3,3'-Diindolylmethane
Template:Short description Script error: No such module "Unsubst". <templatestyles src="Chembox/styles.css"/>
Template:Chembox image cellTemplate:Chembox AllOtherNamesTemplate:Chembox headerbarTemplate:Chembox IndexlistTemplate:Chembox JmolTemplate:Chembox ChEMBLTemplate:Chembox ECHATemplate:Chembox E numberTemplate:Chembox IUPHAR ligandTemplate:Chembox UNIITemplate:Chembox CompToxTemplate:Chembox headerbarTemplate:Chembox HazardsTemplate:Chembox Datapage checkTemplate:Yesno| Template:Longitem | Template:Unbulleted list |
| Template:Longitem | 223072 |
| ChEBI | Template:Unbulleted list |
| ChemSpider | Template:Unbulleted list |
| DrugBank | Template:Unbulleted list |
| EC Number | Template:Unbulleted list |
| KEGG | Template:Unbulleted list |
| Template:Longitem | Template:Unbulleted list |
| RTECS number | Template:Unbulleted list |
| Script error: No such module "collapsible list". | |
| Script error: No such module "collapsible list". | |
| Template:Longitem | Template:Chembox Elements/molecular formula |
| Molar mass | Template:Chem molar mass |
Template:Chembox Footer/tracking container onlyScript error: No such module "TemplatePar".Template:Short description
3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.[1] It and its parent compound Template:Ndash indole-3-carbinol Template:Ndash are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms.[1][2] DIM is sold as a dietary supplement.[1]
Properties
In vitro, DIM has action as a histone deacetylase inhibitor,[1] specifically against HDAC1, HDAC2, and HDAC3.[3] DIM is a metabolite of indole-3-carbinol. [4]
DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.[5][6]
A study conducted in 2023 by researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, found that DIM can reduce biofilms responsible for dental plaque and cavities by 90%.[7] since 2025[update]Template:Dated maintenance category (articles)Script error: No such module "Check for unknown parameters"., no clinical trials have been conducted that confirm the effectiveness of DIM in reducing plaque.
See also
- Glucobrassicin, precursor to indole-3-carbinol
- Phytochemicals
References
<templatestyles src="Reflist/styles.css" />
- ↑ a b c d Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".
External links
- Diindolylmethane Information Resource Center, University of California-Berkeley