ISC

Arts and entertainment

Imperial Space Command, a fictional organization in the books by Catherine Asaro
Indian Society of Cinematographers, a non-profit cultural and educational organisation
International Sculpture Center, a non-profit organization headquartered in Hamilton, New Jersey, US
Intervision Song Contest, an Eastern Bloc version of the Eurovision Song Contest from the 1970s and 1980s
Iraq-Syria Caliphate or simply ISC, fictional terrorist organization (based on ISIS) in the 2017 Indian film Tiger Zinda Hai

International Science Council, a non-governmental organization uniting scientific bodies
International Seismological Centre, a seismology data center
Intersystem crossing, an excited state dynamic in chemistry and physics
Iron–sulfur cluster biosynthesis protein family, machinery for producing iron–sulfur clusters

Initiative for Software Choice, a group of software vendors
Interactive Systems Corporation, a defunct Unix vendor
Internet Storm Center, a program run by the SANS Institute that monitors the level of malicious activity on the Internet
International Supercomputing Conference, a yearly conference on Supercomputing which has been held in Europe
Inverse Symbolic Calculator
Internet Systems Consortium, an organization that develops Internet software
- ISC license, a free software license introduced by the Internet Systems Consortium

Independent Schools Council, a British organization representing independent schools
Indian School Certificate, a national level examination for the upper years (Classes XI and XII) of high school
Information Systems and Controls in the Uniform Certified Public Accountant Examination
Institut supérieur du commerce de Paris, a French business school
International School of Carthage, a private school in Tunis, Tunisia
International School of Curitiba, a school in Curitiba, Brazil
International Students' Committee, organizers of the St. Gallen Symposium in Switzerland
International Student Conference, a nonpartisan rival organization to the International Union of Students
Islamic World Science Citation Database, Iranian regional citation index

International Shooto Commission, an international commission of combat sports called MMA
International Softball Congress, a North American softball tournament organization
International Speedway Corporation, former auto racing race track owner; merged with NASCAR in 2019
ISC (sportswear), an Australian sports apparel manufacturer
International Sportsworld Communicators, the owner of the commercial rights to the World Rally Championship
Indonesia Soccer Championship, a football league system in Indonesia
- Indonesia Soccer Championship A, a top-tier league
- Indonesia Soccer Championship B, a second-tier league

Indigenous Services Canada
Infiltration Surveillance Center, the defunct command center for Operation Igloo White in Nakhon Phanom, Thailand
Intelligence and Security Committee, a committee of the UK Parliament
International Signal and Control, an American defense contractor
International Socialist Commission
International Silver Company, a corporation banding together many existing silver companies in Connecticut
Information Services Corporation, a corporation responsible for the development, management and administration of: registries – land titles, personal property, corporate and survey registries in Saskatchewan
Kandersteg International Scout Centre, Switzerland

Internet Scrabble Club, an online Scrabble website
St Mary's Airport, Isles of Scilly (IATA airport code), an airport in the Isles of Scilly
International service center, a type of United States Postal Service facility