
| [[Bubonic plague]]
| data-sort-value="45,000" | 40,000–50,000
| <ref>{{cite journal |last1=Tognotti |first1=Eugenia |title=Lessons from the History of Quarantine, from Plague to Influenza A|journal=Emerging Infectious Diseases |date=February 2013 |volume=19 |issue=2 |pages=254–259 |doi=10.3201/eid1902.120312 |pmid=23343512 |pmc=3559034 |language=en-us}}</ref><ref>{{cite journal |last1=Wyman|first1=Walter|title=The North American Review|journal=The Black Plague|date=April 1897|volume=164|issue=485|page=442|publisher=University of Northern Iowa|jstor=25118799}}</ref>
|-
| 1759 North America measles outbreak
| 1759
| North America
| [[Measles]]
| data-sort-value="0"|Unknown
| <ref>{{cite book |last1=LeMay |first1=Michael C. |title=Global Pandemic Threats: A Reference Handbook: A Reference Handbook |date=2016 |publisher=ABC-CLIO |isbn=978-1-4408-4283-2 |page=227 |url=https://books.google.com/books?id=_UzODAAAQBAJ&q=1759++measles++north++america&pg=PA227 |access-date=12 February 2020 |language=en |archive-date=6 January 2024 |archive-url=https://web.archive.org/web/20240106083406/https://books.google.com/books?id=_UzODAAAQBAJ&q=1759++measles++north++america&pg=PA227 |url-status=live }}</ref>
|-
| 1760 Charleston smallpox epidemic
| 1760
| [[Charleston, South Carolina|Charleston]], [[British North America]]
| [[Smallpox]]
| data-sort-value="800" | 730–940
| <ref>{{cite journal |last1=Krebsbach |first1=Suzanne |title=The Great Charlestown Smallpox Epidemic of 1760 |journal=The South Carolina Historical Magazine |date=1996 |volume=97 |issue=1 |pages=30–37 |issn=0038-3082|jstor=27570134}}</ref><ref>{{Cite web|url=https://www.usdeadlyevents.com/1760-smallpox-epidemic-charleston-sc-as-well-as-undocumented-native-deaths-730-940|title=1760 — Smallpox Epidemic, Charleston, SC (as well as undocumented Native deaths)–730-940|website=usdeadlyevents.com|date=January 1760|access-date=13 May 2020|archive-date=9 March 2021|archive-url=https://web.archive.org/web/20210309021326/https://www.usdeadlyevents.com/1760-smallpox-epidemic-charleston-sc-as-well-as-undocumented-native-deaths-730-940/|url-status=live}}</ref>
|-
| 1762 Havana yellow fever epidemic
| 1762
| [[Havana]], [[Captaincy General of Cuba|Cuba]]
| [[Yellow fever]]
| data-sort-value="8,000" | 8,000
| <ref name="Thomas Jefferson University"/>
|-
| 1763 Pittsburgh area smallpox outbreak
| 1763
| North America, present-day [[Pittsburgh]] area
| [[Smallpox]]
| data-sort-value="0"|Unknown
| <ref>{{cite journal |last1=Ranlet |first1=Philip |title=The British, the Indians, and Smallpox: What Actually Happened at Fort Pitt in 1763? |journal=Pennsylvania History: A Journal of Mid-Atlantic Studies |date=2000 |volume=67 |issue=3 |pages=427–441 |issn=0031-4528|jstor=27774278}}</ref>
|-
| [[1770–1772 Russian plague]] (part of the [[second plague pandemic]])
| 1770–1772
| [[Russian Empire|Russia]]
| [[Bubonic plague]]
| data-sort-value="50000" | 50,000
| <ref>{{cite journal | last=Melikishvili | first=Alexander | s2cid=7420734 | year=2006 | volume=36 | pages=19–31 | journal=Critical Reviews in Microbiology | title=Genesis of the anti-plague system: the Tsarist period | issue=1 | url=http://cns.miis.edu/antiplague/pdfs/melikishvili.pdf | doi=10.1080/10408410500496763 | citeseerx=10.1.1.204.1976 | pmid=16610335 | access-date=2020-05-26 | archive-date=2009-11-23 | archive-url=https://web.archive.org/web/20091123034404/http://cns.miis.edu/antiplague/pdfs/melikishvili.pdf | url-status=live }}</ref>
|-
| 1772 North America measles epidemic
| 1772
| North America
| [[Measles]]
| data-sort-value="1080"|1,080
| <ref>{{cite web|url=https://www.usdeadlyevents.com/1772-measles-epidemics-charleston-sc-800-900-philadelphia-pa-180-980-1080|title=1772 — Measles Epidemics, Charleston, SC (800–900), Philadelphia, PA (180) –980-1,080|website=usdeadlyevents.com|date=January 1772|access-date=14 January 2021|archive-date=22 January 2021|archive-url=https://web.archive.org/web/20210122034326/https://www.usdeadlyevents.com/1772-measles-epidemics-charleston-sc-800-900-philadelphia-pa-180-980-1080/|url-status=live}}</ref>
|-
| [[1772–1773 Persian Plague]] (part of the [[second plague pandemic]])
| data-sort-value="1772" | 1772–1773
| [[Afsharid Empire|Persia]]
| [[Bubonic plague]]
| data-sort-value="02000001" | 2 million
| <ref name="Shahraki">{{cite journal | pmc=5037359 | pmid=27457063 | doi=10.4178/epih.e2016033 | volume=38 | title=Plague in Iran: its history and current status | year=2016 | author1=Hashemi Shahraki A | author2=Carniel E  | author3=Mostafavi E | journal=Epidemiol Health | page=e2016033}}</ref>
|-
| 1775–1776 England influenza outbreak
| 1775–1776
| England
| [[Influenza]]
| data-sort-value="0"|Unknown
| <ref name="Lancet">{{Cite journal |last1=Prichard |first1=Augustin |last2=Fothergill |first2=John |year=1894 |title=Influenza in 1775 |url=https://zenodo.org/record/1663344 |journal=The Lancet |volume=143 |issue=3673 |pages=175–176 |doi=10.1016/S0140-6736(01)66026-4 |access-date=2019-07-05 |archive-url=https://web.archive.org/web/20200103214437/https://zenodo.org/record/1663344 |archive-date=2020-01-03 |url-status=live}}</ref>
|-
| [[1775–1782 North American smallpox epidemic]]
| 1775–1782
| Native populations in what is now the [[Pacific Northwest]] of the United States
| [[Smallpox]]
| 11,000+
| <ref>Greg Lange,[http://www.historylink.org/essays/output.cfm?file_id=5100 "Smallpox epidemic ravages Native Americans on the northwest coast of North America in the 1770s"] {{Webarchive|url=https://web.archive.org/web/20080526181907/http://www.historylink.org/essays/output.cfm?file_id=5100 |date=2008-05-26}}, 23 Jan 2003, HistoryLink.org, ''Online Encyclopedia of Washington State History'', accessed 2 Jun 2008</ref><ref>{{Cite journal |last1=Houston |first1=C. S. |last2=Houston |first2=S. |year=2000 |title=The first smallpox epidemic on the Canadian Plains: In the fur-traders' words |journal=The Canadian Journal of Infectious Diseases |volume=11 |issue=2 |pages=112–115 |doi=10.1155/2000/782978 |pmc=2094753 |pmid=18159275|doi-access=free }}</ref>
|-
| 1778 Spain dengue fever outbreak
| 1778
| Spain
| [[Dengue fever]]
| data-sort-value="0"|Unknown
|<ref>{{cite book |last1=Rohé |first1=George Henry |last2=Robin |first2=Albert |title=Text-book of Hygiene: A Comprehensive Treatise on the Principles and Practice of Preventive Medicine from an American Standpoint |date=1908 |publisher=Davis |page=[https://archive.org/details/textbookhygiene00robigoog/page/n450 428] |url=https://archive.org/details/textbookhygiene00robigoog |quote=spain 1788 dengue fever. |access-date=12 February 2020 |language=en}}</ref>
|-
|[[1782 Influenza pandemic]]
|1782
|Worldwide
|[[Influenza]]
|Unknown
|
|-
| 1788 Pueblo Indians smallpox epidemic
| 1788
| [[Pueblo Indians]] in northern [[New Spain]] (what is now the [[Southwestern United States]])
| [[Smallpox]]
| data-sort-value="0"|Unknown
| <ref>{{cite book |last1=Waldman |first1=Carl |last2=Braun |first2=Molly |title=Atlas of the North American Indian |date=2009 |publisher=Infobase Publishing |isbn=978-1-4381-2671-5 |page=295 |url=https://books.google.com/books?id=P2HKD9PgC6wC&q=pueblo+indian+1788+smallpox&pg=PA295 |access-date=12 February 2020 |language=en |archive-date=6 January 2024 |archive-url=https://web.archive.org/web/20240106083427/https://books.google.com/books?id=P2HKD9PgC6wC&q=pueblo+indian+1788+smallpox&pg=PA295#v=snippet&q=pueblo%20indian%201788%20smallpox&f=false |url-status=live }}</ref>
|-
| 1789–1790 New South Wales smallpox epidemic
| 1789–1790
| [[New South Wales, Australia|New South Wales]], Australia
| [[Smallpox]]
| data-sort-value="0"|125,251–175,351 (50–70% of native population)
| <ref>''The History of Small-Pox in Australia, 1788–1908'', JHL Cumpston, (1914, Government Printer, Melb.)This epidemic is unlikely to have been a natural event. see, Warren (2013) {{doi|10.1080/14443058.2013.849750}} [http://www.ahc.org.au/history/history.html After Cook and coinciding with Colonisation] ''"With the arrival of the Europeans, the Gadigal population was virtually wiped. In 1789 and 1790 a smallpox epidemic swept through the Aboriginal population around Sydney"'' {{Webarchive|url=https://web.archive.org/web/20080625020532/http://www.ahc.org.au/history/history.html |date=2008-06-25}}</ref><ref>{{Cite web|url=https://www.thefreelibrary.com/The+origin+of+the+smallpox+outbreak+in+Sydney+in+1789.-a0180278188|title=The origin of the smallpox outbreak in Sydney in 1789.|website=thefreelibrary|access-date=14 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308133246/https://www.thefreelibrary.com/The+origin+of+the+smallpox+outbreak+in+Sydney+in+1789.-a0180278188|url-status=dead}}</ref>
|-
| [[1793 Philadelphia yellow fever epidemic]]
| 1793
| [[Philadelphia]], United States
| [[Yellow fever]]
| data-sort-value="5000"|5,000+
| <ref>{{Cite web |url=http://www.libby-genealogy.com/epidemics.htm |title=Epidemics |access-date=2008-06-08 |archive-url=https://web.archive.org/web/20130722144136/http://www.libby-genealogy.com/epidemics.htm |archive-date=2013-07-22 |url-status=live}}</ref>
|-
| 1800–1803 Spain yellow fever epidemic
| 1800–1803
| Spain
| [[Yellow fever]]
| data-sort-value="60001"|60,000+
| <ref>{{Cite web |url=http://www.iberianature.com/material/tigermosquito.htm |title=Tiger mosquitoes and the history of yellow fever and dengue in Spain |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20170804192609/http://www.iberianature.com/material/tigermosquito.htm |archive-date=4 August 2017 |url-status=live}}</ref>
|-
| 1801 Ottoman Empire and Egypt bubonic plague epidemic
| 1801
| [[Ottoman Empire]], [[Egypt]]
| [[Bubonic plague]]
| data-sort-value="0"|Unknown
| <ref name="Davidson1893">{{Cite book |url=https://archive.org/details/b21912245 |title=Hygiene & diseases of warm climates |last=Andrew Davidson |publisher=Pentland |year=1893 |page=[https://archive.org/details/b21912245/page/337 337] |access-date=31 March 2011}}</ref>
|-
| 1802–1803 Saint-Domingue yellow fever epidemic
| 1802–1803
| [[Saint-Domingue]]
| [[Yellow fever]]
| data-sort-value="42000"|29,000–55,000
| <ref name= "medicina">{{Cite web|url=http://s2.medicina.uady.mx/observatorio/docs/er/ac/RE2013_Ac_Marr.pdf|title=The 1802 Saint-Domingue Yellow Fever Epidemic and the Louisiana Purchase (page 78)|date=2013|access-date=12 May 2020|archive-url=https://web.archive.org/web/20160204181607/http://s2.medicina.uady.mx/observatorio/docs/er/ac/RE2013_Ac_Marr.pdf|archive-date=4 February 2016|url-status=dead}}</ref>
|-
| 1812 Russia typhus epidemic
| 1812
| [[Russian Empire|Russia]]
| [[Typhus]]
| 300,000
| <ref name="Typhus, War, and Vaccines"/>
|-
| [[1812–1819 Ottoman plague epidemic]] (part of the [[second plague pandemic]])
| 1812–1819
| [[Ottoman Empire]]
| [[Bubonic plague]]
| data-sort-value="300,001"| 300,000+
| <ref>{{cite web |last1=Lynch |first1=Lily |title=Odessa, 1812: Plague and Tyranny at the Edge of the Empire |url=https://balkanist.net/plague-and-political-tyranny-odessa/ |website=Balkanist |archive-url=https://web.archive.org/web/20200213021356/https://balkanist.net/plague-and-political-tyranny-odessa/ |archive-date=13 February 2020 |date=5 December 2015}}</ref>
|-
| [[1813–1814 Malta plague epidemic]] (part of the [[second plague pandemic]])
| 1813–1814
| [[Malta]]
| [[Bubonic plague]]
| 4,500
| <ref>{{cite news |last1=Mangion |first1=Fabian |title=Maltese islands devastated by a deadly epidemic 200 years ago |url=https://timesofmalta.com/articles/view/maltese-islands-devastated-by-a-deadly-epidemic-200-years-ago.470542 |work=[[Times of Malta]] |date=19 May 2013 |access-date=28 May 2020 |archive-url=https://web.archive.org/web/20200312144053/https://timesofmalta.com/articles/view/maltese-islands-devastated-by-a-deadly-epidemic-200-years-ago.470542 |archive-date=12 March 2020}}</ref>
|-
| [[Caragea's plague]] (part of the [[second plague pandemic]])
| 1813
| [[Moldavia|Romania]]
| [[Bubonic plague]]
| 60,000
| <ref>Ştefan Ionescu, Bucureştii în vremea fanarioţilor (Bucharest in the time of the Phanariotes), Editura Dacia, Cluj, 1974. p. 287-293</ref>
|-
| 1817–1819 Ireland typhus epidemic
| 1817–1819
| Ireland
| [[Typhus]]
| 65,000
| <ref>{{Cite journal |title=Typhus Epidemic in Ireland, 1817–1819: Priests, Ministers, Doctors|journal=Collectanea Hibernica|volume=41|pages=117–152|date=1999|jstor=30004680|last1=Fenning|first1=Hugh|issue=41}}</ref>
|-
| [[First cholera pandemic]]
| 1817–1824
| Asia, Europe
| [[Cholera]]
| data-sort-value="100,001"| 100,000+
| <ref name="Hays2005p193">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=193}}</ref>
|-
| 1820 Savannah yellow fever epidemic
| 1820
| [[Savannah, Georgia]], United States
| [[Yellow fever]]
| 700
| <ref>{{cite web|url=http://projects.leadr.msu.edu/youngamerica/exhibits/show/the-autumnal-fever|title=The Autumnal Fever: The Outbreak of the Yellow Fever in Savannah, Georgia in 1820|website=projects.leadr.msu.edu|access-date=12 May 2020|archive-date=24 February 2021|archive-url=https://web.archive.org/web/20210224231705/http://projects.leadr.msu.edu/youngamerica/exhibits/show/the-autumnal-fever|url-status=dead}}</ref>
|-
| 1821 Barcelona yellow fever epidemic
| 1821
| [[Barcelona]], Spain
| [[Yellow fever]]
| data-sort-value="12500"|5,000–20,000
| <ref name=Britannica>{{cite EB1911 |wstitle=Yellow Fever |volume=28 |pages=910–911}}</ref><ref>{{cite web|url=https://iberianature.com/barcelona/tag/yellow-fever-in-spain|title=Yellow fever in Barcelona|date=14 May 2009|access-date=12 May 2020|archive-date=10 March 2021|archive-url=https://web.archive.org/web/20210310023131/https://iberianature.com/barcelona/tag/yellow-fever-in-spain/|url-status=live}}</ref>
|-
| [[Second cholera pandemic]]
| 1826–1837
| Asia, Europe, North America
| [[Cholera]]
| data-sort-value="100,001"| 100,000+
| <ref name=Hays2005p211>{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=211}}</ref>
|-
| 1828–1829 New South Wales smallpox epidemic
| 1828–1829
| [[New South Wales]], Australia
| [[Smallpox]]
| 19,000
| <ref>{{Cite web |url=http://www.scu.edu.au/schools/gcm/ar/arr/arow/hgkr.html |title=Aboriginal Health History |url-status=dead |archive-url=https://web.archive.org/web/20110927104026/http://www.scu.edu.au/schools/gcm/ar/arr/arow/hgkr.html |archive-date=27 September 2011 |access-date=16 November 2014 |df=dmy-all}}</ref><ref>{{Cite web|url=https://candobetter.net/node/3720|title=The smallpox holocaust that swept Aboriginal Australia – Red hot echidna spikes are burning me|website=candobetter|access-date=14 May 2020|archive-date=3 August 2020|archive-url=https://web.archive.org/web/20200803113510/https://candobetter.net/node/3720|url-status=live}}</ref>
|-
| [[Groningen epidemic]]
| 1829
| Netherlands
| [[Malaria]]
| 2,800
| <ref>{{Cite web|url=https://www.rtvnoord.nl/nieuws/220326/Epidemieen-in-Groningen-De-Groninger-ziekte-1826|title=Epidemieën in Groningen: De Groninger ziekte (1826)|language=nl|website=rtvnoord|date=22 March 2020|access-date=18 April 2020|archive-date=1 April 2020|archive-url=https://web.archive.org/web/20200401142325/https://www.rtvnoord.nl/nieuws/220326/Epidemieen-in-Groningen-De-Groninger-ziekte-1826|url-status=live}}</ref>
|-
| 1829–1833 Pacific Northwest malaria epidemic
| 1829–1833
| [[Pacific Northwest]], United States
| [[Malaria]], possibly other diseases too
| 150,000
| <ref>{{Cite web|url=https://raogk.org/encyclopedia/epidemics|title=A Listing Of Some Worldwide Epidemics|website=raogk|date=16 June 2015|access-date=18 May 2020|archive-date=14 March 2020|archive-url=https://web.archive.org/web/20200314110813/https://raogk.org/encyclopedia/epidemics/|url-status=live}}</ref><ref>{{Cite web|url=https://oregonencyclopedia.org/articles/disease_epidemics_1770s-1850s|title=Disease Epidemics among Indians, 1770s–1850s (essay)|website=oregonencyclopedia|access-date=18 April 2020|archive-date=24 March 2020|archive-url=https://web.archive.org/web/20200324092729/https://oregonencyclopedia.org/articles/disease_epidemics_1770s-1850s/|url-status=live}}</ref>
|-
| 1829–1835 Iran plague outbreak
| 1829–1835
| [[Iran]]
| [[Bubonic plague]]
| data-sort-value="0"|Unknown
| <ref>[http://www.ams.ac.ir/aim/010136/0022.htm A History of the Human Plague in Iran] {{webarchive|url=https://web.archive.org/web/20110719081147/http://www.ams.ac.ir/aim/010136/0022.htm |date=2011-07-19}}, Mohammad Azizi, Farzaneh Azizi</ref>
|-
| 1834–1836 Egypt plague epidemic
| 1834–1836
| [[Egypt]]
| [[Bubonic plague]]
| data-sort-value="0"|Unknown
| <ref name="Kuhnke">Kuhnke, Laverne. ''Lives at Risk: Public Health in Nineteenth-Century Egypt.'' [http://ark.cdlib.org/ark:/13030/ft5t1nb3mq/ ark.cdlib.org] {{Webarchive|url=https://web.archive.org/web/20081120024817/http://ark.cdlib.org/ark:/13030/ft5t1nb3mq/ |date=2008-11-20}}, Berkeley: University of California Press, c1990.</ref>
|-
| [[1837 Great Plains smallpox epidemic]]
| 1837–1838
| [[Great Plains]], United States and Canada
| [[Smallpox]]
| data-sort-value="17,001"| 17,000+
| <ref>{{Cite web |url=https://www.nlm.nih.gov/nativevoices/timeline/293.html |title=Smallpox decimates tribes; survivors join together – Timeline – Native Voices |website=www.nlm.nih.gov |access-date=4 July 2016 |archive-url=https://web.archive.org/web/20160816170039/https://www.nlm.nih.gov/nativevoices/timeline/293.html |archive-date=16 August 2016 |url-status=live}}</ref>
|-
| 1841 Southern United States yellow fever epidemic
| 1841
| [[Southern United States]] (especially [[Louisiana]] and [[Florida]])
| [[Yellow fever]]
| 3,498
| <ref>{{Cite web|url=https://www.usdeadlyevents.com/1841-yellow-fever-esp-fl-la-esp-new-orleans-also-vicksburg-charleston-3498|title=1841 — Yellow Fever, esp. FL & LA, esp. New Orleans, also Vicksburg, Charleston −3,498|website=usdeadlyevents.com|date=January 1840|access-date=12 May 2020|archive-date=8 March 2021|archive-url=https://web.archive.org/web/20210308205739/https://www.usdeadlyevents.com/1841-yellow-fever-esp-fl-la-esp-new-orleans-also-vicksburg-charleston-3498/|url-status=live}}</ref>
|-
| [[1847 North American typhus epidemic]]
| 1847–1848
| Canada
| [[Typhus]]
| data-sort-value="20,001"|20,000+
|<ref name="CCHA">{{Cite journal |last=Gallagher |first=The Reverend John A. |year=1936 |title=The Irish Emigration of 1847 and Its Canadian Consequences |url=http://www.umanitoba.ca/colleges/st_pauls/ccha/Back%20Issues/CCHA1935-36/Gallagher.html |journal=Canadian Catholic Historical Association Report, University of Manitoba Web Site |access-date=2008-03-23 |archive-url=https://web.archive.org/web/20071011072535/http://umanitoba.ca/colleges/st_pauls/ccha/Back%20Issues/CCHA1935-36/Gallagher.html |archive-date=2007-10-11 |url-status=live}}</ref>
|-
| 1847 Southern United States yellow fever epidemic
| 1847
| [[Southern United States]] (especially [[New Orleans]])
| [[Yellow fever]]
| 3,400
| <ref>{{Cite web |url=https://www.usdeadlyevents.com/1847-yellow-fever-esp-new-orleans-also-galveston-mobile-pensacola-vicksburg-3400 |title=1847 –Yellow Fever, esp. New Orleans, also Galveston, Mobile, Pensacola, Vicksburg >3,400|website=usdeadlyevents.com|date=January 1846|access-date=12 May 2020|archive-date=9 March 2021|archive-url=https://web.archive.org/web/20210309030710/https://www.usdeadlyevents.com/1847-yellow-fever-esp-new-orleans-also-galveston-mobile-pensacola-vicksburg-3400/|url-status=live}}</ref>
|-
| 1847–1848 influenza epidemic
| 1847–1848
| Worldwide
| [[Influenza]]
| data-sort-value="0"|Unknown
| <ref name="AJAMA">{{cite journal |year=1849 |title=On the Influenza, or Epidemic Catarrhal Fever of 1847–8 |journal=The American Journal of the Medical Sciences |volume=18 |issue=35 |pages=148–154 |doi=10.1097/00000441-184907000-00018 |pmc=5277660|last1=a s |first1=&NA }}</ref>
|-
| 1848–1849 Hawaii epidemic of infections
| 1848–1849
| [[Hawaiian Kingdom]]
| [[Measles]], [[whooping cough]], [[dysentery]] and [[influenza]]
| 10,000
| <ref>{{cite journal |last1=Schmitt |first1=Robert C. |last2=Nordyke |first2=Eleanor C. |title=Death in Hawai'i: the Epidemics of 1848 – 1849 |journal=Hawaiian Journal of History |date=2001 |volume=35 |hdl=10524/339 }}</ref>
|-
| 1853 New Orleans yellow fever epidemic
| 1853
| [[New Orleans]], United States
| [[Yellow fever]]
| 7,970
| <ref name=Britannica/>
|-
| [[Third cholera pandemic]]
| 1846–1860
| Worldwide
| [[Cholera]]
| data-sort-value="01000001"|1 million+
| <ref name="Hays2005p236">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=236}}</ref>
|-
| 1853 Ottoman Empire plague epidemic
| 1853
| [[Ottoman Empire]]
| [[Bubonic plague]]
| data-sort-value="0"|Unknown
| <ref name="Practitioner">{{Cite book |url=https://books.google.com/books?id=cWUCAAAAYAAJ |title=Practitioner |year=1877 |access-date=29 March 2011}}</ref>
|-
| [[1853 Copenhagen cholera outbreak]]
| 1853
| [[Copenhagen]], Denmark
| [[Cholera]]
| 4,737
| <ref>{{Cite web|url=http://wayback-01.kb.dk/wayback/20100504134515/http://www2.kb.dk/udstillinger/medhist/kolera/efterhistorien.html|archiveurl=https://web.archive.org/web/20150103085703/http://wayback-01.kb.dk/wayback/20100504134515/http://www2.kb.dk/udstillinger/medhist/kolera/efterhistorien.html|url-status=dead|title=Efterhistorien|archivedate=January 3, 2015|website=wayback-01.kb.dk}}</ref>
|-
| [[1854 Broad Street cholera outbreak]]
| 1854
| [[London]], England
| [[Cholera]]
| 616
| <ref name="Snow1855">{{Cite book |url=https://archive.org/details/b28985266 |title=On the mode of communication of cholera |last=John Snow |publisher=John Churchill |year=1855 |access-date=29 March 2011}}</ref>
|-
| 1855 Norfolk yellow fever epidemic
| 1855
| [[Norfolk]] and [[Portsmouth]], England
| [[Yellow fever]]
| 3,000 (2,000 in Norfolk, 1,000 in Portsmouth)
| <ref>{{Cite web|url=https://www.historicforrest.com/norfolkHistoricalSociety/insights/2005_summer/epidemic.html|title=Norfolk's Yellow Fever Epidemic of 1855|publisher=historicforrest.com|access-date=9 May 2020|archive-date=25 June 2020|archive-url=https://web.archive.org/web/20200625155137/https://www.historicforrest.com/norfolkHistoricalSociety/insights/2005_summer/epidemic.html|url-status=live}}</ref>
|-
| [[Third plague pandemic]]
| 1855–1960
| Worldwide
| [[Bubonic plague]]
| data-sort-value="12,000,010"| 12–15 million (India and China)
| <ref>{{Cite journal|last=Pryor|first=E. G.|title=The Great Plague of Hong Kong|date=1975|url=https://www.jstor.org/stable/23881624|journal=Journal of the Hong Kong Branch of the Royal Asiatic Society|volume=15|pages=61–70|jstor=23881624|pmid=11614750|issn=0085-5774|access-date=2021-05-25|archive-date=2023-02-14|archive-url=https://web.archive.org/web/20230214191621/https://www.jstor.org/stable/23881624|url-status=live}}</ref><ref>{{cite journal |last1=Stenseth |first1=Nils Chr |title=Plague Through History |journal=Science |date=8 August 2008 |volume=321 |issue=5890 |pages=773–774 |doi=10.1126/science.1161496 |s2cid=161336516 }}</ref>
|-
| 1855–1857 Montevideo yellow fever epidemic
| 1855–1857
| [[Montevideo]], [[Uruguay]]
| [[Yellow fever]]
| 3,400 (first wave; 900, second wave; 2,500)
| <ref>{{Cite web|url=https://fiebreamarillauy.webnode.com.uy/la-fiebre-amarilla-en-el-siglo-xix/|title=La fiebre amarilla en el siglo XIX|date=13 August 2019|language=es|access-date=24 July 2021|archive-date=24 July 2021|archive-url=https://web.archive.org/web/20210724203230/https://fiebreamarillauy.webnode.com.uy/la-fiebre-amarilla-en-el-siglo-xix/|url-status=live}}</ref>
|-
| 1857 Lisbon yellow fever epidemic
| 1857
| [[Lisbon]], Portugal
| [[Yellow fever]]
| 6,000
| <ref name=Britannica/>
|-
| 1857 Victoria smallpox epidemic
| 1857
| [[Victoria (Australia)|Victoria]], Australia
| [[Smallpox]]
| data-sort-value="0"|Unknown
| <ref>{{Cite web |url=http://www.medicalpioneers.com/colonial.htm |title=Australian Medical Pioneers Index (AMPI) – Colonial Medical Life |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20170629093854/http://medicalpioneers.com/colonial.htm |archive-date=29 June 2017 |url-status=live}}</ref>
|-
| 1857–1859 Europe and the Americas influenza epidemic
| 1857–1859
| Europe, North America, South America
| [[Influenza]]
| data-sort-value="0"|Unknown
| <ref>Beveridge, W.I.B. Influenza, the Last Great Plague (Heinemann, London, 1977){{Page needed|date=July 2013}}</ref>
|-
| [[1862 Pacific Northwest smallpox epidemic]]
| 1862–1863
| [[Pacific Northwest]], Canada and United States
| [[Smallpox]]
| 20,000+
| <ref>{{Cite book|url=https://s3.amazonaws.com/hwdsbcommons/wp-content/uploads/sites/7647/2016/09/ch1_sb_topic4.pdf|title=Creating Canada: 1850–1890|access-date=14 May 2020|page=42|archive-date=3 August 2020|archive-url=https://web.archive.org/web/20200803100412/https://s3.amazonaws.com/hwdsbcommons/wp-content/uploads/sites/7647/2016/09/ch1_sb_topic4.pdf|url-status=live}}</ref><ref>{{cite web|url=https://www.macleans.ca/news/canada/how-a-smallpox-epidemic-forged-modern-british-columbia|title=How a smallpox epidemic forged modern British Columbia|website=macleans.ca|date=August 2017|access-date=14 May 2020|archive-date=18 January 2021|archive-url=https://web.archive.org/web/20210118211838/https://www.macleans.ca/news/canada/how-a-smallpox-epidemic-forged-modern-british-columbia/|url-status=live}}</ref><ref name=Boyd>{{cite book |last1= Boyd |first1= Robert |last2= Boyd |first2= Robert Thomas |title= The Coming of the Spirit of Pestilence: Introduced Infectious Diseases and Population Decline Among Northwest Coast Indians, 1774–1874 |year= 1999 |publisher= University of British Columbia Press |isbn= 978-0-295-97837-6 |chapter= A final disaster: the 1862 smallpox epidemic in coastal British Columbia |chapter-url= https://books.google.com/books?id=P_FdUPbmwCgC&pg=PA172 |pages= 172–201 |access-date= 10 February 2021 |archive-date= 6 January 2024 |archive-url= https://web.archive.org/web/20240106083406/https://books.google.com/books?id=P_FdUPbmwCgC&pg=PA172#v=onepage&q&f=false |url-status= live }}</ref>
|-
| 1861–1865 United States typhoid fever epidemic
| 1861–1865
| United States
| [[Typhoid fever]]
| 80,000
| <ref>{{cite web|title=Typhoid Fever History|url=http://www.news-medical.net/health/Typhoid-Fever-History.aspx|website=news-medical.net|date=22 April 2010|access-date=13 May 2020|archive-date=13 May 2020|archive-url=https://web.archive.org/web/20200513103154/https://www.news-medical.net/health/Typhoid-Fever-History.aspx|url-status=live}}</ref>
|-
| [[Fourth cholera pandemic]]
| 1863–1875
| [[Middle East]]
| [[Cholera]]
| 600,000
| <ref name="Hays2005p267">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=267}}</ref>
|-
| 1867 Sydney measles epidemic
| 1867
| [[Sydney]], Australia
| [[Measles]]
| 748
| <ref name="Dictionary of Sydney">{{Cite web|url=https://dictionaryofsydney.org/entry/epidemics|title=Epidemics|website=dictionaryofsydney.org|date=2008|access-date=16 May 2020|archive-date=28 March 2020|archive-url=https://web.archive.org/web/20200328053832/https://dictionaryofsydney.org/entry/epidemics|url-status=live}}</ref>
|-
| [[Yellow fever in Buenos Aires|1871 Buenos Aires yellow fever epidemic]]
| 1871
| [[Buenos Aires]], Argentina
| [[Yellow fever]]
| data-sort-value="19850"|13,500–26,200
| <ref>{{Cite web|url=http://www.greywall.demon.co.uk/genealogy/yfever/index.html|title=The Yellow Fever Outbreak of 1871|access-date=12 May 2020|archive-date=29 September 2019|archive-url=https://web.archive.org/web/20190929133709/http://www.greywall.demon.co.uk/genealogy/yfever/index.html|url-status=dead}}</ref>
|-
| 1870–1875 Europe smallpox epidemic
| 1870–1875
| Europe
| [[Smallpox]]
| 500,000
| <ref>{{Cite web|url=https://www.strategypage.com/articles/smallpox/6.asp|title=Franco-Prussian War|website=strategypage.com|access-date=14 May 2020|archive-date=3 August 2020|archive-url=https://web.archive.org/web/20200803125628/https://www.strategypage.com/articles/smallpox/6.asp|url-status=live}}</ref><ref>{{cite journal|last1=Jorland|first1=Gerard|url=https://www.cairn-int.info/article-E_SEVE_033_0025--smallpox-and-the-franco-prussian-war-of.htm|title=Smallpox and the Franco-Prussian War of 1870|journal=Les Tribunes de la Santé|date=2011|volume=33|issue=4 |pages=25–30|doi=10.3917/seve.033.0025|doi-access=free|access-date=2020-05-14|archive-date=2023-04-04|archive-url=https://web.archive.org/web/20230404155043/https://www.cairn-int.info/article-E_SEVE_033_0025--smallpox-and-the-franco-prussian-war-of.htm|url-status=live}}</ref>
|-
| 1875 Fiji measles outbreak
| 1875
| [[Fiji]]
| [[Measles]]
| data-sort-value="40,000"| 40,000
| <ref>{{Cite news |url=http://www.britishnewspaperarchive.co.uk/viewer/bl/0000081/18750929/038/0007 |title=Death of Forty Thousand Fijians from Measles |date=29 Sep 1875 |access-date=9 Nov 2012 |publisher=Liverpool Mercury }}</ref>
|-
| [[1875–1876 Australia scarlet fever epidemic]]
| 1875–1876
| Australia
| [[Scarlet fever]]
| 8,000
| <ref name="Dictionary of Sydney"/>
|-
| 1876 Ottoman Empire plague epidemic
| 1876
| [[Ottoman Empire]]
| [[Bubonic plague]]
| 20,000
| <ref>{{Cite web|url=https://www.1902encyclopedia.com/P/PLA/plague-13.html|title=Plague in the 19th Century: (2) 1853–84|website=1902encyclopedia|access-date=16 May 2020|archive-date=3 June 2020|archive-url=https://web.archive.org/web/20200603122211/https://www.1902encyclopedia.com/P/PLA/plague-13.html|url-status=live}}</ref>
|-
| [[Lower Mississippi Valley yellow fever epidemic of 1878|1878 New Orleans yellow fever epidemic]]
| 1878
| [[New Orleans]], United States
| [[Yellow fever]]
| 4,046
| <ref name= "medicina"/>
|-
| [[Lower Mississippi Valley yellow fever epidemic of 1878|1878 Mississippi Valley yellow fever epidemic]]
| 1878
| [[Mississippi Valley]], United States
| [[Yellow fever]]
| 13,000
| <ref name= "medicina"/>
|-
| [[Fifth cholera pandemic]]
| 1881–1896
| Asia, Africa, Europe, South America
| [[Cholera]]
| data-sort-value="298,600"|298,600
| <ref name="Hays2005p303">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=303}}</ref>
|-
| 1885 Montreal smallpox epidemic
| 1885
| [[Montreal]], Canada
| [[Smallpox]]
| 3,164
| <ref>[https://www.amazon.com/Plague-Story-Smallpox-Montreal-Michael/dp/0002156938 Plague A Story of Smallpox in Montreal] {{Webarchive|url=https://web.archive.org/web/20230404141140/https://www.amazon.com/Plague-Story-Smallpox-Montreal-Michael/dp/0002156938 |date=2023-04-04 }} [[Michael Bliss]], 1991, accessed 8 May 2020</ref>
|-
| [[1889–1890 pandemic]]
| 1889–1890
| Worldwide
| [[Influenza]] or [[Human coronavirus OC43|Human coronavirus OC43 / HCoV-OC43]]<ref name="auto"/><ref>{{cite journal |last1=Huynh |first1=Jeremy |last2=Li |first2=Shimena |last3=Yount |first3=Boyd |last4=Smith |first4=Alexander |last5=Sturges |first5=Leslie |last6=Olsen |first6=John C. |last7=Nagel |first7=Juliet |last8=Johnson |first8=Joshua B. |last9=Agnihothram |first9=Sudhakar |last10=Gates |first10=J. Edward |last11=Frieman |first11=Matthew B. |last12=Baric |first12=Ralph S. |last13=Donaldson |first13=Eric F. |title=Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 |journal=Journal of Virology |date=1 December 2012 |volume=86 |issue=23 |pages=12816–12825 |doi=10.1128/JVI.00906-12 |pmid=22993147 |pmc=3497669 }}</ref> (disputed)
| data-sort-value="01000000"|1 million
| <ref name="Board1893">{{Cite book |url=https://archive.org/details/b21459393 |title=Further report and papers on epidemic influenza, 1889–92: with an introduction by the medical officer of the Local Government Board |last=Great Britain. Local Government Board |publisher=Eyre |year=1893 |page=49 |access-date=29 March 2011}}</ref>
|-
| [[1894 Hong Kong plague]] (part of the [[third plague pandemic]])
| 1894–1929
| [[Hong Kong]]
| [[Bubonic plague]]
| 20,000+
| <ref>{{Cite web|date=2016-01-11|title=A lesson from history – Hong Kong's plague epidemic points way ahead in face of crisis|url=https://www.scmp.com/news/hong-kong/article/1899938/lesson-history-hong-kongs-plague-epidemic-points-way-ahead-face|access-date=2021-01-16|website=South China Morning Post|language=en|archive-date=2020-11-09|archive-url=https://web.archive.org/web/20201109000322/https://www.scmp.com/news/hong-kong/article/1899938/lesson-history-hong-kongs-plague-epidemic-points-way-ahead-face|url-status=live}}</ref>
|-
| [[Bombay plague epidemic]] (part of the [[third plague pandemic]])
| 1896–1905
| [[Bombay]], India
| [[Bubonic plague]]
| 20,788
| <ref>{{Cite web|url=https://www.outlookindia.com/website/story/opinion-colonial-experiences-from-the-bombay-plague-of-1896-no-lessons-learned/350389/?next|title=The 1896 Bombay Plague: Lessons In What Not To Do|website=outlookindia|date=9 April 2020|access-date=13 May 2020|archive-date=16 April 2020|archive-url=https://web.archive.org/web/20200416102938/https://www.outlookindia.com/website/story/opinion-colonial-experiences-from-the-bombay-plague-of-1896-no-lessons-learned/350389/?next|url-status=live}}</ref>
|-
| 1896–1906 Congo Basin African trypanosomiasis epidemic
| 1896–1906
| [[Congo Basin]]
| [[African trypanosomiasis]]
| 500,000
| <ref name="African trypanosomiasis">{{Cite web |url=https://www.who.int/trypanosomiasis_african/country/history/en/index5.html|archive-url=https://web.archive.org/web/20080323231311/http://www.who.int/trypanosomiasis_african/country/history/en/index5.html|url-status=dead|archive-date=March 23, 2008|title=The history of sleeping sickness|website=WHO|access-date=12 May 2020}}</ref>
|-
| [[1899 Porto plague outbreak]] (part of the [[third plague pandemic]])
| 1899
| [[Porto]], Portugal
| [[Bubonic plague]]
| 132
| <ref name="Pontes2012">{{cite thesis |last=Pontes |first=David |date=2012 |title=O cerco da peste no Porto: Cidade, imprensa e saúde pública na crise sanitária de 1899 |type=master's degree |publisher=Faculdade de Letras da Universidade do Porto |url=https://repositorio-aberto.up.pt/bitstream/10216/73326/2/28279.pdf |language=pt |access-date=2 March 2020 |archive-date=2 March 2020 |archive-url=https://web.archive.org/web/20200302232248/https://repositorio-aberto.up.pt/bitstream/10216/73326/2/28279.pdf |url-status=live }}</ref>
|-
| [[Sixth cholera pandemic]]
| 1899–1923
| Europe, Asia, Africa
| [[Cholera]]
| data-sort-value="800,001"| 800,000+
| <ref name="Hays2005p345">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=345}}</ref>
|-
| [[San Francisco plague of 1900–1904]] (part of the [[third plague pandemic]])
| 1900–1904
| [[San Francisco]], United States
| [[Bubonic plague]]
| 119
| <ref>{{Cite book |title=Plague Ports: The Global Urban Impact of Bubonic Plague: 1894–1901 |last=Echenberg |first=Myron |publisher=New York University Press |year=2007 |isbn=978-0-8147-2232-9 |location=Sacramento |page=231}}</ref>
|-
| 1900 Sydney bubonic plague epidemic (part of the [[third plague pandemic]])
| 1900
| Australia
| [[Bubonic plague]]
| 103
|<ref>{{Cite web|date=2015-09-03|title=The day bubonic plague hit Sydney|url=https://www.dailytelegraph.com.au/news/nsw/bubonic-plague-sydney-how-a-city-survived-the-black-death-in-1900/news-story/f36b9184eba49c72ae9791c574f7b826|access-date=2020-07-26|website=www.dailytelegraph.com.au|language=en|archive-date=2020-02-12|archive-url=https://web.archive.org/web/20200212224627/https://www.dailytelegraph.com.au/news/nsw/bubonic-plague-sydney-how-a-city-survived-the-black-death-in-1900/news-story/f36b9184eba49c72ae9791c574f7b826|url-status=live}}</ref>
|-
| 1900–1920 Uganda African trypanosomiasis epidemic
| 1900–1920
| [[Uganda]]
| [[African trypanosomiasis]]
| data-sort-value="250,000"|200,000–300,000
| <ref name="African trypanosomiasis"/>
|-
| Papua New Guinea kuru epidemic
| 1901–2009
| [[Papua New Guinea]]
| [[Kuru (disease)|Kuru]]
| 2,700–3,000+
| <ref>{{cite journal |last1=Liberski |first1=Pawel |last2=Gajos |first2=Agata |last3=Sikorska |first3=Beata |last4=Lindenbaum |first4=Shirley |title=Kuru, the First Human Prion Disease † |journal=Viruses |year=2019 |volume=11 |issue=3 |page=232 |doi=10.3390/v11030232 |pmid=30866511 |pmc=6466359 |doi-access=free }}</ref><ref>{{cite report |last1=Zafar Khan |first1=Zartash |title=Kuru: Background, Pathophysiology, Epidemiology |date=20 July 2021 |via=emedicine.medscape.com |url=https://emedicine.medscape.com/article/220043-overview |access-date=31 July 2020 |archive-date=9 October 2023 |archive-url=https://web.archive.org/web/20231009192831/https://emedicine.medscape.com/article/220043-overview |url-status=live }}</ref>
|-
| 1903 Fremantle plague epidemic (part of the [[third plague pandemic]])
| 1903
| [[Fremantle|Fremantle, Western Australia]]
| [[Bubonic plague]]
| 4
| <ref>{{cite wikisource |title=Report on the outbreak of plague at Fremantle |date=1903 |first1=George Hugh Spencer |last1=Blackburne |first2=T. L. |last2=Anderson}}</ref>
|-
| [[1906 malaria outbreak in Ceylon]]
| 1906–1936
| [[British Ceylon|Ceylon]]
| [[Malaria]]
| 80,000
|<ref>{{Cite journal|last1=Wijesundere|first1=Dilkushi Anula|last2=Ramasamy|first2=Ranjan|date=2017-08-28|title=Analysis of Historical Trends and Recent Elimination of Malaria from Sri Lanka and Its Applicability for Malaria Control in Other Countries|journal=Frontiers in Public Health|volume=5|page=212|doi=10.3389/fpubh.2017.00212|issn=2296-2565|pmc=5581355|pmid=28894732|doi-access=free|bibcode=2017FrPH....5..212W }}</ref>
|-
| [[Manchurian plague]] (part of the [[third plague pandemic]])
| 1910–1911
| [[Qing dynasty|China]]
| [[Pneumonic plague]]
| 60,000
| <ref name=":02">{{Cite web|url=https://disasterhistory.org/the-manchurian-plague-1910-11|title=Manchurian plague, 1910–11|last=Meiklejohn|first=Iain|website=Disaster History|language=en-GB|access-date=23 April 2020|archive-date=8 March 2018|archive-url=https://web.archive.org/web/20180308205528/https://disasterhistory.org/the-manchurian-plague-1910-11|url-status=live}}</ref>
|-
| 1916 United States polio epidemic
| 1916
| United States
| [[Poliomyelitis]]
| data-sort-value="7,130" | 7,130
| <ref name="Ochmann and Roser" >{{Cite journal|url=https://ourworldindata.org/polio|title=Polio (graph "Reported paralytic polio cases and deaths in the United States since 1910")|last1=Ochman|first1=Sophie|last2=Roser|first2=Max|journal=Our World in Data|date=9 November 2017|publisher=OurWorldInData.org|access-date=15 May 2020|archive-date=28 March 2018|archive-url=https://web.archive.org/web/20180328105153/https://ourworldindata.org/polio|url-status=live}}</ref>
|-
| [[1918 flu pandemic|1918 influenza pandemic ('Spanish flu')]]
| 1918–1920
| Worldwide
| |[[Influenza A virus subtype H1N1]]
| data-sort-value="58,500,000"| 17–100 million
| <ref name=":1" /><ref>{{cite journal |last1=P. Spreeuwenberg |display-authors=etal|title=Reassessing the Global Mortality Burden of the 1918 Influenza Pandemic. |journal=[[American Journal of Epidemiology]] |volume=187|issue=12|pages=2561–2567|date=1 December 2018 |doi=10.1093/aje/kwy191 |pmid=30202996|pmc=7314216}}</ref><ref>{{Cite journal|last=Borza|first=T.|date=2001-12-10|title=[Spanish flu in Norway 1918-19]|url=https://pubmed.ncbi.nlm.nih.gov/11808016/#affiliation-1|journal=Tidsskrift for den Norske Laegeforening|volume=121|issue=30|pages=3551–3554|issn=0029-2001|pmid=11808016|access-date=2020-12-30|archive-date=2020-08-20|archive-url=https://web.archive.org/web/20200820170537/https://pubmed.ncbi.nlm.nih.gov/11808016/#affiliation-1|url-status=live}}</ref>
|-
| [[Epidemic typhus#20th century|1918–1922 Russia typhus epidemic]]
| 1918–1922
| [[Russian Soviet Federative Socialist Republic|Russia]]
| [[Typhus]]
| data-sort-value="2500000"| 2–3 million
| <ref>{{cite journal| pmc=1036775 | pmid=8246643 | doi=10.1017/s0025727300058725 | volume=37 | title=Typhus and its control in Russia, 1870–1940 | year=1993 | author=Patterson KD | journal=Med Hist |issue = 4| pages=361–381 [378]}}</ref>
|-
| [[1919–1930 encephalitis lethargica epidemic]]
| 1919–1930
| Worldwide
| [[Encephalitis lethargica]]
| data-sort-value="500,000"| 500,000
| <ref name=":2">{{Cite journal|last1=Ravenholt|first1=R. T|last2=Foege|first2=WilliamH|title=1918 Influenza, Encephalitis Lethargica, Parkinsonism|date=1982-10-16|url=http://www.sciencedirect.com/science/article/pii/S0140673682908200|journal=The Lancet|series=Originally published as Volume 2, Issue 8303|language=en|volume=320|issue=8303|pages=860–864|doi=10.1016/S0140-6736(82)90820-0|pmid=6126720|s2cid=45138249|issn=0140-6736|access-date=2020-12-23|archive-date=2021-07-12|archive-url=https://web.archive.org/web/20210712225718/https://www.sciencedirect.com/science/article/abs/pii/S0140673682908200|url-status=live|url-access=subscription}}</ref><ref name=":3">{{Cite journal|last1=McCall|first1=Sherman|last2=Vilensky|first2=Joel A|last3=Gilman|first3=Sid|last4=Taubenberger|first4=Jeffery K|date=May 2008|title=The relationship between encephalitis lethargica and influenza: A critical analysis|journal=Journal of Neurovirology|volume=14|issue=3|pages=177–185|doi=10.1080/13550280801995445|issn=1355-0284|pmc=2778472|pmid=18569452}}</ref><ref>{{cite book |last1=Foster |first1=Harold D. |last2=Hoffer |first2=Abram |chapter=Hyperoxidation of the Two Catecholamines, Dopamine and Adrenaline: Implications for the Etiologies and Treatment of Encephalitis Lethargica, Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Schizophrenia |chapter-url=https://www.sciencedirect.com/science/article/pii/B9780444528094501575 |title=Oxidative Stress and Neurodegenerative Disorders |publisher=Elsevier Science B.V. |access-date=11 February 2020 |pages=369–382 |language=en |date=1 January 2007 |doi=10.1016/B978-044452809-4/50157-5 |isbn=9780444528094 |archive-date=24 February 2020 |archive-url=https://web.archive.org/web/20200224151732/https://www.sciencedirect.com/science/article/pii/B9780444528094501575 |url-status=live }}</ref>
|-
| [[1924 Los Angeles pneumonic plague outbreak]]
| 1924
| [[Los Angeles]], United States
| [[Pneumonic plague]]
| 30
| <ref>{{cite journal | author = Viseltear A.J. | date = March 1974 | title = The Pneumonic Plague Epidemic of 1924 in Los Angeles | journal = Yale J. Biol. Med. | volume = 47 | issue = 1| pages = 40–54| pmid = 4596466 | pmc = 2595158 }}</ref>
|-
| [[1924–1925 Minnesota smallpox epidemic]]
| 1924–1925
| [[Minnesota]], United States
| [[Smallpox]]
| 500
| <ref>{{Cite web |last=Nelson |first=Paul |title=Smallpox Epidemic, 1924–1925 |url=http://www.mnopedia.org/event/smallpox-epidemic-1924-1925 |work=MNopedia |date=2018-01-02 |access-date=2019-07-25 |archive-date=2014-11-04 |archive-url=https://web.archive.org/web/20141104120453/http://www.mnopedia.org/event/smallpox-epidemic-1924-1925 |url-status=live }}</ref>
|-
| 1927 Montreal typhoid fever epidemic
| 1927
| [[Montreal]], Canada
| [[Typhoid fever]]
| 538
| <ref>{{cite book|last1=Berger|first1=Stephen|title=Typhoid and Enteric Fever: Global Status: 2017 edition|url=https://books.google.com/books?id=XFEWDgAAQBAJ&q=%221993%22+%22+%09Typhoid+fever%22+%22mpumalanga%22&pg=PA11|access-date=16 May 2020|isbn=9781498816878|date=20 January 2017|publisher=GIDEON Informatics, Incorporated|archive-date=6 January 2024|archive-url=https://web.archive.org/web/20240106083908/https://books.google.com/books?id=XFEWDgAAQBAJ&q=%221993%22+%22+%09Typhoid+fever%22+%22mpumalanga%22&pg=PA11|url-status=live}}</ref>
|-
| [[1929–1930 psittacosis pandemic]]
| 1929–1930
| Worldwide
| [[Psittacosis]]
| 100+
| <ref name="Honigsbaum2020">{{cite book|last=Honigsbaum|first=Mark|url=https://openaccess.city.ac.uk/id/eprint/23272/1/The%20Pandemic%20Century-ver3.pdf|title=The Pandemic Century: One Hundred Years of Panic, Hysteria and Hubris|publisher=Hurst & Company|year=2020|isbn=9781787381216|location=London|pages=67–98|chapter=3. The Great Parrot Fever Pandemic|access-date=2020-06-27|archive-date=2021-07-12|archive-url=https://web.archive.org/web/20210712225713/https://openaccess.city.ac.uk/id/eprint/23272/1/The%20Pandemic%20Century-ver3.pdf|url-status=live}}</ref>
|-
| [[1937 Croydon typhoid outbreak]]
| 1937
| [[Croydon]], United Kingdom
| [[Typhoid fever]]
| 43
| <ref name="Ravenel1938">{{cite journal|last1=Ravenel|first1=Mazÿk P.|date=May 1938|title=The Croydon Epidemic of Typhoid Fever|journal=[[American Journal of Public Health and the Nation's Health]]|volume=28|issue=5|pages=644–646|doi=10.2105/AJPH.28.5.644|pmid=18014847|pmc=1529192|doi-access=free|author-link1=Mazÿck P. Ravenel}}</ref>
|-
| 1937 Australia polio epidemic
| 1937
| Australia
| [[Polio]]myelitis
| Unknown
| <ref>{{Cite web |author=Professor Joan McMeeken (University of Melbourne) |date=2018-01-18 |title=Remembering Australia's polio scourge |url=https://pursuit.unimelb.edu.au/articles/remembering-australia-s-polio-scourge |access-date=2020-07-26 |website=Pursuit |language=en |archive-date=2020-07-24 |archive-url=https://web.archive.org/web/20200724050158/https://pursuit.unimelb.edu.au/articles/remembering-australia-s-polio-scourge |url-status=live }}</ref>
|-
| 1940 Sudan yellow fever epidemic
| 1940
| [[Anglo-Egyptian Sudan|Sudan]]
| [[Yellow fever]]
| 1,627
| <ref>{{Cite web|url=http://regist2.virology-education.com/presentations/2019/2ICREID/31_Magboul.pdf|title=Yellow Fever in Sudan|access-date=13 May 2020|archive-date=25 February 2021|archive-url=https://web.archive.org/web/20210225220501/http://regist2.virology-education.com/presentations/2019/2ICREID/31_Magboul.pdf|url-status=dead}}</ref>
|-
| 1942–1944 Egypt malaria epidemic
| 1942–1944
| [[Kingdom of Egypt|Egypt]]
| [[Malaria]]
| data-sort-value="0"|Unknown
| <ref name=Kuhnke /><ref name="Gallagher">Gallagher, Nancy. ''Egypt's Other Wars: Epidemics and the Politics of Public Health.'' Syracuse University Press, c1990. American University in Cairo Press. {{ISBN|977-424-295-5}} pp. 4–6</ref>
|-
| 1946 Egypt relapsing fever epidemic
| 1946
| [[Kingdom of Egypt|Egypt]]
| [[Relapsing fever]]
| data-sort-value="0"|Unknown
| <ref name=Kuhnke /><ref name=Gallagher />
|-
| 1947 Egypt cholera epidemic
| 1947
| [[Kingdom of Egypt|Egypt]]
| [[Cholera]]
| data-sort-value="10277"|10,277
| <ref name=Kuhnke /><ref name=Gallagher /><ref>{{cite journal| pmc=2553924 | pmid=20603928 | volume=1 | title=Cholera Epidemic in Egypt (1947): A Preliminary Report | year=1948 | author=Shousha AT | journal=Bull. World Health Organ. |issue = 2| pages=353–81}}</ref>
|-
| 1948–1952 United States polio epidemic
| 1948–1952
| United States
| [[Poliomyelitis]]
| data-sort-value="9000"| 9,000
| <ref name="Ochmann and Roser"/>
|-
| [[1957–1958 influenza pandemic|1957–1958 influenza pandemic ('Asian flu')]]
| 1957–1958
| Worldwide
| [[Influenza A virus subtype H2N2]]
| data-sort-value="2,500,000"| 1–4 million
| <ref name=":1">{{Cite web|last=|first=|date=2013|title=Pandemic Influenza Risk Management WHO Interim Guidance|url=https://www.who.int/influenza/preparedness/pandemic/GIP_PandemicInfluenzaRiskManagementInterimGuidance_Jun2013.pdf?ua=1|url-status=live|archive-url=https://web.archive.org/web/20210121225326/https://www.who.int/influenza/preparedness/pandemic/GIP_PandemicInfluenzaRiskManagementInterimGuidance_Jun2013.pdf?ua=1|archive-date=2021-01-21|access-date=7 December 2020|website=[[World Health Organization]]|page=19}}</ref><ref name="Paul2008">{{Cite book |url=https://books.google.com/books?id=oPSG1PGmZUkC|title=Fundamental Immunology|last=William E. Paul |year=2008 |publisher=Lippincott Williams & Wilkins |isbn=978-0-7817-6519-0 |access-date=29 March 2011 |archive-url=https://web.archive.org/web/20140702155855/http://books.google.com/books?id=oPSG1PGmZUkC |archive-date=2 July 2014 |url-status=live}}</ref><ref name=":0" />
|-
| 1960–1962 Ethiopia yellow fever epidemic
| 1960–1962
| [[Ethiopia]]
| [[Yellow fever]]
| 30,000
| <ref>{{cite journal|title=Reemergence of yellow fever in Ethiopia after 50 years, 2013: epidemiological and entomological investigations|date=15 May 2017|doi=10.1186/s12879-017-2435-4|last1=Lilay|first1=Abrham|last2=Asamene|first2=Negga|last3=Bekele|first3=Abyot|last4=Mengesha|first4=Mesfin|last5=Wendabeku|first5=Milliyon|last6=Tareke|first6=Israel|last7=Girmay|first7=Abiy|last8=Wuletaw|first8=Yonas|last9=Adossa|first9=Abate|last10=Ba|first10=Yamar|last11=Sall|first11=Amadou|last12=Jima|first12=Daddi|last13=Mengesha|first13=Debritu|s2cid=21276606|journal=BMC Infectious Diseases|volume=17|issue=1|page=343|pmid=28506254|pmc=5432991|doi-access=free}}</ref>
|- style="font-weight: bold;"
| [[Seventh cholera pandemic]]
| 1961–present
| Worldwide
| [[Cholera]] ([[El Tor|El Tor strain]])
| data-sort-value="36,000"|36,000 {{citation needed|date=February 2022}}
| <ref name="Hays2005p421">{{Cite book |url=https://archive.org/details/epidemicspandemi0000hays |title=Epidemics and pandemics: their impacts on human history |last=J. N. Hays |publisher=ABC-CLIO |year=2005 |isbn=978-1-85109-658-9 |access-date=29 March 2011 |url-access=registration|page=421}}</ref>
|-
| [[Hong Kong flu]]
| 1968–1970
| Worldwide
| [[Influenza A virus subtype H3N2]]
| data-sort-value="2,500,000"| 1–4 million
| <ref name=":1" /><ref name=Paul2008 /><ref name=":0">{{cite web|url=http://apps.who.int/gb/ebwha/pdf_files/WHA64/A64_10-en.pdf|title=Report of the Review Committee on the Functioning of the International Health Regulations (2005) in relation to Pandemic (H1N1) 2009 |date=2011-05-05|page=37|url-status=live|archive-url=https://web.archive.org/web/20150514145306/http://apps.who.int/gb/ebwha/pdf_files/WHA64/A64_10-en.pdf|archive-date=14 May 2015|access-date=1 March 2015}}</ref>
|-
| 1971 Staphorst polio epidemic
| 1971
| [[Staphorst]], Netherlands
| [[Poliomyelitis]]
| 5
| <ref>{{Cite web|url=https://anderetijden.nl/aflevering/340/Polio-in-Staphorst|title=Polio in Staphorst|language=nl|website=anderetijden|access-date=15 May 2020|archive-date=20 April 2020|archive-url=https://web.archive.org/web/20200420231557/https://anderetijden.nl/aflevering/340/Polio-in-Staphorst|url-status=live}}</ref>
|-
| [[1972 Yugoslav smallpox outbreak]]
| 1972
| [[Socialist Federal Republic of Yugoslavia|Yugoslavia]]
| [[Smallpox]]
| 35
| <ref>{{cite journal| pmid=4826683 | volume=69 | title=[Smallpox in Yugoslavia in 1972 (author's transl)] | year=1974 | author=Ehrengut W | journal=Med Klin | issue=8 | pages=350–352}}</ref>
|-
| [[London flu]]
| 1972–1973
| United States
| [[Influenza A virus subtype H3N2]]
| 1,027
| <ref>{{Cite news |url=https://news.google.com/newspapers?id=HwohAAAAIBAJ&pg=2551,1652625 |title=New, Deadly Flu Strain Detected in Albany Co |date=January 24, 1975 |work=Schenectady Gazette |access-date=August 3, 2012 |agency=Associated Press |page=3 |archive-date=May 22, 2022 |archive-url=https://web.archive.org/web/20220522055841/https://news.google.com/newspapers?id=HwohAAAAIBAJ&pg=2551,1652625 |url-status=live }}</ref>
|-
| 1973 Italy cholera epidemic
| 1973
| Italy
| [[Cholera]] ([[El Tor|El Tor strain]])
| 24
| <ref>{{cite journal | doi = 10.1016/S0140-6736(74)93214-0 | volume=303 | year=1974 | journal=The Lancet | page=669 |author1=De Lorenzo F. |author2=Manzillo G. |author3=Soscia M. |author4=Balestrieri G.G. | title=Epidemic of Cholera el Tor in Naples, 1973 | issue=7859 | pmid=4132328 }}</ref>
|-
| [[1974 smallpox epidemic in India]]
| 1974
| India
| [[Smallpox]]
| 15,000
| <ref name="SmallpoxIndia1974">{{cite web|url=http://www.smallpoxhistory.ucl.ac.uk/ |title=The control and eradication of smallpox in South Asia |website=www.smallpoxhistory.ucl.ac.uk |access-date=2008-12-18 |url-status=dead |archive-url=https://web.archive.org/web/20081019023043/http://www.smallpoxhistory.ucl.ac.uk/ |archive-date=2008-10-19}}</ref>
|-
| [[1977 Russian flu]]
| 1977–1979
| Worldwide
| [[Influenza A virus subtype H1N1]]
| 700,000
| <ref name=":6">{{Cite journal|last1=Michaelis|first1=Martin|last2=Doerr|first2=Hans Wilhem|last3=Cinatl|first3=Jindrich|date=2009-08-01|title=Novel swine-origin influenza A virus in humans: another pandemic knocking at the door|journal=Medical Microbiology and Immunology|language=en|volume=198|issue=3|pages=175–183 (Table 1)|doi=10.1007/s00430-009-0118-5|pmid=19543913|s2cid=20496301|issn=1432-1831|doi-access=free}}</ref><ref name=":7">{{Cite web|last=|first=|date=2020-11-18|title=You're more likely to die from the H1N1 flu if you were born in 1957|url=https://nouvelles.umontreal.ca/en/article/2018/01/19/you-re-more-likely-to-die-from-the-h1n1-flu-if-you-were-born-in-1957/|access-date=2021-01-24|website=University of Montreal|language=en|archive-date=2019-01-31|archive-url=https://web.archive.org/web/20190131183201/https://nouvelles.umontreal.ca/en/article/2018/01/19/you-re-more-likely-to-die-from-the-h1n1-flu-if-you-were-born-in-1957/|url-status=dead}}</ref>
|-
| [[Sverdlovsk anthrax leak]]
| 1979
| Russia
| [[Anthrax]]
| 105
| <ref>{{Cite journal|last1=Meselson|first1=Matthew|last2=Guillemin|first2=J|last3=Hugh-Jones|first3=Martin|last4=Langmuir|first4=A|last5=Popova|first5=I|last6=Shelokov|first6=A|last7=Yampolskaya|first7=O|date=1994-12-01|title=The Sverdlovsk anthrax outbreak of 1979|url=https://www.researchgate.net/publication/15224942|journal=Science|volume=266|issue=5188|pages=1202–8|doi=10.1126/science.7973702|pmid=7973702|bibcode=1994Sci...266.1202M|access-date=2020-07-31|archive-date=2021-07-12|archive-url=https://web.archive.org/web/20210712225710/https://www.researchgate.net/publication/15224942_The_Sverdlovsk_anthrax_outbreak_of_1979|url-status=live}}</ref>
|-
| {{strong|[[HIV/AIDS epidemic]]}}
| {{strong|1981–present}}
| {{strong|Worldwide}}
| {{strong|[[HIV/AIDS]]}}
| data-sort-value="44000000" | {{strong|44 million ({{as of|2025|lc=y}})}}
| <ref>{{Cite web|title=Global HIV and AIDS statistics|url=https://www.unaids.org/en/resources/fact-sheet|access-date=2021-08-23|website=[[Joint United Nations Programme on HIV/AIDS|UNAIDS]]|archive-date=2019-12-04|archive-url=https://web.archive.org/web/20191204021652/https://www.unaids.org/en/resources/fact-sheet|url-status=live}}</ref>
|-
| 1984 Western Sahara plague
| 1984
| [[Western Sahara]]
| [[Bubonic plague]]
| 64
| {{Citation needed|date=May 2020}}
|-
| 1986 Oju yellow fever epidemic
| 1986
| [[Oju, Nigeria|Oju]], [[Nigeria]]
| [[Yellow fever]]
| 5,600+
| <ref>{{Cite journal |title=Epidemic yellow fever in eastern Nigeria, 1986.| pmid=2894558 | doi=10.1016/s0140-6736(88)91425-0 | volume=1 | year=1988 | author1=De Cock KM |author2=Monath TP |author3=Nasidi A |author4=Tukei PM |author5=Enriquez J |author6=Lichfield P |author7=Craven RB |author8=Fabiyi A |author9=Okafor BC |author10=Ravaonjanahary C | journal=Lancet | issue=8586 | pages=630–3| s2cid=31563771 }}</ref>
|-
| 1987 Mali yellow fever epidemic
| 1987
| [[Mali]]
| [[Yellow fever]]
| 145
| <ref>{{Cite web |url=https://www.who.int/csr/don/2005_01_06/en|archive-url=https://web.archive.org/web/20050109054957/http://www.who.int/csr/don/2005_01_06/en/|url-status=dead|archive-date=January 9, 2005|title=Yellow fever in Mali|website=who.int|access-date=12 May 2020}}</ref>
|-
| 1988 Shanghai hepatitis A epidemic
| 1988
| [[Shanghai]], China
| [[Hepatitis A]]
| 31–47
|<ref>{{Cite journal|last=Cooksley|first=W. G.|date=May 2000|title=What did we learn from the Shanghai hepatitis A epidemic?|url=https://pubmed.ncbi.nlm.nih.gov/10870174/|journal=Journal of Viral Hepatitis|volume=7|issue=Suppl 1|pages=1–3|doi=10.1046/j.1365-2893.2000.00021.x|issn=1352-0504|pmid=10870174|s2cid=34673718|access-date=2021-08-04|archive-date=2021-08-04|archive-url=https://web.archive.org/web/20210804051210/https://pubmed.ncbi.nlm.nih.gov/10870174/|url-status=live}}</ref><ref>{{Cite web|date=2013-07-23|title=City getting tougher on blood clam ban|url=https://archive.shine.cn/Metro/health-and-science/City-getting-tougher-on-blood-clam-ban/shdaily.shtml|access-date=2021-08-04|website=Shanghai Daily|archive-date=2019-07-19|archive-url=https://web.archive.org/web/20190719162729/https://archive.shine.cn/Metro/health-and-science/City-getting-tougher-on-blood-clam-ban/shdaily.shtml|url-status=live}}</ref><ref>{{Cite journal|last1=Halliday|first1=Mabel L.|last2=Kang|first2=Lai-Yi|last3=Zhou|first3=Ting-Kui|last4=Hu|first4=Meng-Dong|last5=Pan|first5=Qi-Chao|last6=Fu|first6=Ting-Yuan|last7=Huang|first7=Yu-Sheng|last8=Hu|first8=Shan-Lian|date=1991|title=An Epidemic of Hepatitis A Attributable to the Ingestion of Raw Clams in Shanghai, China|url=https://www.jstor.org/stable/30111993|journal=The Journal of Infectious Diseases|volume=164|issue=5|pages=852–859|doi=10.1093/infdis/164.5.852|jstor=30111993|pmid=1658157|issn=0022-1899|access-date=2021-08-04|archive-date=2023-07-02|archive-url=https://web.archive.org/web/20230702210425/https://www.jstor.org/stable/30111993|url-status=live|url-access=subscription}}</ref>
|-
| 1991 Bangladesh cholera epidemic
| 1991
| [[Bangladesh]]
| [[Cholera]]
| data-sort-value="8921"|8,410–9,432
| <ref name=WHOCholeraTable>[https://web.archive.org/web/20130609154502/http://www.who.int/bulletin/volumes/90/3/BLT-11-093427-table-T3.html Summary of cholera cases and deaths reported in the literature, by date, country and World Health Organization (WHO) mortality stratum] Mohammad Ali, Anna Lena Lopez, Young Ae You, Young Eun Kim, Binod Sah, Brian Maskery & John Clemens, Bulletin of the World Health Organization, Volume 90, Number 3, March 2012, 209-218A ''www.who.int'', accessed 4 May 2020</ref>
|-
| 1991 Latin America cholera epidemic
| 1991–1993
| [[Peru]], [[Chile]], [[Bolivia]], [[Ecuador]], [[Colombia]], Mexico, [[El Salvador]], [[Guatemala]]
| [[Cholera]]
| 8,000
|<ref>{{Cite journal|last1=Tickner|first1=Joel|last2=Gouveia-Vigeant|first2=Tami|date=June 2005|title=The 1991 Cholera Epidemic in Peru: Not a Case of Precaution Gone Awry|journal=Risk Analysis|language=en|volume=25|issue=3|pages=495–502|doi=10.1111/j.1539-6924.2005.00617.x|pmid=16022685|bibcode=2005RiskA..25..495T |s2cid=15792284}}</ref><ref>{{Cite journal|date=1991|title=Cholera in the Americas|journal=Bulletin of the Pan American Health Organization|volume=25|issue=3|pages=267–273|issn=0085-4638|pmid=1742573}}</ref>
|-
| [[1994 plague in India]]
| 1994
| India
| [[Bubonic plague]] and [[Pneumonic plague]]
| 56
| <ref>{{Cite journal |last=Dutt |first=Ashok |date=2006 |title=Surat Plaque of 1994 re-examined |url=http://www.tm.mahidol.ac.th/seameo/2006_37_4/21-3658.pdf |journal=Southeast Asian Journal of Tropical Medicine and Public Health |volume=37 |issue=4 |pages=755–760 |access-date=19 June 2016 |archive-url=https://web.archive.org/web/20160206192456/http://www.tm.mahidol.ac.th/seameo/2006_37_4/21-3658.pdf |archive-date=6 February 2016 |url-status=live |pmid=17121302}}</ref>
|-
| [[United Kingdom BSE outbreak]]
| 1996–2001
| United Kingdom
| [[Variant Creutzfeldt–Jakob disease|Variant Creutzfeldt–Jakob disease / vCJD]]
| 178
| <ref>{{Cite web|url=https://www.bbc.com/news/uk-45906585|title='Mad cow disease': What is BSE?|website=BBC|date=18 October 2018|access-date=12 May 2020|archive-date=3 May 2020|archive-url=https://web.archive.org/web/20200503234655/https://www.bbc.com/news/uk-45906585|url-status=live}}</ref><ref name="vCJD">{{cite web |title=Variant Creutzfeldt–Jakob Disease, Current Data (July 2012) |url=http://www.cjd.ed.ac.uk/vcjdworld.htm |access-date=20 April 2020 |publisher=The National Creutzfeldt–Jakob Disease Surveillance Unit (NCJDSU), [[University of Edinburgh]] |url-status=bot: unknown |archive-url=https://web.archive.org/web/20120721234746/http://www.cjd.ed.ac.uk/vcjdworld.htm |archive-date=21 July 2012 |df=dmy}};</ref>
|-
| 1996 West Africa meningitis epidemic
| 1996
| [[West Africa]]
| [[Meningitis]]
| data-sort-value="10000"|10,000
| <ref>[https://www.nytimes.com/1996/05/08/world/wide-epidemic-of-meningitis-fatal-to-10000-in-west-africa.html Wide Epidemic of Meningitis Fatal to 10,000 in West Africa] {{Webarchive|url=https://web.archive.org/web/20230711163624/https://www.nytimes.com/1996/05/08/world/wide-epidemic-of-meningitis-fatal-to-10000-in-west-africa.html |date=2023-07-11 }} Eoward W. French, 8 May 1996 ''www.nytimes.com'', accessed 26 April 2020</ref>
|-
| [[1998–1999 Malaysia Nipah virus outbreak]]
| 1998–1999
| [[Malaysia]]
| [[Nipah virus infection]]
| 105
| <ref name="Nipah outbreak Malaysia98_99">{{cite journal|url=http://www.mjpath.org.my/2007.2/02Nipah_Virus_lessons.pdf|title=Lessons from the Nipah virus outbreak in Malaysia|author1=Lai-Meng Looi|author2=Kaw-Bing Chua|publisher=Department of Pathology, University of Malaya and National Public Health Laboratory of the Ministry of Health, Malaysia|journal=The Malaysian Journal of Pathology|year=2007|volume=29|number=2|pages=63–7|pmid=19108397|archive-url=https://web.archive.org/web/20190830060915/http://www.mjpath.org.my/2007.2/02Nipah_Virus_lessons.pdf|archive-date=30 August 2019|url-status=live}}</ref>
|-
| 1998–2000 Democratic Republic of the Congo Marburg virus outbreak
| 1998–2000
| [[Democratic Republic of the Congo]]
| [[Marburg virus]]
| 128
| <ref name="auto2">{{Cite web|url=https://www.cdc.gov/vhf/marburg/resources/outbreak-table.html|title=Outbreak Table &#124; Marburg Hemorrhagic Fever &#124; CDC|access-date=2021-08-13|archive-date=2015-01-21|archive-url=https://web.archive.org/web/20150121181229/http://www.cdc.gov/vhf/marburg/resources/outbreak-table.html|url-status=live}}</ref>
|-
| 2000 Central America dengue epidemic
| 2000
| [[Central America]]
| [[Dengue fever]]
| data-sort-value="40"| 40+
| <ref>{{Cite web |url=http://www.paho.org/English/sha/be_v21n4-dengue.htm |title=Dengue in the Americas: The Epidemics of 2000 |access-date=2008-08-05 |archive-url=https://web.archive.org/web/20171017153210/http://www1.paho.org/English/sha/be_v21n4-dengue.htm |archive-date=2017-10-17 |url-status=live}}</ref>
|-
| 2001 Nigeria cholera epidemic
| 2001
| [[Nigeria]]
| [[Cholera]]
| data-sort-value="401"| 400+
| <ref>{{Cite news |url=http://news.bbc.co.uk/1/hi/world/africa/1677526.stm |title=Nigeria cholera outbreak kills 400 |date=2001-11-26 |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20031219043217/http://news.bbc.co.uk/1/hi/world/africa/1677526.stm |archive-date=19 December 2003 |url-status=live}}</ref>
|-
| 2001 South Africa cholera epidemic
| 2001
| [[South Africa]]
| [[Cholera]]
| 139
| <ref>{{Cite web |url=http://www.redcross.org/news/in/health/010312cholera.html |title=Cholera Spreads Through South Africa Townships |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20090603003241/http://www.redcross.org/news/in/health/010312cholera.html |archive-date=3 June 2009 |url-status=dead}}<!--In archive: "The page you requested could not be found."--></ref><ref>[https://web.archive.org/web/20040710091424/http://www.who.int/csr/don/2001_03_16/en/ 2001 – Cholera in South Africa] 16 March 2001 ''www.who.int'', accessed 28 April 2020</ref>
|-
| [[2002–2004 SARS outbreak]]
| 2002–2004
| Worldwide
| [[Severe acute respiratory syndrome|Severe acute respiratory syndrome / SARS]]
| 774
| <ref>{{Cite web | url=https://www.who.int/csr/sars/country/table2004_04_21/en/ | title=WHO &#124; Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 | access-date=5 April 2020 | archive-date=19 March 2020 | archive-url=https://web.archive.org/web/20200319162659/https://www.who.int/csr/sars/country/table2004_04_21/en/ | url-status=live }}</ref>
|-
| 2003–2019 Asia and Egypt avian influenza epidemic
| 2003–2019
| [[China]], [[Southeast Asia]] and [[Egypt]]
| [[Influenza A virus subtype H5N1]]
| 455
| <ref>{{Cite web|url=https://www.who.int/influenza/human_animal_interface/2020_MAY_tableH5N1.pdf|title=Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003 – 2020|date=8 May 2020|access-date=4 January 2020|archive-date=3 June 2020|archive-url=https://web.archive.org/web/20200603072330/https://www.who.int/influenza/human_animal_interface/2020_MAY_tableH5N1.pdf|url-status=live}}</ref>
|-
| 2004 Indonesia dengue epidemic
| 2004
| [[Indonesia]]
| [[Dengue fever]]
| 658
| <ref>[https://web.archive.org/web/20040530112333/http://www.who.int/csr/don/2004_05_11a/en/ Dengue fever in Indonesia – update 4] 11 May 2004 ''www.who.int'', accessed 16 February 2020</ref>
|-
| 2004 Sudan Ebola outbreak
| 2004
| [[Sudan]]
| [[Ebola]]
| 7
| <ref name=WHO2014/>
|-
| 2004–2005 Angola Marburg virus outbreak
| 2004–2005
| [[Angola]]
| [[Marburg virus]]
| 227
| <ref name="auto2"/>
|-
| [[2005 dengue outbreak in Singapore]]
| 2005
| [[Singapore]]
| [[Dengue fever]]
| 27
| <ref>{{Cite journal |last1=Koh |first1=B. K. |last2=Ng |first2=L. C. |last3=Kita |first3=Y. |last4=Tang |first4=C. S. |last5=Ang |first5=L. W. |last6=Wong |first6=K. Y. |last7=James |first7=L. |last8=Goh |first8=K. T. |year=2008 |title=The 2005 dengue epidemic in Singapore: Epidemiology, prevention and control |url=http://www.annals.edu.sg/pdf/37VolNo7Jul2008/V37N7p538.pdf |journal=Annals of the Academy of Medicine, Singapore |volume=37 |issue=7 |pages=538–545 |doi=10.47102/annals-acadmedsg.V37N7p538 |pmid=18695764 |s2cid=31640849 |access-date=2018-10-17 |archive-url=https://web.archive.org/web/20170706065103/http://www.annals.edu.sg/PDF/37VolNo7Jul2008/V37N7p538.pdf |archive-date=2017-07-06 |url-status=live}}</ref>
|-
| 2006 Luanda cholera epidemic
| 2006
| [[Luanda]], [[Angola]]
| [[Cholera]]
| data-sort-value="1200"| 1,200+
| <ref>[http://news.bbc.co.uk/2/hi/africa/4990960.stm Worst cholera outbreak in Angola] {{Webarchive|url=https://web.archive.org/web/20170429080644/http://news.bbc.co.uk/2/hi/africa/4990960.stm |date=2017-04-29}}, [[BBC]]</ref>
|-
| 2006 Ituri Province plague epidemic
| 2006
| [[Ituri Province]], [[Democratic Republic of the Congo]]
| [[Bubonic plague]]
| 61
| <ref>[https://web.archive.org/web/20141015101105/http://www.who.int/csr/don/2006_06_14/en/ Plague in the Democratic Republic of the Congo] 14 June 2006 ''www.who.int'', accessed 26 February 2020</ref><ref>[https://web.archive.org/web/20140227135856/http://www.who.int/csr/don/2006_10_13/en/ Plague in the Democratic Republic of the Congo] 13 October 2006 ''www.who.int'', accessed 26 February 2020</ref>
|-
| 2006 India malaria outbreak
| 2006
| India
| [[Malaria]]
| 17
| <ref>{{Cite web |url=http://www.bio-medicine.org/medicine-news/Malaria-Epidemic-Sweeps-Northeast-India-9507-1/ |title=Malaria Epidemic Sweeps Northeast India |access-date=2008-07-01 |archive-url=https://web.archive.org/web/20170203074542/http://www.bio-medicine.org/medicine-news/Malaria-Epidemic-Sweeps-Northeast-India-9507-1/ |archive-date=2017-02-03 |url-status=live}}</ref>
|-
| [[2006 dengue outbreak in India]]
| 2006
| India
| [[Dengue fever]]
| data-sort-value="50"| 50+
| <ref>{{Cite web |url=http://www.news-medical.net/?id=20348 |title=Dengue epidemic threatens India's capital |date=2 October 2006 |website=News-Medical.net |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20090115204240/http://www.news-medical.net/?id=20348 |archive-date=15 January 2009 |url-status=live}}</ref>
|-
| [[2006 dengue outbreak in Pakistan]]
| 2006
| Pakistan
| [[Dengue fever]]
| data-sort-value="50"| 50+
| <ref>{{Cite journal |last1=Khan |first1=E. |last2=Siddiqui |first2=J. |last3=Shakoor |first3=S. |last4=Mehraj |first4=V. |last5=Jamil |first5=B. |last6=Hasan |first6=R. |year=2007 |title=Dengue outbreak in Karachi, Pakistan, 2006: Experience at a tertiary care center |journal=Transactions of the Royal Society of Tropical Medicine and Hygiene |volume=101 |issue=11 |pages=1114–1119 |doi=10.1016/j.trstmh.2007.06.016 |pmid=17706259}}</ref>
|-
| 2006 Philippines dengue epidemic
| 2006
| [[Philippines]]
| [[Dengue fever]]
| data-sort-value="1000"|1,000
| <ref>[https://www.researchgate.net/publication/267872402_Epidemiology_of_Dengue_Disease_in_the_Philippines_2000-2011_A_Systematic_Literature_Review Epidemiology of Dengue Disease in the Philippines (2000–2011): A Systematic Literature Review] {{Webarchive|url=https://web.archive.org/web/20230711163235/https://www.researchgate.net/publication/267872402_Epidemiology_of_Dengue_Disease_in_the_Philippines_2000-2011_A_Systematic_Literature_Review |date=2023-07-11 }} November 2014 PLoS Neglected Tropical Diseases via ''www.researchgate.net'', accessed 16 February 2020</ref>
|-
| [[2006–2007 East Africa Rift Valley fever outbreak]]
| 2006–2007
| [[East Africa]]
| [[Rift Valley fever]]
| 394
| <ref>[https://www.who.int/news-room/fact-sheets/detail/rift-valley-fever Rift Valley fever] {{Webarchive|url=https://web.archive.org/web/20211009062914/https://www.who.int/news-room/fact-sheets/detail/rift-valley-fever |date=2021-10-09 }} 19 February 2018 ''www.who.int'', accessed 26 April 2020</ref>
|-
| [[Mweka, Democratic Republic of the Congo#Epidemic|Mweka Ebola epidemic]]
| 2007
| [[Democratic Republic of the Congo]]
| [[Ebola]]
| 187
| <ref>[http://www.smh.com.au/news/world/mourners-die-as-fever-grips-congo/2007/08/30/1188067243698.html "Mourners die as fever grips Congo."] {{Webarchive|url=https://web.archive.org/web/20121023063718/http://www.smh.com.au/news/world/mourners-die-as-fever-grips-congo/2007/08/30/1188067243698.html |date=2012-10-23}} ''Sydney Morning Herald'', August 30, 2007</ref>
|-
| 2007 Ethiopia cholera epidemic
| 2007
| [[Ethiopia]]
| [[Cholera]]
| 684
| <ref>{{Cite news |url=https://www.theguardian.com/world/2007/feb/22/ethiopia |title=Fatal outbreak not a cholera epidemic, insists Ethiopia |last=Xan Rice |date=2007-02-22 |work=The Guardian |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20171026111149/https://www.theguardian.com/world/2007/feb/22/ethiopia |archive-date=26 October 2017 |url-status=live}}</ref>
|-
| [[2007 Iraq cholera outbreak]]
| 2007
| [[Iraq]]
| [[Cholera]]
| 10
| <ref>[http://www.nbcnews.com/id/21121516 Cholera outbreak in Iraq growing] {{Webarchive|url=https://web.archive.org/web/20170204003658/http://www.nbcnews.com/id/21121516/ |date=2017-02-04}}, [[Associated Press]]</ref>
|-
| 2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
| 2007
| [[Puerto Rico]], [[Dominican Republic]], Mexico
| [[Dengue fever]]
| 183
| <ref>[http://www.alertnet.org/thenews/newsdesk/NA5209573.htm Dengue fever epidemic hits Caribbean, Latin America] {{Webarchive|url=https://web.archive.org/web/20090803084737/http://www.alertnet.org/thenews/newsdesk/NA5209573.htm |date=2009-08-03}}, Reuters</ref>
|-
| 2007 Uganda Ebola outbreak
| 2007
| [[Uganda]]
| [[Ebola]]
| 37
| <ref name=WHO2014>{{cite press release | title = Ebola virus disease | url = https://www.who.int/en/news-room/fact-sheets/detail/ebola-virus-disease | publisher = [[World Health Organization]] (WHO) | access-date = 26 February 2020 | date = 12 February 2018 | df = dmy-all | archive-date = 18 April 2018 | archive-url = https://web.archive.org/web/20180418095601/http://www.who.int/mediacentre/factsheets/fs103/en/ | url-status = live }}</ref>
|-
| 2007 Netherlands Q-fever epidemic
| 2007–2018
| Netherlands
| [[Q-fever]]
| 95
| <ref>{{Cite web|url=https://www.nu.nl/binnenland/5550881/q-koorts-nog-niet-voorbij-in-totaal-al-95-doden.html|title=Q-koorts nog niet voorbij: In totaal al 95 doden|language=Dutch|website=nu.nl|date=3 November 2018|access-date=4 February 2021|archive-date=9 February 2021|archive-url=https://web.archive.org/web/20210209141633/https://www.nu.nl/binnenland/5550881/q-koorts-nog-niet-voorbij-in-totaal-al-95-doden.html|url-status=live}}</ref>
|-
| 2008 Brazil dengue epidemic
| 2008
| Brazil
| [[Dengue fever]]
| 67
| <ref>[https://edition.cnn.com/2008/HEALTH/conditions/04/03/brazil.dengue/index.html Thousands hit by Brazil outbreak of dengue] {{Webarchive|url=https://web.archive.org/web/20230711162221/https://edition.cnn.com/2008/HEALTH/conditions/04/03/brazil.dengue/index.html |date=2023-07-11 }} ''edition.cnn.com'', accessed 16 February 2020</ref>
|-
| 2008 Cambodia dengue epidemic
| 2008
| [[Cambodia]]
| [[Dengue fever]]
| 407
| <ref>[http://www.alertnet.org/thenews/newsdesk/BKK133167.htm Cambodia suffers worst dengue epidemic, 407 dead] {{Webarchive|url=https://web.archive.org/web/20091111203520/http://www.alertnet.org/thenews/newsdesk/BKK133167.htm |date=2009-11-11}}, Reuters</ref>
|-
| 2008 Chad cholera epidemic
| 2008
| [[Chad]]
| [[Cholera]]
| 123
| <ref>{{Cite web |url=http://www.irinnews.org/report.aspx?reportid=51238 |title=Cholera epidemic in western Chad kills 123 |access-date=2008-06-08 |archive-url=https://web.archive.org/web/20090112054136/http://www.irinnews.org/report.aspx?reportid=51238 |archive-date=2009-01-12 |url-status=live |date=2004-09-02}}</ref>
|-
| 2008–2017 China hand, foot, and mouth disease epidemic
| 2008–2017
| China
| [[Hand, foot, and mouth disease]]
| data-sort-value="3322" | 3,322+
| <ref name=HFMD>{{cite journal |doi=10.3201/eid2403.171303|title=Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015|year=2018|last1=Huang|first1=Jiao|last2=Liao|first2=Qiaohong|last3=Ooi|first3=Mong How|last4=Cowling|first4=Benjamin J.|last5=Chang|first5=Zhaorui|last6=Wu|first6=Peng|last7=Liu|first7=Fengfeng|last8=Li|first8=Yu|last9=Luo|first9=Li|last10=Yu|first10=Shuanbao|last11=Yu|first11=Hongjie|last12=Wei|first12=Sheng|journal=Emerging Infectious Diseases|volume=24|issue=3|pages=432–442 |pmid=29460747|pmc=5823341}}''2008–2015, ≈13 million HFMD cases were reported, including 123,261 severe cases and 3,322 deaths in 31 provinces of mainland China''</ref>
|-
| 2008 India cholera epidemic
| 2008
| India
| [[Cholera]]
| 115
| <ref>[http://news.bbc.co.uk/2/hi/south_asia/6968281.stm Cholera death toll in India rises] {{Webarchive|url=https://web.archive.org/web/20171111043033/http://news.bbc.co.uk/2/hi/south_asia/6968281.stm |date=2017-11-11}}, BBC News</ref>
|-
| 2008 Madagascar plague outbreak
| 2008
| [[Madagascar]]
| [[Bubonic plague]]
| data-sort-value="18"| 18+
| <ref>{{Cite web|url=http://eldib.wordpress.com/2008/01/10/2175/|archive-url=https://web.archive.org/web/20090509210150/http://eldib.wordpress.com/2008/01/10/2175/|url-status=dead|title=Madagascar: eighteen dead from Bubonic Plague, five in hospital since 1 January 2008|archive-date=May 9, 2009}}</ref>
|-
| 2008 Philippines dengue epidemic
| 2008
| [[Philippines]]
| [[Dengue fever]]
| data-sort-value="172" |172
| <ref>{{Cite web |url=http://www.terradaily.com/reports/Dengue_cases_in_Philippines_rise_by_43_percent_government_999.html |title=Dengue cases in Philippines rise by 43 percent: government |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20171017153157/http://www.terradaily.com/reports/Dengue_cases_in_Philippines_rise_by_43_percent_government_999.html |archive-date=17 October 2017 |url-status=live}}</ref>
|-
| [[2008 Zimbabwean cholera outbreak]]
| 2008–2009
| [[Zimbabwe]]
| [[Cholera]]
| data-sort-value="4293"|4,293
| <ref name=WHOZim>{{cite web |url=https://www.who.int/cholera/countries/ZimbabweCountryProfileOct2009.pdf |access-date=16 February 2020 |title=Cholera Country Profile: Zimbabwe |date=31 October 2009 |publisher=World Health Organization – Global Task Force on Cholera Control |archive-date=31 October 2017 |archive-url=https://web.archive.org/web/20171031123847/http://www.who.int/cholera/countries/ZimbabweCountryProfileOct2009.pdf |url-status=live }}</ref>
|-
| [[2009 Bolivian dengue fever epidemic]]
| 2009
| [[Bolivia]]
| [[Dengue fever]]
| 18
| <ref>{{cite journal| pmc=3516305 | pmid=23042846 | doi=10.4269/ajtmh.2012.11-0770 | volume=87 | title=The history of dengue outbreaks in the Americas | year=2012 | author1=Brathwaite Dick O |author2=San Martín JL |author3=Montoya RH |author4=del Diego J |author5=Zambrano B |author6=Dayan GH | journal=Am J Trop Med Hyg | issue=4 | pages=584–593}}</ref>
|-
| [[2009 Gujarat hepatitis outbreak]]
| 2009
| India
| [[Hepatitis B]]
| 49
| <ref>{{Cite web |url=http://www.ndtv.com/convergence/ndtv/story.aspx?id=NEWEN20090084387 |title=NDTV Report |access-date=2009-02-23 |archive-url=https://web.archive.org/web/20090225134231/http://www.ndtv.com/convergence/ndtv/story.aspx?id=NEWEN20090084387 |archive-date=2009-02-25 |url-status=dead}}</ref>
|-
| Queensland 2009 dengue outbreak
| 2009
| [[Queensland]], Australia
| [[Dengue fever]]
| data-sort-value="1.1"| 1+ (503 cases)
| <ref>{{Cite journal |last=McCredie |first=J. |s2cid=41469446 |year=2009 |title=Dengue fever epidemic hits northern Australia |journal=BMJ |volume=338 |issue=mar09 2 |pages=b967 |doi=10.1136/bmj.b967 |pmid=19273518}}</ref>
|-
| [[2009–2010 West African meningitis outbreak]]
| 2009–2010
| [[West Africa]]
| [[Meningitis]]
| data-sort-value="1100"|1,100
| <ref>{{Cite journal |last=Odigwe |first=C. |s2cid=11085562 |year=2009 |title=West Africa has worst meningitis epidemic for 10 years |journal=BMJ |volume=338 |issue=apr21 1 |pages=b1638 |doi=10.1136/bmj.b1638 |pmid=19383759}}</ref>
|-
| rowspan="2" | [[2009 swine flu pandemic]]
| rowspan="2" | 2009–2010
| rowspan="2" | Worldwide
| rowspan="2" | [[Influenza A virus subtype H1N1]]
| data-sort-value="284,000"|Lab confirmed deaths: 18,449 (reported to the [[World Health Organization|WHO]])
|<ref>{{Cite web|url=https://www.cdc.gov/flu/spotlights/pandemic-global-estimates.htm|title=First Global Estimates of 2009 H1N1 Pandemic Mortality Released by CDC-Led Collaboration|date=2019-11-20|website=www.cdc.gov|language=en-us|access-date=2020-03-12|archive-date=2020-03-03|archive-url=https://web.archive.org/web/20200303012120/https://www.cdc.gov/flu/spotlights/pandemic-global-estimates.htm|url-status=live}}</ref>
|-
|Estimated death toll: 284,000 (possible range 151,700–575,400)
|<ref>{{Cite web |title=Pandemic (H1N1) 2009 – update 112 |url=https://www.who.int/csr/don/2010_08_06/en/ |url-status=dead |archive-url=https://web.archive.org/web/20110327194118/http://www.who.int/csr/don/2010_08_06/en/ |archive-date=March 27, 2011 |access-date=October 3, 2020}}()</ref>
|-
| [[2010s Haiti cholera outbreak]]
| 2010–2019
| [[Haiti]]
| [[Cholera]] (strain serogroup O1, serotype Ogawa)
| data-sort-value="10075"|10,075
| <ref>{{cite web |title=Epidemiological Update Cholera 28 Dec 2017 |website=www.paho.org |url=http://www.paho.org/hq/index.php?option=com_docman&task=doc_download&Itemid=&gid=43291&lang=pt |access-date=15 May 2020 |archive-date=12 July 2021 |archive-url=https://web.archive.org/web/20210712225758/https://www.paho.org/hq/dmdocuments/2017/2017-dec-28-phe-epi-update-cholera.pdf |url-status=live }}</ref>
|-
| 2010–2014 Democratic Republic of the Congo measles outbreak
| 2010–2014
| [[Democratic Republic of the Congo]]
| [[Measles]]
| data-sort-value="4,501"| 4,500+
| <ref>{{Cite web |url=http://www.doctorswithoutborders.org/press/release.cfm?id=5132&cat=press-release |title=Doctorswithoutborders.org |website=MSF USA |url-status=dead |archive-url=https://web.archive.org/web/20110927220605/http://www.doctorswithoutborders.org/press/release.cfm?id=5132&cat=press-release |archive-date=27 September 2011 |access-date=16 November 2014}}</ref><ref>{{Cite web |url=http://www.msf.org/article/democratic-republic-congo-more-measles-vaccinations-needed |title=Democratic Republic of Congo: More measles vaccinations needed |website=Médecins Sans Frontières (MSF) International |access-date=16 November 2014 |archive-url=https://web.archive.org/web/20141102114052/http://www.msf.org/article/democratic-republic-congo-more-measles-vaccinations-needed |archive-date=2 November 2014 |url-status=live}}</ref>
|-
| 2011 Vietnam hand, foot, and mouth disease epidemic
| 2011
| [[Vietnam]]
| [[Hand, foot, and mouth disease]]
| 170
| <ref>[https://news.yahoo.com/vietnam-alert-common-virus-kills-81-children-071532226.html Vietnam on alert as common virus kills 81 children – Yahoo News] {{Webarchive|url=https://web.archive.org/web/20160305003723/http://news.yahoo.com/vietnam-alert-common-virus-kills-81-children-071532226.html |date=2016-03-05}}. News.yahoo.com (2011-08-19). Retrieved on 2014-05-12.</ref><ref>{{Cite journal |last1=Nguyen |first1=Ngoc TB |last2=Pham |first2=Hau V. |last3=Hoang |first3=Cuong Q. |last4=Nguyen |first4=Tien M. |last5=Nguyen |first5=Long T. |last6=Phan |first6=Hung C. |last7=Phan |first7=Lan T. |last8=Vu |first8=Long N. |last9=Tran Minh |first9=Nguyen N. |year=2014 |title=Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, 2011 |journal=BMC Infectious Diseases |volume=14 |issue=1 |pages=341 |doi=10.1186/1471-2334-14-341 |pmc=4068316 |pmid=24942066 |doi-access=free }}</ref>
|-
| [[2011 dengue outbreak in Pakistan]]
| 2011
| Pakistan
| [[Dengue fever]]
| data-sort-value="350"| 350+
| <ref>[http://www.emro.who.int/surveillance-forecasting-response/surveillance-events/conference-on-dengue-control.html Surveillance, forecasting and response International conference on dengue control, 27–29 February 2012] {{Webarchive|url=https://web.archive.org/web/20230711162017/http://www.emro.who.int/surveillance-forecasting-response/surveillance-events/conference-on-dengue-control.html |date=11 July 2023 }} ''www.emro.who.int'' accessed 16 February 2020</ref>
|-
| [[2012 yellow fever outbreak in Darfur, Sudan]]
| 2012
| [[Darfur]], [[Sudan]]
| [[Yellow fever]]
| 171
| <ref>{{Cite journal |last1=Yuill |first1=Thomas M. |last2=Woodall |first2=John P. |last3=Baekeland |first3=Susan |year=2013 |title=Latest outbreak news from ProMED-mail. Yellow fever outbreak–Darfur Sudan and Chad |journal=International Journal of Infectious Diseases |volume=17 |issue=7 |pages=e476–e478 |doi=10.1016/j.ijid.2013.03.009|doi-access=free }}</ref>
|- style="font-weight: bold;"
| [[MERS outbreak]]
| 2012–present
| Worldwide
|[[Middle East respiratory syndrome|Middle East respiratory syndrome / MERS-CoV]]
| data-sort-value="941"|941 ({{as of|2021|May|8|lc=y}})
| <ref>{{Cite web|date=1 February 2021|title=Geographical distribution of confirmed MERS-CoV cases by country of infection and year|url=https://www.ecdc.europa.eu/en/publications-data/geographical-distribution-confirmed-mers-cov-cases-country-infection-and-year|access-date=28 February 2021|website=European Centre for Disease Prevention and Control|archive-date=26 March 2021|archive-url=https://web.archive.org/web/20210326093527/https://www.ecdc.europa.eu/en/publications-data/geographical-distribution-confirmed-mers-cov-cases-country-infection-and-year|url-status=live}}</ref><ref>{{Cite web|date=8 May 2021|title=Saudi Arabia reports 8th MERS case of 2021|url=http://outbreaknewstoday.com/saudi-arabia-reports-8th-mers-case-of-2021-2021/|access-date=5 June 2021|website=Outbreak News Today|archive-date=5 June 2021|archive-url=https://web.archive.org/web/20210605200816/http://outbreaknewstoday.com/saudi-arabia-reports-8th-mers-case-of-2021-2021/|url-status=dead}}</ref>
|-
| [[2013 dengue outbreak in Singapore]]
| 2013
| [[Singapore]]
| [[Dengue fever]]
| 8
|
|-
| 2013 Vietnam measles outbreak
| 2013–2014
| [[Vietnam]]
| [[Measles]]
| 142
| <ref>{{Cite news |url=https://www.smh.com.au/world/vietnam-measles-outbreak-kills-more-than-100-people-mostly-children-20140418-zqwkk.html |title=Vietnam measles outbreak kills more than 100 people, mostly children |date=18 April 2014 |work=[[Sydney Morning Herald]] |access-date=3 March 2020 |archive-date=3 March 2020 |archive-url=https://web.archive.org/web/20200303072443/https://www.smh.com.au/world/vietnam-measles-outbreak-kills-more-than-100-people-mostly-children-20140418-zqwkk.html |url-status=live }}</ref>
|-
| [[Western African Ebola virus epidemic]]
| 2013–2016
| Worldwide, primarily concentrated in [[Guinea]], [[Liberia]], [[Sierra Leone]]
| |[[Ebola]]
| data-sort-value="11301"| 11,323+
| <ref>{{Cite web|url=https://www.cdc.gov/vhf/ebola/history/2014-2016-outbreak/index.html|title=2014–2016 Ebola Outbreak in West Africa (section titled 'Impact')|date=2019-08-22|website=www.cdc.gov|language=en-us|access-date=2020-02-14|archive-date=2019-06-17|archive-url=https://web.archive.org/web/20190617162803/https://www.cdc.gov/vhf/ebola/history/2014-2016-outbreak/index.html|url-status=live}}</ref><ref>{{Cite web |url=http://apps.who.int/gho/data/view.ebola-sitrep.ebola-summary-latest?lang=en |title=Situation summary Latest available situation summary, 26 June 2015. World Health Organization (2015-06-19). Retrieved on 2015-06-20. |access-date=27 June 2015 |archive-url=https://web.archive.org/web/20160605002217/http://apps.who.int/gho/data/view.ebola-sitrep.ebola-summary-latest?lang=en |archive-date=5 June 2016 |url-status=live}}</ref><ref>{{Cite journal |last1=Gignoux |first1=Etienne |last2=Idowu |first2=Rachel |last3=Bawo |first3=Luke |last4=Hurum |first4=Lindis |last5=Sprecher |first5=Armand |last6=Bastard |first6=Mathieu |last7=Porten |first7=Klaudia |year=2015 |title=Use of Capture–Recapture to Estimate Underreporting of Ebola Virus Disease, Montserrado County, Liberia |journal=Emerging Infectious Diseases |volume=21 |issue=12 |pages=2265–2267 |doi=10.3201/eid2112.150756 |pmc=4672419 |pmid=26583831}}</ref>
|-
| [[2013–2014 chikungunya outbreak]]
| 2013–2015
| [[Americas]]
| [[Chikungunya]]
| 183
| <ref>{{Cite web |url=http://www.paho.org/hq/index.php?option=com_topics&view=article&id=343&Itemid=40931&lang=es |title=Número de casos informados de artritis epidémica chikungunya en las Américas – SE 5 (February 6, 2015) |publisher=Pan American Health Organization |access-date=February 11, 2015 |archive-url=https://web.archive.org/web/20150218071201/http://www.paho.org/hq/index.php?option=com_topics&view=article&id=343&Itemid=40931&lang=es |archive-date=February 18, 2015 |url-status=live}}</ref>
|-
| 2013–19 [[avian influenza]] epidemic
| 2013–2019
| China
| [[Influenza A virus subtype H7N9]]
| 616
| <ref>{{Cite web |date=2019-12-04 |title=FAO H7N9 situation update – Avian Influenza A(H7N9) virus |url=http://www.fao.org/ag/againfo/programmes/en/empres/H7N9/situation_update.html |access-date=2020-06-10 |website=www.fao.org |archive-date=2020-06-17 |archive-url=https://web.archive.org/web/20200617211856/http://www.fao.org/ag/againfo/programmes/en/empres/H7N9/situation_update.html |url-status=live }}</ref>
|-
| [[21st century Madagascar plague outbreaks]]
| 2014–2017
| [[Madagascar]]
| [[Bubonic plague]]
| 292
| <ref>{{Cite web |url=https://www.who.int/csr/don/21-november-2014-plague/en/ |title=Plague – Madagascar |website=WHO |publisher=World Health Organization |access-date=5 July 2016 |archive-url=https://web.archive.org/web/20190502001426/https://www.who.int/csr/don/21-november-2014-plague/en/ |archive-date=2 May 2019 |url-status=dead}}</ref>
|-
| [[Flint water crisis]]
| 2014–2015
| [[Flint, Michigan]], United States
| [[Legionnaires' disease]]
| 12
| <ref>{{Cite news|url=https://www.npr.org/sections/health-shots/2018/02/05/582482024/lethal-pneumonia-outbreak-caused-by-low-chlorine-in-flint-water|title=Lethal Pneumonia Outbreak Caused by Low Chlorine in Flint Water|newspaper=NPR.org|access-date=2021-06-16|archive-date=2023-07-11|archive-url=https://web.archive.org/web/20230711110132/https://www.npr.org/sections/health-shots/2018/02/05/582482024/lethal-pneumonia-outbreak-caused-by-low-chlorine-in-flint-water|url-status=live}}</ref>
|-
| [[2014 Odisha hepatitis outbreak]]
| 2014–2015
| India
| Primarily [[Hepatitis E]], but also [[Hepatitis A]]
| 36
|<ref name="Grapples">{{Cite news |url=http://www.deccanherald.com/content/460129/odisha-grapples-jaundice-outbreak.html |title=Odisha grapples with jaundice outbreak |date=17 February 2015 |work=[[Deccan Herald]] |access-date=17 February 2015 |archive-url=https://web.archive.org/web/20150217120135/http://www.deccanherald.com/content/460129/odisha-grapples-jaundice-outbreak.html |archive-date=17 February 2015 |url-status=live}}</ref>
|-
| [[2015 Indian swine flu outbreak]]
| 2015
| India
| [[Influenza A virus subtype H1N1]]
| data-sort-value="2035"|2,035
| <ref name="THE2">{{Cite web |url=http://indianexpress.com/article/india/india-others/swine-flu-deaths-at-1895-cases-near-32k-mark/ |title=Swine flu deaths at 1895; number of cases near 32K mark |last=Press Trust of India |date=March 21, 2015 |publisher=[[The Indian Express]] |access-date=March 21, 2015 |archive-url=https://web.archive.org/web/20151012003206/http://indianexpress.com/article/india/india-others/swine-flu-deaths-at-1895-cases-near-32k-mark/ |archive-date=October 12, 2015 |url-status=live}}</ref><ref name="DeadlySwineFlu">{{Cite news |url=https://www.bbc.com/news/world-asia-india-31547455 |title=India struggles with deadly swine flu outbreak |date=20 February 2015 |work=[[BBC News]] |access-date=21 February 2015 |archive-url=https://web.archive.org/web/20150221082410/http://www.bbc.com/news/world-asia-india-31547455 |archive-date=21 February 2015 |url-status=live}}</ref><ref name="GJDeadlySwineFlu">{{Cite news |url=http://www.business-standard.com/article/pti-stories/swine-flu-claims-5-more-lives-toll-mounts-to-387-in-gujarat-115031500609_1.html |title=Death toll Gujarat |date=15 March 2015 |work=[[Business Standard]] |access-date=15 March 2015 |archive-url=https://web.archive.org/web/20150402093322/http://www.business-standard.com/article/pti-stories/swine-flu-claims-5-more-lives-toll-mounts-to-387-in-gujarat-115031500609_1.html |archive-date=2 April 2015 |url-status=live}}</ref>
|-
| [[2015–16 Zika virus epidemic]]
| 2015–2016
| Worldwide
| [[Zika virus]]
| 53
| <ref>{{cite web|url=https://www.worldwideoutbreak.com/blog/cool_timeline/2015-16-zika-virus-epidemic|title=2015–16 Zika Virus Epidemic|website=worldwideoutbreak|access-date=12 May 2020|archive-date=3 August 2020|archive-url=https://web.archive.org/web/20200803152135/https://www.worldwideoutbreak.com/blog/cool_timeline/2015-16-zika-virus-epidemic/|url-status=live}}</ref>
|-
| [[2016 Angola and DR Congo yellow fever outbreak|2016 Angola and Democratic Republic of the Congo yellow fever outbreak]]
| 2016
| [[Angola]] and [[Democratic Republic of the Congo]]
| [[Yellow fever]]
| 498 (377 in Angola, 121 in Congo)
| <ref>{{Cite web |url=http://www.promedmail.org/post/4123983 |title=Yellow fever – countries with dengue: alert 2016-03-28 20:39:56 Archive Number: Archive Number: 20160328.4123983 |website=ProMED-mail |publisher=International Society for Infectious Diseases |access-date=29 March 2016 |archive-url=https://web.archive.org/web/20160410065146/http://www.promedmail.org/post/4123983 |archive-date=10 April 2016 |url-status=live}}</ref>
|-
| [[2016–2022 Yemen cholera outbreak]]
| 2016–2023
| [[Yemen]]
| [[Cholera]]
| data-sort-value="4004"|4,004 ({{as of|2023|6|11|lc=y|df=US}})
| <ref>{{Cite web|url=https://reliefweb.int/report/yemen/cholera-situation-yemen-december-2020|title=Cholera situation in Yemen, December 2020|website=reliefweb.int|publisher=[[World Health Organization]]|date=5 March 2021|access-date=21 May 2021|archive-date=13 May 2021|archive-url=https://web.archive.org/web/20210513160701/https://reliefweb.int/report/yemen/cholera-situation-yemen-december-2020|url-status=live}}</ref>
|-
| 2017 Nigeria Lassa fever epidemic
| 2017–2023
| [[Nigeria]]
| [[Lassa fever]]
| 1103 (as of April 2023)
| <ref>{{Cite web|url=https://reliefweb.int/report/nigeria/ncdc-lassa-fever-situation-report-epi-week-18-03-09-may-2021|title=NCDC Lassa fever Situation Report Epi Week 18: 03 – 09 May 2021|date=9 May 2021|access-date=21 May 2021|archive-date=13 May 2021|archive-url=https://web.archive.org/web/20210513113918/https://reliefweb.int/report/nigeria/ncdc-lassa-fever-situation-report-epi-week-18-03-09-may-2021|url-status=live}}</ref>
|-
| [[2017 dengue outbreak in Peshawar]]
| 2017
| [[Peshawar]], Pakistan
| [[Dengue fever]]
| 69
| <ref>{{cite web|url=https://reliefweb.int/disaster/ep-2017-000133-pak|publisher=WHO|title=Pakistan: Dengue Outbreak – Sep 2017|date=16 December 2019|access-date=15 May 2020|website=reliefweb.int|archive-date=3 August 2020|archive-url=https://web.archive.org/web/20200803063745/https://reliefweb.int/disaster/ep-2017-000133-pak|url-status=live}}</ref>
|-
| [[2017 Gorakhpur hospital deaths]]
| 2017
| India
| [[Japanese encephalitis]]
| data-sort-value="1317"|1,317
| <ref>[https://www.indiatvnews.com/news/india-encephalitis-outbreak-gorakhpur-muzaffarpur-jev-aes-eastern-uttar-pradesh-northern-bihar-527836 Encephalitis outbreak: AES is a perennial issue in eastern Uttar Pradesh, northern Bihar] {{Webarchive|url=https://web.archive.org/web/20230711161944/https://www.indiatvnews.com/news/india-encephalitis-outbreak-gorakhpur-muzaffarpur-jev-aes-eastern-uttar-pradesh-northern-bihar-527836 |date=2023-07-11 }} Bihar's AES data summary looks more like a repeat of 2017 when a major JEV outbreak in Uttar Pradesh's Gorakhpur claimed the lives of many children. 17 June 2019 ''www.indiatvnews.com'', accessed 17 February 2020</ref>
|-
| [[2017 dengue outbreak in Sri Lanka]]
| 2017
| [[Sri Lanka]]
| [[Dengue fever]]
| 440
|<ref>{{Cite web|title=Trends|url=http://www.epid.gov.lk/web/index.php?option=com_casesanddeaths&Itemid=448&lang=en|access-date=2020-12-25|website=www.epid.gov.lk|archive-date=2020-04-09|archive-url=https://web.archive.org/web/20200409175345/http://www.epid.gov.lk/web/index.php?option=com_casesanddeaths&Itemid=448&lang=en|url-status=live}}</ref>
|-
| [[2018 Nipah virus outbreak in Kerala]]
| 2018
| India
| [[Nipah virus infection]]
| data-sort-value="17"| 17
| <ref>{{Cite news|url=https://www.thenewsminute.com/article/nipah-virus-contained-last-two-positive-cases-have-recovered-kerala-health-min-82809|title=Nipah virus contained, last two positive cases have recovered: Kerala Health Min|date=2018-06-11|work=The News Minute|access-date=2020-02-16|archive-date=2019-02-08|archive-url=https://web.archive.org/web/20190208224936/https://www.thenewsminute.com/article/nipah-virus-contained-last-two-positive-cases-have-recovered-kerala-health-min-82809|url-status=live}}</ref>
|-
| [[Kivu Ebola epidemic]]
| 2018–2020
| [[Democratic Republic of the Congo]] and [[Uganda]]
| [[Ebola]]
| data-sort-value="2271"| 2,280
|<ref>{{cite web|title=Operations Dashboard for ArcGIS|url=https://who.maps.arcgis.com/apps/opsdashboard/index.html#/e70c3804f6044652bc37cce7d8fcef6c|website=who.maps.arcgis.com|date=25 June 2020|access-date=28 June 2020|archive-date=21 August 2019|archive-url=https://web.archive.org/web/20190821210526/https://who.maps.arcgis.com/apps/opsdashboard/index.html#/e70c3804f6044652bc37cce7d8fcef6c|url-status=live}}</ref><ref>{{Cite web |url=https://www.afro.who.int/publications/ebola-virus-disease-outbreak-uganda-situation-reports |title=Ebola Virus Disease Outbreak Uganda Situation Reports |website=WHO {{!}} Regional Office for Africa |language=en |access-date=3 September 2019 |archive-url=https://web.archive.org/web/20190620130334/https://www.afro.who.int/publications/ebola-virus-disease-outbreak-uganda-situation-reports |archive-date=20 June 2019 |url-status=live}}</ref><ref>{{cite web |title=DR Congo's deadliest Ebola outbreak declared over |url=https://www.bbc.com/news/world-africa-53179323 |website=BBC News |access-date=25 June 2020 |date=25 June 2020 |archive-date=31 December 2020 |archive-url=https://web.archive.org/web/20201231180943/https://www.bbc.com/news/world-africa-53179323 |url-status=live }}</ref>
|-
| 2018 NDM-CRE outbreak in Italy
| 2018–2019
| Italy
| [[New Delhi metallo-beta-lactamase 1|New Delhi metallo-beta-lactamase]]-producing [[Carbapenem-resistant enterobacteriaceae]]
| 31 (as of September 2019)
|<ref>{{Cite web|url=https://www.ndtv.com/world-news/superbug-that-surfaced-in-delhi-strikes-in-italys-tuscany-2100068|title=Superbug That Surfaced In Delhi Strikes In Italy's Tuscany|date=12 September 2019|access-date=8 February 2021|website=ndtv.com|archive-date=25 December 2021|archive-url=https://web.archive.org/web/20211225042826/https://www.ndtv.com/world-news/superbug-that-surfaced-in-delhi-strikes-in-italys-tuscany-2100068|url-status=live}}</ref>
|-
| [[2019–2020 measles outbreak in the Democratic Republic of the Congo]]
| 2019–2020
| [[Democratic Republic of the Congo]]
| [[Measles]]
| 7,018+
| <ref>{{Cite news |url=http://outbreaknewstoday.com/drc-more-ebola-and-plague-cases-reported-end-of-measles-epidemic-declared-74655/ |title=DRC: More Ebola and plague cases reported, End of measles epidemic declared |language=en |access-date=2020-09-07 |archive-date=2020-08-30 |archive-url=https://web.archive.org/web/20200830182855/http://outbreaknewstoday.com/drc-more-ebola-and-plague-cases-reported-end-of-measles-epidemic-declared-74655/ |url-status=dead }}</ref>
|-
| [[2019–2020 New Zealand measles outbreak]]
| 2019–2020
| New Zealand
| [[Measles]]
| 2
| <ref name="NZmeasles">{{Cite web |date=24 February 2020 |title=Measles weekly report |url=https://surv.esr.cri.nz/PDF_surveillance/MeaslesRpt/2020/measlesReport20200210.pdf |access-date=4 March 2021 |website=Public Health Surveillance |archive-date=19 February 2020 |archive-url=https://web.archive.org/web/20200219000610/https://surv.esr.cri.nz/PDF_surveillance/MeaslesRpt/2020/measlesReport20200210.pdf |url-status=dead }}</ref>
|-
| [[2019 measles outbreak in the Philippines]]
| 2019
| [[Philippines]]
| [[Measles]]
| 415
| <ref>{{cite news |last1=Tomacruz |first1=Sofia |title=At least 70 deaths due to measles – DOH |url=https://www.rappler.com/nation/223208-doh-report-deaths-due-to-measles-february-2019 |access-date=11 February 2019 |work=Rappler |date=11 February 2019}}</ref>
|-
| [[2019 Kuala Koh measles outbreak]]
| 2019
| Kuala Koh, [[Malaysia]]
| [[Measles]]
| 15
| <ref>{{cite web|url=https://says.com/my/news/mysterious-illness-causing-deaths-of-kampung-kuala-koh-orang-asli-identified-as-measles|title=A Measles Outbreak Is The Cause of 15 Orang Asli Deaths In Kelantan|first=Alyssa J.|last=Oon|publisher=Says.com|date=17 June 2019|access-date=27 August 2019|archive-url=https://web.archive.org/web/20190827033231/https://says.com/my/news/mysterious-illness-causing-deaths-of-kampung-kuala-koh-orang-asli-identified-as-measles|archive-date=27 August 2019|url-status=live}}</ref>
|-
| [[2019 Samoa measles outbreak]]
| 2019
| [[Samoa]]
| [[Measles]]
| 83
| <ref name="Samoa83">{{cite news|url=https://www.rnz.co.nz/international/pacific-news/406802/two-more-deaths-from-measles-in-samoa-over-new-year-period|title=Two more deaths from measles in samoa over new year period|date=2020-01-07|work=Radio New Zealand|url-status=live|archive-url=https://web.archive.org/web/20200107105921/https://www.rnz.co.nz/international/pacific-news/406802/two-more-deaths-from-measles-in-samoa-over-new-year-period|archive-date=2020-01-07}}</ref>
|-
| [[2019–2020 dengue fever epidemic]]
| 2019–2020
| [[Asia-Pacific]], [[Latin America]]
| [[Dengue fever]]
| data-sort-value="3,931" | 3,931
| <ref>{{cite news |title=Dengue and severe dengue |url=https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue |work=World Health Organization (WHO) |date=2 March 2020}}</ref>
|- style="font-weight: bold;"
| [[COVID-19 pandemic]]
| 2019{{efn|The COVID-19 pandemic started as a regional [[Disease outbreak|outbreak]]/[[epidemic]] of COVID-19 in China in late 2019. The World Health Organization referred to it as a "pandemic" on 11 March 2020.<ref>{{cite web |title=WHO Director-General's opening remarks at the media briefing on COVID-19 – 11 March 2020 |url=https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 |website=World Health Organization |language=en}}</ref> The starting time of this epidemic is thus 2019, regardless of the time when it became a pandemic.|name="COVID2"}}–present
| Worldwide
| [[COVID-19]]
| data-sort-value="15000000 | 7.1–36.5 million
| <ref name=Economist2023>{{cite news|title=The pandemic's true death toll |newspaper=The Economist |url=https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates |archive-url=https://web.archive.org/web/20240208015904/https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates|date=26 July 2023|archive-date=8 February 2024}}</ref>
|-
| [[Kivu Ebola epidemic#Subsequent outbreaks and other regional health issues|2020 Democratic Republic of the Congo Ebola outbreak]]
| 2020
| [[Democratic Republic of the Congo]]
| [[Ebola]]
| 55
| <ref>{{cite web |title=UNICEF welcomes end of Ebola outbreak in the Equateur Province of the DRC |url=https://www.unicef.org/press-releases/unicef-welcomes-end-ebola-outbreak-equateur-province-drc |website=www.unicef.org |access-date=18 November 2020}}</ref>
|-
| [[2020 dengue outbreak in Singapore]]
| 2020
| [[Singapore]]
| [[Dengue fever]]
| 32
| <ref>{{cite web |title=Dengue surveillance data, Oct – Dec 2020 |url=https://www.nea.gov.sg/docs/default-source/default-document-library/q4-2020-dengue-surveillance-data-(112kb).pdf |publisher=National Environment Agency}}</ref>
|-
| 2020 Nigeria yellow fever epidemic
| 2020
| [[Nigeria]]
| [[Yellow fever]]
| 296 (as of 31 December 2020)
| <ref>{{Cite web|last=|first=|date=31 Dec 2020|title=YELLOW FEVER SITUATION REPORT week 53 (December 31 2020)|url=https://ncdc.gov.ng/diseases/sitreps/?cat=10&name=An%20update%20of%20Yellow%20Fever%20outbreak%20in%20Nigeria|access-date=27 Jan 2021|website=Nigeria Centre for Disease Control}}</ref>
|-
|[[2021 South Sudan disease outbreak]]
|2021
|[[South Sudan]]
|Unknown
|97 (as of December 2021)
|<ref>{{Cite web |last=Heilman |first=Greg |date=2021-12-24 |title=What disease does WHO say is causing deaths in South Sudan? |url=https://en.as.com/en/2021/12/24/latest_news/1640353876_492073.html |access-date=2022-10-24 |website=Diario AS |language=en}}</ref>
|-
| 2021 India black fungus epidemic
| 2021–2022
| India
| [[Black fungus (COVID-19 condition)]]
| 4,332
| <ref>{{Cite web|date=22 July 2021|title=India reports 45,374 Black fungus cases, 4,332 deaths so far, says Health Ministry|url=https://www.aninews.in/news/national/general-news/india-reports-45374-black-fungus-cases-4332-deaths-so-far-says-health-ministry20210722140700/|access-date=22 July 2021|website=[[Asian News International]]}}</ref>
|-
| [[2022 hepatitis of unknown origin in children]]
| 2021–2022
| Worldwide
| [[Hepatitis]] by [[Adenovirus]] variant AF41 (Unconfirmed)
| strong|18
| <ref>{{Cite web|title=Mystery liver disease kills three more children after "unexpected significant increase" in cases reported|url=https://www.cbsnews.com/news/hepatitis-children-3-deaths-indonesia/|website=[[CBS News]]|date=3 May 2022 }}</ref><ref>{{Cite web|title=CDC investigating 109 cases of severe hepatitis in kids across two dozen states, including 5 deaths|url=https://www.cnbc.com/2022/05/06/cdc-investigating-severe-hepatitis-in-children.html|website=[[CNBC]]|date=6 May 2022 }}</ref><ref>{{Cite news|title=UPDATE: Israel report death of a child as Acute Hepatitis cases rise to 228 cases in mysterious global outbreak|url=https://euroweeklynews.com/2022/05/04/who-acute-hepatitis-cases-in-children-rise-to-228-cases-in-mysterious-global-outbreak/|website=Euro Weekly News|date=4 May 2022 }}</ref>
|-
|- style="font-weight: bold;"
| [[2022–2024 Southern Africa cholera outbreak]]
| 2022–present
| Southern Africa
| [[Cholera]]
| 3000+
|<ref>{{cite web|url=https://www.unicef.org/esa/reports/cholera-outbreak-eastern-and-southern-africa-2023|title=The cholera outbreak in Eastern and Southern Africa isn't just an outbreak, it's an emergency for children|work=[[UNICEF]]|date=2023}}</ref>
|-
| [[2022–2023 mpox outbreak]]
| 2022–2023
| Worldwide
| [[Mpox]]
| 280
|<ref>{{cite web |last1=Steenhuysen |first1=Julie |title=Texas reports first U.S. death in person with monkeypox |url=https://www.reuters.com/world/us/texas-reports-first-us-death-person-with-monkeypox-2022-08-30/ |website=Reuters |language=en |date=30 August 2022}}</ref><ref>{{cite web |last1=Faus |first1=Joan |title=Spain reports second monkeypox-related death in Europe |url=https://www.reuters.com/world/europe/spain-confirms-first-monkeypox-related-death-country-reports-2022-07-29/ |website=Reuters |access-date=9 September 2022 |language=en |date=30 July 2022}}</ref><ref>{{cite web |title=Monkeypox |url=https://africacdc.org/wp-content/uploads/2022/08/AfricaCDC_MonkeypoxBrief5_11Aug22_EN.docx.pdf |website=African CDC |access-date=9 September 2022}}</ref><ref>{{cite web |title=RDC : 3 décès et 69 nouveaux cas de Variole de singe enregistrés au Sankuru |url=https://actualite.cd/2022/08/12/rdc-3-deces-et-69-nouveaux-cas-de-variole-de-singe-enregistres-au-sankuru |website=Actualite.cd |access-date=9 September 2022 |language=fr |date=12 August 2022}}</ref>
|-
| [[2022 Uganda Ebola outbreak]]
| 2022–2023
| Uganda
| [[Sudan ebolavirus]]
| 77
|<ref>{{cite web |title=Ebola outbreak in Uganda declared over |url=https://bnonews.com/index.php/2023/01/ebola-outbreak-in-uganda-declared-over/ |website=[[BNO News]] |access-date=11 January 2023 |language=en |date=11 January 2023}}</ref>
|-
|- style="font-weight: bold;"
| [[2023–2024 Zambian cholera outbreak]] (part of the [[2022–2024 Southern Africa cholera outbreak]])
| 2023–present
| Zambia
| [[Cholera]]
| 685
|<ref>{{cite web|url=https://www.unicef.org/zambia/stories/cholera-threatens-lives-zambia|title=Cholera Threatens Lives of Children and their Families in Parts of Zambia|work=[[UNICEF]]}}</ref>
|-
|2023 South Poland Legionellosis outbreak
|2023
|Poland
|[[Legionnaires' disease]]
|41
|<ref>{{cite web |title=Legionellosis – Poland |url=https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON487 |website=www.who.int |access-date=16 January 2024 |language=en}}</ref><ref>{{cite news |title=Poland: Legionnaire's bacteria outbreak kills 19 – DW – 09/02/2023 |url=https://www.dw.com/en/poland-legionnaires-bacteria-outbreak-kills-19/a-66704372 |access-date=27 September 2023 |work=dw.com |language=en}}</ref>
|- style="font-weight: bold;"
| [[African mpox epidemic]]
| 2023–present
| Worldwide, primarily Africa
| [[Mpox]]
| 812
|<ref>{{cite web|url=https://www.wsj.com/world/africa/mpox-africa-who-global-health-emergency-f96d1033 |title=Rapid Spread of Mpox in Africa Is Global Health Emergency, WHO Says |website=www.wsj.com |access-date=2024-08-16}}</ref>
|- style="font-weight: bold;"
| [[2023–2024 Bangsamoro measles outbreak]]
| 2023–present
| [[Bangsamoro]], Philippines
| [[Measles]]
| 14
|
|-
|[[2023–2024 Oropouche virus disease outbreak]]
|2023–2024
|Brazil
|[[Oropouche fever]]
|2
|<ref>{{Cite web |title=Oropouche: The mysterious 'sloth virus' with no treatment |url=https://www.bbc.com/future/article/20240829-oropouche-the-mysterious-sloth-virus-with-no-treatment |access-date=2024-08-30 |website=www.bbc.com |date=29 August 2024 |language=en-GB}}</ref><ref>{{Cite journal |last=Lenharo |first=Mariana |date=2024-08-26 |title=Mysterious Oropouche virus is spreading: what you should know |url=https://www.nature.com/articles/d41586-024-02746-2 |journal=Nature |language=en |doi=10.1038/d41586-024-02746-2|pmid=39187671 |url-access=subscription }}</ref><ref>{{Cite journal |last=Morrison |first=Andrea |date=2024 |title=Oropouche Virus Disease Among U.S. Travelers — United States, 2024 |journal=MMWR. Morbidity and Mortality Weekly Report |language=en-us |volume=73 |issue=35 |pages=769–773 |doi=10.15585/mmwr.mm7335e1 |issn=0149-2195|doi-access=free |pmid=39236058 |pmc=11376504 }}</ref>
|-
|'''[[2024 dengue outbreak in Latin America and the Caribbean|2024 American dengue epidemic]]'''
|'''2024–present'''
|'''Latin America and the Caribbean'''
|'''[[Dengue virus]]'''
|'''8,186'''
|<ref>{{Cite web|url=https://foreignpolicy.com/2024/06/14/latin-america-dengue-outbreak-covid-pandemic-brazil/|title=Dengue Surge Grips Latin America|first=Catherine|last=Osborn|date=August 26, 2024}}</ref>
|-
|'''[[2024 Kwango province malaria outbreak]]'''
|'''2024–present'''
|'''Democratic Republic of the Congo'''
|'''[[Malaria]]'''
|'''143'''
|<ref>{{Cite web|url=https://www.contagionlive.com/view/severe-malaria-identified-as-cause-of-outbreak-in-drc-s-kwango-province|title=Severe Malaria Identified as Cause of Outbreak in DRC's Kwango Province|first=Sophia|last=Abene|date=December 18, 2024}}</ref>
|-
|'''[[HMPV pandemic|HMPV outbreak in East Asia]]'''
|'''2024–present'''
|'''East Asia'''
|'''[[Human metapneumovirus]] (HMPV)'''
|'''Unknown'''
|
|}

==See also==
{{portal|Pandemic}}
* {{annotated link|Globalization and disease}}
* {{annotated link|History of smallpox}}
* {{annotated link|List of Ebola outbreaks}}
* {{annotated link|List of infectious diseases}}
* {{annotated link|List of natural disasters by death toll#Deadliest epidemics}}
* {{annotated link|Timeline of plague}}

== Explanatory notes ==
{{notelist}}

==References==
{{reflist}}

==Further reading==
* Eisenberg, Merle, and Lee Mordechai. "The Justinianic Plague and Global Pandemics: The Making of the Plague Concept." ''American Historical Review'' 125.5 (2020): 1632–1667.
* {{Cite journal |last=Hunter |first=Philip |year=2007 |title=Inevitable or avoidable? Despite the lessons of history, the world is not yet ready to face the next great plague |journal=EMBO Reports |volume=8 |issue=6 |pages=531–534 |doi=10.1038/sj.embor.7400987 |pmc=2002527 |pmid=17545992}}
* {{cite book |title=Epidemics and Society: From the Black Death to the Present |year=2019 |first=Frank M. |last=Snowden |publisher=Yale University Press |isbn=978-0300192216}}

== External links ==
* {{commons category-inline|Epidemics}}

{{cbignore|bot=medic}}{{Disasters}}
{{Natural disasters}}
{{Epidemics}}
{{History of infectious disease}}
{{History of medicine}}
{{Public health}}

{{DEFAULTSORT:Epidemics, List Of}}
[[Category:Epidemics| ]]
[[Category:Lists of disease outbreaks]]
[[Category:Globalization-related lists]]
[[Category:Lists by death toll]]
[[Category:Pandemics]]